Xiaoying Ren

Zhengzhou University

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Huijun Du

Shanghai Electric (China)

Yunan Gao

Harbin Medical University

Wei Yang

Yunnan Agricultural University

Ming Gong

Shanghai Academy of Agricultural Sciences

Juncai Bai

Zhengzhou Central Hospital

Yongxiang Song

Affiliated Hospital of Zunyi Medical College

Yujing Wang

First People's Hospital of Chongqing

Shaolin Chen

Northwest A&F University

Ruifang Zhu

Zhengzhou University

Gaohua Chang

Zhengzhou University

Cooperative Institutions

Zhengzhou University

Harbin Medical University

Fourth Affiliated Hospital of Harbin Medical University

Zunyi Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Affiliated Hospital of Guizhou Medical University

Shanghai Jiao Tong University

Soochow University

First Affiliated Hospital of Soochow University

Nanjing Forestry University

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Construction of a ferroptosis-related eight gene signature for predicting the prognosis and immune infiltration of thyroid cancer

Frontiers in Endocrinology (2022)

Xiaoying Ren Huijun Du Weilun Cheng Yujing Wang Yuanxin Xu

Background Thyroid cancer is the most common malignant tumor of the endocrine system. Most patients with thyroid cancer have a good prognosis, although a small proportion experience recurrence and metastasis and have a poor prognosis. Ferroptosis is a novel form of regulated cell death (RCD); previous studies have confirmed that ferroptosis was associated with thyroid cancer. The purpose of this study was to investigate the key ferroptosis-related genes in thyroid cancer and their relationship with prognosis and immune cell infiltration. Methods In this study, 497 thyroid cancer RNA expression datasets were downloaded from the cancer genome atlas (TCGA) cohort and a prognostic risk model for eight ferroptosis-related genes (FRGs) was constructed by Lasso-Cox regression. The prognostic value of the risk model and the correlation of prognostic features with immune scores and tumor immune cell infiltration were systematically analyzed. Results The prognostic risk model for eight FRGs ( DPP4 , TYRO3 , TIMP1 , CDKN2A , SNCA , NR4A1 , IL-6 and FABP4 ) were constructed and validated in training and testing cohorts. Kaplan-Meier curve and receiver operating characteristic (ROC) curve analysis confirmed that that the ferroptosis-related eight gene signature had good predictive value for the prognosis of thyroid cancer (THCA) patients. Multivariate regression analysis further showed that the risk score of the prognostic model could be used as an independent prognostic factor for THCA patients. Functional enrichment analysis showed that DEGs in high risk and low risk groups were involved in immune-related biological processes and that there were significant differences in immune cell infiltration between the two risk groups. Conclusion We identified eight key genes related to ferroptosis in THCA patients. Further studies are now needed to investigate the mechanisms involved; these genes may represent clinical diagnostic and prognostic biomarkers.

10.3389/fendo.2022.997873

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Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD)

Oxidative Medicine and Cellular Longevity (2022)

Huijun Du Xiaoying Ren Juncai Bai Wei Yang Yunan Gao

Ferroptosis is a multistep regulated cell death process induced by iron accumulation and lipid peroxidation. Classical GPX4-dependent pathway and GPX4-independent pathways can independently and synergistically inhibit ferroptosis and jointly maintain the oxidative balance of the body. WHO defines obesity as "a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired," and obesity is also defined as an adiposity-based chronic disease (ABCD). Obesity is a systemic disease that leads to metabolic abnormalities in various systems, resulting in a series of complications including obesity cardiomyopathy, atherosclerosis, nonalcoholic fatty liver disease, and diabetes mellitus. Emerging evidence shows that ferroptosis is closely associated with the occurrence and progression of various diseases. In recent years, ferroptosis has been found to play critical roles in obesity and its complications. This review discusses the mechanisms of how ferroptosis is initiated and controlled and discusses the research progress of ferroptosis in obesity and its complications.

GPX4

10.1155/2022/1052699

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Preoperative bowel preparation promotes intestinal functional recovery after esophagectomy

African Health Sciences (2023)

Junliang Ma Shaolin Chen Xiaoying Ren Han Hao Ming Gong

Background: Patients are prone to intestinal dysfunction after esophagectomy. The value of preoperative bowel preparation before esophagectomy is controversial. There is a lack of evidence as to whether preoperative bowel preparation can help patients improve bowel function and shorten the recovery time of bowel function. Objectives: The objectives of this study were to explore whether preoperative bowel preparation can promote the recovery of intestinal function after esophagectomy. Methods: We analysed 139 patients who underwent elective radical esophagectomy in the Department of Thoracic Surgery at the Second Affiliated Hospital of Xi'an Jiaotong University from May 2016 to December 2018. The enrolled patients were divided into the study group (bowel preparation group) and the control group (no bowel preparation group) of 71 cases and 68 cases. Patients in the study group were given dissolved polyethylene glycol electrolyte powder and a cleansing enema the day before surgery. Patients in the control group were neither given polyethylene glycol electrolyte powder nor cleansing enemas before surgery. The postoperative recovery of the two groups were compared. Results: Postoperative bed rest time, bowel function recovery time and the time of first flatus and defecation after surgery were significantly shorter in patients with bowel preparation than in those without bowel preparation, and the differences were statistically significant. (P=0.038, P﹤0.001, P﹤0.001, P﹤0.001; respectively). Conclusions: Preoperative bowel preparation can promote the recovery of patients with esophageal cancer, especially the recovery of bowel function, which can reduce the pain caused by abdominal distension and improve the quality of life of patients. Keywords: Intestinal dysfunction; esophagectomy; retrospective cohort study.

Esophagectomy

Bowel preparation

Enema

Abdominal distension

Bowel function

10.4314/ahs.v23i3.62

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A prognostic model for cervical cancer based on ferroptosis-related genes

Frontiers in Endocrinology (2022)

Huijun Du Yumei Tang Xiaoying Ren Fan Zhang Wei Yang

Background Ferroptosis is widely involved in the occurrence and development of various cancers, but a specific mechanism involving ferroptosis in cervical cancer is still unclear. Methods Based on the expressions of ferroptosis-related genes, a prognostic model was constructed using lasso regression, and the overall predictive performance of this model was verified. An in-depth analysis of the prognostic model was then conducted. Results The prognostic model showed good predictive performance in both the validation and test sets. Mechanism analysis indicated that differences in the tumor microenvironment were the basis of the predictive ability of the model. Notably, CA9 mRNA was significantly overexpressed in cervical carcinoma, tissues but not in normal cervix tissues. A pair of ceRNAs (CA9/ULBP2) could be involved in the carcinogenesis and development of cervical cancer, and the potential target might be hsa-miR-34a. In addition, predicted miRNAs and drugs for these DEGs were identified. Conclusions We constructed a prognostic model with good predictive performance, based on the expression of ferroptosis-related genes. Further research found that the ceRNA pairs of ULBP2/CA9 could regulate cervical cancer through hsa-miR-34a. These results identified the mechanism of ferroptosis in cervical cancer, and might provide novel therapeutics for cervical cancer patients.

10.3389/fendo.2022.991178

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Gender-specific association between snoring and total sleep duration with type 2 diabetes mellitus in rural adults

Sleep And Breathing (2024)

Xili Jiang Ruifang Zhu Ruiying Li Xiaokang Dong Yinghao Yuchi

Association (psychology)

Sleep

10.1007/s11325-024-03133-x

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