Arham Javed

Shifa International Hospital

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Maira Mahmood

CMH Lahore Medical College and Institute of Dentistry

Uzma Jabbar

GIFT University

Muhammad Jawad Khan

National University of Sciences and Technology

Muhammad Rafiq

COMSATS University Islamabad

Afrose Liaquat

Shifa Tameer-e-Millat University

Farah Niazi

Amity University

Mazhar Mushtaq

Sulaiman Al Rajhi Colleges

Naim Ahmad Nizami

University of Sargodha

Irum Fayyaz

CMH Lahore Medical College and Institute of Dentistry

Rukhshan Khurshid

CMH Lahore Medical College and Institute of Dentistry

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CMH Lahore Medical College and Institute of Dentistry

COMSATS University Islamabad

Shifa Tameer-e-Millat University

University of Lahore

University of Karachi

Shalamar Hospital

Sulaiman Al Rajhi Colleges

International Center for Chemical and Biological Sciences

Fatima Jinnah Medical University

Shifa International Hospital

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Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease

Genes (2023)

Muhammad Rafiq Abdullahi Dandare Arham Javed Afrose Liaquat Afraz Ahmad Raja

Coronary heart disease (CHD) is a global health concern, and its molecular origin is not fully elucidated. Dysregulation of ncRNAs has been linked to many metabolic and infectious diseases. This study aimed to explore the role of circRNAs in the pathogenesis of CHD and predicted a candidate circRNA that could be targeted for therapeutic approaches to the disease. circRNAs associated with CHD were identified and CHD gene expression profiles were obtained, and analyzed with GEO2R. In addition, differentially expressed miRNA target genes (miR-DEGs) were identified and subjected to functional enrichment analysis. Networks of circRNA/miRNA/mRNA and the miRNA/affected pathways were constructed. Furthermore, a miRNA/mRNA homology study was performed. We identified that hsa_circ_0126672 was strongly associated with the CHD pathology by competing for endogenous RNA (ceRNA) mechanisms. hsa_circ_0126672 characteristically sponges miR-145-5p, miR-186-5p, miR-548c-3p, miR-7-5p, miR-495-3p, miR-203a-3p, and miR-21. Up-regulation of has_circ_0126672 affected various CHD-related cellular functions, such as atherosclerosis, JAK/STAT, and Apelin signaling pathways. Our results also revealed a perfect and stable interaction for the hybrid of miR-145-5p with NOS1 and RPS6KB1. Finally, miR-145-5p had the highest degree of interaction with the validated small molecules. Henchashsa_circ_0126672 and target miRNAs, notably miR-145-5p, could be good candidates for the diagnosis and therapeutic approaches to CHD.

Competing Endogenous RNA

Pathogenesis

Circular RNA

10.3390/genes14030550

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Urinary Retinol-binding protein 4 versus serum creatinine: Predictors of impaired renal function in patients with type 2 diabetes.

Rawal Medical Journal (2019)

Arham Javed Maira Mahmood Uzma Jabbar Muhammad Waqas Rabbani Faiza Aamer

Objectives: To find the role of urinary retinol binding protein 4 (RBP-4) compared to serum creatinine, as a better predictors of impaired renal function in patients with type 2 diabetes. Methodology: In this cross sectional study, 60 patients with T2D and 20 controls were included. Age of patients was in the range of 35-60 years with duration of diabetes

Retinol binding protein

Impaired renal function

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Biochemical parameters and comparison with CA 15-3 in premenopausal females with BRCA -

Rawal Medical Journal (2020)

Maira Mahmood Arham Javed Uzma Jabbar Muhammad Fahim ul Haq Naim Ahmad Nizami

Objective: To find the correlation of CA 15-3 with serum Ferritin and serum LDH in different stages BRCA. Methodology: A case control study was designed and included 70 patients with different stages of BRCA. Twenty normal subjects with no history of any disease or malignancy were taken as healthy controls. Estimation of serum LDH, serum CA 15-3 and serum ferritin was carried out by standard methods. Results: The levels of CA 15-3 along with serum ferritin and serum LDH were progressively increased in BRCA women from stage IV to stage 4. A significant correlation was observed between CA 15-3, serum LDH and serum Ferritin in advanced stages of BRCA. Conclusion: Levels of serum CA 15-3, serum ferritin and serum LDL are associated with tumor extent as their significantly increased values were observed in BRCA. A significant correlation was observed between and advanced stages of BRCA. Keywords: Tumor markers, LDH, ferritin.

Serum concentration

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Association of leukocyte telomere attrition in coronary artery disease in Pakistani population: A case-control study with meta-analysis

Clinica Chimica Acta (2023)

Muhammad Rafiq Afrose Liaquat Arham Javed Saeed Ullah Shah Rashid Hussain

Pathogenesis

10.1016/j.cca.2023.117416

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Assessment of health status in fiber glass workers: Role of chromium with biological antioxidants.

The Professional Medical Journal (2020)

Uzma Jabbar Maira Mahmood Arham Javed Naim Ahmad Nizami Mazhar Mushtaq

Objectives: The aim of study is to find out the role of chromium with biological antioxidant and how these can relate with the health of fiber glass workers. Study Design: Cross Sectional Study. Setting: Fiber glass industry Lahore. Period: July 2018 to Feb 2019. Material & Methods: Study was included the fifty workers of fiber glass industry with 4-5 years experience or time of exposure. A questionnaire was filled by each participant. Twenty individuals were taken as controls. Their blood sample was drawn to estimate the level of chromium and of biological antioxidants that include serum Catalase, Superoxide Dismutase, Glutathione and Malondialdehye. Results: Mean age of workers was 35 year with BMI 23.80 kg/m2. Their work duration in Fiber glass factory was 6-7 years. Levels of serum chromium and the biological antioxident was significantly high (P<0.001) in fiber glass workers as compared to the levels of these parameters of control. A positive weak correlation was observed between serum chromium and antioxidants MDA, SOD and catalase. On the other hand a moderate inverse correlation was observed between serum chromium and antioxidant GSH. Conclusion: It is concluded that high level of chromium in workers of fiber glass factory is responsible for increased levels of antioxidants in their body, which in long run may develop the diseases especially of respiratory tract.

10.29309/tpmj/2020.27.06.4114

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Homocysteine as a prognostic indicator for women with pregnancy-induced hypertension-a proportional study of homocysteine levels in normal versus pre-eclamptic women.

The Professional Medical Journal (2021)

Mudasir Zia Maira Mahmood Kiran Namoos Irum Fayyaz Huma Ashraf

Objective: To find the probable role of Homocysteine as a prognostic indicator for women with Pregnancy-Induced Hypertension and comparison of Homocysteine Levels in Normal Versus pre-eclamptic women. Study Design: Cross Sectional Comparative study. Setting: Gynecology Unit of Lahore General Hospital, Lahore. Period: May 2017 to Oct 2017. Material & Methods: Thirty four consented pre-eclamptic pregnant women with age range 29 to 35 years were included in the study. 20 age matched pregnant women with no history of any clinical problem were taken as controls. A questionnaire based on age, obstetric details including detail of gravida, family history etc was filled by both subjects and controls. Anthropometric parameters were noted based on height and weight. Blood sample of both patients and controls was drawn for estimation of blood urea, serum creatinine, and homocysteine. Results: Mean age of women was 31 year with BMI 27.0 Kg/m2. Levels of serum homocysteine were significantly more women with pre-eclampsia in comparison with cases of controls. However the values of blood urea and serum creatinine were insignificantly high in pre-eclamptic women in comparison with their controls. Conclusion: Serum homocysteine as a biomarker may help to find out its additive importance in the prediction of pre-eclampsia and the severity of its related complications.

Advanced maternal age

10.29309/tpmj/2021.28.09.6018

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Oxidative Stress Mediates the Association between Thyroid Dysfunction and Breast Cancer

The Indonesian Biomedical Journal (2023)

Maira Mahmood Mazhar Mushtaq Aamenah Malik Rukhshan Khurshid Faiza Aamir

BACKGROUND: Breast Cancer (BC) and thyroid dysfunction are commonly observed ailments in females, and two may occur synchronously. The present study was conducted to find the role of oxidative stress and its association with thyroid dysfunction and BC.METHODS: In this cross-sectional study, 288 and 100 subjects were included in case and control groups, respectively. Serum samples were obtained from consented subjects. Thyroid profile, thyroid antibodies, antioxidant and oxidant profiles, as well as cathepsin S (CTSS), prolactin, and estradiol levels were estimated using specific enzyme-linked immunosorbent assay kits. The data was analyzed using independent Student's t-test and Pearson correlation test.RESULTS: BC cases had higher levels of thyroid antibodies and thyroid stimulating hormone than controls. Prolactin and estradiol levels were also deranged in the case group. Higher oxidative stress biomarkers were evident in the case group; 8-hydroxy-2'-deoxyguanosine (8-OHdG), a DNA damage marker, increased concomitantly. Correlation analysis showed a positive correlation between the antioxidant (catalase) and the oxidant (8-OHdG) levels. Furthermore, the higher level of CTSS in BC cases than in the controls is the hallmark of this study, demonstrating the pathogenesis and progression of the disease.CONCLUSION: Results suggest the mediating role of oxidative stress in the association between thyroid dysfunction and BC. It concludes that the parameters assessed in this study could be indicative of disease progression and metastasis in BC as well as thyroid dysfunction.KEYWORDS: breast cancer, thyroid, oxidant, antioxidant, ROS

Thyroid disease

10.18585/inabj.v15i4.2487

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