C. Rancoule

Nantes Université

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Nicolas Magné

Institute Cancer De La Loire Lucien Neuwirth

Alexis Vallard

Centre Hospitalier Universitaire de Martinique

Sophie Espenel

Institut Gustave Roussy

Jean‐Baptiste Guy

CEA LITEN

Julien Langrand-Escure

Institute Cancer De La Loire Lucien Neuwirth

Majed Ben Mrad

Institute Cancer De La Loire Lucien Neuwirth

Jane‐Chloé Trone

Institute Cancer De La Loire Lucien Neuwirth

Claire Rodriguez‐Lafrasse

Hospices Civils de Lyon

Cyrus Chargari

Institut Gustave Roussy

A. Rehailia-Blanchard

Institute Cancer De La Loire Lucien Neuwirth

Cooperative Institutions

Inserm

106

Institute Cancer De La Loire Lucien Neuwirth

101

Centre National de la Recherche Scientifique

Université Claude Bernard Lyon 1

Centre Hospitalier Universitaire de Saint-Étienne

Université Toulouse III - Paul Sabatier

Université de Toulouse

Institut des Maladies Métaboliques et Cardiovasculaires

Centre Léon Bérard

Institut Gustave Roussy

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Radiosensibilité et/ou résistance des cancers ORL : aspects biologiques

Bulletin du Cancer (2015)

Jean‐Baptiste Guy C. Rancoule Benoîte Méry Sophie Espenel Anne‐Sophie Wozny

Radioresistance

Radiosensitivity

10.1016/j.bulcan.2015.10.016

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Citations (7)

Impact of Radiation Therapy on Biological Parameters in Cancer Patients: Sub-analysis from the RIT Prospective Epidemiological Study

Cancer Investigation (2022)

Nicolas Magné Élisabeth Daguenet Wafa Bouleftour Laurine Conraux Fabien Tinquaut

Scarce data investigate the impact of radiotherapy (RT) on biology markers. An analysis of ancillary study of RIT (Radiation Impact on Thromboembolic events) prospective trial was carried out. All patients with non-metastatic solid tumors and treated with radiotherapy and/or brachytherapy in curative and consenting to have blood samples were included. A significant decrease in white blood count, (i.e. lymphocytes, monocytes, neutrophils and basophils) and platelet counts was observed after RT and maintained at 6 months. Whereas, eosinophils, D-dimers and hemoglobin levels were affected respectively 3 months and 6 months after RT initiation. Conversely, red cells count and CRP level were not affected by RT. This study is an advocacy to develop an understanding of basic immune system in relation with RT.

White blood cell

10.1080/07357907.2022.2139838

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Citations (4)

Gene therapy and cell therapy for the management of radiation damages to healthy tissues: Rationale and early results

Cancer/Radiothérapie (2019)

J. Khalifa S. François C. Rancoule D. Riccobono Nicolas Magné

Bystander effect

Radiobiology

Oxygen enhancement ratio

10.1016/j.canrad.2019.07.002

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Citations (1)

Effects of Dietary Eicosapentaenoic Acid (EPA) Supplementation in High-Fat Fed Mice on Lipid Metabolism and Apelin/APJ System in Skeletal Muscle

PLoS ONE (2013)

C. Bertrand Angelica Pignalosa Estelle Wanecq C. Rancoule Aurélie Batut

Various studies have shown that eicosapentaenoic acid (EPA) has beneficial effects on obesity and associated disorders. Apelin, the ligand of APJ receptor also exerts insulin-sensitizing effects especially by improving muscle metabolism. EPA has been shown to increase apelin production in adipose tissue but its effects in muscle have not been addressed. Thus, the effects of EPA supplementation (36 g/kg EPA) in high-fat diet (HFD) (45% fat, 20% protein, 35% carbohydrate) were studied in mice with focus on muscle lipid metabolism and apelin/APJ expression. Compared with HFD mice, HFD+EPA mice had significantly less weight gain, fat mass, lower blood glucose, insulinemia and hepatic steatosis after 10 weeks of diet. In addition, EPA prevented muscle metabolism alterations since intramuscular triglycerides were decreased and β-oxidation increased. In soleus muscles of HFD+EPA mice, apelin and APJ expression were significantly increased compared to HFD mice. However, plasma apelin concentrations in HFD and HFD+EPA mice were similar. EPA-induced apelin expression was confirmed in differentiated C2C12 myocytes but in this model, apelin secretion was also increased in response to EPA treatment. In conclusion, EPA supplementation in HFD prevents obesity and metabolic alterations in mice, especially in skeletal muscle. Since EPA increases apelin/APJ expression in muscle, apelin may act in a paracrine/autocrine manner to contribute to these benefical effects.

Apelin

Carbohydrate Metabolism

10.1371/journal.pone.0078874

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Citations (54)

Rhabdomyosarcomes d’origine gynécologique chez l’adulte : revue générale et principes de prise en charge

Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction (2016)

J.-B. Guy François Casteillo Alexis Vallard Sophie Espenel Fabien Forest

Multimodal therapy

Embryonal rhabdomyosarcoma

10.1016/j.jgyn.2016.03.011

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Citations (2)

Oxygénothérapie hyperbare et radiothérapie : entre mythe et réalité

Cancer/Radiothérapie (2016)

Sophie Espenel C Raffoux Alexis Vallard M Andreu García J.-B. Guy

10.1016/j.canrad.2016.05.008

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Citations (0)

Evaluation of the Cell Invasion and Migration Process: A Comparison of the Video Microscope-based Scratch Wound Assay and the Boyden Chamber Assay

Journal of Visualized Experiments (2017)

Jean‐Baptiste Guy Sophie Espenel Alexis Vallard Priscillia Battiston-Montagne Anne‐Sophie Wozny

The invasion and migration abilities of tumor cells are main contributors to cancer progression and recurrence. Many studies have explored the migration and invasion abilities to understand how cancer cells disseminate, with the aim of developing new treatment strategies. Analysis of the cellular and molecular basis of these abilities has led to the characterization of cell mobility and the physicochemical properties of the cytoskeleton and cellular microenvironment. For many years, the Boyden chamber assay and the scratch wound assay have been the standard techniques to study cell invasion and migration. However, these two techniques have limitations. The Boyden chamber assay is difficult and time consuming, and the scratch wound assay has low reproducibility. Development of modern technologies, especially in microscopy, has increased the reproducibility of the scratch wound assay. Using powerful analysis systems, an "in-incubator" video microscope can be used to provide automatic and real-time analysis of cell migration and invasion. The aim of this paper is to report and compare the two assays used to study cell invasion and migration: the Boyden chamber assay and an optimized in vitro video microscope-based scratch wound assay.

Gentamicin protection assay

Scratch

Video microscopy

10.3791/56337-v

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Citations (24)

Bilateral Breast Cancer After Prophylactic Bilateral Pulmonary Irradiation.

PubMed (2017)

El Meddeb Ha Chehata Jm Samia Kanoun C. Rancoule Guy Jb

The purpose of this article is to report a new case of a probably radio-induced bilateral breast cancer occurred after prophylactic bilateral pulmonary irradiation in the treatment of osteosarcoma. A 42-year-old woman, treated at the age of 12 years for osteosarcoma at the right lower limb with chemotherapy (methotrexate, adriamycin and cisplatin) followed by non-conservative surgery and adjuvant radiotherapy. Eighteen years after, she developed her first breast cancer, and five years later, her second contralateral breast cancer. The patient was treated for her two non-metastatic cancers and is currently in complete remission. This publication adds to several previous publications the very probable effect of ionizing radiation in the occurrence of secondary cancers.

Adjuvant Chemotherapy

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Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report

Cancer Chemotherapy and Pharmacology (2019)

E. Couty Alexis Vallard Sandrine Sotton S. Ouni Max-Adrien Garcia

Concomitant

Dacarbazine

Systemic therapy

10.1007/s00280-019-03806-5

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