Aline Carralas Queiroz de Leão

Universidade de São Paulo

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Roberta Schiavon Nogueira

Secretaria da Saúde

Maria Silvia Biagioni Santos

Instituto de Infectologia Emílio Ribas

Leda Fátima Jamal

Secretaria da Saúde

Anna S. Levin

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Patrícia Rady Müller

Secretaria da Saúde

Sofia Luz Antonorsi

Giselle de Faria Romero Soldi

Instituto Adolfo Lutz

Elaine Monteiro Matsuda

Centro Universitário Fundação Santo André

ÁF

Álvaro Furtado Costa

Rita de Cássia Soler

Instituto de Infectologia Emílio Ribas

Cooperative Institutions

Universidade de São Paulo

Secretaria da Saúde

Instituto de Infectologia Emílio Ribas

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Instituto Adolfo Lutz

Universidade Federal de São Paulo

Instituto de Medicina Tropical

Universidade Brasil

Centro Universitário Fundação Santo André

Instituto de Medicina Avançada

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in São Paulo, Brazil

Archives of Virology (2018)

Luana Portes Ozório Coelho Elaine Monteiro Matsuda Roberta Schiavon Nogueira Mônica Jacques de Moraes Leda Fátima Jamal

Dolutegravir

Regimen

Viremia

HIV drug resistance

10.1007/s00705-018-04122-8

Cite

Citations (12)

Acinetobacter spp. are associated with a higher mortality in intensive care patients with bacteremia: a survival analysis

BMC Infectious Diseases (2016)

Aline Carralas Queiroz de Leão Paulo Rossi Menezes Maura Salaroli de Oliveira Anna S. Levin

It has been challenging to determine the true clinical impact of Acinetobacter spp., due to the predilection of this pathogen to colonize and infect critically ill patients, who often have a poor prognosis. The aim of this study was to assess whether Acinetobacter spp. bacteremia is associated with lower survival compared with bacteremia caused by other pathogens in critically ill patients. This study was performed at Hospital das Clínicas, University of São Paulo, Brazil. There are 12 intensive care units (ICUs) in the hospital: five Internal Medicine ICUs (emergency, nephrology, infectious diseases and respiratory critical care), three surgical ICU (for general surgery and liver transplantion), an Emergency Department ICU for trauma patients, an ICU for burned patients, a neurosurgical ICU and a post-operative ICU. A retrospective review of medical records was conducted for all patients admitted to any of the ICUs, who developed bacteremia from January 2010 through December 2011. Patients with Acinetobacter spp. were compared with those with other pathogens (Klebsiella pneumoniae, Staphylococcus aureus, Enterobacter spp., Enterococcus spp., Pseudomonas aeruginosa). We did a 30-day survival analysis. The Kaplan-Meier method and log-rank test were used to determine the overall survival. Potential prognostic factors were identified by bivariate and multivariate Cox regression analysis. One hundred forty-one patients were evaluated. No differences between patients with Acinetobacter spp. and other pathogens were observed with regard to age, sex, APACHE II score, Charlson Comorbidity Score and type of infection. Initial inappropriate antimicrobial treatment was more frequent in Acinetobacter bacteremia (88 % vs 51 %). Bivariate analysis showed that age > 60 years, diabetes mellitus, and Acinetobacter spp. infection were significantly associated with a poor prognosis. Multivariate model showed that Acinetobacter spp. infection (HR = 1.93, 95 % CI: 1.25–2.97) and age > 60 years were independent prognostic factors. Acinetobacter is associated with lower survival compared with other pathogens in critically ill patients with bacteremia, and is not merely a marker of disease severity.

Bacteremia

Medical microbiology

10.1186/s12879-016-1695-8

Cite

Citations (42)

DESCONTINUAÇÃO DE TRATAMENTO E EVENTOS ADVERSOS EM UMA COORTE DE PACIENTES EM USO DE ESQUEMA ANTIRRETROVIRAL CONTENDO DOLUTEGRAVIR

The Brazilian Journal of Infectious Diseases (2018)

Aline Carralas Queiroz de Leão Álvaro Furtado Costa Roberta Schiavon Nogueira Leda Fátima Jamal Maria Silvia Biagioni Santos

Dolutegravir

10.1016/j.bjid.2018.10.024

Cite

Citations (0)

Impacto das bacteremias por Acinetobacter spp. em relação a bacteremias causadas por outras bactérias na sobrevida de pacientes internados em unidade de terapia intensiva

Aline Carralas Queiroz de Leão

Introduction: It has been challenging to determine the true clinical impact of Acinetobacter spp., given the predilection of this pathogen to colonize and infect critically ill patients, who often have a poor prognosis irrespective of secondary infective complications.Objective: The aim of this study was to assess whether the survival of patients with Acinetobacter spp.bacteremia is lower than that of patients with bacteremia caused by other bacteria prevalent in intensive care unit.Setting: A retrospective review of medical records was conducted for all patients admitted to the ICUs who developed bacteremia from January 2010 through December 2011.Patients with Acinetobacter spp.were compared with those with other pathogens (Klebsiella pneumoniae, Staphylococcus aureus, Enterobacter spp., Enterococcus spp., Pseudomonas aeruginosa).We did a 30-day survival analysis.The Kaplan-Meier method and log-rank test were used to determine the overall survival.Potential prognostic factors were identified by bivariate and multivariate Cox regression analysis.Results: 141 patients were evaluated.No differences between patients with Acinetobacter spp.and other pathogens were observed with regard to age, sex, APACHE II score, Charlson Comorbidity Score and type of infection.Bivariate analysis showed that age>60 years, diabetes mellitus, Acinetobacter spp.infection, inappropriate treatment, Pitt Bacteremia score >3, presence of septic shock, mechanical ventilation, use of central line and number of organ failures > 2 were significantly associated with a poor prognosis.We did two models of logistic regression analysis.Model A showed that inappropriate treatment and Pitt score > 3 points were statistically associated with mortality.In model B, Acinetobacter spp.infection (HR= 1.93, 95%CI: 1.25-2.97)and age > 60 years were independent prognostic factors.Conclusion: Patients with Acinetobacter spp.bacteremia had lower survival compared with patients with bacteremia caused by other bacteria prevalent in intensive care unit.

Bacteremia

Acinetobacter baumannii

10.11606/d.5.2015.tde-04082015-095159

Cite

Citations (0)

Efficacy and Safety of Liposomal Amphotericin B for the Treatment of Mucosal Leishmaniasis from the New World: A Retrospective Study

American Journal of Tropical Medicine and Hygiene (2015)

Mirella Alves Cunha Aline Carralas Queiroz de Leão Rita de Cássia Soler José Ângelo Lauletta Lindoso

The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.

Amphotericin B deoxycholate

10.4269/ajtmh.15-0033

Cite

Citations (48)

TRATAMENTO DE CRIPTOCOCOSE DISSEMINADA COM ANFOTERICINA LIPOSSOMAL EM GESTANTE COM INFECÇÃO PELO HIV

The Brazilian Journal of Infectious Diseases (2018)

Aline Carralas Queiroz de Leão Maria Silvia Biagioni Santos Ariane de Castro Coelho Daniela Vinhas Bertolini Diego Oliveira Teixeira

10.1016/j.bjid.2018.10.264

Cite

Citations (0)