Anita Prechl

Gedeon Richter (Hungary)

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ÁK

Árpád Könczöl

Semmelweis University

Attila Hunyadi

University of Szeged

ÁS

Áron Szigetvári

Gedeon Richter (Hungary)

György Tibor Balogh

Semmelweis University

Miklós Dékány

Gedeon Richter (Hungary)

András Spaits

Budapest University of Technology and Economics

Hedvig Bölcskei

Gedeon Richter (Hungary)

György Kalaus

Budapest University of Technology and Economics

Zoltán Béni

Gedeon Richter (Hungary)

Viktor Ilkei

Gedeon Richter (Hungary)

Cooperative Institutions

Budapest University of Technology and Economics

Hungarian Academy of Sciences

Gedeon Richter (Hungary)

Eötvös Loránd University

Budapest Institute

Semmelweis University

University of Szeged

University of Debrecen

Budapest Business University

First Technical University

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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Angewandte Chemie International Edition (2017)

Róbert Örkényi János Éles Ferenc Faigl Péter Vincze Anita Prechl

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co- and by-products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual-mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.

Flow chemistry

Morpholine

10.1002/anie.201703852

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Citations (33)

酸触媒を用いたフェノールMannich反応による5,7‐ジヒドロキシル化フラボノイド類のC8‐位選択的な生物模倣変換:ケルセチン及び(-)‐エピカテキン骨格を持つフラボノイドアルカロイド類の合成

Tetrahedron (2017)

Viktor Ilkei András Spaits Anita Prechl Mueller Judit Árpád Könczöl

Source

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Citations (0)

Supercritical fluid extraction of Vitex agnus castus fruit

The Journal of Supercritical Fluids (2008)

Dániel Cossuta Béla Simándi Erika Vági Judit Hohmann Anita Prechl

Supercritical fluid extraction

Hexane

Bar (unit)

10.1016/j.supflu.2008.07.014

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Citations (34)

Topical analgesic, anti-inflammatory and antioxidant properties of Oxybaphus nyctagineus: Phytochemical characterization of active fractions

Journal of Ethnopharmacology (2014)

Árpád Könczöl Rita Engel Krisztina Szabó Katalin Hornok Szilvia Tóth

Phytochemical

Anti-inflammatory

Carrageenan

10.1016/j.jep.2014.06.020

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Citations (6)

Pilot-scale extraction and fractional separation of onion oleoresin using supercritical carbon dioxide

Journal of Food Engineering (2000)

Béla Simándi Ágnes Sass-Kiss B. Czukor András Deák Anita Prechl

Supercritical Carbon Dioxide

Steam distillation

Supercritical fluid extraction

Hexane

Oleoresin

10.1016/s0260-8774(00)00081-9

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Citations (25)

Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B

Beilstein Journal of Organic Chemistry (2016)

Viktor Ilkei András Spaits Anita Prechl Áron Szigetvári Zoltán Béni

Starting from racemic naringenin ((±)- 1 ), a mixture of dracocephin A stereoisomers 6-(2”-pyrrolidinone-5”-yl)naringenin (±)- 2a–d and its regioisomer, dracocephin B 8-(2”-pyrrolidinone-5”-yl)naringenin (±)- 3a–d originally isolated from Dracocephalum rupestre , have been synthesized in a one-pot reaction. The separation of 2a–d and 3a–d was achieved by preparative HPLC. The four stereoisomers of each natural product were separated by analytical chiral HPLC and their absolute configuration was studied by the combination of HPLC–ECD measurements and TDDFT–ECD calculations. The synthesized flavonoid alkaloids were further characterized by physicochemical and in vitro pharmacological studies.

Structural isomer

Natural product

Absolute Configuration

10.3762/bjoc.12.247

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Citations (12)

C8-selective biomimetic transformation of 5,7-dihydroxylated flavonoids by an acid-catalysed phenolic Mannich reaction: Synthesis of flavonoid alkaloids with quercetin and (–)-epicatechin skeletons

Tetrahedron (2017)

Viktor Ilkei András Spaits Anita Prechl Judit Müller Árpád Könczöl

Mannich reaction

Biomimetic Synthesis

10.1016/j.tet.2017.01.068

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Citations (17)

Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Angewandte Chemie (2017)

Róbert Örkényi János Éles Ferenc Faigl Péter Vincze Anita Prechl

Abstract Continuous‐flow multistep synthesis is combined with quasi‐continuous final‐product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4‐difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co‐ and by‐products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual‐mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.

Flow chemistry

Morpholine

10.1002/ange.201703852

Cite

Citations (2)