Fatemeh Vahid Roudsari

Mashhad University of Medical Sciences

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Mohammad Taghi Shakeri

Mashhad University of Medical Sciences

Sedigheh Ayati

Mashhad University of Medical Sciences

Masoud Shahabian

Aja University of Medical Sciences

Sedigheh Ayaty

Ghaem Hospital

Farnoush Farshidi

Mashhad University of Medical Sciences

Hossein Ayatollahi

Mashhad University of Medical Sciences

M Hasanzadeh Mofrad

Mashhad University of Medical Sciences

Maliheh Hasanzadeh

Mashhad University of Medical Sciences

Ù́

ÙØ±Ù†ÙˆØ ́ Ùø±Ø ́Ùšø ̄Ùš

Osun State University

Marzieh Ghasemi

Zahedan University of Medical Sciences

Cooperative Institutions

Mashhad University of Medical Sciences

Ghaem Hospital

Osun State University

Imam Reza Hospital

Isfahan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Tehran University of Medical Sciences

Islamic Azad University, Mashhad

Sakarya University

North Khorasan University of Medical Sciences

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Medical abortion at first trimester of pregnancy with misoprostol.

PubMed (2008)

Sedigheh Ayati Fatemeh Vahid Roudsari Naiereh Khadem Mohammad Taghi Shakeri

To evaluate the efficacy of medical abortion at first trimester of pregnancy with vaginal misoprostol.This is a descriptive analytic study. It was performed on 100 women at first trimester of pregnancy referred to teaching hospitals related to the Medical Sciences of Mashhad University, Mashhad, Iran for termination of pregnancy in 2006. Each patient received first dose of misoprostol (800 microg/vaginal), the second dose (800 microg/vaginal) was administered 24 hours after the first dose if expulsion of conceptus was not successful and curettage was performed if product of conception remained.From 100 patients, 83 women (83%) had successful complete abortion, and 17 cases required curettage. Among them, pregnancy was terminated in 55 (62%) with first dose of misoprostol and 28 (34%) of them required second dose. No important side-effects were noted due to vaginal misoprostol treatment.Termination of pregnancy by medical methods at first trimester of pregnancy with vaginal misoprostol is safe, cost effective, and without side-effects.

Medical abortion

Curettage

Products of conception

Vaginal bleeding

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Citations (5)

Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy

International Journal of Reproductive BioMedicine (IJRM) (2009)

Fatemeh Vahid Roudsari Sedigheh Ayati Hossein Ayatollahi Habibollah Esmaeily Maliheh Hasanzadeh

Background: Preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. It is suggested that cytokines such as Tumor Necrosis Factor-alpha (TNF-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction. Objective: The aim of this study was comparison of maternal serum TNF-α in severe and mild preeclampsia versus normal pregnancy. Materials and Methods: This study was performed on 37 women with preeclampsia (17 mild and 20 severe preeclampsia) and 41 normotensive pregnant women with similar gestational age at third trimester of pregnancy. All the preeclamptic cases had blood pressure ≥ 140/90 mmHg, and proteinuria ≥ 300 mg in a 24-h urine sample. Maternal serum TNF-α concentration was compared in all of them. Results: The level of TNF-α concentration was not statistically different between the studied groups. No significant correlation was found between preeclampsia and control group as they were compared in the view of maternal serum TNF-α concentration. Conclusion: These findings suggest that serum TNF-α is not significantly associated with preeclampsia.

Pathogenesis

Endothelial Dysfunction

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Fertility Rate Following Laparoscopy in Infertile Women

DOAJ (DOAJ: Directory of Open Access Journals) (2009)

Fatemeh Vahid Roudsari S Ayati M Hasanzadeh Bashtian Mohammad Taghi Shakeri

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THE ASSOCIATION OF SELF EFFICACY WITH HEALTH LOCUS OF CONTROL AND PSYCHOLOGICAL DISTRESS IN INFERTILE WOMEN

Haniyeh Jafari Robab Latifnejad Roudsari Mo Modarres Fatemeh Vahid Roudsari

Locus of control

Association (psychology)

Psychological Distress

Self-Efficacy

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Comparison of vaginal misoprostol with foley catheter for cervical ripening and induction of labor.

PubMed (2011)

Fatemeh Vahid Roudsari Sedigheh Ayati Marzieh Ghasemi M Hasanzadeh Mofrad Mohammad Taghi Shakeri

At times, despite an unripe cervix, induction of labor may be needed. In these cases, a safe and suitable method should be considered for cervical ripening and pregnancy termination. The aim of this study is the comparison of vaginal misoprostol with Foley catheter for cervical ripening and induction of labor. This randomized clinical trial was performed on 108 pregnant women who had referred to the teaching hospitals of Mashhad University of Medical Sciences during a time period of September 2007 to March 2008. These women were randomly divided into two groups: Misoprostol (including 49 patients) and Foley catheter (including 59 patients). For the first group, 25 microgram vaginal misoprostol was administered every 4 h up to maximum 6 doses. For the second group, Foley catheter 18 F, inflated with 50 cc of sterile water, was placed through the internal os of the cervix. Data was analyzed using SPSS software. p < 0.05 was considered statistically significant. Two groups were similar in the view of demographic characteristics, cesarean indications, maternal and fetal outcomes and neonatal outcomes. Vaginal delivery was significantly higher in misoprostol group (89.9 vs. 62.7, p < 0.01). The mean of delivery time was significantly shorter in misoprostol group (11.08 ± 5.6 vs. 13.6 ± 16.0 h, p < 0.05). In the cases of pregnancy termination and unripe cervix, two methods of misoprostol and Foley catheter were considered suitable, but it seemed that misoprostol decreases the delivery time and was needed for the cesarean section.

Foley catheter

Foley

Labor Induction

Bishop score

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Citations (20)

Pilot prevalence evaluation of Chlamydia Trachomatis by PCR in female infertile referred to study center of infertility in Mashhad

L Goshayeshi Fatemeh Vahid Roudsari Kiarash Ghazvini Hosein Nomani Saeid Amel Jamehdar

Female infertility

Center (category theory)

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Citations (1)

Misoprostol alone or in combination with methotrexate for termination of pregnancy at first trimester.

PubMed (2010)

Fatemeh Vahid Roudsari Sedigheh Ayati Nafiseh Saghafy Mohammad Taghi Shakeri

Abortion is an important problem in obstetrics throughout the world. The common and standard method for pregnancy termination at first trimester is surgery (curettage). Nowadays, an effective method of pregnancy termination at first trimester is medical treatments. The aim of this study is to compare misoprostol alone or in combination with methotrexate for pregnancy termination at first trimester. This study is a randomized clinical trial. A total of 200 pregnant women at first trimester were randomizedly divided into two groups for termination of pregnancy. The first group received 800 μg vaginal misoprostol. If conceptus residual remained, the same dose of misoprostol was repeated. The second group received 50 mg/m² intramuscular methotrexate, and then 800 μg vaginal misoprostol was administered after 72 h. If conceptus residual remained, the same dose of misoprostol was repeated after 24 h. Abdominal ultrasonography was performed at seventh day for both groups. Should conceptus residual remained or if pregnancy continued, curettage was performed. The results were analyzed statistically in terms of chi-square, and student's t-test, using the SPSS software. A P-value equal or smaller than 0.05, was considered statistically significant. In this study, 83% of the first group and 81% of the second group had successful abortion. There was a significant correlation between the dose of misoprostol and abortion (P = 0.001) and between type of pregnancy and need for curettage (P < 0.000) in both groups, but there was no significant correlation between gestational age and the numberof doses administered (P = 0.932).In conclusion it seems that pregnancy termination by misoprostol alone or in combination with methotrexate is a safe and cost-effective method.

Curettage

Conceptus

Medical abortion

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Citations (4)

Comparison of Vaginal Misoprostol with Foley Catheter for Cer-vical Ripening and Induction of Labor

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Ù...Ø±Ø¶Ùšù‡ Ù‚Ø§Ø ù...Ùš ØμØ ̄ÙŠÙ‚Ù‡ Ø¢ÙŠØaÙŠ Ù...ØÙ...Ø ̄ ØaÙ‚ÙŠ Ø ́Ø§ÙƒØ±ÙŠ ÙØ±Ù†ÙˆØ ́ Ùø±Ø ́Ùšø ̄Ùš Fatemeh Vahid Roudsari

Abstract Background: Sometimes despite an unripe cervix, induction of labor may be needed. In these cases, safe and suitable method should be considered for cervical ripening and pregnancy termination. The aim of this study was to assess the comparison of vaginal misoprostol with foley catheter for cervical ripening and induction of labor. Methods: This randomized clinical trial was performed on 110 pregnant women referred to the teaching hospit-als of Mashhad University of Medical Sciences during a time period of September 2007 to March 2008. The women were randomly divided into two groups: misoprostol (49 cases) and foley catheter (59 cases). For first group, 25 microgram vaginal misoprostol every 4 hour up to maximum 6 doses was administered. For second group, foley catheter 18F inflated with 50 cc of sterile water was placed through the internal os of the cervix. Data was analyzed by SPSS software. P < 0.05 was considered statistically significant. Findings: Two groups were similar in the view of demographic characteristics, cesarean indications, maternal-fetal outcomes and neonatal outcomes. Vaginal delivery was significantly higher in misoprostol group (89.9 vs. 62.7, P = 0.001). The mean of delivery time was significantly shorter in misoprostol group (11.08 Â± 5.6 vs. 13.6 Â± 16.0 h, P < 0.05). Conclusion: In the case of need to pregnancy termination and unripe cervix, two methods of misoprostol and foley catheter are suitable, but it seems that misoprostol decreases time of delivery and need to cesarean more than the other. Keywords: Misoprostol, Foley catheter, Cervix ripening, Induction of labor.

Foley catheter

Foley

Bishop score

Labor Induction

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Citations (28)

CA-125 in normal pregnancy and threatened abortion

International Journal of Reproductive BioMedicine (IJRM) (2007)

Sedigheh Ayaty Fatemeh Vahid Roudsari Fatemeh Tavassoly

Background: CA-125 is a glycoprotein and its origin is uncertain during pregnancy. It arises during the first trimester and return to a non-pregnancy range in late pregnancy. Objective: The aim of this study was to compare CA-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy. Materials and Methods: This was a prospective case study carried out on 50 healthy pregnant (group 1) and 50 threatened abortion women (group 2). We compared the levels of CA-125 in these groups and followed them to be informed of the outcome of pregnancy. Results: Fifty percent of women were in 20-24 years old group, primigravida and in the first trimester of pregnancy. The mean level of CA-125 in group 1 was 26.2 ± 3.25 IU/ml and in group 2 was 37.44 ± 2.72 IU/ml. The mean level of CA-125 in finally aborted patients was 58.17±7.25 IU/ml and in normal pregnant women, who continue to term, was 26.61±1.76 IU/ml. The CA-125 level in threatened women,whose pregnancy continued and did not abort, was 30.89 IU/ml. There was statistically significant difference between mean serum CA-125 levels of two groups (p 0.1). In group 2, there was a statistically significant difference in the level of CA-125 between those who developed abortion and those whose pregnancy continued but not aborted (p < 0.05). Conclusion: Measurement of serum CA-125 may be an inexpensive, easily available, sensitive and specific predictor of outcome in threatened abortion, which results the loss of pregnancy.

Threatened abortion

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Citations (13)

Efficacy of Combination Therapy with Methotrexate and Misoprostol in Termination of Pregnancy in the First Trimester

DOAJ (DOAJ: Directory of Open Access Journals) (2009)

Fatemeh Vahid Roudsari Sedigheh Ayati Mohammad Taghi Shakeri

Background: Induced abortion is the medical or surgical termination of pregnancy before fetal viability. It has maternal or fetal indications. The aim of the present study was to evaluate the efficacy of the combination of methotrexate and misoprostol for termination of the pregnancy in the first trimester. Methods: This analytic study was performed on 100 women at the first trimester of pregnancy (<14 th week), during 20042006. Each woman received intramuscular methotrexate (50 mg/m 2

Combination therapy

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Citations (1)