Hina Shehnaz

University of Faisalabad

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Amir Haider

Government of Pakistan

Haq Nawaz

University of Faisalabad

Muhammad Irfan Majeed

University of Agriculture Faisalabad

Laila Shahnaz

University of Karachi

Muhammad Imran

King Khalid University

Rabiea Umer

University of Faisalabad

Najma Sultana

University of Karachi

M. Saeed Arayne

University of Karachi

Urwa Shahid

University of Faisalabad

Muhammad Tjammal Rehman

University of Agriculture Faisalabad

Cooperative Institutions

University of Agriculture Faisalabad

University of Faisalabad

University of Karachi

Sindh Madressatul Islam University

National Institute for Biotechnology and Genetic Engineering

COMSATS University Islamabad

Pir Mehr Ali Shah Arid Agriculture University

Government College University, Faisalabad

University of Engineering and Technology Lahore

Federal Urdu University

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Carboxyterfenadine antacid interaction monitoring by UV spectrophotometry and RP-HPLC techniques

Arabian Journal of Chemistry (2013)

Hina Shehnaz Amir Haider M. Saeed Arayne Najma Sultana

Carboxyterfenadine, a primary metabolite of terfenadine, a second generation antihistaminic compound was introduced in therapy as a successor of terfenadine due to its cardiac arrhythmia. There are number of drug interactions of fexofenadine with erythromycin, ketoconazole and alike reported in the literature. In this paper, fexofenadine antacid interaction has been studied in presence of sodium bicarbonate, megaldrate, calcium carbonate, magnesium carbonate, aluminum hydroxide, magnesium hydroxide, magnesium trisilicate, simethicone (dimethylpolysiloxane) and calcium hydroxide by UV–Vis spectrophotometer and high performance liquid chromatography (HPLC). These in vitro fexofenadine–antacid interactions were carried out in simulated gastric and intestinal juices and in buffer of pH 7.4 (simulating blood pH) on BP 2005 dissolution apparatus. The results show non-concordant availability of fexofenadine envisaged due to formation of unstable charge transfer complexes.

Antacid

Fexofenadine

Terfenadine

Spectrophotometry

10.1016/j.arabjc.2013.01.011

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Citations (3)

Characterization of Illicit Drugs by Surface-Enhanced Raman Spectroscopy (SERS) and Principal Component Analysis (PCA)

Analytical Letters (2024)

Maryam Tahira Mulja Munir Haq Nawaz Muhammad Irfan Majeed Muhammad Wasim

Addictive, illicit drugs pose a high threat of relapse. The deaths related to illicit drugs have substantially increased in the last decade. Globally, the illicit drug trade poses a significant challenge to public health and law enforcement. It is essential to utilize advanced analytical methodologies that can characterize illegal substances precisely to monitor these drugs. Surfaced-enhanced Raman spectroscopy (SERS) has become a valuable tool, providing distinct capabilities for analyzing illegal substances. Surface enhancement enables far more sensitive detection and identification of illicit drugs by suppressing the fluorescence and enhancing the Raman signals. In this regard, a simple method with limited sample processing has been established to characterize illicit drugs that include methamphetamine (MAMP) (ice), bhang, marijuana (cannabis), opium, and diacetylmorphine (heroin). Moreover, principal component analysis (PCA) was employed for the identification of the characteristic SERS spectral features of these drugs. This article examines the potential application of SERS in the characterization of illicit substances, focusing on its ability to contribute significantly to law enforcement and forensic investigation.

Illicit drug

Surface-Enhanced Raman Spectroscopy

Drugs of abuse

Drug Detection

Identification

10.1080/00032719.2023.2301500

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BIOREMEDIATION POTENTIAL OF SOME LOCAL GRASSES OF KARACHI CITY

FUUAST Journal of Biology (2019)

Hina Shehnaz Sidra Naz Laila Shahnaz Kausar Yasmine Tahir Naqqash

The study was conducted to explore bioremediation potential of four commonly growing grass species e.g. Khabal (Cynodon dactylon) (Linnaeus) Persoon, Vetiver (Vetiveria zizanioides) (Linnaeus) Nash, Elephant (Pennisetum purpureum) Schumach. and jungle rice (Echinochloa colona) (Linnaeus) Link, common inhabitants of industrial disposal point, Sharafi Goth, Karachi, Pakistan. The highest fresh and dry weight recorded in Elephant grass (Pennisetum purpureum) i.e. 360g and 257g respectively. While the maximum shoot (147 cm) and root lengths (249 & 217 cm) were also revealed by the same species. The highest value of Lead (0.8 mg/kg) was observed in Vetiver (Vetiveria zizanioides), while Elephant (Pennisetum purpureum) showed the maximum bioaccumulation of Zinc (2.41 mg/kg) was observed in contaminated soil. However, high uptake level of Copper (2.44 mg/kg) and Cadmium (0.31 mg/kg) was observed from the mixed soil of Khabal (Cynodon dactylon). Whereas, Jungle rice (Echinochloa colona) exhibited remarkably low remediation capability. Keywords: Phytoremediation, Local Grass Species (Khabal, Vetiver, Elephant and Jungle rice grass), Heavy metals, Bioaccumulation Factor.

Pennisetum purpureum

Eleusine indica

Cynodon dactylon

Digitaria

Cynodon

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Citations (2)

Phycochemical investigation of brown alga Sargassum tenerrimum from Karachi coast.

Pakistan Journal of Botany (2017)

Laila Shahnaz Amir Haider Hina Shehnaz

Sargassum

Brown seaweed

Brown algae

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Author response for "Surface-enhanced Raman spectroscopy for studying the interaction of organometallic compound bis(1,3-dihexylimidazole-2-yl) silver(<scp>i</scp>) hexafluorophosphate (<scp>v</scp>) with the biofilm of <i>Escherichia coli</i>"

Tania Tabussam Hina Shehnaz Muhammad Irfan Majeed Haq Nawaz Abeer Ahmed Alghamdi

Hexafluorophosphate

10.1039/d3ra08667d/v2/response1

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Identification of Adulterated Cooking Oil by Raman Spectroscopy

Food Analytical Methods (2024)

Hina Shehnaz Ayesha Ashraf Muhammad Irfan Majeed Haq Nawaz Maira Afzal

Identification

Edible oil

10.1007/s12161-024-02626-5

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Citations (1)

Novel NARC-G1 garlic: comparative allicin quantification with morpho-biochemical & genetic profiling

Brazilian Journal of Biology (2022)

S SHAMSHAD Syed Kumail Ali Rizvi Hina Shehnaz Shakeel Ahmad Jatoi Laila Shahnaz

Garlic (Allium sativum) is an important cash food crop, and the biotechnology industry has considerable interest in the plant because of its medicinal importance. These medicinal properties are attributed to organosulphur compounds as the accumulation of these compounds varies according to genotype, locality, light quality, and cultivation practices. In this study, we compared a newly developed garlic variety NARC-G1 by National Agricultural Research Centre (NARC), Islamabad, Pakistan with three different garlic cultivars and highlighted the distinctive attributes like phenotypic characteristics, the content of allicin, elemental profile, and gene polymorphism. Phenotypic analysis showed NARC-G1 has significantly higher bulb weight (66.36g ± 18.58), single clove weight (5.87g ± 1.041), and clove width (17.41mm ± 0.95) which directly correlates to the size of the garlic. The analytical analysis showed the highest allicin content (4.82 ± 0.001) in NARC-G1. Genotyping of the alliinase in all four cultivars showed indels in the gene resulting in distinguishable changes in organosulphur compounds' profile. NARC-G1 is unique from other garlic cultivars and could be the best choice for mass production with proper cultivation and irrigation management. Moreover, for Pakistan NARC-G1 could be a potential contender to earn the industrial benefits with inland cultivation instead of importing garlic alleviating the economic burden.

Bulb

Liliaceae

10.1590/1519-6984.262697

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Citations (1)

Direct and residual impacts of zeolite on the remediation of harmful elements in multiple contaminated soils using cabbage in rotation with corn

Chemosphere (2020)

Altaf Hussain Lahori Monika Mierzwa–Hersztek Erdona Demiraj Raja Umer Sajjad Imran Ali

Amendment

10.1016/j.chemosphere.2020.126317

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Citations (40)

Antihistaminic and other biological activities of 2-methylpropanamide and benzamide derivatives of carboxyterfenadine

Arabian Journal of Chemistry (2015)

M. Saeed Arayne Najma Sultana Hina Shehnaz Saf-ur-Rehman Mandukhail Anwarul Hassan Gilani

In the present study the 2-methylpropanamide and benzamide derivatives of carboxyterfenadine, have been synthesized by nucleophilic substitution at carboxylic acid moiety (C-33) of tertiary carbon C-19 substituted with benzene ring. The proficient and high yielding series was carried out in two steps by continuous monitoring with TLC. The carboxylic group was utilized in the formation of 2-methylpropanamide and benzamide derivatives of carboxyterfenadine. The derivatives were characterized by spectroscopic techniques including mass. The starting material (2-[4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidino]butyl]phenyl]-2-methylpropanoic acid) itself is H1 receptor antagonist. Hence, all these compounds A–E were biologically evaluated for antihistaminic and anticholinergic activity, using isolated guinea pig ileum tissues.

Benzamide

Moiety

Benzoic acid

10.1016/j.arabjc.2015.01.004

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Citations (7)

Surface-enhanced Raman spectroscopy for studying the interaction of organometallic compound bis(1,3-dihexylimidazole-2-yl) silver(i) hexafluorophosphate (v) with the biofilm of Escherichia coli

RSC Advances (2024)

Tania Tabussam Hina Shehnaz Muhammad Irfan Majeed Haq Nawaz Abeer Ahmed Alghamdi

SERS study of interaction of organometallic compound bis(1,3-dihexylimidazole-2-yl) silver( i ) hexafluorophosphate ( v ) with the biofilm of Escherichia coli .

Surface-Enhanced Raman Spectroscopy

10.1039/d3ra08667d

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Citations (0)