Menghan Gao

Chinese Academy of Medical Sciences & Peking Union Medical College

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Weiqi Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Huimin Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Deli Jiang

Jiangsu University

Hong Deng

Peking Union Medical College Hospital

Runmeng Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Yiyi Zhang

Guangxi University

Shichao Sun

Beijing University of Chemical Technology

Min Chen

Jiangsu University

Yiyi Zhang

Xizang Minzu University

Hong Deng

North Sichuan Medical University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Jiangsu University

Shandong First Medical University

Peking Union Medical College Hospital

Southern Medical University

Chinese Academy of Sciences

Wuhan University of Technology

Soochow University

Peking University

University of Electronic Science and Technology of China

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Self-Assembled Nanogels Based on Ionic Gelation of Natural Polysaccharides for Drug Delivery

Frontiers in Bioengineering and Biotechnology (2021)

Huimin Wang Hong Deng Menghan Gao Weiqi Zhang

The polysaccharides (PS) have been widely used as biomaterials in drug delivery, due to their excellent biocompatibility, ease of functionalization, and intrinsic biological activities. Among the various PS-based biomaterials, the self-assembled PS nanogels (NG) featuring facile preparation are attracting evergrowing interests in various biomedical applications. Specifically, NG derived from the self-assembly of natural PS well maintain both the physicochemical and biological properties of PS while avoiding the chemical modification or alteration of PS structure, representing a potent drug delivery system for various therapeutic agents. In this review, the natural PS, such as chitosan, alginate, and hyaluronan, for self-assembled NG construction and their advantages in the applications of drug delivery have been summarized. The residues, such as amine, carboxyl, and hydroxyl groups, on these PS provide multiple sites for both ionic cross-linking and metal coordination, which greatly contribute to the formation of self-assembled NG as well as the drug loading, thus enabling a wide biomedical application of PS NG, especially for drug delivery. Future developments and considerations in the clinical translation of these self-assembled PS NG have also been discussed.

Biocompatibility

Surface Modification

10.3389/fbioe.2021.703559

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Citations (32)

Co-assembly of cisplatin and dasatinib in hyaluronan nanogel to combat triple negative breast cancer with reduced side effects

International Journal of Biological Macromolecules (2024)

Runmeng Liu Wei Hou J. Li Xiaorong Gou Menghan Gao

Nanogel

Triple-negative breast cancer

Triple negative

10.1016/j.ijbiomac.2024.132074

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Citations (2)

Nanoparticle-Based Combination Therapy for Ovarian Cancer

International Journal of Nanomedicine (2023)

Yingli Wu Yu Yang Xiaolin Lv Menghan Gao Xujin Gong

Abstract: Ovarian cancer is one of the most common malignant tumors in gynecology with a high incidence. Combination therapy, eg, administration of paclitaxel followed by a platinum anticancer drug is recommended to treat ovarian cancer due to its advantages in, eg, reducing side effects and reversing (multi)drug-resistance compared to single treatment. However, the benefits of combination therapy are often compromised. In chemo and chemo/gene combinations, co-deposition of the combined therapeutics in the tumor cells is required, which is difficult to achieve due to dramatic pharmacokinetic differences between combinational agents in free forms. Moreover, some undesired properties such as the low-water solubility of chemodrugs and the difficulty of cellular internalization of gene therapeutics also hinder the therapeutic potential. Delivery of dual or multiple agents by nanoparticles provides opportunities to tackle these limits. Nanoparticles encapsulate hydrophobic drug(s) to yield aqueous dispersions facilitating its administration and/or to accommodate hydrophilic genes facilitating its access to cells. Moreover, nanoparticle-based therapeutics can not only improve drug properties (eg, in vivo stability) and ensure the same drug disposition behavior with controlled drug ratios but also can minimize drug exposure of the normal tissues and increase drug co-accumulation at targeted tissues via passive and/or active targeting strategies. Herein, this work summarizes nanoparticle-based combination therapies, mainly including anticancer drug-based combinations and chemo/gene combinations, and emphasizes the advantageous outcomes of nanocarriers in the combination treatment of ovarian cancer. In addition, we also review mechanisms of synergetic effects resulting from different combinations. Keywords: ovarian cancer, nanoparticles, combination therapy, chemotherapy, gene therapy

Nanocarriers

Combination therapy

10.2147/ijn.s394383

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Citations (12)

Nanowire-assembled Co₃O₄@NiS core–shell hierarchical with enhanced electrochemical performance for asymmetric supercapacitors

Nanotechnology (2020)

Suci Meng Yintao Wang Jingjing He Wei Quan Menghan Gao

In this study, a three-dimensional (3D) hierarchical Co3O4@NiS core-shell heterostructure supported on nickel foam (NF) has been constructed. This Co3O4@NiS/NF can directly serve as a binder-free electrode for a pseudocapacitor, which could achieve a high specific capacitance of 1395.3 F g-1 at a current density of 1 A g-1 in 6 M KOH electrolyte, and an ideal rate capability of 711 F g-1 at a current density of 10 A g-1. Additionally, the electrode has a high capacitance retention of 89.9% after 5000 cycles. The asymmetric supercapacitor exhibits the maximum energy density of 61.34 W h kg-1 at a power density of 800 W kg-1, as well as an excellent cycling life of 89.3% capacitance retention. The enhanced electrochemical performance can be mainly ascribed to the special 3D core-shell nanowire arrays nanostructure with great conductivity, enlarged surface area, abundant accessible active sites and intrinsic stability. We anticipate that the present Co3O4@NiS/NF could be a promising electrode material for energy storage applications.

Pseudocapacitor

Power density

10.1088/1361-6528/ab81c7

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Citations (8)

Interfacial engineering of CeO₂ on NiCoP nanoarrays for efficient electrocatalytic oxygen evolution

Nanotechnology (2021)

Menghan Gao Zhihong Wang Shichao Sun Deli Jiang Min Chen

Transition metal phosphides (TMP)-based oxygen evolution reaction (OER) catalysts constructed by interface engineering strategy have a broad prospect due to their low cost and good performance. Herein, a novel CeO2/NiCoP nanoarray with intimate phosphide (NiCoP)-oxide (CeO2) interface was developed via in situ generation on nickel foam (NF). This structure is conducive to increasing active sites and accelerating charge transfer, and may be conducive to regulating electronic structure and adsorption energy. As expected, optimal 1.4-CeO2/NiCoP/NF delivers a low overpotential of 249 mV at the current density of 10 mA cm-2 with a Tafel slope of 77.2 mV dec-1. CeO2/NiCoP/NF boasts one of the best OER catalytic materials among recently reported phosphides (TMP)-based OER catalysts and composite catalysts involving CeO2. This work provides an effective strategy for the construction of hetero-structure with CeO2 with oxygen vacancies to improve the OER performance of phosphides.

Overpotential

Oxygen evolution

Phosphide

10.1088/1361-6528/abe0e5

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Citations (26)

A Hybrid Nanogel to Preserve Lysosome Integrity for Fluorescence Imaging

ACS Nano (2021)

Weiqi Zhang Baoji Du Menghan Gao Ching‐Hsuan Tung

Fluorescence imaging of lysosomes provides a powerful tool to probe the lysosome physiology in living cells, yet the continuous light exposure inevitably causes lysosome damage and phototoxicity, which remains a formidable challenge. Here the long-term lysosome tracking with minimized photodamage was realized using a multifunctional nanoprobe, a platinum nanoparticle, and a quinacrine co-loaded nanogel. To construct the hybrid nanogel, cisplatin first functioned as cross-linker to withhold all components and then was reduced to a platinum nanoparticle in situ by ethanol. The platinum nanoparticle enabled a long-term quinacrine fluorescence imaging of lysosome by scavenging the light induced reactive oxygen species which could damage lysosomal membranes.

Nanogel

Fluorescence-lifetime imaging microscopy

Phototoxicity

10.1021/acsnano.1c05864

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Citations (21)

Tailoring the surface charges of iron-crosslinked dextran nanogels towards improved tumor-associated macrophage targeting

Carbohydrate Polymers (2023)

Hong Deng Xue Yang Huimin Wang Menghan Gao Yiyi Zhang

Nanocarriers

Nanomaterials

Surface charge

Surface Engineering

Cancer Therapy

10.1016/j.carbpol.2023.121585

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Citations (4)

Hyaluronan nanogel co-loaded with chloroquine to enhance intracellular cisplatin delivery through lysosomal permeabilization and lysophagy inhibition

Carbohydrate Polymers (2023)

Menghan Gao Hong Deng Yiyi Zhang Huimin Wang Runmeng Liu

Nanogel

Nanocarriers

10.1016/j.carbpol.2023.121415

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Citations (11)

Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy

Current Topics in Medicinal Chemistry (2020)

Menghan Gao Hong Deng Weiqi Zhang

Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility, biodegradability, and low immunogenicity, making it one of the most attractive biopolymers used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered to construct different drug-loading nanoparticles (NPs) for CD44-targeted anti-tumor therapy. When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained, which features as a highly effective and self-targeting strategy to combat cancers with CD44 overexpression. The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many types of HA-based multidrug nano-carriers constructed by different formulation strategies, including drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier takes the full advantages of HA as an NP matrix, drug carriers and targeting ligand, representing a simplified and biocompatible platform to realize the targeted and synergistic combination therapy against the cancers. In this review, recent progress of HA-based multidrug nano-carriers for combination cancer therapy is summarized and the potential challenges for translational applications have been discussed.

Biocompatibility

Cancer Therapy

Combination therapy

10.2174/1568026620666200922113846

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Citations (18)

Radiotherapy Potentiates the P-Selectin Targeted Cancer Drug Delivery Based on a Cisplatin and Mitoxantrone Coassembled Fucoidan Nanogel

ACS Materials Letters (2023)

Huimin Wang Hong Deng Menghan Gao Yiyi Zhang Runmeng Liu

Targeted delivery of coencapsulated drugs can increase therapeutic indices of cancers including improved tumor inhibition and safety profile. However, most cancers lack tumor specific receptors (antigens) to guide the targeted delivery. Tumoral P-selectin can be rapidly upregulated after ionization radiation, indicating it is a highly selective target for drug delivery. In this work, we had fucoidan, a natural polysaccharide with intrinsic affinity toward P-selectin, and the chemotherapeutics cisplatin and mitoxantrone coassembled into a composite nanogel (FCM), and meanwhile exploited its P-selectin targeted therapeutic potentials in combination with radiotherapy using a murine breast cancer model. The radiation significantly enhanced the P-selectin level in tumor and subsequently boosted the cancer-targeted delivery of FCM. In current FCM, fucoidan not only acted as matrix for drugs encapsulation but also functioned as targeting ligand, thus providing a facile and P-selectin targeted codelivery of chemotherapeutics that could be potentiated by tumor radiation.

Nanogel

Fucoidan

Targeted drug delivery

10.1021/acsmaterialslett.3c00747

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Citations (5)