Domenico Cassano

Joint Research Centre

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Valerio Voliani

Center for Nanotechnology Innovation

V. Pizza

University of Salerno

Anna Capasso

Livestrong Foundation

Vincenzo Busillo

University of Siena

Melissa Santi

National Enterprise for NanoScience and NanoTechnology

Ana Katrina Mapanao

Paul Scherrer Institute

Salvador Pocoví‐Martínez

Center for Nanotechnology Innovation

Giovanni Signore

University of Pisa

Stefano Luin

Istituto Nanoscienze

Rita La Spina

Joint Research Centre

Cooperative Institutions

Italian Institute of Technology

North Carolina State University

Center for Nanotechnology Innovation

University of Portsmouth

Clemson University

Universidad del Noreste

University of Arizona

Ohio University

UNSW Sydney

University of Pisa

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Promising Applications in Medicine

Domenico Cassano Valerio Voliani

This chapter contains sections titled:

10.1002/9781119418962.ch3

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P074. Almotriptan in the acute treatment of Vestibular migraine: a retrospective study

The Journal of Headache and Pain (2015)

Domenico Cassano V. Pizza Vincenzo Busillo

Vestibular migraine (VM) has become a well-defined diagnostic entity, based on recurrent vertigo attacks, unexplained by other central or peripheral otologic abnormalities, occurring in patients with a history of migraine headache. The duration of vertigo attacks varies from seconds to days, usually lasting minutes to hours, mostly occurring independently of headaches.

Pain medicine

10.1186/1129-2377-16-s1-a114

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Biosafety and Biokinetics of Noble Metals: The Impact of Their Chemical Nature

ACS Applied Bio Materials (2019)

Domenico Cassano Ana Katrina Mapanao Maria Summa Ylea Vlamidis Giulia Giannone

Effective excretion of nanostructured noble metals is still one of the most challenging bottlenecks for their employment in clinical practice. Besides the persistence issue, the clinical translation of inorganic nanomaterials is also affected by a bewildering lack of investigations regarding their quantitative biokinetics. Here, we have quantitatively correlated the chemical nature of the three most interesting noble metals for biomedical applications to their biosafety and biokinetics in, respectively, zebrafish and murine models. Gold, silver, and platinum ultrasmall-in-nano architectures with comparable size elicit, after intravenous administration, different excretion pathways depending on their intrinsic metallic nature. Understanding the in vivo fate of noble metal nanoparticles is a significant breakthrough to unlock their clinical employment for the establishment of treatments for neoplasms, infectious diseases, and neurological disorders.

Noble metal

Biosafety

Nanomaterials

10.1021/acsabm.9b00630

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Citations (54)

Efficacy and Tolerability of a combination product with L-Tryptophan, Griffonia simplicifolia, Vitamin PP and Vitamin B6 in pediatric migraine prophylaxis: an open study

V. Pizza Vincenzo Busillo Domenico Cassano A. Agresta Anna Capasso

The aim of this study was to evaluate the efficacy and tolerability of combination product with L- tryptophan, Griffonia simplicifolia, Vitamin PP and Vitamin B6 in prophylaxis therapy of pediatric migraine. Fifthy outpatients (32 F, 18 M), mean age 10.7 years (SD 5.8), range 4-18 years, suffering from ICHD-2 migraine without aura were enrolled. The mean duration of disease was 2.9 (SD 1.6) years, range 1-4 years. At baseline the mean frequency of attacks was 7.6/month (SD 3.3), range 4-12; the mean number of drugs intaking for acute attacks was 6.6 tablets/month (SD 2.2). During the six month evaluation period the combination product with L-tryptophan, griffonia simplicifolia, vitamin PP and vitamin B6 was administered (at dose 100 mg, 480 mg, 18 mg and 1 mg/die, respectively). All patients filled a headache-diary card during the evaluation.

Tolerability

Griffonia simplicifolia

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The relationship between obsessive-compulsive personality and obsessive-compulsive disorder: data obtained by the Personality Disorder Examination

European Psychiatry (1993)

Domenico Cassano Gianfranco Del Buono Francesco Catapano

Summary We administered the Personality Disorder Examination (PDE) to 31 patients meeting DSM III criteria for obsessive-compulsive disorder (OCD) and to an age-and sex-matched healthy control group. Seventeen patients (54.8%) and four controls (12.9%) met criteria for one or more DSM III Axis II diagnoses. The most frequent Axis II diagnoses in patients were avoidant, passive-aggressive and compulsive personality disorder. Compulsive personality disorder was diagnosed in 6 OCD patients (19.3%). The prevalence of this disorder did not change according to sex, age of onset or duration of OCD, and severity of obsessive-compulsive symptoms.

Avoidant personality disorder

10.1017/s0924933800002959

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Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma

Cancers (2021)

Caitlin Ung Maria Tsoli Jie Liu Domenico Cassano Salvador Pocovı́-Martı́nez

Diffuse Intrinsic Pontine Gliomas (DIPGs) are highly aggressive paediatric brain tumours. Currently, irradiation is the only standard treatment, but is palliative in nature and most patients die within 12 months of diagnosis. Novel therapeutic approaches are urgently needed for the treatment of this devastating disease. We have developed non-persistent gold nano-architectures (NAs) functionalised with human serum albumin (HSA) for the delivery of doxorubicin. Doxorubicin has been previously reported to be cytotoxic in DIPG cells. In this study, we have preclinically evaluated the cytotoxic efficacy of doxorubicin delivered through gold nanoarchitectures (NAs-HSA-Dox). We found that DIPG neurospheres were equally sensitive to doxorubicin and doxorubicin-loaded NAs. Colony formation assays demonstrated greater potency of NAs-HSA-Dox on colony formation compared to doxorubicin. Western blot analysis indicated increased apoptotic markers cleaved Parp, cleaved caspase 3 and phosphorylated H2AX in NAs-HSA-Dox treated DIPG neurospheres. Live cell content and confocal imaging demonstrated significantly higher uptake of NAs-HSA-Dox into DIPG neurospheres compared to doxorubicin alone. Despite the potency of the NAs in vitro, treatment of an orthotopic model of DIPG showed no antitumour effect. This disparate outcome may be due to the integrity of the blood-brain barrier and highlights the need to develop therapies to enhance penetration of drugs into DIPG.

Neurosphere

10.3390/cancers13061278

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Citations (17)

Epilepsy And Multiple Sclerosis: Comorbidity Or Unique Pathology?

Vincenzo Busillo V. Pizza Domenico Cassano Antonio Busillo Maria Rosaria Somma

Hippocampal sclerosis

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Conclusions and Perspectives

Domenico Cassano Valerio Voliani

No Abstract.

10.1002/9781119418962.ch7

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Inorganic Species-Doped Polypropylene Nanoparticles for Multifunctional Detection

ACS Applied Nano Materials (2021)

Domenico Cassano Rita La Spina Jessica Ponti Ivana Bianchi Douglas Gilliland

Plastic debris accounts for the most substantial part of marine pollution and its degradation byproducts are omnipresent. Beyond representing a serious potential hazard for the marine ecosystem, micro- and nanoplastics may easily enter the human food chain with effects on health that are still poorly understood and undefined. In particular, while polypropylene (PP) is amongst the most commonly detected plastic fragments, studies to evaluate its traceability and role in food chain are still very limited mainly due to a lack of easy synthesis routes for model PP micro- and nanoparticles. In this work, we have developed a protocol for high-throughput production of PP nanoparticles in the size range 80–350 nm, via the oil-in-water emulsion technique in the presence of the sodium cholate bile salt as a nonhazardous surfactant. In addition, the traceability of PP has been achieved by introducing selected markers into PP nanoparticles containing inorganic metals and/or fluorescent dyes such as plasmonic ultrasmall gold nanoparticles, quantum dots, and/or luminescent dyes. Moreover, PP nanoparticles are stable in an aqueous environment due to the biocompatible surfactant and enable the detection by multiple techniques, thanks to their modulable core. Therefore, they represent a significant advance in the development of model plastic nanomaterials for different applications, which might include toxicity and biodistribution studies.

Nanomaterials

10.1021/acsanm.0c03039

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DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Neuro-Oncology (2020)

Caitlin Ung Maria Tsoli Jie Liu Domenico Cassano Dannielle Upton

Abstract DIPGs are the most aggressive pediatric brain tumors. Currently, the only treatment is irradiation but due to its palliative nature patients die within 12 months. Effective delivery of chemotherapy across the blood-brain barrier (BBB) has been a key challenge for the eradication of this disease. We have developed a novel gold nanoparticle functionalised with human serum albumin (Au-NP, 98.8 ±19 nm) for the delivery of doxorubicin. In this study, we evaluated the cytotoxic efficacy of doxorubicin delivered through gold nanoparticles (Au-NP-Dox). We found that DIPG neurospheres were equally sensitive to doxorubicin and Au-NP-Dox (at equimolar concentration) by alamar blue assay. Colony formation assays demonstrated a significantly more potent effect of Au-NP-Dox compared to doxorubicin alone, while the Au-NP had no effect. Furthermore, western blot analysis indicated increased apoptotic markers cleaved Parp, caspase 3/7 and phosphorylated H2AX in Au-NP-Dox treated DIPG neurospheres. Live cell content and confocal imaging demonstrated significantly higher uptake of Au-NP-Dox compared to doxorubicin alone. Treatment of a DIPG orthotopic mouse model with Au-NP-Dox showed no signs of toxicity with stable weights being maintained during treatment. However, in contrast to the above in vitro findings the in vivo study showed no anti-tumor effect possibly due to poor penetration of Au-NP-Dox into the brain. We are currently evaluating whether efficacy can be improved using measures to open the BBB transiently. This study highlights the need for rigorous in vivo testing of new treatment strategies before clinical translation to reduce the risk of administration of ineffective treatments.

10.1093/neuonc/noaa222.047

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