Zhenzhou Shen

Yellow River Institute of Hydraulic Research

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Zhimin Shao

Fudan University Shanghai Cancer Center

Mian Li

Yellow River Institute of Hydraulic Research

Peiqing Xiao

Yellow River Institute of Hydraulic Research

Jishan Yang

Yellow River Institute of Hydraulic Research

Wenyi Yao

Yellow River Institute of Hydraulic Research

Gen‐Hong Di

Fudan University Shanghai Cancer Center

Wenyi Yao

Yellow River Institute of Hydraulic Research

Peiqing Xiao

Yellow River Institute of Hydraulic Research

J. Lu

Dalian Medical University

Jiong Wu

Shanghai Medical College of Fudan University

Cooperative Institutions

Fudan University Shanghai Cancer Center

Yellow River Institute of Hydraulic Research

Texas Oncology

Roche (Switzerland)

Fudan University

Chinese Academy of Sciences

Shanghai Medical College of Fudan University

Sarah Cannon

The University of Texas MD Anderson Cancer Center

GEICAM – Spanish Breast Cancer Group

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breast cancer risk: a meta-analysis of case-control studies with subgroups of ethnic and menopausal statue

Yiwei Jiang Liheng Zhou Tingting Yan Zhenzhou Shen Zhimin Shao

Background: Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast cancer. However, studies on the association between polymorphism and breast cancer have yielded inconsistent results. We performed a meta-analysis including ethnic subgroup and menopausal statue subgroup to investigate the association of SULT1A1 Arg213His polymorphism with breast cancer. Methods: PubMed, EBSCO and Web of Science databases were searched for the correlative articles up to January 2010 (10362 breast cancer patients and 14250 controls). The risk (odds ratio, OR) was used to estimate the association between SULT1A1 polymorphism and breast cancer risk. All of the data from each study use either fixed-effects or random-effects. Results: We found that SULT1A1 Arg213His had no exact effect to increase the risk of breast cancer (OR = 1.07, 95% CI: 0.97-1.17, P = 0.164), but it did increase the risk of breast cancer among postmenopausal women in the dominant model (OR = 1.28, 95%CI: 1.04-1.58, P = 0.019). No similar effect was found among premenopausal breast cancer women (OR = 1.06, 95%CI: 0.88-1.27, P = 0.537). There was a significant increase in breast cancer risk among Asian women (OR = 2.03, 95% CI: 1.00-4.14, P = 0.051) but not Caucasian women in recessive model. There was publication bias among postmenopausal women subgroup (P = 0.002), however by using the trim and fill method, if the publication bias was the only source of the funnel plot asymmetry, it needed two more studies to be symmetrical. The value of Log OR did not change too much after the adjustment and the fail-safe number of missing studies that would bring the P-value changed was 17. Conclusions: We concluded that the polymorphism of SULT1A1 Arg213His might be one of the high risk factors for breast cancer in Asian women and in postmenopausal women for all races. We should point out that the publication bias among postmenopausal women may partly account for the result, but the conclusion might not affected deeply by the publication bias.

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Effects of check dam construction on sediment production and topographic changes in a gully in the Loess Plateau: A rainfall simulation experiment

Hydrological Processes (2024)

Shaobo Xue Peng Li Zhiwei Cui Zhanbin Li Zhenzhou Shen

Abstract To maintain a reasonable sediment regulation system in the Loess Plateau, it is critical to determine the effects of check dam construction on sediment production and topographic changes. An indoor simulation experiment was conducted to investigate sediment production at the outlet section of the gully and micro‐topographic changes within the channel before and after dam construction. The results showed that check dam significantly affected the run‐off and sediment transport processes in the watershed. Specifically, the cross‐sectional morphology index ( η ) and the width‐depth ratio increased by 10.23% and 40.44%, respectively, while sediment content and particle size decreased by 39.29% and 18.58%, respectively. Additionally, the relative importance of section parameters and micro‐topographic parameters that affect sediment production rate and particle size was ranked using the random forest algorithm. The roughness after check dam construction was identified as a relatively important topographic factor affecting sediment production and particle selection by erosion. These findings provide valuable information for future check dam construction and development in the Loess Plateau region.

Loess plateau

10.1002/hyp.15271

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Transformation of Rainfall(Aug 6,2018) characteristics in Yinchuan city

IOP Conference Series Earth and Environmental Science (2019)

Hongying Li Zhenzhou Shen Guoqiang Yu Qiannan Yang Jing Xin-ai

Abstract The rainfall feature were analyzed at Yinchuan city in this paper, the rainfall feature was detected by LPM laser raindrop spectrometer, including rainfall raindrops speed and raindrops size. The data shows that the rainfall raindrops speed and size of natural raindrops were relatively strongly; In the process of individual rainfall, the rainfall raindrops final speed of the rain is mainly distribution between 0.6-5.8m/s, the biggest of the final speed is generally 1.0m/s; and rainfall raindrops is mainly composed of the particle size of 0.125- 0.5mm rainfall raindrops. The rainfall raindrops speed of 0.125mm diameter is mainly distribute between 0.6-1.8m/s, the rainfall raindrops speed of 0.25mm particle size is mainly distribute between 0.8-1.8m/s, the rainfall raindrops speed of 0.375mm distribute in the 1-1.8m/s, the rainfall raindrops speed of 0.5mm particle size of the raindrops mainly distribute in the 1.0-2.2m/s.

Particle (ecology)

10.1088/1755-1315/295/2/012035

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2115 POSTER Randomized phase 3 clinical trial comparing 130-nanometer albumin bound paclitaxel with solvent-based paclitaxel in Chinese patients with metastatic breast cancer

European Journal of Cancer Supplements (2007)

Zhong Guan F.Y. Feng L.Q. Li J. Zefei Zhenzhou Shen

Nanometre

10.1016/s1359-6349(07)70877-7

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Driving force characteristic under different Land use ways slope

Zhenzhou Shen Wenyi Yao Zhanbin Li Peiqing Xiao Mian Li

Analyzed the erosion characteristic on different rainfall and different underlying horizon in base of yellow river institute of hydraulic research at 2008. The date shows: the soil erosion amount of bare slope and arable slope is 100 times that of grass slope; the steady soil erosion amount of small rainfall is 1/4 times that of middle rainfall and is 1/30 times that of heavy rainfall on grass slope; the change of flow shear force at 90mm/h rainfall in different land use ways, when they get the fluctuate steady state, the flow shear force of bare slope and farmland is about 2000Pa, the flow shear force of 20%, 40%, 60%, 80% grass cover slope are 2/5, 3/10, 1/4, 1/5 times to 2000Pa. At the experiment condition, the corrosion resistance of soil is 5.89g/Pa.min-1, the critical flow shear force to cause rill erosion is 0.31Pa.

Arable land

Shear force

Rill

Flow conditions

10.1109/icae.2011.5943809

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Abstract P2-19-07: Current trends of breast reconstruction after mastectomy for breast cancer patients in China

Cancer Research (2013)

Y Chen Jianfeng Chen Jianfeng Chen Bang‐Hung Yang L Li

Abstract Background: To ascertain the current trends of breast reconstruction (BR) for breast cancer patients in China, we conducted a retrospective study in Committee of Breast Cancer Society, Chinese Anti-Cancer Association. Methods: We designed a questionnaire for this study, and it included questions on surgeon demographics, number of mastectomy and BR, type and timing of BR, reconstructive choices in the setting of preoperative or postoperative radiotherapy (RT) or chemotherapy, complication, oncoplastic surgery, fat grafting, physician and patient satisfaction, etc. All data were collected until 2012. Questionnaires were sent to 52 members of Committee of Breast Cancer Society by e-mail. By Jun-2013, 30 questionnaires (response rate 57.7%) had been returned. Among all, 3 were excluded for not performing BR. Finally, 27 respondents were included. Results: All but one of these 27 hospitals were Class Three Grade A hospitals in China. A total of 402 surgeons worked in the general surgery or oncological surgery department, among them, only 84 (20.9%) were able to perform BR. Surgeons from 10 hospitals would also choose to cooperate with the plastic department to finish the complicated reconstructive procedure. In 2012, 21026 mastectomies were performed; among them, 679 (3.2%) received immediate BR, 102 (0.5%) received delayed BR while 192 (0.9%) received delayed-immediate one. At the same time, 414 (2.0%) had their breast reconstructed by implant while 393 (1.9%) chose the autologous ones, the choices of reconstructive type were not recorded for other 166 (0.8%) cases. According to these 27 respondents, 88.9% predominantly performed prosthetic (1265 cases in all) or latissimus dorsi myocutaneous flap (LDMF) with or without an implant (1571 cases in all) BR from the time of their first BR operation to the end of 2012. During the same period, 327 pedicled transverse rectus abdominis myocutaneous (TRAM) BR were performed in 20 hospitals, while 169 free TRAM BR, which requiring technique of microsurgery, were carried out in 9 hospitals (68.6% were performed by a single surgeon from Nov-2006). The overall complication rate of BR was 12.4%. As RT had low to medium effect on increasing the operational difficulties and influencing the esthetic outcomes of BR, about 75% surgeons would choose delayed autologous BR in patients who had previous RT. Autologous flaps were also recommended for patients who need postoperative RT, but the timing still remained controversial. The overall cosmetic outcomes of the reconstructed breasts satisfied the majority of physicians and patients. Conclusion: With the growing number of breast cancer patients who need to undergo mastectomy, more and more BR are needed to improve the quality of life for them, but the ratio is still low in China, partially because of the lack of qualified plastic surgeons. As free flap BR requiring microsurgical techniques seems still complicated for most surgeons, implant and LDMF BR are the most common choices for patients nowadays in China. In addition, the effect of radiotherapy will be an important consideration when deciding the type and timing of BR. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-19-07.

Reconstructive Surgery

10.1158/0008-5472.sabcs13-p2-19-07

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Research progress of soil erosion in Pisha stone area of Yellow River

Zhenzhou Shen

<p>The soil-covered Pisha stone area is the core source area of coarse sediment in the Yellow River and has become the focal point of ecological control of the Yellow River Basin. It is thus vital to study the spatial distribution of erosion coupling between geomorphology, vegetation, and water in the soil-covered Pisha stone area. Some valuable research results have been obtained already by using high-definition remote sensing aerial photographs and-high precision data from unmanned aerial vehicles. In particular, the image resolution obtained by unmanned remote sensing reveals small watershed topographic features and the characteristics of vegetation structure. Thus, the use of remote sensing is vital for research involving the spatial distribution of soil erosion in the slopes of the Pisha stone area and the dynamics of the geomorphic spatial structure of the slopes. In addition, the negative correlation between the spatial structure of the vegetation community and the energy dissipation impedance of erosion requires further study. Research into soil erosion in the Pisha stone area thus represents an urgent scientific need whose outcome will directly affect the theoretical foundation of a comprehensive model for treating soil erosion in this area.</p>

10.5194/egusphere-egu22-3475

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RT-PCR, real-time PCR and western blot analysis of PRDX6 differentially expressed in MDA-MB-231HM (l

Da‐Qiang Li Yi-Feng Hou Jiong Wu Jinsong Lu Gen‐Hong Di

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[Relation of tumor size, lymph node status and prognosis in breast cancer].

PubMed (1991)

Zhenzhou Shen

Tumor size and the extent of axillary lymph node involvement are the two most important prognostic factors for breast cancer, but their relation is not clear. Data on 2189 cases of radical surgery from 1956-1985 showed a linear relation between tumor size and percentage of cases with positive lymph node involvement. A negative relation was noted between tumor size, the extent of lymph node involvement and prognosis. There was a significance difference in survival rate between one group, two group or more lymph nodes involve. The worst prognosis was seen in those patients with level 3 lymph nodes involve. Tumor size and lymph node status were found to be independent but additive prognostic indicators. If there was no lymph node involvement, the survival rate was decreased because of tumor size. In cases of 1-3 and 4-6 lymph nodes involved, the survival rate was not different when tumor size was less than 5 cm, but there was a significant difference when tumor size large than 5 cm. In cases of more than 7 nodes involved, the survival rate decreased regardless of tumor size. Lymph node metastasis was more important than tumor size in prognosis. The relation of different TNM combination with prognosis was investigated, and the importance of the treatment of internal mammary lymph node in breast cancer was emphasized.

Breast tumor

Axillary lymph nodes

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IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma cell lines and patients specimens

Acta Academiae Medicinae Shanghai (1996)

Zhimin Shao Ming Jiang Zhenzhou Shen

A total nine human breast carcinoma cell lines and 20 breast carcinoma samples were analyzed. Using western blot, in situ hybridization, cell growth curve and DNA synthesis protein and mRNA expression levels of IGFBP-3 gene and its biological function was analysed. Results showed:(1) IGFBP-3 was only secreted in estrogen receptor (ER)-negative breast carcinoma cell lines while it can not be detected in ER-positive cell lines. (2) IGFBP-3 mRNA in breast cancer samples obtained from patients was significantly higher in ER-negative samples than ER-positive ones. (3) IGF-mediated proliferative activating and DNA synthesis of human breast cancer cell line MCF-7 can be markedly enhanced by IFGBP-3. The expression level of IGFBP-3 may be a prognosis indictor in human breast carcinoma patients.

Breast carcinoma

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