РИ

Р И Овчинников

Institut de Médecine de la Reproduction

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СИ

С. И. Гамидов

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

A. Yu. Popova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

НГ

Н. Г. Гасанов

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Gamidov Si

ТВ

Т. В. Шатылко

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Mazo Eb

СХ

С. Х. Ижбаев

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

ЕБ

Е Б Мазо

Pirogov Russian National Research Medical University

Iremashvili Vv

N. P. Naumov

Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky

Cooperative Institutions

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Sechenov University

Ministry of Health of the Russian Federation

Pirogov Russian National Research Medical University

Peoples' Friendship University of Russia

Moscow State University of Medicine and Dentistry

"National Medical Research Center for Rehabilitation and Balneology" of the Ministry of Health of the Russian Federation

Lomonosov Moscow State University

Moscow State University

Saratov State Medical University

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Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin® Forte) for treatment of male infertility

Urologiia (2019)

С. И. Гамидов Р И Овчинников A. Yu. Popova

Oxidative stress of sperm is a common pathologic condition, which can be detected in 30-80% infertile men. It is established that dietary consumption of antioxidants and microelements contributes to an increase of conception probability in subfertile couples, and also reduces the risk of reproductive losses. Drug complexes influencing various factors of spermatogenesis disturbance (oligo-, astheno-, teratozoospermia), oxidative stress and the level of sperm DNA fragmentation are of greatest and reasonable interest.To study the effects of complex acetyl-l-carnitine, l-carnitine fumarate and alpha-lipoic acid (SpermActin Forte) on oxidative stress, ejaculate quality and sperm DNA fragmentation in men with infertility.A total of 80 infertile men aged 25-40 years with increased level of sperm DNA fragmentation and oxidative stress were included in open-label, prospective, randomized study. In Group A (n=20) patients received a placebo for 180 days, and in Group B patients were prescribed to SpermActin Forte, 1 sachet of 10 g once a day. The criteria for the efficiency of therapy included sperm analysis, the level of sperm DNA fragmentation, the level of sperm oxidative stress, as well as information about achievement of pregnancy, obtained by interviewing all participants.In patients taking antioxidant complex SpermActin Forte there were significant positive changes in the main parameters of sperm analysis, including sperm mobility and morphology starting from the third month of therapy. The level of free oxygen radicals (as indicator of oxidative stress) in Group B also significantly decreased (by 86%). A more profound decrease in DNA fragmentation was seen in Group B compared to Group A (21.5% vs. 3.6%). Pregnancy was achieved in 1 and 13 cases in Group A and B, respectively.The use of the SpermActin Forte antioxidant complex allowed to improve sperm analysis in most patients, and these changes were significant starting from the third month of therapy. Stimulation of spermatogenesis using the antioxidant complex SpermActin Forte is an effective and safe method of treating male infertility.

10.18565/urology.2019.4.61-68

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New aspects of the use of sildenafil in the treatment of erectile dysfunction

DOAJ (DOAJ: Directory of Open Access Journals) (2015)

С. И. Гамидов Р И Овчинников A. Yu. Popova

10.21518/2079-701x-2015-11-54-59

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ROLE OF MALE INFERTILITY IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS (A LITERATURE REVIEW)

Andrology and Genital Surgery (2017)

С. И. Гамидов Р И Овчинников A. Yu. Popova N. P. Naumov Н. Г. Гасанов

Тhe literature review is devoted to the most important medical and social problem of modern medicine — the male infertility. Nowadays the assessment and treatment of male infertility can identify a number of problems: the lack of standard tests for assessing fertility, incomplete knowledge of the pathophysiology of infertility, a shortage of specialists in the field of andrology and male infertility, as well as a lack of necessary technical resources. The lack of proven methods of pharmacotherapy can be added to this list. In comparison with the successes in the detection and treatment of female infertility, the diagnosis and therapy of male, especially idiopathic, remain ineffective and are largely empirical in nature. It is difficult to identify at what rates of spermogram the most frequent failures of the ART program occur, to compare the indicators of failures of ART with the parameters of pathozoospermia to reveal the regularity. Not all pathological mechanisms of fertility disorders in men have developed correct diagnostic tests at the present time, this significantly reduces the prognostic value of the spermogram and makes the question of assessing the disturbances in the character of the spermogram and its effect on the effectiveness of ART procedures extremely topical. There will be discussed the development and effectiveness of ART in the world and in Russia, the role of unfavorable lifestyle factors in infertile couples, the role of male infertility factors and the dependence of the effects of spermogram indices on the results of ART.

Economic shortage

Male fertility

10.17650/2070-9781-2017-18-3-28-36

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Citations (2)

[Postcompression test in diagnosis of vasculogenic erectile dysfunction].

PubMed (2005)

Mazo Eb Gamidov Si Р И Овчинников Andranovich Sv Iremashvili Vv

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Male infertility associated with oxidative stress of spermatozoa: pathogenesis and therapeutic approach

Meditsinskiy sovet = Medical Council (2022)

Р И Овчинников

Infertility is defined as not being to get pregnant for a couple after at least a year of regular sexual life. The condition has become a global health issue affecting about 187 million couples worldwide, and about half of the cases are associated with male factors. There are several external and internal factor infertility. Oxidative stress, which is a common cause of several conditions associated with male infertility is one of the main factors. High levels of reactive oxygen species (ROS) decrease sperm quality through reducing sperm motility and increasing damage to DNA, protein, and lipids. If DNA strand breaks are not repaired, a cell undergoes apoptosis, programmed cell death. The combination antioxidants are considered effective in improving male fertility parameters due to synergistic effects of various components. The mechanism of action of most of them is directed toward reducing ROS concentration, thereby improving sperm quality. In addition, this review considers other natural molecules - myo-inositol and D-chiro-inositol, which improve sperm quality. They are involved in many signalling mechanisms in spermatozoa that regulate cytoplasmic calcium levels, mitochondrial capacity and function. On the other hand, D-chiro-inositol is involved in the inhibition of steroidogenic aromatase enzymes, thereby increasing testosterone levels. In this review, we analyse the processes associated with oxidative stress in male fertility and the mechanisms of action of various molecules, as well as consider treatment options for management of various male reproductive system disorders.

10.21518/2079-701x-2022-16-5-46-53

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Новые аспекты применения силденафила в лечении эректильной дисфункции

Meditsinskiy sovet = Medical Council (2015)

С. И. Гамидов Р И Овчинников Анна Попова

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Assessment of influence of “BESTFertil” supplement on semen analysis parameters, oxidative stress markers and sperm DNA fragmentation index in infertile males

Andrology and Genital Surgery (2019)

С. И. Гамидов A. Yu. Popova Н. Г. Гасанов Р И Овчинников Т. В. Шатылко

Background. Idiopathic male infertility remains an important problem in andrology and reproduction, despite steady advances in diagnostics and treatment of conditions associated with impaired fertility in men. Only available option of conservative treatment for idiopathic male infertility is an empiric antioxidant therapy. Materials and methods. Fifty five men from infertile couples without any identifiable cause of male infertility who received "BESTFertil" supplement were enrolled in this study. Semen analysis parameters (sperm density, percentage of sperm with progressive motility (categories A and B), sperm morphology, leukocyte concentration), MAR-test results, reactive oxygen species concentration as measured by chemiluminescence assay and sperm DNA fragmentation index evaluated using TUNEL method were registered and compared with baseline values after 90 days of treatment. Patient compliance was assessed by a number of capsules taken throughout the study period. Results. There was a significant difference in percentage of sperm with normal morphological features (median 2 % vs 4 %; p <0.001) and in percentage of A + B motile sperm (medium 31.2 % vs 41.15 %; p <0.001). Also, a statistically significant decrease in sperm DNA fragmentation index (median 17.8 % vs 15 %; p <0.001) and reactive oxygen species concentration in seminal plasma (median 0.7 mV/s vs 0.5 mV/s; p = 0.002). Forty-three (78.2 %) patients were fully compliant, 11 (20 %) patients had compliance over 90 %, and 1 patient was 89 % compliant. No treatment-related adverse events were observed. Conclusion. "BESTFertil"supplement may be used in empiric therapy of idiopathic male infertility and has a good safety profile. Separate intake of morning and evening supplement doses increases efficacy of multicomponent antioxidant therapy by preventing possible interaction between biochemically incompatible components. Treatment with "BESTFertil"supplement leads to a decrease in reactive oxygen species seminal concentration and sperm DNA fragmentation index.

Semen Analysis

10.17650/2070-9781-2019-20-1-91-98

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Влияние курения на сексуальную функцию у мужчин

Кремлевская медицина. Клинический вестник (2014)

С. И. Гамидов Р И Овчинников Д. В. Щербаков Р.В. Коротеев

Обзор научных публикаций о влиянии курения на сексуальную функцию мужчин. Ключевые слова: эректильная дисфункция, курение, артериогенная эректильная дисфункция. Smoking effect on the male sexual function Gamidov S.I, Ovchinnikov R.I., Sherbakov D.V., Koroteyev R.V. «Сlinical hospital» of the Department of affairs management of President of Russian Federation, Moscow Pirogov’s Russian State Medical University, Moscow Summary Survey of scientific publications about the influence of smoking on the sexual function of men. Key words: smoking, sexual function, the erectile dysfunction.

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[Viagra, cialis, impase--which of them, to whom, when and how?].

Urologiia (2004)

Е Б Мазо С. И. Гамидов Р И Овчинников

The study has been performed of the efficacy in the treatment of erectile dysfunction (ED) of oral drugs affecting nitric oxide: impase and phosphodiesterase-5 (PDE-5) inhibitors--sildenafil citrate (viagra), tadalafil (sialis)--alone and in combination with impase. A total of 218 ED patients aged 21-73 years (mean age 58.1 +/- 13.2 years) were divided into 3 groups comparable by the number of the patients, age, suspected etiology, pathogenesis and ED severity. Group 1 (n = 81) took viagra in the individually adjusted dose for 6 months; group 2 (n = 64) received sialis in a dose 20 mg for 6 months; group 3 (n = 73) took impase 1 tablet each other day sublingually for 6 months. Overall efficacy made up 77.8, 81.3 and 56.2% for viagra, sialis and impase, respectively. In view of different mechanism of action of PDE-5 inhibitors (viagra, sialis) and impase we combined the drugs in those who failed monotherapy or had drastic side effects. The combination raised efficacy of pharmacotherapy from 56.2 to 92.2%. We came to the conclusion that in psychogenic, isolated neurogenic, compensated and subcompensated arteriogenic ED of a mild or moderate degree, the treatment can be started with impase. If it was uneffective, in severe ED or moderate venoocclusive ED it is better to use PDE-5 inhibitors (viagra, sialis). If one of the latter fails, the other should be administered. If the inhibitors have low efficacy or in side effects, it is indicated to use their combination with impase.

Combination therapy

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[Morphological characteristics of ovarian biopsy specimens in infertility].

PubMed (2013)

Е. А. Дубова Р И Овчинников Popova AIu Pavlov Ka Shchegolev Ai

The authors present the results of their studies and the data available in the literature on the morphological examination of ovarian biopsy specimens in fertility. They highlight the specific features of preparation of histologic specimens. The types of male infertility and impaired spermatogenesis are given and their morphological diagnostic criteria are indicated.

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