Amber J. Kiliti

Georgetown University Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Sizhi Paul Gao

Memorial Sloan Kettering Cancer Center

Hannah Wise

Memorial Sloan Kettering Cancer Center

Barry S. Taylor

Loxo Oncology at Lilly (United States)

Wenhuo Hu

Memorial Sloan Kettering Cancer Center

Aphrothiti J. Hanrahan

Memorial Sloan Kettering Cancer Center

David B. Solit

Memorial Sloan Kettering Cancer Center

Anton Wellstein

Georgetown University Medical Center

Anna T. Riegel

Georgetown University Medical Center

Neal Rosen

Memorial Sloan Kettering Cancer Center

Brett S. Carver

Memorial Sloan Kettering Cancer Center

Cooperative Institutions

Memorial Sloan Kettering Cancer Center

Kettering University

Georgetown University

Georgetown University Medical Center

Cornell University

Molecular Oncology (United States)

University of Pennsylvania

New York Proton Center

Vince Lombardi Cancer Clinic

MedStar Georgetown University Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer

Frontiers in Endocrinology (2023)

Amber J. Kiliti Ghada M. Sharif Mary Beth Martin Anton Wellstein Anna T. Riegel

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. ERα regulates gene transcription through recruitment of essential coregulators, including the steroid receptor coactivator AIB1 (Amplified in Breast Cancer 1). AIB1 itself is an oncogene that is overexpressed in a subset of breast cancers and is known to play a role in tumor progression and resistance to endocrine therapy through multiple mechanisms. Here we review the normal and pathological functions of AIB1 in regard to its ERα-dependent and ERα-independent actions, as well as its genomic conservation and protein evolution. We also outline the efforts to target AIB1 in the treatment of breast cancer.

Estrogen receptor alpha

10.3389/fendo.2023.1250218

Cite

Citations (7)