Jonas Belchior Tamanini

Universidade Estadual de Campinas (UNICAMP)

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Carlos Takahiro Chone

Universidade Estadual de Campinas (UNICAMP)

Eduardo Vieira Couto

Universidade Estadual de Campinas (UNICAMP)

Fábio Lau

Universidade Estadual de Campinas (UNICAMP)

Fabio Portella Gazmenga

Universidade Estadual de Campinas (UNICAMP)

Vanessa Carvalho de Oliveira

Universidade Estadual de Campinas (UNICAMP)

Guita Stoler

Universidade Estadual de Campinas (UNICAMP)

Guilherme Paiva Gabriel

Universidade Estadual de Campinas (UNICAMP)

Raquel Mezzalira

Instituto Penido Burnier

Gustavo Mercuri

Universidade Estadual Paulista (Unesp)

Daniel Naves Araújo Texeira

Universidade Estadual de Campinas (UNICAMP)

Cooperative Institutions

Universidade Estadual de Campinas (UNICAMP)

Hospital de Clínicas da Unicamp

Universidade Federal do Rio Grande do Sul

Primary Source

Pontifícia Universidade Católica de Campinas

Universidade de São Paulo

Universidade Federal do Maranhão

Hospital de Clínicas de Porto Alegre

Universidade Federal da Bahia

Google (United States)

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Treatment outcome of oropharyngeal squamous cell carcinoma through propensity score analysis

Brazilian Journal of Otorhinolaryngology (2023)

Fábio Lau Matheus Lisatchok Jonas Belchior Tamanini Fabio Portella Gazmenga Daniel Naves Araújo Texeira

According to an extensive database, the Objective is to compare surgical versus non-surgical treatment through Propensity Score (PS) for patients with Oropharyngeal Squamous Cell Carcinoma (OPSCC). We retrospectively evaluated epidemiological data from 8075 patients with OPSCC diagnosed between 2004 and 2014 and used PS matching to analyze possible prognostic factors for its outcomes with regression analyses. Cox multiple regression analysis to study survival after PS matching shows that type of treatment was associated with death with a hazard ratio of 1.753 (p < 0.05) of non-surgical treatment. However, it was not associated with recurrence (p > 0.05). In the surgical treatment group, overall survival was 79.9% at one year, 36.4% at five years, and 20.5% at ten years. Disease-free survival was 90.1%, 64.8%, and 56.0% at 1, 5, and 10-years, respectively. In the non-surgical treatment group, overall survival was 60.6% at one year, 21.8% at five years, and 12.7% at ten years. Disease-free survival was 90.8%, 67.2%, and 57.8% at 1, 5, and 10-years, respectively. Patients in the surgical treatment group had better outcomes related to survival. Recurrence is associated with the survival of OPSCC cancer. Recurrence-free survival is similar to both treatments. 2C.

10.1016/j.bjorl.2023.101335

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Dissociation between vHIT and caloric test: A marker of Menière's disease? – A systematic review

Brazilian Journal of Otorhinolaryngology (2022)

Jonas Belchior Tamanini Maria Gabriela Bonilha Vallim Carbinatto Guilherme Paiva Gabriel Raquel Mezzalira Guita Stoler

10.1016/j.bjorl.2022.10.043

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Neuroendocrine adenoma of middle ear: a case report and endoscopic approach

Brazilian Journal of Otorhinolaryngology (2024)

Nicolau Moreira Abrahão Guilherme Corrêa Guimarães Jonas Belchior Tamanini Sofia Fontes de Oliva Costa Pedro Ferreira

10.1016/j.bjorl.2024.101432

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Prognostic factors in oropharyngeal squamous cell carcinoma in the state of São Paulo, Brazil: 10-year follow-up

Figshare (2023)

Fábio Lau Jonas Belchior Tamanini Fabio Portella Gazmenga Gustavo Mercuri Vanessa Carvalho de Oliveira

Abstract Objective: To descriptively analyze the epidemiological data, clinical stage, and outcomes of oropharyngeal squamous cell carcinoma in the state of São Paulo, Brazil, and to estimate the influence of clinical stage and treatment type on overall and disease-free survival. Methods: We retrospectively analyzed epidemiological data from the São Paulo Cancer Center Foundation database relative to patients with oropharyngeal squamous cell carcinoma diagnosed between 2004 and 2014 in the state of São Paulo. Univariate and multivariate Cox regression analyses were performed to assess factors associated with the outcomes. A forward stepwise selection procedure was used. Survival curves were estimated by the Kaplan-Meier method and compared by the Gehan-Breslow-Wilcoxon test. Results: A total of 8075 individuals with oropharyngeal squamous cell carcinoma were identified. Of these, 86.3% were diagnosed at an advanced stage and 13.7% at an early stage. Only 27.2% of patients were treated surgically, whereas 57.5% were treated medically. Patients undergoing surgery had longer overall survival than those receiving medical treatment in both early- and advanced-stage oropharyngeal squamous cell carcinoma. However, there was no significant difference in disease-free survival between surgical and medical treatment. Conclusion: No significant difference in disease-free survival between medical and surgical treatment suggests similar complete remission rates with both approaches. Patients receiving medical treatment had shorter overall survival, which may be due to complications from chemotherapy and radiotherapy. However, we cannot confirm this relationship based on the data provided by the São Paulo Cancer Center Foundation. Prospective studies are warranted to assess whether the lower overall survival rate in patients receiving medical treatment is secondary to complications from chemotherapy and radiotherapy. Level of evidence: 2C.

10.6084/m9.figshare.21936676

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Prognostic factors in oropharyngeal squamous cell carcinoma in the state of São Paulo, Brazil: 10-year follow-up

Brazilian Journal of Otorhinolaryngology (2022)

Fábio Lau Jonas Belchior Tamanini Fabio Portella Gazmenga Gustavo Mercuri Vanessa Carvalho de Oliveira

To descriptively analyze the epidemiological data, clinical stage, and outcomes of oropharyngeal squamous cell carcinoma in the state of São Paulo, Brazil, and to estimate the influence of clinical stage and treatment type on overall and disease-free survival.We retrospectively analyzed epidemiological data from the São Paulo Cancer Center Foundation database relative to patients with oropharyngeal squamous cell carcinoma diagnosed between 2004 and 2014 in the state of São Paulo. Univariate and multivariate Cox regression analyses were performed to assess factors associated with the outcomes. A forward stepwise selection procedure was used. Survival curves were estimated by the Kaplan-Meier method and compared by the Gehan-Breslow-Wilcoxon test.A total of 8075 individuals with oropharyngeal squamous cell carcinoma were identified. Of these, 86.3% were diagnosed at an advanced stage and 13.7% at an early stage. Only 27.2% of patients were treated surgically, whereas 57.5% were treated medically. Patients undergoing surgery had longer overall survival than those receiving medical treatment in both early- and advanced-stage oropharyngeal squamous cell carcinoma. However, there was no significant difference in disease-free survival between surgical and medical treatment.No significant difference in disease-free survival between medical and surgical treatment suggests similar complete remission rates with both approaches. Patients receiving medical treatment had shorter overall survival, which may be due to complications from chemotherapy and radiotherapy. However, we cannot confirm this relationship based on the data provided by the São Paulo Cancer Center Foundation. Prospective studies are warranted to assess whether the lower overall survival rate in patients receiving medical treatment is secondary to complications from chemotherapy and radiotherapy.2C.

T-stage

10.1016/j.bjorl.2022.07.003

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Dissociation between video head impulse test and caloric test: a marker of menière's disease? – A systematic review and meta-analysis

Brazilian Journal of Otorhinolaryngology (2023)

Jonas Belchior Tamanini Raquel Mezzalira Maria Gabriela Bonilha Vallim Guilherme Paiva Gabriel Guita Stoler

To analyze, by means of a systematic review and meta-analysis, the proportion of patients with Meniere's disease who have altered caloric test and vHIT, as well as to determine the prevalence of altered caloric test and normal vHIT dissociation in the diagnosis of Meniere's disease.The literature search had no restriction regarding the period of publication on the following indexed data platforms: PubMed, PubMed PMC, BVS-Bireme, Web of Science, Embase and Cochrane Library. Articles that evaluated patients with Meniere's disease who underwent caloric test and vHIT were included. Two researchers independently conducted the analysis of the articles, promoting the selection and capture of data, following the recommendations of the PRISMA method, and complying with the criteria for articles inclusion and exclusion defined in the research protocol. In case of disagreement during the selection process, a third researcher was included for analysis.From a total of 427 initial studies, the researchers selected 12 articles, published between 2014 and 2021, with a total of 708 patients evaluated, with a mean age of 52.72 years old. The prevalence of patients with Meniere's disease with altered caloric reflex test was 64% (95% CI 57%‒71%), while the prevalence of altered vHIT was only 28% (95% CI 16%-40%). The prevalence of the altered caloric test + normal vHIT dissociation was 47% (95% CI 37%-57%).The video head impulse test and the caloric test are valuable tools for vestibular assessment. The dissociation of findings between these two tests in patients with Meniere's disease was more prevalent in this meta-analysis and may be a result of the tonotopy of specialized hair cells in the ampullary crest. The prevalence of altered caloric test was 64% and anormal vHIT was 28%. The dissociation caloric asymmetry and normal vHIT was observed in 47% of the patients.

Caloric test

Caloric theory

10.1016/j.bjorl.2023.101279

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