Kathleen C. Horner

Inserm

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Yves Cazals

Laboratoire de Neurosciences Cognitives

Jean‐Denis Troadec

Centre National de la Recherche Scientifique

Gregory R. Bock

Endesa (Spain)

Michel Dallaporta

Laboratoire de Neurosciences Cognitives

A. D. Hawkins

Marine Scotland

ÉF

Évelyne Ferrary

Université Paris Cité

Olivier Sterkers

Assistance Publique – Hôpitaux de Paris

Juliette Pio

Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille

A Guilhaume

Laboratoire d'Astrophysique de Bordeaux

J.-P. Erre

Hôpital Pellegrin

Cooperative Institutions

Inserm

Centre National de la Recherche Scientifique

Aix-Marseille Université

Hôpital Pellegrin

Institut de Neurobiologie de la Méditerranée

Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille

Université de Bordeaux

Université Paris Cité

Stanford University

Laboratoire de Neurosciences Cognitives

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THE EFFECTS OF EXPERIMENTAL HYDROPS VERSUS INCREASED INTRACOCHLEAR PRESSURE ON AUDITORY FUNCTION IN THE GUINEA PIG

Le Journal de Physique Colloques (1990)

Kathleen C. Horner Yves Cazals

Endolymphatic hydrops

New guinea

10.1051/jphyscol:1990228

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Citations (0)

Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2007)

Minnie Hsieh Daekee Lee Sara Panigone Kathleen C. Horner Ruby Chen

10.17615/qfa3-cf84

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Distortion products in early stage experimental hydrops in the guinea pig

Hearing Research (1989)

Kathleen C. Horner Yves Cazals

Endolymphatic hydrops

Audiogram

Otoacoustic emission

Stereocilia (inner ear)

10.1016/0378-5955(89)90060-9

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Citations (14)

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Journal of Clinical Investigation (2004)

Silvia Masciarelli Kathleen C. Horner Chengyu Liu Sun Hee Park Mary D Hinckley

Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis, we generated PDE3A-deficient mice by homologous recombination. The Pde3a–/– females were viable and ovulated a normal number of oocytes but were completely infertile, because ovulated oocytes were arrested at the germinal vesicle stage and, therefore, could not be fertilized. Pde3a–/– oocytes lacked cAMP-specific PDE activity, contained increased cAMP levels, and failed to undergo spontaneous maturation in vitro (up to 48 hours). Meiotic maturation in Pde3a–/– oocytes was restored by inhibiting protein kinase A (PKA) with adenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS) or by injection of protein kinase inhibitor peptide (PKI) or mRNA coding for phosphatase CDC25, which confirms that increased cAMP-PKA signaling is responsible for the meiotic blockade. Pde3a–/– oocytes that underwent germinal vesicle breakdown showed activation of MPF and MAPK, completed the first meiotic division extruding a polar body, and became competent for fertilization by spermatozoa. We believe that these findings provide the first genetic evidence indicating that resumption of meiosis in vivo and in vitro requires PDE3A activity. Pde3a–/– mice represent an in vivo model where meiotic maturation and ovulation are dissociated, which underscores inhibition of oocyte maturation as a potential strategy for contraception.

Germinal vesicle

Cyclic nucleotide phosphodiesterase

10.1172/jci200421804

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Citations (28)

Sympathectomy improves the ear's resistance to acoustic trauma – could stress render the ear more sensitive?

European Journal of Neuroscience (2001)

Kathleen C. Horner Fabrice Giraudet Michel Lucciano Yves Cazals

Abstract Emotional stress is a phenomenon experienced by many people at some time in their lives. Some of its early manifestations, such as unbearable loudness of ambient sounds and sensations of dizziness, might be linked to inner ear dysfunction. Although the inner ear is supplied with a substantial sympathetic innervation, previous studies have failed to demonstrate any significant functional impact. We show here that in the awake guinea pig and following unilateral ablation of the superior cervical ganglion, the temporary threshold shift induced by a 1‐min exposure to 8 kHz pure tone at 96 dB sound pressure level was reduced by as much as 40 dB. Of interest, the protective effect was bilateral suggesting an intimate relationship between the sympathetic and the olivocochlear efferent systems. The data presented here provide new evidence for a key role for the sympathetic system in modulating temporary threshold shifts following exposure to moderate sound stimulation. This opens new perspectives for investigation of sympathetic control in noise‐induced permanent hearing losses.

Superior cervical ganglion

Auditory fatigue

10.1046/j.0953-816x.2000.01386.x

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Citations (35)

Electrochemical Composition of the Cochlear Fluids in the Early Experimental Hydrops:Preliminary Results

Acta Oto-Laryngologica (1989)

István Sziklai Kathleen C. Horner Évelyne Ferrary Olivier Sterkers Claude Amiel

AbstractThe composition of endolymph and perilymph was studied in the guinea pig cochlea after 2 and 6 weeks of blockage of the vestibular aqueduct in an experimental model of hydrops. Compound action potential was monitored several times in the observation period. The endocochlear potential was measured and the endolymph was sampled at the first and third turns of the scala media. The Na, K, and CI concentrations were determined in nanolitre aliquots of endolymph and of perilymph, the latter sampled from the basal scala vestibuli. After 2 weeks, no change in endolymphatic electrochemical composition was observed. After 6 weeks, endocochlear potential was decreased by 25% at both cochlear turns; K concentration was decreased in endolymph of the basal turn and CI concentration was decreased in both turns; the calculated osmolality (Na+K+Cl) was decreased in both turns. These results indicate that the blockage of the vestibular aqueduct induced early auditory dysfunction whereas alterations of the electrochemical composition of endolymph occurred later after a time lag of more than 2 and less than 6 weeks.Key Words: guinea pigendolymphperilymphNaKCl concentrationsendocochlear potential

Perilymph

Endolymph

Endocochlear potential

Endolymphatic hydrops

Cochlear duct

10.3109/00016488909127524

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Citations (10)

Receptors for leptin in the otic labyrinth and the cochlear–vestibular nerve of guinea pig are modified in hormone-induced anorexia

Hearing Research (2010)

Kathleen C. Horner Jean‐Denis Troadec Marie‐Pierre Blanchard Michel Dallaporta Juliette Pio

Anorexia

10.1016/j.heares.2010.09.009

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Citations (7)

Reversible hearing impairment induced by lithium in the guinea pig

Neuroreport (1997)

Kathleen C. Horner Zhiwu Huang Denise Higuerie Yves Cazals

LITHIUM salts remain one of the most widely used treatments for depressive illness. The mechanisms involved probably include reduction in free inositol. Visual perceptive disturbances can be a side effect of the treatment. We report here for the first time that chronic lithium treatment in the guinea pig induces a predominantly low frequency hearing loss and, in the longer term, loss of sensitivity is observed across the whole audiogram. The changes are reversed when treatment is arrested. The observations could be accounted for, at least partially, by a lithium-induced perturbation of the phosphoinositide cascade within the inner ear.

10.1097/00001756-199704140-00005

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Citations (10)

Immunoreactivity for taurine in the cochlea: its abundance in supporting cells

Hearing Research (1997)

Kathleen C. Horner C. Aurousseau

Tectorial membrane

Endolymphatic hydrops

Immunolabeling

Endolymphatic sac

10.1016/s0378-5955(97)00057-9

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