Ed Laufer

Research Field

Ephrin

Motor Control

10.1016/j.neuron.2008.11.011

Cite

Citations (137)

Hedgehog signalling in endocrine development and disease

Journal of Endocrinology (2008)

Peter King Leonardo Guasti Ed Laufer

The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent findings in the field of vertebrate Hh signalling and also describe contributions of Hh signalling to the development, maintenance and pathology of endocrine tissues.

Signalling

Signalling pathways

Indian hedgehog

10.1677/joe-08-0161

Cite

Citations (66)

Faculty Opinions recommendation of Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2011)

Ed Laufer

LGR5

Homeostasis

10.3410/f.5964956.13138055

Cite

Citations (1)

A role for hairy1 in regulating chick limb bud growth

Developmental Biology (2003)

Daniel Vasiliauskas Ed Laufer Claudio D. Stern

Mesenchyme

Limb bud

Limb development

Apical ectodermal ridge

10.1016/s0012-1606(03)00360-9

Cite

Citations (32)

Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages

Developmental Biology (2009)

Ed Laufer Alex Paul Peter King

Progenitor

Steroidogenic factor 1

10.1016/j.ydbio.2009.05.387

Cite

Citations (0)

Hox genes and serial homology

Nature (1993)

Cliff Tabin Ed Laufer

Homology

Sequence homology

10.1038/361692a0

Cite

Citations (53)

bHLH transcription factor regulation of vertebrate limb pattern

Developmental Biology (2006)

Ed Laufer Dayana Krawchuk Shoshana J. Weiner Paul Riccio Shannon Giorgianni

Transcription

Limb development

10.1016/j.ydbio.2006.04.424

Cite

Citations (0)

Foxp1 and Lhx1 Coordinate Motor Neuron Migration with Axon Trajectory Choice by Gating Reelin Signalling

PLoS Biology (2010)

Elena Palmesino D. Rousso Tzu‐Jen Kao Avihu Klar Ed Laufer

Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown. We addressed this question in the context of the myotopic map formed by limb muscles innervated by spinal lateral motor column (LMC) motor axons where the Eph receptor signals specifying growth cone trajectory are restricted by Foxp1 and Lhx1 transcription factors. We show that the localisation of LMC neuron cell bodies can be dissociated from axon trajectory choice by either the loss or gain of function of the Reelin signalling pathway. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation.

10.1371/journal.pbio.1000446

Cite

Citations (82)

Retinoid Signaling in Progenitors Controls Specification and Regeneration of the Urothelium

Developmental Cell (2013)

Devangini Gandhi Andrei Molotkov Ekatherina Batourina Kerry Schneider Hanbin Dan

Keratin 5

Progenitor

10.1016/j.devcel.2013.07.017

Cite

Citations (146)

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud