Valerio Podio

Ospedale San Luigi Gonzaga

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Giancarlo Castellano

Richmond University Medical Center

T. Angusti

Ospedale San Luigi Gonzaga

G Bisi

University of Turin

Riccardo Bertolo

University of Verona

Andrea Skanjeti

Hospices Civils de Lyon

Cristian Fiori

University of Turin

F. Porpiglia

University of Turin

Fabio Broglio

University of Turin

Ezio Ghigo

University of Turin

Maria Rosa Valetto

Zadig (Italy)

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University of Turin

114

Azienda Ospedaliero Universitaria San Giovanni Battista

Ospedale San Luigi Gonzaga

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

Fondazione Ricerca Molinette

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Ospedale Maggiore

University of Bologna

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Radionuclide angiocardiographic evaluation of the cardiovascular effects of recombinant human IGF-I in normal adults

European Journal of Endocrinology (1999)

G Bisi Valerio Podio MR Valetto Fabio Broglio Giovanni Bertuccio

OBJECTIVE: IGF-I possesses specific myocardial receptors and is able to promote cardiac remodelling and even inotropic effects in both humans and other animals. In fact, reduced cardiac mass and performance are present in GH deficiency and these alterations are counteracted by recombinant human (rh) GH replacement, restoring IGF-I levels. Recently, the acute administration of 60 microg/kg rhIGF-I has also been reported to be able to improve cardiac performance evaluated by echocardiography or impedance cardiography in normal subjects. The aim of our study was to verify the effects of a subcutaneous low dose of rhIGF-I (20 microg/kg) on cardiac performance in humans. METHODS: In six healthy male adults (mean+/-S. e.m.: 35.7+/-4.3 years of age), the effects of rhIGF-I on left ventricular function evaluated by radionuclide angiocardiography and on circulating IGF-I, GH, insulin, glucose and catecholamines levels were studied. RESULTS: Administration of rhIGF-I increased circulating IGF-I (peak at +150 min vs baseline: 330.2+/- 9.6 vs 199. 7+/-8.7 microg/l, P<0.03) to levels which persisted similarly up to +180min. Neither GH nor catecholamine levels were modified by rhIGF-I administration, while insulin and glucose levels showed a slight but significant decrease. Basal left ventricular ejection fraction (61.8+/-2.0%) significantly increased at +180 min after rhIGF-I (65.3+/-2.7%, P<0.03). No change was recorded in mean blood pressure while a non-significant trend towards a reduction of heart rate was present by +120 min. CONCLUSIONS: These findings indicate that even subcutaneous administration of a low dose of rhIGF-I has acute inotropic effects as evaluated by radionuclide angiocardiography in healthy adults.

Basal (medicine)

10.1530/eje.0.1400322

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Citations (26)

612 RENAL DAMAGE FOLLOWING WARM ISCHEMIA DURING LAPAROSCOPIC PARTIAL NEPHRECTOMY: RESULTS OF A PROSPECTIVE STUDY

European Urology Supplements (2011)

F. Porpiglia Chiara Fiori Rodolfo Russo Riccardo Bertolo T. Angusti

Warm ischemia

10.1016/s1569-9056(11)60602-7

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[Effect of high-dose verapamil on systolic and diastolic cardiac function of non-cardiological patients and review of the literature].

PubMed (1991)

D Giroud Jean Delonca Valerio Podio R Egeli A Righetti

We studied the effects of high doses of oral verapamil (480 mg daily) in a group of 28 patients undergoing intravenous drug therapy for terminal digestive tumor. One additional patient was prematurely withdrawn from the study due to the occurrence of second degree atrioventricular block, which regressed after the interruption of verapamil. Gated radionuclide angiocardiography was performed before and after treatment (mean duration 2 days). Verapamil induced a significant reduction of blood pressure and heart rate (132 +/- 19 mm Hg vs 124 +/- 18 mm Hg, p = 0.005 for systolic blood pressure, 80 +/- 13 mm Hg vs 76 +/- 9 mm Hg, p = 0.04 for diastolic blood pressure and 81 +/- 17 bpm vs 77 +/- 13 bpm, p = 0.02 for heart rate). Left ventricular ejection fraction and peak filling rate were not impaired (65 +/- 7% vs 64 +/- 7%, p = NS and 2.52 +/- 0.65 EDV/s vs 2.42 +/- 0.51 EDV/s, p = NS), while peak ejection rate decreased slightly (2.96 +/- 0.72 EDV/s vs 2.72 +/- 0.50 EDV/s, p = 0.01). Conversely, there was significant alteration of right ventricular systolic indexes (50 +/- 7% vs 46 +/- 7%, p = 0.01 for the ejection fraction and 2.06 +/- 0.53 EDV/s vs 1.88 +/- 0.44 EDV/s, p = 0.008 for the peak ejection rate), without change in the peak filling rate (1.54 +/- 0.46 EDV/s vs 1.46 +/- 0.46 EDV/s, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)

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Cardiac effects of hexarelin in hypopituitary adults

European Journal of Pharmacology (1999)

G Bisi Valerio Podio Maria Rosa Valetto Fabio Broglio Giovanni Bertuccio

Basal (medicine)

Secretagogue

10.1016/s0014-2999(99)00537-3

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Citations (57)

252 Renal damage after laparoscopic partial nephrectomy in patients with normal contralateral kidney: Results after four year scintigraphic follow-up

European Urology Supplements (2012)

F. Porpiglia Cristian Fiori Riccardo Bertolo F. Mele Roberto Russo

10.1016/s1569-9056(12)60249-8

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Duodenal administration of solid lipid nanoparticles loaded with different percentages of tobramycin

Journal of Pharmaceutical Sciences (2003)

Roberta Cavalli Alessandro Bargoni Valerio Podio Elisabetta Muntoni Gian Paolo Zara

Solid lipid nanoparticle

10.1002/jps.10368

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Citations (132)

Evaluation of left ventricular diastolic function at rest and during exercise by gated radionuclide angiocardiography in coronary artery disease patients.

PubMed (1991)

Stefano Ciaroni Jean Delonca Valerio Podio A Righetti

The peak filling rate (PFR) is an index of the diastolic function and has been proposed as an excellent parameter for the evaluation and early detection of left ventricular (LV) dysfunction. This study contributes to the assessment of LV diastolic function at rest and during submaximal exercise in 19 normal subjects and in 42 patients with coronary artery disease (CAD). The PFR was compared to the ejection fraction (EF) and the peak ejection rate (PER)--both indexes of systolic LV function--after acquiring a high-resolution time-activity curve (time/frame between 10 and 30 msec) with gated radionuclide angiocardiography. In 23 patients with normal EF at rest (greater than or equal to 50%), PFR and PER were abnormally low in 87% and 43% of the cases respectively. During submaximal exercise in 13 CAD patients, EF, PFR and PER varied very little from baseline values but were significantly reduced compared to the values of normal subjects. The PFR proved to be a very sensitive indicator of LV dysfunction in coronary patients but was not capable of discriminating between one-, two- or three-vessel disease. Our results tend to show the PFR to be a good indicator of LV dysfunction at rest and during exercise and its usefulness for the assessment of LV function is becoming more and more evident in clinical practice.

Angiocardiography

Ventricular Function

Rest (music)

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Evidence of functional alterations in sympathetic activity after myocardial infarction

European Heart Journal (1993)

Maria Teresa Spinnler Federico Lombardi Carolina Moretti Giulia Sandrone Valerio Podio

To assess whether the presence of areas of efferent sympathetic denervation might contribute to alterations in sympathetic and vagal neural regulatory activities observed after myocardial infarction, we attempted to correlate the changes in the spectral components ofRR variability with the 1–123 MIBG and Thallium-201 uptake defects. Ten patients with first and uncomplicated myocardial infarction were studied. Thallium-201 and 1–123 MIBG scintigraphy as well as spectral analysis of heart rate variability were performed 7 days, 4, 12 and 30 months after the acute event. Regional abnormalities in 1–123 MIBG uptake were more extensive than the perfusion defects indicated by Thallium-201 images and remained constant throughout the entire period of observation. In the early post-infarction period, spectral analysis of RR variability was characterized by a predominant LF (74±6nu) and a smaller HF (16±3nu) component indicating a sympathetic predominance. Thereafter, we observed a progressive reduction in LF and a gradual increase in HF which were consistent with a normalization of sympatho-vagal balance. These data indicate that after a myocardial infarction, the presence and persistence of areas of sympathetic functional denervation do not seem to play a major role in determining the changes in sympathetic and vagal neural regulatory activities directed to the heart.

Sympathetic Denervation

Sympathetic activity

10.1093/eurheartj/14.10.1334

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Citations (27)

92 Renal scanning functional outcomes of “clampless” laparoscopic partial nephrectomy: The viable harmless alternative to “clamped”?

European Urology Supplements (2014)

F. Porpiglia Riccardo Bertolo Daniele Amparore T. Angusti Valerio Podio

10.1016/s1569-9056(14)60093-2

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Left ventricular function at 24 hours, 14 days and 6 months after acute myocardial infarction

European Heart Journal (1987)

A Righetti Valerio Podio Osman Ratib Christine Attenhofer Jost V. Stucki

To determine the natural history of left ventricular function at rest and during exercise and to assess the impact of this variable on subsequent mortality, 165 patients were studied with radionuclide angiography within 24 hours of acute myocardial infarction. The ejection fraction of the 19 patients who died during the 6 month follow-up was lower than that of the 146 survivals: 41 +/- 16% vs 50 +/- 13% (P less than 0.001). Before hospital discharge (14 +/- 4 days), 83 patients had a rest and submaximal exercise radionuclide study. The ejection fraction of the 42 patients with anterior infarction was 44 +/- 12% and remained unchanged during exercise, while the 41 patients with posterior infarction had a resting value of 54 +/- 9% which increased to 57 +/- 10% (P less than 0.001) during exercise. The ejection fraction during exercise increased slightly but significantly in 37/61 patients with single vessel disease, while it did not change in the 24/61 patients with multivessel disease. At a mean of 4 +/- 1 months following infarction, 58 patients underwent a symptom-limited exercise radionuclide study. Mean value of resting ejection fraction for the group or anterior-posterior infarction subgroups did not change from initial or predischarge values. The 27 patients with anterior infarction showed no change in ejection fraction during exercise, while the 31 patients with posterior infarction increased their ejection fraction from 53 +/- 11% to 57 +/- 12% (P less than 0.001). Thus, ejection fraction measured by radionuclide angiography 24 hours following acute myocardial infarction provides useful prognostic information.(ABSTRACT TRUNCATED AT 250 WORDS)

Radionuclide angiography

10.1093/eurheartj/8.suppl_g.15

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Citations (5)