Róża Szweda

Adam Mickiewicz University in Poznań

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i-10 index

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Co-Authors

Barbara Trzebicka

Centre of Polymer and Carbon Materials

Sara Kozub

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Dawid Szweda

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Jean‐François Lutz

Université de Strasbourg

Weronika Forysiak

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Andrzej Dworak

Centre of Polymer and Carbon Materials

Paweł Cwynar

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Maksymilian Szatko

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Dominik Kosowski

Centre of Polymer and Carbon Materials

Johanna Brazard

University of Geneva

Cooperative Institutions

Centre National de la Recherche Scientifique

Polish Academy of Sciences

Université de Strasbourg

Centre of Polymer and Carbon Materials

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Institut Charles Sadron

Lodz University of Technology

Łukasiewicz Research Network

Aix-Marseille Université

University of Łódź

Author Statistics

Papers

Citation

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i-10 index

Research Field

Revealing the Effect of Stereocontrol on Intermolecular Interactions between Abiotic, Sequence-Defined Polyurethanes and a Ligand

ACS Biomaterials Science & Engineering (2024)

Maksymilian Szatko Weronika Forysiak Sara Kozub Tadeusz Andruniów Róża Szweda

The development of precision polymer synthesis has facilitated access to a diverse library of abiotic structures wherein chiral monomers are positioned at specific locations within macromolecular chains. These structures are anticipated to exhibit folding characteristics similar to those of biotic macromolecules and possess comparable functionalities. However, the extensive sequence space and numerous variables make selecting a sequence with the desired function challenging. Therefore, revealing sequence–function dependencies and developing practical tools are necessary to analyze their conformations and molecular interactions. In this study, we investigate the effect of stereochemistry, which dictates the spatial location of backbone and pendant groups, on the interaction between sequence-defined oligourethanes and bisphenol A ligands. Various methods are explored to analyze the receptor-like properties of model oligomers and the ligand. The accuracy of molecular dynamics simulations and experimental techniques is assessed to uncover the impact of discrete changes in stereochemical arrangements on the structures of the resulting complexes and their binding strengths. Detailed computational investigations providing atomistic details show that the formed complexes demonstrate significant structural diversity depending on the sequence of stereocenters, thus affecting the oligomer–ligand binding strength. Among the tested techniques, the fluorescence spectroscopy data, fitted to the Stern–Volmer equation, are consistently aligned with the calculations, thus validating the developed simulation methodology. The developed methodology opens a way to engineer the structure of sequence-defined oligomers with receptor-like functionality to explore their practical applications, e.g., as sensory materials.

Sequence (biology)

10.1021/acsbiomaterials.4c00456

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Citations (4)

Preparation and characterization of doxorubicin nanocarriers based on thermoresponsive oligo(ethylene glycol) methyl ether methacrylate polymer-drug conjugates

European Polymer Journal (2018)

Daria Lipowska-Kur Róża Szweda Barbara Trzebicka Andrzej Dworak

Nanocarriers

Conjugate

Diethylene glycol

10.1016/j.eurpolymj.2018.10.008

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Citations (20)

One-pot approach for multi-step, iterative synthesis of sequence-defined oligocarbamates

European Polymer Journal (2022)

Paweł Cwynar Paweł Pasikowski Róża Szweda

Sequence (biology)

10.1016/j.eurpolymj.2022.111706

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Citations (11)

Characterization of sequence-defined oligomers by NMR and GPC

Zenodo (CERN European Organization for Nuclear Research) (2024)

Róża Szweda

Sequence (biology)

Characterization

10.5281/zenodo.10555130

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Citations (0)

Synthesis of oligoarylacetylenes with defined conjugated sequences using tailor-made soluble polymer supports

Chemical Communications (2017)

Róża Szweda Christophe Chendo Laurence Charles Paul N. W. Baxter Jean‐François Lutz

The use of polystyrene-based soluble polymer supports greatly simplifies the synthesis and characterization of self-aggregating sequence-defined oligoarylacetylenes.

Polystyrene

Characterization

Sequence (biology)

10.1039/c7cc03633g

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Citations (28)

Synthesis of Stereocontrolled Polyurethanes with Defined Monomer Order by Step-economy Approach

Anuj Sharma Paweł Cwynar Vijaj Gupta Róża Szweda

Polyurethanes are valuable materials in the industrial sector due to their broad scope of various applications. Traditional synthesis methods rely on step-growth polymerization, which inherently lacks precise molecular weight and structure control. Consequently, pursuing a synthetic strategy for stereocontrolled, sequence-defined polyurethanes represent a substantial challenge in soft material design. This study demonstrates an approach to synthesising discrete, stereo-regulated polyurethanes with defined monomer order by combining the one-pot synthesis method with iterative exponential growth. This work presents a methodology to fabricate non-biological polymers with structural precision characteristics for biomacromolecules. By varying the composition of different monomers and gradually increasing the chiral monomer content or altering its position within the polymer chain, we can influence the secondary structures of polyurethanes and, consequently, their properties and functions. Furthermore, we demonstrated the production of polymers with non-symmetrical sequences, showcasing the feasibility of tailoring polymer chains to specific requirements and preserving complete sequence control. This synthetic strategy paves the way for the facile fabrication of abiotic polymers that could emulate the characteristics of artificial proteins.

Sequence (biology)

Step-growth polymerization

10.26434/chemrxiv-2023-xxcfb

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Citations (1)

Thermoresponsive polymer-peptide/protein conjugates

Progress in Polymer Science (2016)

Barbara Trzebicka Róża Szweda Dominik Kosowski Dawid Szweda Łukasz Otulakowski

Bioconjugation

Biomolecule

Conjugate

10.1016/j.progpolymsci.2016.12.004

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Citations (78)

Well-defined Conjugated Macromolecules in Sensing

Agata Krywko‐Cendrowska Dawid Szweda Róża Szweda

Macromolecules with well-defined structures in terms of molar mass and monomer sequence became interesting building blocks for modern materials. The precision of the macromolecular structure makes fine-tuning of the properties of resulting materials possible. Conjugated macromolecules exhibit excellent optoelectronic properties that make them exceptional candidates for sensors construction. The importance of chain length and monomer sequence is particularly important in conjugated systems. The sequence lengths, monomer sequence and structural modification often influence the energy bang gap between HOMO and LUMO orbitals of the molecules that reflect in their properties. Moreover, the supramolecular aggregation that is often observed in oligo-conjugated systems is usually strongly affected by even minor structural changes that are used for sensor designs. This review summarizes the examples of well-defined conjugated macromolecules based on oligo(arylene ethynylene)s skeleton used for sensor applications. The sensing mechanisms and importance of uniformity of structure are discussed.

Sequence (biology)

10.20944/preprints202004.0148.v1

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Citations (4)

One-pot approach for multi-step, iterative synthesis of sequence-defined oligocarbamates

Paweł Cwynar Paweł Pasikowski Róża Szweda

High-yielding and scalable methods for iterative synthesis of sequence-defined macromolecules is a great challenge in modern polymer chemistry. Sequence-defined macromolecules are fabricated by multi-step iterative processes that involve high reagents and solvents consumption. Moreover, every step causes yield losses that result in low overall yield. Despite the envisioned valuable functions and applications of sequence-defined polymers, the synthetic limitations constitute a barrier for the exploitation of their practical potential. Here, we investigated the one-pot synthesis of oligocarbamates without the purification of intermediates. To control monomer sequence without isolation, we introduced a monitoring feedback loop to fuel the exact amount of reagents to the reaction mixture, assuring full conversion of each reaction. Based on a one-pot strategy, we have developed a facile approach for the preparation of uniform, oligocarbamates with full control of monomer order and defined stereochemistry. The great advantage of the presented methodology is the scalability of the process (demonstrated for synthesis of 50 g) and high yield (up to 90%). Oligomers obtained on a large scale can be further used as precursors for the synthesis of polymers with high molar mass. One-pot methods combined with chemoselective reactions bear the potential to overcome existing synthesis limitations and unlock the practical use of sequence-defined macromolecules. The presented concept might be further extended to different multi-step processes.

Sequence (biology)

Two step

10.26434/chemrxiv-2022-4pg74

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Citations (0)

Smart Polymeric Nanocarriers of Met-enkephalin

Biomacromolecules (2016)

Róża Szweda Barbara Trzebicka Andrzej Dworak Łukasz Otulakowski Dominik Kosowski

This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene glycol) monomethyl ether methacrylate) is synthesized by AGET ATRP using modified met-enkephalin as a macroinitiator. The abrupt heating of bioconjugate water solution leads to the self-assembly of bioconjugate chains and the formation of mesoglobules of controlled sizes. Mesoglobules formed by bioconjugates are stabilized by coating with cross-linked two-layer shell via nucleated radical polymerization of N-isopropylacrylamide using a degradable cross-linker. The targeting peptide RGD, containing the fluorescence marker carboxyfluorescein, is linked to a nanocarrier during the formation of the outer shell layer. In the presence of glutathione, the whole shell is completely degradable and the met-enkephalin conjugate is released. It is anticipated that precisely engineered nanoparticles protecting their cargo will emerge as the next-generation platform for cancer therapy and many other biomedical applications.

Bioconjugation

Nanocarriers

Conjugate

Atom-transfer radical-polymerization

10.1021/acs.biomac.6b00725

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Citations (21)