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MD

Melissa D. Harris

National Institutes of Health

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Co-Authors

Mohammad A. Pahlavani

Geriatric Research Education and Clinical Center

Arlan Richardson

Oklahoma City VA Medical Center

Susan A. Moore

Université de Montréal

Saima N. Nayab

Eastman Dental Hospital

Alyssa Caldwell McGee

University of Colorado Denver

Robert J. Lechleider

MacroGenics (United States)

Richard Weindruch

Nu Skin (United States)

Anita B. Roberts

National Cancer Institute

Shin‐ichi Tominaga

Jichi Medical University

Makiko Fujii

Yokohama National University

Cooperative Institutions

National Institutes of Health

National Cancer Institute

University of Dundee

The University of Texas at San Antonio

The University of Texas Health Science Center at San Antonio

Geriatric Research Education and Clinical Center

Wellcome Trust

Center for Cancer Research

Eastman Dental Hospital

University College London

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Expression of Heat Shock Protein 70 in Rat Spleen Lymphocytes is Affected by Age but Not by Food Restriction

Journal of Nutrition (1996)

Mohammad A. Pahlavani Melissa D. Harris Susan A. Moore Arlan Richardson

10.1093/jn/126.9.2069

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Citations (31)

The Age-Related Decline in the Induction of IL-2 Transcription Is Correlated to Changes in the Transcription Factor NFAT

Cellular Immunology (1995)

Mohammad A. Pahlavani Melissa D. Harris Arlan Richardson

NFAT

Transcription

10.1006/cimm.1995.1190

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Citations (37)

SNIP1 Is a Candidate Modifier of the Transcriptional Activity of c-Myc on E Box-Dependent Target Genes

Molecular Cell (2006)

Makiko Fujii Lyudmila Lyakh Cameron P. Bracken Junya Fukuoka Morisada Hayakawa

Proto-Oncogene Proteins c-myc

10.1016/j.molcel.2006.11.006

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Citations (62)

Effect of dehydroepiandrosterone on mitogen-induced lymphocyte proliferation and cytokine production in young and old F344 rats

Immunology Letters (1995)

Mohammad A. Pahlavani Melissa D. Harris

Androstenediol

10.1016/0165-2478(95)00057-c

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Citations (20)

The Increase in the Induction of IL-2 Expression with Caloric Restriction Is Correlated to Changes in the Transcription Factor NFAT

Cellular Immunology (1997)

Mohammad A. Pahlavani Melissa D. Harris Arlan Richardson

NFAT

Caloric theory

Transcription

10.1006/cimm.1997.1155

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Citations (28)

The age-related changes in DNA binding activity of AP-1, NF-κB, and OCT-1 transcription factors in lymphocytes from rats

Mohammad A. Pahlavani Melissa D. Harris

Transcription

c-Fos

Northern blot

10.1007/bf02434070

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Citations (22)

Activation of p21ras/MAPK Signal Transduction Molecules Decreases with Age in Mitogen-Stimulated T Cells from Rats

Cellular Immunology (1998)

Mohammad A. Pahlavani Melissa D. Harris Arlan Richardson

FYN

MAPK cascade

10.1006/cimm.1998.1274

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Citations (51)

In Vitro Effects of Melatonin on Mitogen-Induced Lymphocyte Proliferation and Cytokine Expression in Young and Old Rats

Immunopharmacology and Immunotoxicology (1997)

Mohammad A. Pahlavani Melissa D. Harris

Melatonin (MLT) treatment in vivo has been shown to have immunomodulatory and anti-immunosenescent effects in the mouse model. In the present report, the in vitro effect of MLT on mitogen-induced lymphocyte proliferation and cytokine expression was evaluated in a rat model. Splenic lymphocytes were isolated from young (6 months) and old (24 months) F344 rats and were incubated with MLT in the presence or absence of mitogens. The proliferative response to concanavalin A (ConA) or PMA plus ionomycin was measured in splenocytes or T cells isolated from young and old rats. In addition, the induction of interleukin-2 (IL-2) and interferon-gamma (IFN-γ) production was measured in MLT-treated and untreated lymphocytes isolated from young and old rats. The ConA-induced lymphocyte proliferation and IL-2 expression were significantly lower and induction of IFN-γ production was significantly higher in splenocytes and purified T cells isolated from old rats compared to splenocytes and T cells isolated from young rats. Treatment of lymphocytes with MLT did not significantly alter ConA-induced lymphocyte proliferation or IL-2 or IFN-γ expression in lymphocytes isolated from either young or old rats. On the basis of these data, we conclude that in vitro MLT treatment had no immunomodulatory effect on lymphocytes from rats.

Splenocyte

Ionomycin

10.3109/08923979709046979

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Citations (28)

The Expression of Heat Shock Protein 70 Decreases with Age in Lymphocytes from Rats and Rhesus Monkeys

Experimental Cell Research (1995)

Mohammad A. Pahlavani Melissa D. Harris Susan A. Moore Richard Weindruch Arlan Richardson

Heat shock factor

Transcription

10.1006/excr.1995.1160

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Citations (70)

Mild heat shock modifies the effect of Staphyloccncus aureus proteins on osteoblast OPG (osteoprotogerin) synthesis

Saima N. Nayab Alyssa Caldwell McGee Melissa D. Harris S Meghji

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