Mafalda Santos

Centro Hospitalar de Vila Nova de Gaia

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Domingues Rodrigues

Centro Hospitalar de Vila Nova de Gaia

Filipa Marquês

University of Coimbra

Sara Soares

Centro Hospitalar do Porto

Raquel Fernandes

Polytechnic Institute of Cávado and Ave

Eduardo Santos

Escola Superior de Enfermagem de Coimbra

Filipa Enes

Andreia Ferreira

Centro Hospitalar de Vila Nova de Gaia

Rita Jesus

Ana Andrade

University of Minho

Carlos Aguíar

Hospital de Santa Cruz

Cooperative Institutions

Centro Hospitalar de Vila Nova de Gaia

Universidade do Porto

Centro Hospitalar do Porto

Hospital de Santa Cruz

Universidade de São Paulo

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

University of Coimbra

Centro Hospitalar de Lisboa Ocidental

University of Minho

Centro Hospitalar de Trás os Montes e Alto Douro

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Composite Ultrathin Membranes for Clarification and Primary Recovery of Biobased Itaconic Acid from Fermentation Broths

Mafalda Santos Tim Causon Bart Van der Bruggen Alois Jungbauer

Itaconic acid is a biobased organic acid with clear potential to become a relevant renewable building-block chemical. However, to compete with petrochemical processes, the production cost of biobased processes, particularly the downstream processing contribution, needs to be reduced. In this work, composite membranes comprising ultrathin films of crosslinked poly[(o-cresyl glycidyl ether)-co-formaldehyde] and branched polyethyleneimine on mixed cellulose ester supports were developed for application in the primary recovery of itaconic acid from fermentation broths. In contrast to commercial and literature-reported counterparts, these membranes exhibit low itaconic acid rejections over a wide range of pH, ionic strength, organic acid concentration and operating pressure. Moreover, these membranes can efficiently recover itaconic acid from clarified fermentation broth as well as unclarified fermentation broth of Pichia pastoris cultivations, with average rejections below 15% recorded over 8 hours of operation. Lastly, a comparison between these membranes and literature-reported strategies for primary recovery of biobased organic acids highlighted that, with a recovery of 99%, the membranes developed in this work are among the best performing recovery strategies reported to date. The efficient recovery of itaconic acid from unclarified fermentation broth opens the possibility to perform clarification and primary recovery simultaneously, thus simplifying the downstream processing of biobased itaconic acid considerably

Itaconic acid

Primary (astronomy)

10.2139/ssrn.4724409

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Painful Nonunion after Missed Juvenile Tillaux Fracture in an Athlete - Case Report and Description of a New Fixation Technique.

PubMed (2019)

Ricardo Santos-Pereira Catarina Aleixo Márcio Augusto de Oliveira André Sarmento Mafalda Santos

The Tillaux fracture is a rare subtype of tibial physeal fracture that usually occurs in adolescents. There are only a few case series or reports published in the literature and, to our knowledge, this is the first time, a painful nonunion is reported after this type of fracture.A 13-year-old athlete presented to our orthopedic department because of persistent pain after an acute ankle injury 2months before. She was diagnosed with a Tillaux fracture that eventually progressed to nonunion after conservative treatment. Surgery was performed to treat the nonunion, and the fracture fragment was fixed using a soft suture anchor.The Tillaux fracture pattern requires a high level of clinical suspicion and careful evaluation since it can be misdiagnosed as a simple ankle sprain in adolescents and progress to persistent ankle pain without appropriate treatment.Our surgical technique of suture anchor fixation avoids the risk of fragmentation of the fracture fragment and was able to provide an excellent clinical result.

Knee pain

10.13107/jocr.2250-0685.1184

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Fractura por estrés del cuello del fémur en una niña hiperactiva tratada con metilfenidato. Reporte de caso. [Femoral neck stress fracture in a hyperactive child taking methylphenidate. Case report].

Revista de la Asociación Argentina de Ortopedia y Traumatología (2018)

Rita Grazina Rafael Portela Gustavo Martins Andreia Ferreira Domingues Rodrigues

Las fracturas por estrés afectan, con mayor frecuencia, a personas físicamente activas con hueso normal y son infrecuentes en los niños con placa de crecimiento abierta. Aun más infrecuentes son las fracturas por estrés del cuello femoral en la población pediátrica. Sin embargo, constituyen entidades muy importantes debido al riesgo de complicaciones graves, como la necrosis avascular. Se describe el caso de una niña de 7 años medicada con metilfenidato que sufrió una fractura por estrés del cuello del fémur atípica. La paciente consulta por dolor inguinal derecho sin limitaciones en las actividades cotidianas. La radiografía muestra una fractura por estrés del cuello del fémur, que se confirma con tomografía. Se instaura un tratamiento conservador, y la paciente está asintomática a las cuatro semanas. Este caso representa una alerta sobre esta infrecuente entidad en la que podrían presentarse errores diagnósticos. Investigaciones recientes también sugieren la posible participación de fármacos, como el metilfenidato, en la desmineralización ósea, que podría constituir un posible factor de riesgo de fractura. AbstractStress fractures most commonly affect physically active individuals with normal bone, and they are rare in children with open growth plates. Even rarer are femoral neck stress fractures in pediatric age. Nevertheless, they constitute a very important entity due to the risk of severe complications, such as avascular necrosis. A seven-year-old girl, treated with methylphenidate, who suffered an atypical femoral neck stress fracture is presented. Patient complained of right inguinal pain without daily life activity limitations. The radiograph showed a stress femoral neck fracture, confirmed by CT imaging. Conservative treatment was instituted and the patient became asymptomatic after 4 weeks.This case report alerts the clinicians about this rare entity that might be misdiagnosed. Recent research also suggests a possible involvement of drugs, such as methylphenidate, in bone demineralization, which might constitute a possible risk factor for fractures.

Avascular Necrosis

10.15417/730

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Tibia Valga due to Focal Fibrocartilaginous Dysplasia: Case Report

Journal of Pediatric Orthopaedics B (2002)

Mafalda Santos Eug nio Valente Ant nio Almada José Neves

Focal fibrocartilaginous dysplasia is a rare benign entity, previously described as a factor responsible for causing tibia vara at the walking age. We report here the case of a child with tibia valga due to focal fibrocartilaginous dysplasia of the lateral part of the proximal tibia. To our knowledge, this is the first observation of a lesion located in the lateral proximal tibia. Clinical, radiographic and magnetic resonance imaging surveillance was performed. Spontaneous resolution of the lesion with correction of the angular deformity did occur.

Hip Dysplasia

10.1097/00009957-200204000-00015

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Acute osteomyelitis and varicella-zoster infection: Is there a relation?

International Journal of Orthopaedics Sciences (2024)

Daniela Roque Morgado Daniel Vilaverde Andreia Ferreira Domingues Rodrigues Mafalda Santos

10.22271/ortho.2024.v10.i4a.3616

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Classification of Pediatric Supracondylar Fractures: Comparison between the Gartland and the Lagrange & Rigault Classifications

Revista Iberoamericana de Cirugía de la Mano (2018)

Rita Grazina Márcio de Oliveira José Marinhas Andreia Ferreira André Costa

Background The supracondylar fracture of the humerus is one of the most common fractures in pediatric age. Many classifications were proposed, with Gartland being the most widely used one and Lagrange and Rigault (L&R) the most used in French-speaking countries. Objectives The goal of this study was to compare the Wilkins-modified Gartland classification with the L&R classification in terms of reproducibility. Methods Three observers with similar training levels classified 35 fractures according to both classifications twice to evaluate both intra and interobserver variation. Results The mean intraobserver variation was 0.78 and 0.77 for Gartland and L&R classifications, respectively, and the mean interobserver variation was 0.55 and 0.62 for Gartland and L&R classifications, respectively. Conclusions Both classifications reveal adequate to usage in clinical and investigational practices, which is consistent with the literature.

10.1055/s-0038-1675427

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Artrite séptica neonatal – o desafio do diagnóstico

Andreia Ferreira Bruno Miguel Pereira Barbosa Ana Sousa Pereira Catarina Maia Mafalda Santos

Introduction: The diagnosis of septic arthritis in newborns is difficult and requires a high degree of suspicion. Case report: We present a case of a newborn who developed right brachial plexus palsy on the 10th day of life. By day 17, limited abduction of the right hip led to the suspicion of developmental dysplasia of the hip. An ultrasound corroborated this diagnosis and the newborn was referred to Pediatric Orthopedics. After proper study the diagnosis of a polyarticular septic arthritis was confirmed. At the age of eight years the child has a right upper limb deformity and shortening. Discussion/conclusion: The delay in diagnosis and treatment of this pathology leads to future sequels that may be irreversible. This report underlines how difficult and important is

Hip Dysplasia

10.25753/birthgrowthmj.v23.i4.8789

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Misaligned shoulders

DOAJ (DOAJ: Directory of Open Access Journals) (2021)

Íris Santos Silva Aníbal Correia Rita Santos Catarina Aleixo Mafalda Santos

10.25753/birthgrowthmj.v30.i2.19122

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Pneumococcal Meningitis in an Adolescent with Fever and Foot Ache

Case Reports in Pediatrics (2013)

Catarina Dias Cláudia Pedrosa Jorge Romariz Mafalda Santos Lúcia Rodrigues

Invasive pneumococcal disease predominantly affects younger children, elderly, and immunocompromised patients. Pneumococcal meningitis is a particularly important form of presentation, considering its high rate of morbimortality. We present the case of a previously healthy 12-year-old adolescent male who was hospitalized due to suspicion of osteoarticular infection in his left foot. A few hours later, he developed meningeal signs, exhibiting slight pleocytosis and Streptococcus pneumoniae isolates in both cerebrospinal fluid and blood. Imaging studies were inconclusive regarding the nature of the foot disorder. We considered the hypothesis of osteomyelitis of the navicular bone as the most likely, for which he completed six weeks of antibiotic therapy. There was a favorable clinical evolution, along with complete absence of osteoarticular or neurological sequelae. The relevance of this clinical case resides in the unusual presentation of invasive pneumococcal disease in this age group, as well as in the rare form of orthopedic involvement.

Pleocytosis

Foot (prosody)

Presentation (obstetrics)

10.1155/2013/516746

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Red Blood Cell Distribution Width: Diagnostic Value in Pediatric Acute Appendicitis

International Journal of Medical Reviews and Case Reports (2022)

Mafalda Santos Raquel Costa Joana Campos Patrícia Horta Concei Salgado

Introduction and Objectives: Acute appendicitis (AA) is one of the most common causes of urgent surgery in children and is still associated with diagnostic difficulties. As the red blood width (RDW) and mean platelet volume (MVP) may be related to inflammatory processes, this study aims to evaluate the diagnostic value of RDW in AA in pediatric population. Methods: A retrospective and observational study was conducted. Data was collected from medical records of all patients with clinical suspicion of AA who underwent appendectomy at a secundary hospital during a period of 36 months. Preoperative analytical values were analyzed and compared with a control group. Results: Medical records of 305 patients with a mean age of 12.1 years were analyzed. Children with simple or perforated appendicitis had significantly higher RDW than those with a normal appendix. Compared with the controls mean RDW was significantly higher in the acute appendicitis group (14.16 ± 1.2% vs.13.09 ± 0.9%, p <0.05). No statistically significant differences were found in the analytical parameter VPM in the diagnosis of AA. Conclusion: In this study, children with an histologically diagnosed acute appendicitis have higher RDW than children without appendicitis. Being a parameter included in the blood count and without additional costs, it may represent a valuable aid in the diagnosis of acute appendicitis in children. Further research is needed due to the limited number of studies on this topic in childhood.

Mean platelet volume

Medical record

Complete blood count

10.5455/ijmrcr.172-1646334342

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