Qi Peng

Jiangxi Agricultural University

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Bin Li

Jiangsu Academy of Agricultural Sciences

Baochao Fan

Jiangsu Academy of Agricultural Sciences

Jinzhu Zhou

Xidian University

Deping Song

Jiangxi Agricultural University

Jizong Li

Yangzhou University

Yuxin Tang

South China Agricultural University

Rongli Guo

Jiangsu Academy of Agricultural Sciences

Fanfan Zhang

Animal Science Research Institute

Dongyan Huang

Jiangxi Agricultural University

Shuqing Zhao

Shandong University of Traditional Chinese Medicine

Cooperative Institutions

Jiangsu Academy of Agricultural Sciences

Jiangxi Agricultural University

Chinese Academy of Sciences

Yangzhou University

Nanjing Agricultural University

Ministry of Agriculture and Rural Affairs

Huazhong Agricultural University

Tsinghua University

Sun Yat-sen University

University of Washington

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Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation

Antiviral Research (2007)

J. L. Jiménez Jun Cao L. Jackson Qi Peng Hanwen Wu

Identification

Envelope (radar)

10.1016/j.antiviral.2007.01.009

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C3a-C3aR interaction regulates the allostimulatory function of dendritic cells

American Journal of Transplantation (2007)

Wuding Zhou Qi Peng Kai Li Katie Anderson Steven H. Sacks

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Pathogenicity, infective dose and altered gut microbiota in piglets infected with porcine deltacoronavirus

Virology (2021)

Jizong Li Jinzhu Zhou Shuqing Zhao Rongli Guo Chunyan Zhong

10.1016/j.virol.2021.12.006

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Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study

Future Microbiology (2024)

Yan Han Gongbin Lan Qi Peng Wei Zhang Ying Wang

Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.

Mendelian Randomization

10.1080/17460913.2024.2417608

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The heterogeneity, mechanism of regulation and function of human mast cell tryptase.

Qi Peng

Tryptase

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Anaphylatoxin C5a is an important regulator of natural killer cell function

Molecular Immunology (2010)

Ke Li Naiyin Wang Qi Peng Steven H. Sacks Alfonso Martin‐Fontecha

Cell function

10.1016/j.molimm.2010.05.106

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Citations (1)

Exploration of mechanisms by which production of C3 by DCs upregulates their potency to stimulate T cells

Immunology (2005)

Katie Anderson Qi Peng Steven H. Sacks Wuding Zhou

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[Transcriptional regulation of aco gene cluster in Bacillus thuringiensis].

PubMed (2015)

Guannan Wang Qi Peng Qingyun Zheng Jie Li Jie Zhang

We analyzed the transcriptional regulation of aco gene cluster and the phenotype of acoR mutant, to determine the effect of acoR deletion on sporulation efficiency and Cry protein production.Sequence of aco gene cluster in Bacillus thuringiensis was analyzed by sequence alignment. RT-PCR was carried out to reveal the transcriptional units of the aco gene cluster. acoR insertion mutant was constructed by homologous recombination. Transcriptional activity was analyzed by promoter fusions with lacZ gene. Comparison of the Cry1Ac protein production was determined by protein quantitation.The aco gene cluster was composed of four genes. The acoABCL formed one transcriptional unit. The transcriptional activity of acoA promoter sharply decreased in sigL and acoR mutants, respectively. Deletion of acoR had no effect on growth and Cry protein production, but decreased the motility of cells and sporulation efficiency.The aco gene cluster is controlled by Sigma 54 and activated by AcoR. Deletion of acoR has no effect on Cry protein production, but decreased the motility of the cells.

Gene cluster

Bacillus thuringiensis

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A new sesquiterpene from the gorgonian coral Menella sp.

Natural Product Research (2016)

Qi Peng Fen Liu Huan Sun Xiao-Jian Liao Mei-Ran Feng

A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral Menella sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC50 values being 20.8 and 30.6 μM, respectively.

Gorgonian

HeLa

10.1080/14786419.2016.1166496

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Citations (5)

Hydraulic Modeling of A Curtain-Walled Dissipater by the Coupling of RANS and Boussinesq Equations

中国海洋工程(英文版) (2002)

Qi Peng

A hybrid numerical method for the hydraulic modeling of a curtain-walled dissipater of reflected waves from breakwa-ters is presented. In this method, a zonal approach that combines a nonlinear weakly dispersive wave (Boussinesq-type equation) method and a Reynolds-Averaged Navier-Stokes (RANS) method is used. The Boussinesq-type equation is solved in the far field to describe wave transformation in shallow water. The RANS method is used in the near field to re-solve the turbulent boundary layer and vortex flows around the structure. Suitable matching conditions are enforced at the interface between the viscous and the Boussinesq region. The Coupled RANS and Boussinesq method successfully resolves the vortex characteristics of flow in the vicinity of the structure, while unexpected phenomena like wave re-reflection are effectively controlled by lengthening the Boussinesq region. Extensive results on hydraulic performance of a curtain-walled dissipater and the mechanism of dissipation of reflected waves are presented, providing a reference for minimization of the breadth of the water chamber and for determination of the submerged depth of the curtain wall.

Boussinesq approximation (buoyancy)

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Citations (1)