Hongxia Yao

Hainan General Hospital

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Congming Wu

China Agricultural University

Lie Lin

Hainan Medical University

Xiangjun Fu

University of Electronic Science and Technology of China

Yipeng Ding

Hainan General Hospital

Ming Hou

Qilu Hospital of Shandong University

Yueying Li

Zhongnan Hospital of Wuhan University

Qian‐Fei Wang

Chinese Academy of Sciences

Xiaohui Zhang

Peking University

Hu Zhou

Henan Cancer Hospital

Zeping Zhou

Kunming Medical University

Cooperative Institutions

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Hainan General Hospital

Shanghai Jiao Tong University

Hainan Medical University

Huazhong University of Science and Technology

Capital Medical University

Peking University People's Hospital

Central South University

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TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population

Oncotarget (2017)

Hongxia Yao Mengling Duan Lie Lin Congming Wu Xiangjun Fu

The promoter of MEG3, which encodes the long non-coding RNA (lncRNA) MEG3, is often hypermethylated in acute myeloid leukemia (AML). Additionally, the Tet methylcytosine dioxygenase 2 gene (TET2) is frequently inactivated, which can lead to impaired DNA methylation and promote AML development. We examined the association between TET2 and MEG3 promoter hypermethylation in Hainan patients with AML. The expression of MEG3, TET2, miR-22-3p, and miR-22-5p was assessed in bone marrow samples from AML patients and healthy controls using real-time quantitative PCR. Using Sequenom MassARRAY technology, we compared MEG3 promoter methylation in AML patients and healthy controls. MEG3 expression was lower in AML patients than in the controls (P = 0.136). Moreover, there was greater methylation of MEG3 promoter in the AML patients than the controls (P < 0.05). Methylation of the MEG3 promoter correlated negatively with TET2 expression (P < 0.05, r < 0). Likewise there was a negative correlation between TET2 activity and MEG3 promoter methylation (P < 0.05, r < 0). These results suggest that hypermethylation of the MEG3 promoter in AML may result from decreased TET2 activity. These data provide insight into the molecular mechanisms underlying AML development and progression.

MEG3

10.18632/oncotarget.15440

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A life-threatening bleeding prediction model for immune thrombocytopenia based on personalized machine learning: a nationwide prospective cohort study

Science Bulletin (2023)

Zhuo‐Yu An Yejun Wu Yu Hou Heng Mei Weixia Nong

Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications in patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to critical bleeding in ITP, large sample size data, consistent definitions, large-scale multicenter findings, and prediction models for critical bleeding events in patients with ITP are unavailable. For the first time, in this study, we applied the newly proposed critical ITP bleeding criteria by the International Society on Thrombosis and Hemostasis for large sample size data and developed the first machine learning (ML)-based online application for predict critical ITP bleeding. In this research, we developed and externally tested an ML-based model for determining the risk of critical bleeding events in patients with ITP using large multicenter data across China. Retrospective data from 8 medical centers across the country were obtained for model development and prospectively tested in 39 medical centers across the country over a year. This system exhibited good predictive capabilities for training, validation, and test datasets. This convenient web-based tool based on a novel algorithm can rapidly identify the bleeding risk profile of patients with ITP and facilitate clinical decision-making and reduce the occurrence of adversities.

Major bleeding

10.1016/j.scib.2023.08.001

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Progress in the Treatment of Hematological Diseases with Rituximab

Open Journal of Blood Diseases (2021)

Xiangjun Fu Lie Lin Hongxia Yao Li Huang Can Meng

Rituximab is a mouse and human chimeric CD20 (anti-B cell) specific monoclonal antibody that has been approved by the U.S. Food and Drug Administration for the treatment of lymphoma. The expression of CD20 antigen is expressed in the whole ontogeny of B cells, starting from the premature B cells in bone marrow to the differentiation of plasma cells in secondary lymphoid tissues. The wide distribution of CD20 molecules allows rituximab to eliminate a large number of B cells. Rituximab is the core drug for the treatment of hematological diseases, often combined with drugs as a first-line treatment. Long-term hormone therapy often results in serious adverse reactions, and new therapies, which can avoid widespread immunotoxicity, have great potential for treating diseases of the blood system.

10.4236/ojbd.2021.111002

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Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population

Archivos de Bronconeumología (2020)

Hui Lu Yixiu Yang Xianghong Chen Cibing Wu Jie Zhao

Heterozygote advantage

10.1016/j.arbres.2019.11.026

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Citations (1)

Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population

Archivos de Bronconeumología (2020)

Hui Lü Yixiu Yang Xianghong Chen Cibing Wu Jie Zhao

Heterozygote advantage

10.1016/j.arbr.2019.11.025

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[Effects of sodium ozagrel in primary thrombocytosis combined with thrombosis].

PubMed (2009)

Hongxia Yao Li Huang Congming Wu Lie Lin Zhao-Qian Huang

This study was aimed to investigate the incidence of thrombosis in patients with primary thrombocytosis (PT) and its correlation with function changes of platelets, and to explore the effect of thromboxane A2 (TXA2) inhibitor-ozagrel sodium on platelet activity and its efficacy for prevention and treatment of thrombosis. The CD62P and PAC-1 levels on platelet surface were detected by flow cytometry; the levels of TXB2 (metabolic product of TXA2) and 6-keto-PGFIalpha (metabolic product of prostacyclin) were detected by FLISA. The function change of platelets and its correlation with thrombosis were observed and compared in PT patients with and without thrombosis. The results indicated that the TXB2, PAC-1 and CD62P level, and TXB2/6-keto-PGF1alpha ratio in PT patients with thrombosis were higher than those in PT patients without thrombosis before treatment with ozagrel sodium (p<0.01). After treatment with ozagrel sodium, the function indexes of platelets such as CD62P, PAC-1, TXB2 and TXB2/6-keto-PGF1alpha except 6-keto-PGF1alpha in PT patients with and without thrombosis decreased obviously (p<0.01), but there was no significant difference in TXB2, 6-keto-PGF1alpha and TXB2/6-keto-PGF1alpha levels between PT patients with and without thrombosis except CD62P and PAC-1. It is concluded that the multi-index of platelets in PT patients with thrombosis are higher than that in PT patients without thrombosis, the activation of platelet function is a high risk factor for thrombosis of PT patients. The ozagrel sodium can obviously reduce the platelet activation, decrease the production of TXA2 and ameliorate the TXB2/6-keto-PGF1alpha ratio. The ozagrel sodium not only possesses therapeutic effect, but also preventive efficacy for thrombosis.

Thrombocytosis

Thromboxane B2

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Clinical and CT diagnostic analysis of ectopic pheochromocytoma

China Practical Medicine (2011)

Hongxia Yao

Objective To investigate clinical and CTfeaturesof ectopic pheochromocytoma.Methods 15 cases ectopic pheochromocytoma with complete medical records and operation pathology,proved by CT were retrospectively analyzed.Results The rate of tumors found with CT was 100%.In 15 cases,13 cases were preoperative diagnosed,and the accuracy of CT diagnosis was 86.7%.There were 13 benign and 2 malignant cases,and the incidence of malignant ectopic pheochromocytoma was 13.3%.Conclusion CT is the most effective imaging modality in ectopic pheochromocytoma diagnosis,localization and determination of pathologic nature.CT examination coupled with clinical features and imaging characteristics is very meaningful in accurate diagnosis,making operation programs and reducing operation mistakes of ectopic pheochromocytoma.

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The advance in the therapy of therapy-resistant keloids

Int J Radiat Med Nuel Med (2009)

Hongxia Yao Jinshan Zhang

Keloids are huamn benign dermal tumors, excessive fibroproliferative disorders that enlarge and extend beyond the margins of the origin wounds. Some keloids have proven to be very resistant to treatment, for example, several treatment modalities including surgical excision in combination with radiotherapy in the form of roentgen radiation (X-ray), pharmaceuticals, intralesional corticosteroids or calcium ions blocking agents, silicone gel sheets, physical therapy such as pressuretherapy, lasertherapy, cryotherpay might be less efficacious, and sometimes they cannot be performed because of limited conditions. Some keloids have higher recurrence rates. It is difficult to treat some keloids with complications of infection, ~(32)P-phosphours combination with vittamin E may be iuseful to treat therapy-resistant keloids. Key words: Keloids; Vitamin E; Phosphorus radioisotopes

Keloid

Treatment modality

Combination therapy

10.3760/cma.j.issn.1673-4114.2009.04.014

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[Committed hematopoeitic differentiation of embryonic stem cell].

PubMed (2002)

Qiyang Xie Jie-ge Jiao Yuanhua Huang Hongxia Yao Rong Tu

To explore a stable technology for inducing ES cell to committed hematopoietic differentiation.The effects of various inductive factors on BLast Colony-Forming Cell (BL-CFC) were investigated. In vitro differentiative system for ES cells was employed in this study.A high linear correlation between the number of D3.5 EB-derived cells plated and the number of blast cell colonies was developed, r = 0.9931. With high frequency of blast colonies observed (1.08-1.2 colonies per 100 cells). 20%-30% D4T conditioned medium (D4T CM) showed the most significant growth potentials of blast colonies. D4T CM, EPO or KL alone had no blast colony growth promoting effect (P > 0.05). But VEGF alone had high significant blast colony growth promoting effect (P < 0.001). However, any two factors combination from above four factors exerted better growth promoting effect than VEGF alone (EPO + D4T CM, P < 0.05; KL + D4T CM, P < 0.01; VEGF + D4T CM, P < 0.001). There were no significant difference among VEGF + KL and EPO + D4T CM or KL + D4T CM, and KL + D4T CM (P > 0.05). While the combination of VEGF + D4T CM was better than KL + D4T CM, VEGF + KL or EPO + D4T CM (P < 0.001). Moreover, the combination of VEGF + KL + D4T CM + EPO, had the highest significant blast colony growth promoting effect (P < 0.001). And the highest frequency of blast colonies was observed (1.5-1.2 colonies per 100 cells).VEGF may be the main factor which stimulates the growth of significant numbers of blast cell colonies. D4T CM maybe contains strong cofactors. EPO and KL are the main factors for the induction of BL-CFC to committed hematopoietic differentiation. D3.5 EB-derived cells are more sensitive to various stimulators and have strong blast colony growth promoting effect than that of D3.25 EB-derived cells.

Precursor cell

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A New Path of Grammer Teaching in Senior High Schools

Hongxia Yao

The definition of focus on form is analyzed and its application to grammar teaching in senior high schools is explored.It is pointed out that focus on form is an efficient way which integrates form into meaning in teaching second language.The operational steps are put forward: providing comprehensible input which contains the goal structures,guiding the students discovery learning,explicit teaching,the communicating tasks in which the goal structures have to be used and offering the feedback to the finished task and correcting mistakes.

Focus on form

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