Fengzhu Guo

Tianjin University of Science and Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Zhilei Tan

Tianjin University of Science and Technology

Shiru Jia

Tianjin University of Science and Technology

Bo Tao

Huazhong University of Science and Technology

Jiandong Cui

Tianjin University of Science and Technology

Qin-Zhi Su

Tianjin University of Science and Technology

Haoran Zheng

Jinzhou Medical University

Peipei Han

Shanghai University of Medicine and Health Sciences

Cheng Zhong

Tianjin University of Science and Technology

Zichen Wang

Peking University

Shuai Song

Tianjin University of Science and Technology

Cooperative Institutions

Tianjin University of Science and Technology

Tianjin Economic-Technological Development Area

Tianjin University

Shanghai Jiao Tong University

Jilin University

Zhejiang University

State Key Laboratory of Food Nutrition and Safety

Jilin Medical University

Beijing Institute of Technology

State Key Laboratory of Chemical Engineering

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Breeding of Streptomyces diastatochromogenes for Mass-Producing ε-Poly-L-Lysine by Composite Mutation

Lecture notes in electrical engineering (2013)

Shuai Song Zhilei Tan Fengzhu Guo Xue Zhang Qingchao Song

Strain (injury)

Mutation Breeding

10.1007/978-3-642-37916-1_37

Cite

Citations (2)

Effect of Yeast Extract on Production of ε-poly-L-lysine by Streptomyces diastatochromogenes

Lecture notes in electrical engineering (2017)

Fengzhu Guo Haoran Zheng Xue Zhang Ya‐Wen Cheng Zhilei Tan

Yeast extract

Strain (injury)

10.1007/978-981-10-4801-2_24

Cite

Citations (1)

Effect of glycine on ε-poly-L-lysine production of Streptomyces diastatochromogenes Cbγ4

Fengzhu Guo

To investigate the effect of glycine on e-poly-L-lysine(e-PL) production of Streptomyces diastatochromogenes Cbγ4,certain concentrations of glycine were added in the seed culture.When 3g/L glycine was added at the early stage in seed culture,the accumulation of e-PL reached 0.51g/L,which was increased by 27.5% than that of the control group,and the aspartokinase activity was improved obviously.In 5-L jar fermentation,the biomass and the consume rate of glucose were greatly enhanced by adding 3g/L glycine in seed culture,and the e-PL yield was increased to 12.87g/L,meanwhile,the conversion rate of carbon resource to e-PL was 30.6% higher than the control group.Therefore,glycine could be used as a novel nutrient for e-PL production.

Yeast extract

Cite

Citations (0)

Effects of ε-Poly-l-lysine on the cell wall of Saccharomyces cerevisiae and its involved antimicrobial mechanism

International Journal of Biological Macromolecules (2018)

Zhilei Tan Bo Tao Fengzhu Guo Jiandong Cui Shiru Jia

Mode of Action

Cell membrane

Mechanism of Action

10.1016/j.ijbiomac.2018.07.094

Cite

Citations (46)

Metabolomic Analysis of Biosynthesis Mechanism of ε-Polylysine Produced by Streptomyces diastatochromogenes

Frontiers in Bioengineering and Biotechnology (2021)

Ziyuan Wang Fengzhu Guo Tianyu Dong Zhilei Tan Mohamed Abdelraof

ε-Polylysine (ε-PL), a natural preservative with broad-spectrum antimicrobial activity, has been widely used as a green food additive, and it is now mainly produced by Streptomyces in industry. In the previous study, strain 6#-7 of high-yield ε-PL was obtained from the original strain TUST by mutagenesis. However, the biosynthesis mechanism of ε-PL in 6#-7 is still unclear. In this study, the metabolomic analyses of the biosynthesis mechanism of ε-PL in both strains are investigated. Results show that the difference in metabolisms between TUST and 6#-7 is significant. Based on the results of both metabolomic and enzymatic activities, a metabolic regulation mechanism of the high-yield strain is revealed. The transport and absorption capacity for glucose of 6#-7 is improved. The enzymatic activity benefits ε-PL synthesis, such as pyruvate kinase and aspartokinase, is strengthened. On the contrary, the activity of homoserine dehydrogenase in the branched-chain pathways is decreased. Meanwhile, the increase of trehalose, glutamic acid, etc. makes 6#-7 more resistant to ε-PL. Thus, the ability of the mutagenized strain 6#-7 to synthesize ε-PL is enhanced, and it can produce more ε-PLs compared with the original strain. For the first time, the metabolomic analysis of the biosynthesis mechanism of ε-PL in the high-yield strain 6#-7 is investigated, and a possible mechanism is then revealed. These findings provide a theoretical basis for further improving the production of ε-PL.

Strain (injury)

Metabolic pathway

Metabolome

10.3389/fbioe.2021.698022

Cite

Citations (5)

Antimicrobial ε-poly-l-lysine induced changes in cell membrane compositions and properties of Saccharomyces cerevisiae

Food Control (2015)

Bo Tao Peipei Han Qin-Zhi Su Ping Fu Fengzhu Guo

Ergosterol

Cell membrane

10.1016/j.foodcont.2015.09.018

Cite

Citations (51)