Jean‐Louis Montastruc

Université de Toulouse

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Maryse Lapeyre‐Mestre

Université de Toulouse

163

Haleh Bagheri

Centre Hospitalier Universitaire de Toulouse

118

Geneviève Durrieu

Inserm

François Montastruc

Centre Hospitalier Universitaire de Toulouse

Jean‐Michel Sénard

Institut des Maladies Métaboliques et Cardiovasculaires

Olivier Rascol

Inserm

Christine Damase‐Michel

Pharmacochimie et Pharmacologie pour le Développement

Isabelle Lacroix

Pharmacochimie et Pharmacologie pour le Développement

Agnès Sommet

Université de Toulouse

Vanessa Rousseau

Centre Hospitalier Universitaire de Toulouse

Cooperative Institutions

Inserm

523

Centre Hospitalier Universitaire de Toulouse

356

Université de Toulouse

323

Université Toulouse III - Paul Sabatier

284

Hôpital Purpan

183

Centre National de la Recherche Scientifique

154

Hôpital Rangueil

152

Pharmacochimie et Pharmacologie pour le Développement

121

Assistance Publique – Hôpitaux de Paris

Center of Immunology Pierre Fabre

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Spinal Anesthesia Failure After Local Anesthetic Injection Into Cerebrospinal Fluid

Obstetric Anesthesia Digest (2012)

Régis Fuzier B. Bataille V. Fuzier A.-S. Richez J. P. Maguès

Log in Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] Invalid username or password. Try again or register an account. default message Login No user account? Register for free. Register for free. Lippincott Journals Subscribers, use your username or email along with your password to log in. Forgot Password? or Register Register for a free account Existing User Log In Existing User Log In Registered users can save articles, searches, and manage email alerts. All registration fields are required. What's your profession? Academic Medicine Acute Care Nursing Addiction Medicine Administration Advanced Practice Nursing Allergy & Immunology Allied Health Alternative & Complementary Medicine Anesthesiology Anesthesiology Nursing Audiology & Ear and Hearing Basic Science Cardiology Cardiothoracic Surgery Cardiovascular Nursing Cardiovascular Surgery Child Neurology Child Psychiatry Chiropractics Clinical Sciences Colorectal Surgery Community Health Critical Care Critical Care Nursing Dentistry Dermatology Emergency Medicine Emergency Nursing Endocrinology Endoncrinology Forensic Medicine Gastroenterology General Surgery Genetics Geriatrics Gynecologic Oncology Hand Surgery Head & Neck Surgery Hematology/Oncology Hospice & Palliative Care Hospital Medicine Infectious Disease Infusion Nursing Internal/General Medicine Internal/General Medicine Residency Library Sciences Maternal Child Nursing Medical Oncology Medical Research Neonatal/Perinatal Neonatal/Perinatal Nursing Nephrology Neurology Neurosurgery Nursing-administrative Nursing-all Specialties Nursing-education Nutrition & Dietetics Obstetrics & Gynecology Obstetrics & Gynecology Nursing Occupational & Environmental Medicine Oncology Nursing Oncology Surgery Ophthalmology/Optometry Oral & Maxillofacial Surgery Orthopedic Nursing Orthopedics/Spine/Sports Medicine Surgery Otolaryngology Pain Medicine Pathology Pediatric Surgery Pediatrics Pharmacology Pharmacy Physical Medicine & Rehabilitation Physical Therapy & Womens Health Physical Therapy Plastic Surgery Podiatary-general Podiatry-general Primary Care/Family Medicine/General Practice Psychiatric Nursing Psychiatry Psychology Public Health Pulmonology Radiation Oncology/Therapy Radiology Rheumatology Skills & Procedures Sleep Medicine Sport & Exercise/Training/Fitness Sports Medicine Surgical Nursing Transitional Care Transplant Surgery Trauma Nursing Trauma Surgery Urology Womens Health Wound Care Other What's your speciality? Addiction Medicine Allergy & Clinical Immunology Anesthesiology Audiology & Speech-Language Pathology Cardiology Cardiothoracic Surgery Critical Care Medicine Dentistry, Oral Surgery & Medicine Dermatology Dermatologic Surgery Emergency Medicine Endocrinology & Metabolism Family or General Practice Gastroenterology & Hepatology Genetic Medicine Geriatrics & Gerontology Hematology Hospitalist Immunology Infectious Diseases Internal Medicine Legal/Forensic Medicine Nephrology Neurology Neurosurgery Nursing Nutrition & Dietetics Obstetrics & Gynecology Oncology Ophthalmology Orthopedics Otorhinolaryngology Pain Management Pathology Pediatrics Plastic/ Reconstructive Sugery Pharmacology & Pharmacy Physiology Psychiatry Psychology Public, Environmental & Occupational Health Radiology, Nuclear Medicine & Medical Imaging Physical Medicine and Rehabilitation Respiratory/Pulmonary Medicine Rheumatology Sport Medicine/Science Surgery (General) Trauma Surgery Toxicology Transplantation Surgery Urology Vascular Surgery Virology I don't have a medical specialty What's your work setting? Hospital Under 250 Beds Hospital Over 250 Beds Eldercare or Hospice Facility Psychiatric or Rehabilitative Facility Private Practice Group Practice Corporation (Pharmaceutical, Biotechnology, Engineering, etc.) Doctoral University or Medical School Masters or 4-Year Academic University Community College Government Other I have read & acknowledge the End User License Agreement. I have read & accept the terms of the Privacy Policy. Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious Issues Collections Obstetric Airway ManagementMaternal EmbolismRegional Anesthesia for Cesarean SectionGeneral Anesthesia for Cesarean SectionAnalgesia for LaborObstetric HemorrhagePre-Eclampsia/EclampsiaPharmacologyTraumaInfection and SepsisMaternal ObesityMaternl Morbidity and MortalityNeonatal Morbidity and MortalityObstetric ComplicationsAnesthetic ComplicationsNon-Obstetric Maternal DiseaseCritical CareDrug Abuse in PregnancyEthicsSystems Based Practice For Authors Information for AuthorsLanguage Editing Services Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search

Surgical oncology

10.1097/01.aoa.0000414087.68086.c9

Cite

Citations (0)

Pharmacovigilance and drug safety: Fair prescribing and clinical research

Therapies (2022)

Jean‐Louis Montastruc

10.1016/j.therap.2022.03.001

Cite

Citations (68)

First French Experience of ADR Reporting by Patients After a Mass Immunization Campaign with Influenza A (H1N1) Pandemic Vaccines

Drug Safety (2012)

Geneviève Durrieu Aurore Palmaro Laure Pourcel Céline Caillet Angeline Faucher

Pandemic

MedDRA

Adverse drug reaction

10.1007/bf03261980

Cite

Citations (30)

La pharmacovigilance et l'évaluation du risque médicamenteux: intérêt, fonctionnement et méthodes

Revue du Rhumatisme (2006)

Jean‐Louis Montastruc Agnès Sommet Isabelle Lacroix Pascale Olivier Geneviève Durrieu

INT

10.1016/j.rhum.2006.09.008

Cite

Citations (2)

Idazoxan, an alpha‐2 antagonist, and L‐DOPA‐induced dyskinesias in patients with Parkinson's disease

Movement Disorders (2001)

Olivier Rascol Isabelle Arnulf H. Peyro‐Saint Paul Christine Brefel‐Courbon Marie Vidailhet

Abstract Dyskinesia is a frequent and disabling side effect in patients with Parkinson's disease treated with chronic dopatherapy. Preclinical data in the 1‐methyl‐4‐phenyl‐1,2,3,6,‐tetrahydropyridine (MPTP) monkey suggest that alpha‐2 antagonists may reduce dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia. We assessed, in a pilot randomised placebo‐controlled study, the effects of single oral doses (10 mg, 20 mg, and 40 mg) of idazoxan, an alpha‐2 antagonist, on motor parkinsonian disability and L‐DOPA‐induced dyskinesia following an acute oral challenge of L‐DOPA in 18 patients with Parkinson's disease. The severity of L‐DOPA‐induced dyskinesia improved after 20 mg idazoxan pretreatment, while there was no concommittant deterioration in the antiparkinsonian response to L‐DOPA. These results suggest that blocking alpha‐2 receptors in patients with Parkinson's disease might improve L‐DOPA‐induced dyskinesia without the cost of a return of parkinsonian symptomatology. Further studies are required to assess whether this property could have potential therapeutic applications in the long‐term management of dyskinetic patients with Parkinson's disease. © 2001 Movement Disorder Society.

Idazoxan

Carbidopa

10.1002/mds.1143

Cite

Citations (148)

Drug-Induced Dental Caries, Lessons from a Disproportionality Analysis in Vigibase®: Beware of Bisphosphonates, Atropinic, Immunosuppressant and Hyperglycaemic Drugs

Clinical Therapeutics (2017)

Emilie Patras de Campaigno Inès Kebir Maryse Lapeyre‐Mestre Jean‐Louis Montastruc Fabien Despas

10.1016/j.clinthera.2017.05.129

Cite

Citations (0)

Vomiting and constipation associated with tramadol and codeine: a comparative study in VigiBase®

European Journal of Clinical Pharmacology (2018)

François Montastruc Justine Bénevent Leila Chebane Vanessa Rousseau Geneviève Durrieu

10.1007/s00228-018-2536-z

Cite

Citations (3)

Rapport sur les anticoagulants oraux directs (AOD) (antérieurement appelés « nouveaux anticoagulants oraux » ou NACO)

Bulletin de l Académie Nationale de Médecine (2014)

G Bouvenot Jean–Paul Bounhoure Jean‐Louis Montastruc A Vacheron

10.1016/s0001-4079(19)31265-8

Cite

Citations (3)

Reserpine induces vascular α₂‐adrenergic supersensitivity and platelet α₂‐adrenoceptor up‐regulation in dog

British Journal of Pharmacology (1990)

Luís Estañ Jean‐Michel Sénard Marie‐Antoinette Tran Jean‐Louis Montastruc M Berlan

The aim of the present study was to investigate the influence of catecholamine levels on the regulation of α 2 ‐adrenoceptor sensitivity in dogs. Blood pressure and heart rate values at rest, plasma catecholamine levels, platelet and adipocyte α 2 ‐adrenoceptors as well as the α 2 ‐mediated cardiovascular responses to clonidine (10 μg kg −1 i.v., after α 1 ‐, β‐adrenoceptor plus muscarinic blockade) or noradrenaline (0.5, 1, 2 and 4 μg kg −1 i.v. after α 1 ‐ and β‐adrenoceptor blockade) were measured before and after reserpine treatment (0.1 mg kg −1 day −1 s.c. over 15 days). Reserpine induced a significant decrease in resting systolic and diastolic blood pressures (213 ± 2/87 ± 6 mmHg before vs 158 ± 5/59 ± 3mmHg after treatment) as well as in heart rate (91 ± 2 beats min −1 before vs 76 ± 3 beats min −1 after treatment). A 5 min tilt test performed under chloralose anesthesia, failed to modify blood pressure before treatment whereas it induced a significant fall in the same animals after the 15 day treatment. Plasma levels of noradrenaline significantly decreased (262 ± 58 vs 66 ± 31 pg ml −1 ) whereas plasma adrenaline levels were unchanged. The α 2 ‐mediated pressor responses to noradrenaline were significantly increased after reserpine. Clonidine induced a marked pressor effect (+72 and +45% in systolic and diastolic blood pressures respectively) after reserpine treatment. This effect was suppressed by administration of RX‐821002, a new specific α 2 ‐adrenoceptor antagonist. Reserpine treatment significantly increased platelet α 2 ‐adrenoceptor number (identified with [ 3 H]‐yohimbine or [ 3 H]‐RX821002) with no change in K d values. α 2 ‐Adrenoceptor number remained unchanged in adipocytes (identified with [ 3 H]‐RX821002). These results show that a 15 day treatment with reserpine induces a vascular α 2 ‐adrenergic supersensitivity and an up‐regulation in platelet α 2 ‐adrenoceptors. In contrast, this phenomenon does not involve all the tissues since adipocyte α 2 ‐adrenoceptors escape the effect of reserpine. We suggest that the levels of plasma noradrenaline play an important role in the regulation of the platelet and vascular α 2 ‐adrenoceptors. In contrast, adipocyte α 2 ‐adrenoceptors are not affected by changes in plasma noradrenaline levels.

Reserpine

10.1111/j.1476-5381.1990.tb12710.x

Cite

Citations (25)

Adverse drug reactions in patients older than 70 years during the heat wave occurred in France in summer 2003: a study from the French PharmacoVigilance Database

Pharmacoepidemiology and Drug Safety (2006)

Fleur Michenot Agnès Sommet Haleh Bagheri Maryse Lapeyre‐Mestre Jean‐Louis Montastruc

To evaluate adverse drug reactions (ADRs) in patients older than 70 years reported during the 2003 summer heat wave in France to the French Network of Pharmacovigilance Centres and to discuss the interest of such a pharmacovigilance database in the surveillance of such sanitary alerts.All 'serious' ADRs occurred in patients older than 70 years between 1st July and 31st August 2003, reported to the French network of Pharmacovigilance Centres and recorded in the French PharmacoVigilance Database, were analysed with respect to age, gender, type of ADR, drug(s) involved as well as imputability of heat wave.The total number of 'serious' ADRs registered in the French PharmacoVigilance Database in patients older than 70 years was similar in 2003 (a year with heat wave) and in 2002 (a year without heat wave). Sixty-eight ADRs [27 'possible' (I1), 27 'plausible' (I2) and 14 'likely' (I3)] related to heat occurred in 2003, with a maximal peak between the 28th July and the 17th August. The most frequently ADRs were metabolic (dehydratation, hydroelectrolytic disturbances) and neuropsychiatric (confusion, falls, coma). Drugs more frequently involved were diuretics, angiotensin converting enzyme inhibitors, antidepressants (mainly serotonin reuptake inhibitors), proton pump inhibitors, digoxin, benzodiazepines, oral hypoglycemics and sartans.This study underlines the role of heat wave in the occurrence of 'serious' ADRs in elderly. However, the French PharmacoVigilance Database was not enough sensitive to be used as an efficient surveillance system during such an acute episode, like a heat wave (at least while underreporting remains so important).

Adverse drug reaction

Drug reaction

Heat wave

10.1002/pds.1284

Cite

Citations (32)