Objective To investigate the clinical efficacy of mesalazine combined with bifico in the treatment of ulcerative co -litis （UC） and its effect on toll-like receptor 4 （TLR4） and myeloid differentiation factor 88 （MyD88）.Methods A total of 86 cases of UC was randomly divided into the observation and control groups with 43 cases in each group .The observation group was given me-salazine combined bifico treatment , and the control group was given mesalazine , and eight weeks as a course of treatment .The clinical efficacy was observed .Serum TLR4 and MyD88 were tested.Adverse reaction in treatment was recorded .Results The total effective rate （95.35%） in observation group was significantly higher than that （81.40%） in control group（ P 0.05 ） .Conclusions Mesalazine combined with bifico in the treatment of UC is safe and effective . The effect may be related to regulation of peripheral blood TLR 4 and MyD88 content .
Key words:
Colitis,ulcerative/drug therapy; Mesalamine/therapeutic use; Probiotics/therapeutic use; Toll-like receptor 4/blood; Myeloid differentiation factor 88/blood
