Takumi Yamabuki

Teine Keijinkai Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yataro Daigo

The University of Tokyo

Masaki Miyamoto

Hokkaido University

Satoshi Kondo

National Institute of Advanced Industrial Science and Technology

Satoshi Hayama

Muroran Institute of Technology

Eiju Tsuchiya

Kanagawa Cancer Center

Tatsuya Kato

Hokkaido University Hospital

Tomoo Ito

Kobe University

Nagato Sato

Kushiro City General Hospital

Nobuhisa Ishikawa

Hiroshima Prefectural Hospital

Daizaburo Hirata

Iwate Medical University

Cooperative Institutions

Hokkaido University

Hokkaido University Hospital

The University of Tokyo

Hakodate National Hospital

National Hospital Organization

Teine Keijinkai Hospital

Hiroshima University

Kanagawa Prefectural Hospital Organization

Red Cross Hospital

Sapporo Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Paget's disease associated with lung cancer. A case report.

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2002)

Takumi Yamabuki Naofumi Yoshida Shigeki ABESHIMA Naoto Hasegawa Noriaki Kanno

症例は76歳,男性.肛門部に湿疹様病変を自覚し,他院にて慢性湿疹として治療されていた.当科初診時,やや境界不明瞭で表面凹凸の扁平隆起性病変を伴った湿疹様の皮膚病変を認めた.また,胸部X線検査,胸部CTにて直径約2.Ocmのspiculaを伴った結節影を認め,経気管支肺生検を施行したところ,扁平上皮癌の病理診断が得られた.手術は,肺機能を考慮し,二期手術とすることとしたが患者の希望が強く肛門部手術を先行した.病理組織学的に肛門周囲の皮膚病変はPaget病,肺腫瘍は扁平上皮癌の確定診断が得られた.患者は術後9カ月を経た現在,健在である.乳房外Paget病は消化器癌のみならず肺癌など他臓器癌を合併することがあり注意深い精査が必要である.

10.3919/jjsa.63.644

Cite

Citations (1)

Supplementary Figures 1-4 from Activation of Holliday Junction–Recognizing Protein Involved in the Chromosomal Stability and Immortality of Cancer Cells

Tatsuya Kato Nagato Sato Satoshi Hayama Takumi Yamabuki Tomoo Ito

Supplementary Figures 1-4 from Activation of Holliday Junction–Recognizing Protein Involved in the Chromosomal Stability and Immortality of Cancer Cells

Immortality

10.1158/0008-5472.22367568

Cite

Citations (0)

Supplementary Figure 2A from Phosphorylation and Activation of Cell Division Cycle Associated 8 by Aurora Kinase B Plays a Significant Role in Human Lung Carcinogenesis

Satoshi Hayama Yataro Daigo Takumi Yamabuki Daizaburo Hirata Tatsuya Kato

Supplementary Figure 2A from Phosphorylation and Activation of Cell Division Cycle Associated 8 by Aurora Kinase B Plays a Significant Role in Human Lung Carcinogenesis

Human lung

Aurora inhibitor

10.1158/0008-5472.22370487

Cite

Citations (0)

Spontaneous retroperitoneal hematoma: a case report

Journal of Medical Case Reports (2023)

Takuma Kurotaki Naoya Okada Yasuo Sakurai Takumi Yamabuki Minoru Takada

Abstract Background Spontaneous retroperitoneal hematoma is defined as bleeding in the retroperitoneal space without any triggers such as trauma, invasive procedures, and abdominal aortic aneurysm. Case presentation A 48-year-old Japanese man who experienced sudden abdominal pain, severe hypotension, and decreased hemoglobin was diagnosed with spontaneous retroperitoneal hematoma. Contrast-enhanced computed tomography revealed massive left retroperitoneal hematoma; however, neither extravasation nor causative aneurysm was noted. Through conservative management with close monitoring, he was treated and discharged on the tenth hospital day without any morbidity. Conclusions Spontaneous retroperitoneal hematoma treatment comprises conservative management, transcatheter arterial embolization, and surgical intervention. The mortality rate of spontaneous retroperitoneal hematoma is so high that the optimal treatment timing needs to be carefully judged on the basis of detailed evaluation, and management algorithm with clear criteria.

Retroperitoneal Hemorrhage

Retroperitoneal space

Extravasation

Arterial Embolization

Presentation (obstetrics)

Surgical oncology

Conservative Management

10.1186/s13256-023-03794-4

Cite

Citations (0)

Lymphoepithelial Cyst of the Pancreas

Case Reports in Gastroenterology (2012)

Hiromitsu Domen Masanori Ohara Noriko Kimura Mizuna Takahashi Takumi Yamabuki

Cystic lesions of the pancreas can be divided into true cysts, pseudocysts, and cystic neoplasms. Lymphoepithelial cysts (LECs) are a type of true cyst that can mimic pseudocysts and cystic neoplasms. LECs are rare lesions; fewer than 90 cases have been reported in the English language literature. The case of a 60-year-old man with an LEC of the pancreas is reported. He was admitted with upper abdominal discomfort. Computed tomography showed a 64 × 39 mm cystic mass in the retroperitoneum behind the duodenum and inferior caval vein. Magnetic resonance imaging revealed a right-sided mass on T1-weighted imaging, with a clear boundary between the mass and its surroundings, except for the pancreas. The mass had an inhomogeneous intensity on T2-weighted imaging. Within the mass, small floating nodules with low intensity were seen. Endoscopic ultrasound showed many high-echoic nodules and smaller grains scattered everywhere in the mass. Fine needle aspiration and cytologic examination were performed. Characteristic chylaceous fluid was obtained in which anucleate squamous cells were found. There were also a few atypical large cells with irregularly shaped marked nucleoli and degenerative cytoplasm. Cytologic diagnosis was suspicious for malignancy. The lesion was diagnosed as a retroperitoneal cyst, probably of pancreatic origin. Since a neoplastic lesion could not be ruled out, surgery was performed. The lesion was palpable on the dorsal side of the second portion of the duodenum. The mass was completely resected. Macroscopically, the lesion was a multilocular cyst with a thin septal wall. The cyst was filled with cottage cheese-like substance. Microscopically, the cyst wall was composed of stratified squamous epithelium and dense subepithelial lymphatic tissue with developed lymph follicles. The epithelial cells had no atypia. The histopathologic diagnosis was LEC of the pancreas. The patient's postoperative course was good.

10.1159/000343421

Cite

Citations (16)

PS01.206: ASSESSMENT OF THE GASTRIC CONDUIT RECONSTRUCTION USING INDOCYANINE GREEN FLUORESCENT IMAGING DURING ESOPHAGECTOMY

Diseases of the Esophagus (2018)

Takumi Yamabuki Masanori Ohara Tsukasa Kaneko Aki Fujiwara Ryou Takahashi

Abstract Background Recently, indocyanine green (ICG) fluorescent imaging has been applied as a real-time navigation tool in various surgical fields. We used ICG fluorescent imaging for gastric conduit reconstruction during esophagectomy. Methods A total of 92 consecutive patients with esophageal cancer who received gastric conduit reconstruction during esophagectomy from February 2011 to December 2017 were enrolled in the present study. We made gastric conduit with hand-assisted laparoscopic surgery (HALS) following esophagectomy. A gastric conduit with a width of 3cm was usually fashioned. After evaluation of the blood flow to the gastric conduit using ICG fluorescent imaging, anastomosis was done by circular stapler. Results The study group was comprised of 73 males and 19 females and the median age was 70 years (range 54–85 years). Nineteen patients received preoperative chemotherapy and eleven patients received preoperative chemo-radiotherapy. Forty-eight patients underwent thoracoscopic esophagectomy, nineteen patients underwent thoracotomy and twenty-five patients underwent laparoscope assisted transhiatal esophagectomy. In eighty-five patients, reconstruction was done via the posterior mediastinal route, while six patients ware treated by the retrosternal route, and the subcutaneous route was used in one patient. Cervical anastomosis was done in 84 patients and intrathoracic anastomosis was done in eight patients. The complications of the gastric conduit reconstruction were anastomotic leakage in one (1.1%) patient and stricture of the anastomosis site requiring esophageal dilatation in 26 (28.3%) patients. Periodic esophageal dilatation was done in 13 (14.1%) patients. There was one case of stricture of the gastric conduit, one case of bleeding of the gastric conduit and one case of fistula between the gastric conduit and the lung. Conclusion The gastric conduit reconstruction using ICG fluorescent imaging during esophagectomy may contribute to a reduction in the incidence of anastomotic leakage. However, further advancement of the relevant skills is required to improve the incidence of stricture of the anastomosis site. Disclosure All authors have declared no conflicts of interest.

Esophagectomy

Indocyanine Green

Thoracotomy

10.1093/dote/doy089.ps01.206

Cite

Citations (0)

Supplementary Figure 3 from Phosphorylation and Activation of Cell Division Cycle Associated 8 by Aurora Kinase B Plays a Significant Role in Human Lung Carcinogenesis

Satoshi Hayama Yataro Daigo Takumi Yamabuki Daizaburo Hirata Tatsuya Kato

Supplementary Figure 3 from Phosphorylation and Activation of Cell Division Cycle Associated 8 by Aurora Kinase B Plays a Significant Role in Human Lung Carcinogenesis

Human lung

Aurora inhibitor

10.1158/0008-5472.22370484.v1

Cite

Citations (0)

Activation of CDCA1-KNTC2, Members of Centromere Protein Complex, Involved in Pulmonary Carcinogenesis

Cancer Research (2006)

Satoshi Hayama Yataro Daigo Tatsuya Kato Nobuhisa Ishikawa Takumi Yamabuki

Abstract We found cotransactivation of cell division associated 1 (CDCA1) and kinetochore associated 2 (KNTC2), members of the evolutionarily conserved centromere protein complex, in non–small cell lung carcinomas (NSCLC). Immunohistochemical analysis using lung cancer tissue microarray confirmed high levels of CDCA1 and KNTC2 proteins in the great majority of lung cancers of various histologic types. Their elevated expressions were associated with poorer prognosis of NSCLC patients. Knockdown of either CDCA1 or KNTC2 expression with small interfering RNA significantly suppressed growth of NSCLC cells. Furthermore, inhibition of their binding by a cell-permeable peptide carrying the CDCA1-derived 19-amino-acid peptide (11R-CDCA1398-416) that correspond to the binding domain to KNTC2 effectively suppressed growth of NSCLC cells. As our data imply that human CDCA1 and KNTC2 seem to fall in the category of cancer-testis antigens, and that their simultaneous up-regulation is a frequent and important feature of cell growth/survival of lung cancer, selective suppression of CDCA1 or KNTC2 activity and/or inhibition of the CDCA1-KNTC2 complex formation could be a promising therapeutic target for treatment of lung cancers. (Cancer Res 2006; 66(21): 10339-48)

Tissue microarray

10.1158/0008-5472.can-06-2137

Cite

Citations (144)

Giant primary angiosarcoma of the small intestine showing severe sepsis

World Journal of Gastroenterology (2014)

Mizuna Takahashi Masanori Ohara Noriko Kimura Hiromitsu Domen Takumi Yamabuki

Primary malignant tumors of the small intestine are rare, comprising less than 2% of all gastrointestinal tumors.An 85-year-old woman was admitted with fever of 40 ℃ and marked abdominal distension.Her medical history was unremarkable, but blood examination showed elevated inflammatory markers.Abdominal computed tomography showed a giant tumor with central necrosis, extending from the epigastrium to the pelvic cavity.Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected.Because no improvement occurred in response to antibiotics, surgery was performed.Laparotomy revealed giant hemorrhagic tumor adherent to the small intes-tine and occupying the peritoneal cavity.The giant tumor was a solid tumor weighing 3490 g, measuring 24 cm × 17.5 cm × 18 cm and showing marked necrosis.Histologically, the tumor comprised spindle-shaped cells with anaplastic large nuclei.Immunohistochemical studies showed tumor cells positive for vimentin, CD31, and factor Ⅷ-related antigen, but negative for c-kit and CD34.Angiosarcoma was diagnosed.Although no postoperative complications occurred, the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively.The prognosis of small intestinal angiosarcoma is very poor, even after volume-reducing palliative surgery.

Stromal tumor

Abdominal distension

Abdominal cavity

10.3748/wjg.v20.i43.16359

Cite

Citations (14)

Metachronous pancreatic acinar cell carcinoma discovered in early stage during follow-up of breast cancer: report of a case

Clinical Journal of Gastroenterology (2012)

Satoshi Hayama Makoto Ohmi Atsuya Yonemori Takumi Yamabuki Hitoshi Inomata

Surgical oncology

Colorectal Surgery

Breast carcinoma

10.1007/s12328-012-0297-2

Cite

Citations (1)