Fernanda Soldatelli Valente

Universidade Federal de Santa Maria

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Emerson Antônio Contesini

Universidade Federal do Rio Grande do Sul

Simone Passos Bianchi

Universidade Federal do Rio Grande do Sul

Silvana Bellini Vidor

Instituto Federal Farroupilha

Alfredo Quites Antoniazzi

Universidade Federal de Santa Maria

Fábio Vasconcellos Comim

Universidade Federal de Minas Gerais

L. G. Miyazato

Universidade Federal de Santa Maria

Lady Katerine Serrano Mujica

Universidad Cooperativa de Colombia

Aline Silva Gouvêa

Centro Universitário de Rio Preto

Melissa Orlandin Premaor

Universidade Federal de Minas Gerais

Aline Schafrum Macedo

Universidade de São Paulo

Cooperative Institutions

Universidade Federal do Rio Grande do Sul

Universidade Federal de Santa Maria

Hospital de Clínicas de Porto Alegre

Hospital de Clínicas

Universidade de São Paulo

Universidade Federal de Minas Gerais

Hospital Universitário de Santa Maria

Universidade Estadual Paulista (Unesp)

Universidade de Ribeirão Preto

University of Rio Grande and Rio Grande Community College

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Relação entre tempo de cirurgia, temperatura da pele e do enxerto e sobrevivência do enxerto em modelo murino de enxertos livres de pele de espessura total

Cristiano Ely Kipper Silvana Bellini Vidor Paula Barros Terraciano Fernanda Soldatelli Valente Cristiana Palma Kuhl

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Avaliação de produtividade de colônia de camundongo (Mus musculus) modelo para mucopolissacaridoses (MPS): estudo comparativo entre utilização de progenitores em heterozigose e homozigose recessiva

Revista da Sociedade Brasileira de Ciência em Animais de Laboratório (2014)

F Meyer Fernanda Soldatelli Valente Talita Giacomet de Carvalho Guilherme Baldo Úrsula da Silveira Matte

A mucopolissacaridose tipo I (MPS I) e uma doenca herdada de forma autossomica recessiva causada por uma deficiencia da enzima lisossomica alfa-L-iduronidase (IDUA)1,2. Modelos animais de MPS I3 sao ferramentas importantes para o melhor entendimento da doenca e identificacao de novas terapeuticas.

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Flutter atrial e taquicardia ventricular em cão com síndrome dilatação e vólvulo gástrico

ACTA SCIENTIAE VETERINARIAE (2011)

Frederico Aécio Carvalho Soares Simone Passos Bianchi Fernanda Soldatelli Valente Elisa Barp Neuwald

RESUMO Background: Gastric-dilation volvulus complex (GDV) is an acute condition characterized by dilation of the stomach associated with rotation around its mesenteric axis. Cardiac arrhythmias, especially of ventricular origin are frequently found in animals with GDV. Ventricular tachycardia is characterized by three or more ventricular premature complexes in sequence. Atrial fl utter is a supraventricular arrhythmia uncommon in dogs, characterized by rapid atrial rate and altered atrial depolarization resulting in bidirectional saw-toothed atrial complexes. The aim of this work is describe the cardiac arrhythmias and electrocardiographic patterns observed in a postoperative period of seven days in a dog with GDV syndrome. Case: A 2-year-old female dog of Fila Brasileiro breed was presented to veterinary hospital due to an acute onset of abdominal distension. Clinical fi ndings included hyperemic mucous membranes, capillary refi ll time of less than two seconds, normal sounds in cardiac auscultation, heart rate of 160 beats per min, tachypnea, normal femoral pulses and an increased abdominal volume compatible with accumulation of gas. The surgical procedure was the treatment of choice for correction of GDV syndrome. The stomach was dilated, rotated 180 degrees clockwise and possibly with a necrotic area. The spleen was congested and infarcted. During surgery, the patient had a period of low oximetry and two isolated ventricular premature complexes, treated with lidocaine in bolus. In the postoperative period, the electrocardiographic monitoring revealed the presence of two types of arrhythmia. Ventricular tachycardia occurred one day after surgery, being treated with lidocaine in bolus and constant rate infusion. On the third day, the dog developed atrial fl utter, treated with digoxin. On the fourth day, cardiac rhythm returned to normal and showed no further changes up to 7 days after surgery, when the dog was discharged. Discussion: The presence of cardiac arrhythmias in the postoperative period is one of the factors that makes the prognosis worse in dogs with GDV. The etiological mechanism of cardiac arrhythmias in this syndrome has not been elucidated. Among the possibilities are myocardial ischemia, release of myocardial depressant factors, release of catecholamines, electrolyte imbalances and acidosis. Ventricular tachycardia is a relatively common arrhythmia in cases of GDV, which can progress to ventricular fi brillation, the leading cause of deaths from cardiac arrhythmia in dogs with the disease. Among supraventricular arrhythmias, atrial premature complexes were reported, however atrial fl utter was not described before in this syndrome. Moreover, the dog developed cardiac arrhythmia until about 72 h after surgery, unlike another reports. An electrocardiographic pattern changed was the size of the P wave, suggesting left atrial enlargement, but thoracic radiography showed a normal-sized cardiac silhouette. Moreover, the animal showed T wave amplitude greater than 25% of the R wave amplitude, which may be related to low oximetry observed at the start of surgery, possible electrolyte imbalances or be physiological. The present case reinforces the importance of electrocardiographic monitoring in the postoperative GDV, including a period of up to 72 h after surgery. Moreover, it is concluded that atrial fl utter may be another type of arrhythmia caused by secondary changes of GDV syndrome and confi rms the effectiveness of antiarrhythmic therapy with lidocaine in cases of ventricular tachycardia.

Tachypnea

Bolus (digestion)

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[Adipose-derived stem cells in the proliferation phase of the healing process in cold burns]

Figshare (2021)

Fernanda Soldatelli Valente N. Franco Matheus Pippi da Rosa Emanuelle Bortolotto Degregori Cibele Lima Lhamas

ABSTRACT Cryosurgery has been used to treat different diseases of systems and organs, although adverse effects have been reported such as delayed wound healing, large scars, esthetical deformation and functional impairment. Injuries caused naturally by the exposure to extreme cold weather conditions mostly result in gangrene. This study aims to evaluate the influence of adipose-derived stem cells (ADSCs) in the proliferation phase on cutaneous wound healing. Through the application of liquid nitrogen by the spraying technique, a 15 millimeter diameter lesion was produced in the dorsal region of each rat. The wound received treatment according to the group it belonged: 1) ADSCs application on the 15th day (treated group); 2) application of 0.9% sodium chloride solution on the 15th day (sham group); 3) no intervention until euthanasia (control group). The group treated with ADSCs showed the highest wound average contraction rate; this group got a significant statistical difference in relation to the sham group when it refers to neovascularization. The ADSCs therapy provides an important clinical evolution of wounds. This was verified at the end of the evaluation period through narrower and longer scars.

10.6084/m9.figshare.14280090

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Carcinoma de células escamosas na glândula salivar em felino doméstico

MEDVEP. Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação (2012)

Víviam Nunes Pignone Cláudia Stringhini Faraco Fernanda Soldatelli Valente Priscilla da Rosa Camaratta Eduardo José Ludwig

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Abnormalities in Microarchitecture and Reduced Mechanical Bone Strength in a Rat Model of Polycystic Ovary Syndrome

Journal of the Endocrine Society (2021)

Fábio Vasconcellos Comim Lady Katerine Serrano Mujica Fernanda Soldatelli Valente L. G. Miyazato Manuela Wolker Manta

Abstract Evidence from the literature is contentious about the impact of polycystic ovary syndrome (PCOS) on the skeleton, suggesting a possible negative role of this condition on non-obese women. We investigated this hypothesis employing a well-characterized testosterone propionate (TP) rodent model of PCOS to address the consequences of androgenization on bone microarchitecture, histology, and mechanical strength. For this study, Wistar rats (n= 38) were divided in 4 groups: 1) “Control OVX” (single dose of corn oil s.c. at day 5 of life and ovariectomy at day 100, n=9); 2) “Control SHAM” (n=9); 3) “Androgenized OVX”(single dose of TP 1.25 mg s.c. at day 5 of life and ovariectomy at day 100, n=10); and 4) “Androgenized SHAM” (n=10). Full characterization of estrous cycles and weight was performed during growth, and all animals were euthanized at day 180. Successful ovariectomy was confirmed by neglected levels of serum estradiol. Endpoints evaluated include bone micro CT (femur and spinal column), bone histology (number of osteoclasts and osteoblasts in the femur), and mechanical tests. The study was approved by the local Ethics Committee. At the end of the study (day 180), Androgenized OVX rats were heavier than the other three groups. MicroCT Analysis: Androgenized SHAM rats exhibited a significantly higher trabecular mass in the spine (BV/BT) (mean + SEM) 49.21 + 2.42 % versus Control SHAM 36.42 + 1.39 % (Student T-test p=0.001). Following ovariectomy, BV/BT in Androgenized OVX was 40.4 + 2.83 % against 20.34 + 1.85 % in Control OVX (Student T-test p=0.0003). Lumbar trabecular thickness(μm) was also higher in Androgenized OVX (p=0.0065) as well the Trabecular number (n/mm)(p=0.0003). A similar increase in trabecular mass was observed in the femur. Androgenized SHAM rats had a significant higher BV/BT (%), trabecular thickness(μm), and decreased trabecular separation (p < 0.001). However, a significant reduction in cortical bone (thickness) was noted (Student T-test p=0.001). A histological study of the distal femur of Androgenized SHAM rats also show a significantly increased number of osteoclasts and decreased number of osteoblasts than Control SHAM (0< 001). When submitted to the mechanical test, Androgenized Sham rats presented a decreased strength (p<0.01) in relation to its controls. After ovariectomy, there was a reduction in bone in all oophorectomized groups. However, differently than the vertebral bones, no differences regarding bone mechanical strength or stiffness as well microCT values, or bone histology parameters were noted in the femur of Control OVX or Androgenized OVX. Our results suggest that androgenization in a rodent model of PCOS leads, at the same time, to a generalized increase in trabecular (cancellous) bone mass (especially in the spine), associated with a reduced cortical bone mass and decreased strength of the femur.

Testosterone propionate

Histology

10.1210/jendso/bvab048.1552

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Ureter ectópico extramural em cadela

ACTA SCIENTIAE VETERINARIAE (2013)

Simone Passos Bianchi Aline Silva Gouvêa Aline Schafrum Macedo Fernanda Soldatelli Valente Gabriela Reis Ledur

Background: Ureteral ectopia is a congenital abnormality of the terminal segment of one or both ureters, in which the ureteral orifi ce is located distal to the trigone of the bladder. Ureteral ectopia results from dysembryogenesis of the ureteral bud due to its abnormal positioning along the mesonephric duct. It is frequently associated with other congenital anomalies of the lower urinary tract as urethral sphincter dysfunction, hydroureter and hydronephrosis. Ectopic ureters are classifi ed into two categories: extramural and intramural. Extramural ectopic ureters completely bypass the urinary bladder without anatomic attachment, opening directly into the urethra, vagina or uterus. Continuous or intermittent urinary incontinence is the most frequently reported clinical symptom associated with ureteral ectopia, and it is far more frequent in young bitches than in male dogs. Repositioning the distal segment of the ureter and ureteral orifi ce directly into the bladder may restore urinary continence throughout neoureterocistostomy. Case: A 3-month-old female poodle weighting 4 kg was referred to the Teaching Veterinary Hospital of the Federal University of Rio Grande do Sul (HCV-UFRGS), State of Rio Grande do Sul, Brazil, due to urinary incontinence, dysuria and severe vulvar pyodermatitis since it was 9 weeks old. Normal posturing and voiding of urine did occur, although only small volumes of urine were eliminated. Abdominal ultrasound revealed hydronephrosis and hydroureter of both right kidney and ureter. The ureter terminated distal to the urinary bladder, although the exact location of the termination could not be determined, ectopic ureter was suggested. Exploratory celiotomy was performed in order to confi rm the diagnosis and obtain surgical correction. During the surgery it was possible to identify the hydroureter attaching on the distal urethra bypassing the bladder. Surgical correction was performed using the standard neoureterocistostomy technique. Recovery was uncomplicated and lasted 4 weeks, certifi ed with weekly ultrasound exams. Discussion: Although ureteral ectopia has been reported in both purebred and mixed breed dogs, it has been documented to occur with greater frequency in specifi c breeds such as toy poodle, as observed in this case. Urinary incontinence, as observed, is the most frequently reported clinical symptom of patients with ureteral ectopia. Physical examination is often within normal limits with the exception of moist or urine-stained hair in the perivulvar region. Mild to severe perivulvar dermatitis secondary to urine scalding are commonly reported clinical signs, and were present in this case. Ultrasound examination was an effi cient method to identify anatomic anomalies of the inferior urinary tract leading correctly to an exploratory celiotomy, in order to both confi rm and correct the congenital defect. The neoureterocistostomy was satisfactory to reimplant the ureter on the bladder without complications. The degree of urinary incontinence is variable and cannot be used to determine the specifi c location of the ureteral orifi ce, or distinguish between the presence of unilateral or bilateral ectopic ureters and cannot exclude other differential diagnosis. Incontinence in male dogs with this affection may not occur as commonly due to the longer external urethral sphincter that may oppose the passage of urine distally, resulting in retrograde bladder fi lling. Surgical prognosis and recovery was good considering the patient had no other clinical affections.

Hydroureter

Ectopic ureter

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Gestação ectópica associada à mumificação fetal em cadela: relato de caso

Nosso Clínico (2014)

Fernanda Soldatelli Valente Simone Passos Bianchi Fabiane Reginatto dos Santos Alessandra Ventura da Silva Víviam Nunes Pignone

Pica (typography)

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Bone strength is reduced in a neonatal androgenized rat model

Bone Reports (2023)

Lady Katerine Serrano Mujica Carolina dos Santos Amaral Fernanda Soldatelli Valente L. G. Miyazato Soraia Macari

Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, and we aimed to use it to investigate the impact of androgens on microarchitecture (by micro-CT), bone mechanical strength, bone formation and resorption markers in rats with intact ovaries (SHAM) who underwent oophorectomy.Wistar rats (Rattus norvegicus albinus) were employed for the experiments in this study. The protocol of androgenization consisted of the application of 1.25 mg s.c. testosterone propionate beteween days 2-5 of life, while the controls received the same amount of corn oil s.c. as previously established. Androgenized SHAM rats exhibited chronic anovulation identified by vaginal cytology and a reduction in the proportion of corpus luteum in the ovary in comparison to control SHAM rats. The realization of the ovariectomy or SHAM procedure occurred on Day 100 of life. All groups (n = 8) were followed-up for 180 days to address the study endpoints.Micro-CT from androgenized female rats (SHAM) showed a divergence between the trabecular and cortical bone profiles. Compared to SHAM controls, these rats had an increase in trabecular bone mass with a diminution in bone resorption C-terminal telopeptide of type 1 collagen (CTX) (p < 0.05), a concomitant decrease in cortical area and thickness in the femur, and a reduction in the strength of the femur on the mechanical test (p < 0.01).Our results suggest that a reduction in the cortical thickness and cortical area observed in PCOS model rats was associated with a reduced strength of the femur, despite increased trabecular formation. Ovariectomy in the androgenized OVX group limited the progression rate of cortical bone loss, resulting in bone resistance and cortical thickness comparable to those observed in the control OVX group.

Testosterone propionate

Bone remodeling

N-terminal telopeptide

Anovulation

10.1016/j.bonr.2023.101710

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Ablação de canal auditivo vertical em um cão

ACTA SCIENTIAE VETERINARIAE (2011)

Fernanda Soldatelli Valente Kauê Danilo Helene Lemos dos Reis Frederico Aécio Carvalho Soares Tatiane da Silva Mottin Emerson Antônio Contesini

Background: The external otitis is an infl ammatory process that gets at the pinna and the external acoustic meatus of many animals; it can be a pathological...

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