Hao Yin

Zhongnan Hospital of Wuhan University

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Daniel G. Anderson

Massachusetts Institute of Technology

Wen Xue

University of Massachusetts Chan Medical School

Roman L. Bogorad

Massachusetts Institute of Technology

Victor Koteliansky

Skolkovo Institute of Science and Technology

Ying Zhang

Fujian Medical University

Róbert Langer

Massachusetts Institute of Technology

Haiwei Mou

The Wistar Institute

Zhiping Weng

University of Massachusetts Chan Medical School

Qiubing Chen

Zhongnan Hospital of Wuhan University

Cheng‐Di Dong

National Kaohsiung Marine University

Cooperative Institutions

Wuhan University

Chinese Academy of Sciences

Massachusetts Institute of Technology

Sichuan University

Harvard University

Zhongnan Hospital of Wuhan University

University of Massachusetts Chan Medical School

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

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Experimental study on seismic behavior of full-scale fully prefabricated steel frame: Members and joints

Engineering Structures (2018)

Gang Shi Hao Yin Fangxin Hu Yao Cui

10.1016/j.engstruct.2018.04.087

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Citations (17)

Prostaglandin I2 and E2 mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury

Hepatology (2006)

Hao Yin Linling Cheng Robert Langenbach Cynthia Ju

Studies of the molecular and cellular mechanisms of concanavalin A (ConA)-induced liver injury have provided important knowledge on the pathogenesis of many liver diseases involving hepatic inflammation. However, studies identifying hepato-protective factors based on the mechanistic understanding of this model are lacking. Evidence suggests that certain prostaglandin (PG) products of cyclooxygenase (COX)-1 and COX-2 provide important anti-inflammatory and cytoprotective functions in some pathophysiological states. In the present study, we demonstrate a protective role of COX-2 derived PGs in ConA-induced liver injury. COX-2−/− mice developed much more severe liver damage upon ConA treatment compared with wild-type and COX-1−/− mice. Treatment of COX-2−/− mice with misoprostol (a PGE1/2 analog) or beraprost (a PGI2 analog) significantly decreased ConA-induced liver injury. Data from both in vivo and in vitro experiments demonstrated that misoprostol and beraprost acted directly on hepatic leukocytes, including natural killer (NK)T and T cells, and down-regulated their production of interferon (IFN)-γ, which are critical in mediating ConA-induced tissue damage. Collectively, the results provide strong evidence that the protective effects of COX-2 within the liver are mediated through the production of PGE2 and PGI2, which exert anti-inflammatory functions. These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases. (Hepatology 2007;45:159–169.)

Pathogenesis

10.1002/hep.21493

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Citations (50)

miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cells

Figshare (2014)

Zheng Wang Hao Yin Yuanwei Zhang Yukun Feng Zhaofeng Yan

Defective DNA damage response (DDR) is frequently associated with carcinogenesis. Abrogation of DDR leads to chromosomal instability, a most common characteristic of tumors. However, the molecular mechanisms underlying regulation of DDR are still elusive. The ubiquitin ligase RNF8 mediates the ubiquitination of γH2AX and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DDR and inhibits chromosomal instability. Though RNF8 is a key player involved in DDR, regulation of its expression is still poorly understood. Here, we show that miR-214 could abrogate DDR by repressing RNF8 expression through direct binding to 3′-untranslated region (3′ UTR) of RNF8 mRNA in human ovarian cancer cells. Antagonizing miR-214 by expressing its inhibitors in A2780 cells significantly increased RNF8 expression and thus promoted DNA damage repair. Consistent with the role of miR-214 in regulating RNF8 expression, the impaired DNA repair induced by miR-214 overexpression can be rescued by overexpressing RNF8 mRNA lacking the 3′ UTR. Together, our results indicate that down-regulation of RNF8 mediated by miR-214 impedes DNA damage response to induce chromosomal instability in ovarian cancers, which may facilitate the understanding of mechanisms underlying chromosomal instability.

10.6084/m9.figshare.1232161

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miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cells

Figshare (2015)

Zheng Wang Hao Yin Yuanwei Zhang Yukun Feng Zhaofeng Yan

Chromosome instability

10.6084/m9.figshare.1232161.v3

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Finite element analysis on the seismic behavior of fully prefabricated steel frames

Engineering Structures (2018)

Hao Yin Gang Shi

Rebar

Bolted joint

Precast concrete

Slab

Tension (geology)

10.1016/j.engstruct.2018.06.096

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Citations (17)

Optimization of small portable hoist load-capacity model

AIP conference proceedings (2017)

Yuanheng Tang Hao Yin Zuo-tang Liang Cheng Xu

Small Portable Hoist (SPH) is needed in many special occasions; the load-capacity (LC) is one of the most important metrics. There are few researches direct related on SPH and the LC is calculated by Euler's formula in most published related literatures. Because of the SPH's unique, experimental research is carried out on the LC, an optimization of Euler's formula is got by analyzing the effects of wrap angle φ, end tension FB, and relative size of r and R. This optimization is more accurate and it deepens the understanding of the friction between wheel and the bending rope.

Hoist (device)

10.1063/1.4981594

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Author response for "Association between homocysteine and white matter hyperintensities in rural‐dwelling Chinese people with asymptomatic intracranial arterial stenosis: A population‐based study"

Xiang Wang Hao Yin Xiaokang Ji Shaowei Sang Sai Shao

Association (psychology)

10.1002/brb3.2205/v2/response1

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A CTL‐Inspired Killing System Using Ultralow‐Dose Chemical‐Drugs to Induce a Pyroptosis‐Mediated Antitumor Immune Function (Adv. Mater. 13/2024)

Advanced Materials (2024)

Hao Yin Congying Xie Zhigui Zuo Danli Xie Qinyang Wang

In article 2309839, Qinyang Wang and co-workers have developed a CTL-inspired system that mimics the process of T-cells attacking tumour cells.The system delivers chemotherapeutic drugs to cancer cells under the control of NIR light.The researchers found that this killing system enables an ultra-low dose of chemotherapeutic drugs to trigger pyroptosis-mediated anti-tumour immune function, leading to tumour regression. ANTITUMOR IMMUNOTHERAPY

Pyroptosis

CTL*

10.1002/adma.202470095

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Precision cancer mouse models through genome editing with CRISPR-Cas9

Genome Medicine (2015)

Haiwei Mou Zachary Kennedy Daniel G. Anderson Hao Yin Wen Xue

Abstract The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, requiring manipulation of embryonic stem cells and multiple steps. The recent development of the clustered regularly interspersed short palindromic repeats (CRISPR)-Cas9 system, a powerful genome-editing tool for efficient and precise genome engineering in cultured mammalian cells and animals, is transforming mouse-model generation. Here, we review how CRISPR-Cas9 has been used to create germline and somatic mouse models with point mutations, deletions and complex chromosomal rearrangements. We highlight the progress and challenges of such approaches, and how these models can be used to understand the evolution and progression of individual tumors and identify new strategies for cancer treatment. The generation of precision cancer mouse models through genome editing will provide a rapid avenue for functional cancer genomics and pave the way for precision cancer medicine.

Human genetics

10.1186/s13073-015-0178-7

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Citations (107)

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

Journal of Hepatology (2015)

Hao Yin Roman L. Bogorad Carmen Barnes Stephen C. Walsh Iris Zhuang

Functional Genomics

10.1016/j.jhep.2015.11.028

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Citations (9)