Sidorenko Sv

North-Western State Medical University named after I.I. Mechnikov

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Vladimir Gostev

North-Western State Medical University named after I.I. Mechnikov

Yu. V. Lobzin

North-Western State Medical University named after I.I. Mechnikov

АС

А. С. Колбин

St Petersburg University

Elena N. Ilina

Federal Medical-Biological Agency

V. A. Ageevets

Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency

O. S. Kalinogorskaya

Federal Medical-Biological Agency

ИА

И. А. Цветкова

Saint Petersburg State Pediatric Medical University

Roman S. Kozlov

Smolensk State Medical University

СМ

С. М. Харит

Saint Petersburg State Pediatric Medical University

Julia V. Sopova

Institute of Cytology

Cooperative Institutions

Ministry of Health of the Russian Federation

163

Federal Medical-Biological Agency

Sechenov University

Russian Academy of Sciences

First Pavlov State Medical University of St. Petersburg

Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency

St Petersburg University

Pirogov Russian National Research Medical University

Scientific Center of Children's Health

North-Western State Medical University named after I.I. Mechnikov

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The Influence of Deletion in the Non-Catalytic Domain of GdpP Mediated by Genome Editing with CRISPR/Cas9 on the Phenotype of <i>Staphylococcus aureus</i>

Генетика (2023)

Julia V. Sopova M. E. Velizhanina D. А. Кandina Vladimir Gostev P. S. Chulkova

10.31857/s0016675823090126

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Citations (0)

Federal Clinical Guidelines on Vaccination of pneumococcal infection in children and adults

Russian Journal of Preventive Medicine (2023)

С. Н. Авдеев M. Kh. Alyeva Baranov Aa A. V. Bikmieva Н. И. Брико

Pneumococcal vaccination

10.17116/profmed2023260923

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Citations (7)

Development of local morphological changes after intradermal inoculation of Q-fever chemovaccine.

PubMed (1989)

M Resl Sidorenko Sv Zhuljabin Ei

Development of morphological changes was studied in the site of intradermal inoculation of Q-fever chemovaccine. The chemovaccine was obtained by trichloroacetic acid extraction from Coxiella burnetii, strain Nine mile, phase I cells. The effect of two vaccine doses (0.2 mg and 1.0 mg) was compared in two groups of guinea pigs (each consisting of 21 animals). After inoculation of 1.0 mg vaccine abscesses formed in the dermis and in subcutaneous tissue along with dystrophic changes of skeletal muscles. Reparation of these lesions progressed sufficiently slowly and was not completed before 60 days after vaccine inoculation. The regeneration of skeletal muscles was of budding type. After inoculation of 0.2 mg of chemovaccine minimal lesions occurred in the subcutaneous tissue only. However, already within 48 hr this vaccine dose evoked a strong reparation response. Interesting was the finding of Kurloff cells in the haemorrhagic foci. The results suggest that the low-reactogenic chemovaccine dose of 0.2 mg might be sufficiently immunogenic after subcutaneous administration.

Trichloroacetic acid

Subcutaneous injection

Intradermal injection

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Citations (1)

Molecular genetic characterization of methicillin-resistant Staphylococcus aureus isolates recovered from Moscow clinics

Molecular Genetics Microbiology and Virology (2010)

М. В. Афанасьев S. V. Karakashev Elena N. Ilina Al-Salami-A.-M. Salem Sidorenko Sv

Multilocus sequence typing

SCCmec

SNP genotyping

10.3103/s0891416810020035

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Citations (2)

[Clinical and economic expedience of ertapenem therapy of complicated urinary tract infection].

PubMed (2011)

А. С. Колбин Sidorenko Sv Ksenia Zagorodnikova В. Б. Мусатов Iakovlev Aa

Clinical and economic investigation of various antibiotics use in the treatment of complicated urinary tract infection (CUTI) was performed under the Russian economic environment. The drugs of comparison were ertapenem, ceftriaxone and levofloxacin. Direct costs and their structure were shown, and the cost efficiency was calculated. Alternative analysis and one-side susceptibility analysis were performed. In complicated urinary tract infections when the major pathogens were Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis it was clinically and economically reasonable to start the treatment with ceftriaxone or ertapenem, while levofloxacin could be an alternative strategy. When the effects of the acquired resistance on the treatment effectiveness were evaluated (SIS model) it was shown that the pathogens susceptibility to ertapenem was preserved for a significantly longer time than that to ceftriaxone or levofloxacin (60 months). Such a parameter may serve as an additional evidence of the reasonable use of ertapenem as the starting treatment of CUTI.

Ertapenem

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Citations (1)

[Effect of antibiotics on Francisella tularensis].

PubMed (1992)

Sidorenko Sv Lebedeva Ik D'iakov Si Zakharov Va

The minimum inhibitory concentrations of rifampicin, doxycycline, sisomicin, ciprofloxacin and phosmidomycin for various strains of Francisella tularensis were 0.5 to 2.0, 0.5 to 2.0, 0.125 to 0.4, 0.625 to 0.125 and 2.0 to 12.5 micrograms/ml, respectively. Ciprofloxacin and sisomicin had a marked bactericidal effect. The bactericidal effect of rifampicin was insignificant. Doxycycline and phomidomycin had practically no such effect. All the antibiotics had a post effect. The level of the post-antibiotic effect was different and depended on the antibiotic concentration.

Sisomicin

Francisella

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Citations (0)

Minimum inhibitory concentrations of aztreonam–avibactam, ceftazidime–avibactam and meropenem in clinical isolates of Klebsiella pneumoniae harboring carbapenemase genes

The Journal of Antibiotics (2024)

V. A. Ageevets O. S. Sulian Alisa Avdeeva P. S. Chulkova I. V. Ageevets

Ceftazidime/avibactam

Aztreonam

Avibactam

Beta-Lactamase Inhibitors

10.1038/s41429-024-00758-8

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Citations (2)

First detection of VIM-4 metallo-β-lactamase-producing Escherichia coli in Russia

Clinical Microbiology and Infection (2012)

O. Shevchenko D.Y. Mudrak E.Yu. Skleenova Varvara K. Kozyreva Elena N. Ilina

10.1111/j.1469-0691.2012.03827.x

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Citations (25)

Динамика распространения резистентности к беталактамным антибиотикам среди Streptococcus pneumoniae и её клиническая значимость

Antibiot Khimioter = Antibiotics and Chemotherapy (2010)

Tatiana Savinova Sidorenko Sv С В Буданов С А Грудинина

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Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Russia

Journal of Antimicrobial Chemotherapy (2018)

Didem Törümküney Nikolay Mayanskiy Mikhail V. Edelstein Sidorenko Sv Р. В. Кожевин

To determine antibiotic susceptibility in isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2014-16 from Russia.MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.A total of 279 S. pneumoniae and 279 H. influenzae were collected. Overall, 67.0% of S. pneumoniae were penicillin susceptible by CLSI oral/EUCAST and 93.2% by CLSI intravenous (iv) breakpoints. All were fluoroquinolone susceptible, with amoxicillin, amoxicillin/clavulanic acid and ceftriaxone susceptibility ≥92.8% by CLSI and PK/PD breakpoints. Isolates showed lower susceptibility to cefuroxime, cefaclor, macrolides and trimethoprim/sulfamethoxazole by CLSI criteria: 85.0%, 76.7%, 68.8% and 67.7%, respectively. Generally, susceptibility was slightly lower by EUCAST criteria, except for cefaclor, for which the difference in susceptibility was much greater. Penicillin-resistant isolates had low susceptibility (≤60%) to all agents except fluoroquinolones. All 279 H. influenzae were ceftriaxone susceptible, 15.4% were β-lactamase positive and ≥97.5% were amoxicillin/clavulanic acid susceptible (CLSI, EUCAST and PK/PD breakpoints). Four isolates were fluoroquinolone non-susceptible by current EUCAST criteria. A major discrepancy was found with azithromycin susceptibility between CLSI (99.3%) and EUCAST and PK/PD (2.2%) breakpoints. Trimethoprim/sulfamethoxazole was poorly active (62.7% susceptible).Susceptibility to penicillin (oral), macrolides and trimethoprim/sulfamethoxazole was low in S. pneumoniae from Russia. However, isolates were fully susceptible to fluoroquinolones and ≥92.8% were susceptible to amoxicillin, amoxicillin/clavulanic acid and ceftriaxone. Isolates of H. influenzae only showed reduced susceptibility to ampicillin, cefaclor, clarithromycin and trimethoprim/sulfamethoxazole. Some differences were detected between CLSI, EUCAST and PK/PD breakpoints, especially with cefaclor, cefuroxime and macrolides. These data suggest further efforts are required to harmonize international breakpoints.

Cefaclor

Sulfamethoxazole

Trimethoprim

Broth microdilution

10.1093/jac/dky065

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Citations (26)