How to help enterprises develop “upstream” and improve employee innovative behavior has become an important challenge faced by leaders. For researchers, their innovative behavior comes not only from their own internal drive, but also from the climate of inclusive leadership. In the face of dynamic and complex environment, employee resilience to “going upstream” is particularly precious. Therefore, based on self-determination theory and dynamic ability theory, this paper discusses the influence of inclusive leadership on innovative behavior through employee resilience and the moderation of prosocial motivation. Through the analysis and processing of 398 effective questionnaires of leader-employee matching in 20 Chinese science and technology enterprises, the results show that inclusive leadership has a significant positive impact on employee innovative behavior; employee resilience plays a mediating role in the effects of inclusive leadership on employee innovative behavior; prosocial motivation can moderate the indirect effect of inclusive leadership on employee resilience, and further moderates the intermediary role of employee resilience. The research conclusion reveals the “black box” of the effects of inclusive leadership on employee innovative behavior, and it provides suggestions on strengthening the inclusiveness of leadership, improving employee resilience and how to manage employees with different levels of prosocial motivation.
Background: The risk/benefit tradeoff of dual antiplatelet therapy after percutaneous coronary intervention may vary in East Asian patients as compared with their non-East Asian counterparts. Methods: The double-blind, placebo-controlled, randomized TWILIGHT trial (Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention) enrolled patients undergoing high-risk percutaneous coronary intervention. After 3 months of treatment with ticagrelor plus aspirin, event-free and adherent patients remained on ticagrelor and were randomly assigned to receive aspirin or placebo for 1 year. The primary end point was Bleeding Academic Research Consortium type 2, 3, or 5 bleeding; the key secondary end point was the first occurrence of death from any cause, nonfatal myocardial infarction, or nonfatal stroke. Results: Of 9006 enrolled and 7119 randomized patients in TWILIGHT, 1169 patients (13.0%) were enrolled at 27 Chinese sites in this prespecified substudy, of whom 1028 (14.4%) patients were randomized after 3 months. The incidence of the primary end point was 6.2% in the ticagrelor+aspirin group versus 3.5% in the ticagrelor+placebo group between randomization and 1 year (hazard ratio, 0.56 [95% CI, 0.31–0.99]; P =0.048). The key secondary end point occurred in 3.4% of patients in the ticagrelor+aspirin group versus 2.4% in the ticagrelor+placebo group (hazard ratio, 0.70 [95% CI, 0.33–1.46]; P =0.34). There was no interaction between the region of randomization (China versus the rest of the world) and randomized treatment assignment in terms of the primary or key secondary end points. Conclusions: Ticagrelor monotherapy significantly reduced clinically relevant bleeding without increasing ischemic events as compared with ticagrelor plus aspirin in Chinese patients undergoing high-risk percutaneous coronary intervention. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02270242.
This study is to observe the distribution of intestinal flora and the changes of inflammatory factors in elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus. A total of 106 elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus (complicated group), 106 elderly patients with simple type 2 diabetes mellitus (diabetic group), and 106 healthy elderly people (control group) were selected. The fasting blood glucose (FBG), 1-h postprandial blood glucose (1hPG), 2-h postprandial blood glucose (2hPG), 3-h postprandial blood glucose (3hPG), and hemoglobin A1c (HbA1c) in complicated group and the diabetic group were higher than those in the control group ( P < 0.05 or P < 0.01). The duration of diabetes, FBG, 3hPG, and HbA1c in the complicated group were higher than those in the diabetic group, while the 2hPG was lower than that in the diabetic group ( P < 0.05). Compared with control group, the number of Enterobacteria in the diabetic group and complicated group was increased, while the numbers of Bacteroides, Bifidobacteria, and Lactobacillus were decreased ( P < 0.05 or P < 0.01). Compared with the diabetic group, the number of Enterobacteria in complicated group was increased, while the numbers of Bacteroides, Bifidobacteria, and Lactobacillus were decreased ( P < 0.05 or P < 0.01). Compared with control group, the levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β), and C-reactive protein (CRP) decreased in the diabetic group and complicated group, and the lowest in the complicated group. Conversely, the levels of interleukin 10 (IL-10) and interleukin 12 (IL-2) increased in the diabetic group and complicated group, and the highest in the complicated group ( P < 0.05 or P < 0.01). Multiple logistic regression analysis showed that the duration of diabetes, HbA1c, Enterobacteria, TNF-α, IL-6, and IL-10 were the influencing factors of myocardial ischemia complicated with type 2 diabetes mellitus ( P < 0.05 or P < 0.01). In conclusion, in the elderly patients with myocardial ischemia complicated with type 2 diabetes mellitus, the number of intestinal probiotics and the level of anti-inflammatory factors decreased, and the number of pathogenic bacteria and the level of inflammatory factors increased. Enterobacteria, TNF-α, IL-6, and IL-10 may play an important role in the development of myocardial ischemia in type 2 diabetes mellitus.
Despite advances in the treatment of ST-segment elevation myocardial infarction (STEMI), little is known about how this evolving knowledge is applied in current clinical practice in China.
Objective
To evaluate hospital performance and temporal trends in the management of STEMI.
Design, Setting, and Participants
This study used data from the Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome Project, a nationwide quality improvement registry, in collaboration with the American Heart Association and the Chinese Society of Cardiology. Participants included patients with STEMI admitted to 143 tertiary hospitals across China from November 2014 to July 2019, and data were analyzed from November 2020 to December 2021.
Main Outcomes and Measures
Levels, hospital-level variations, and trends for utilization rates of the 9 management strategies with Class I recommendations in Chinese and US guidelines.
Results
A total of 57 560 hospitalizations with STEMI were included. Overall, 20.0% of patients received all the care according to the 9 guideline-recommended strategies. The performance rate of quality measures was low for reperfusion therapy (61.0%, 35 115/57 560 patients), β-blocker at discharge (68.3%, 37 750/55 285 patients), angiotensin-converting enzyme inhibitor or angiotensin receptor blocker at discharge (55.1%, 2524/4578 patients), and smoking cessation counseling (36.5%, 9586/26 265 patients) among those who were eligible. Of 25 563 patients who underwent primary percutaneous coronary intervention (PCI), 66.8% underwent this procedure within 90 minutes of hospital arrival. Of 1128 patients who underwent fibrinolysis therapy, 253 (22.4%) underwent this treatment within 30 minutes of hospital arrival. Measures with high performance rates included receipt of dual antiplatelet therapy within 24 hours (95.5%, 54 263/56 848 patients) and at discharge (91.8%, 51 452/56 019 patients) and receipt of statin at discharge (93.0%, 52 214/56 141 patients) for those eligible. There was significant variation between hospitals in all-or-none score (ranging from 0 to 61.9%) and performance of individual measures. The quality of care improved during the study period, especially for reperfusion therapy, primary PCI within the first 90 minutes of hospital arrival, and smoking cessation counseling.
Conclusions and Relevance
The quality of care for patients hospitalized with STEMI does not meet guideline-recommended strategies in China, with only 1 in 5 patients receiving all the care according to the 9 guideline-recommended strategies. Large disparities in the quality of care exist across hospitals.
Objective:To explore the change of cardiac electricity in coronary heart disease(CHD) patients complicated with obstructive sleep apnea hypopnea syndrome(OSAHS). Method:The 24-hour Dynamic Electrocardiogram(DECG) was detected in group Ⅰ with 42 CHD patients and group Ⅱ with 47 CHD patients complicated with OSAHS.We analyzed the cardiac arrhythmia,the time domain and frequency domain of heart rate variability(HRV) and defined heart rate turbulence(HRT) index in patients with ventricular premature beats. Result:Group Ⅱ experienced significantly higher incidence rate of atrial arrhythmia and ventricular arrhythmia than group Ⅰ.HRV time domain index SDNN([91.51±16.43] vs [128.12±13.78]ms,P0.05),SDANN Index([83.44±16.21] vs [117.32±17.68]ms,P0.05) and SDNN Index([33.15±9.89] vs [48.17±11.69]ms,P0.05) were significantly lower than those of group Ⅰ.The difference of HRT index TO and TS values between groups Ⅰ and Ⅱ were distinct(P0.05). Conclusion:Arrhythmia incidence in CHD patients complicated with OSAHS is significantly higher,with lower HRV and reduced HRT.
For households as a socially composed micro-group, the rise of household housing liabilities can have a significant impact on household asset allocation. This paper utilises the latest data from the China Household Finance Survey (CHFS) 2019 to construct Probit and Tobit models to measure the actual impact of housing liabilities on household asset allocation, respectively. It is found that due to the mortgage repayment pressure brought about by rising housing liabilities, households will adjust their asset allocation accordingly, i.e., increase the allocation of risk-free assets represented by savings and reduce the allocation of risky assets represented by stocks and funds, which provides empirical reference for policy formulation to prevent household debt risk.
There have been many misunderstandings of the prolonged-action calcium channel blockers in hypertension therapy.In this article we will review recent advances in research and clinical effects using evidence from randomized controlled clinical trials of blood pressure lowering,target organ protection,and some issues related to the prolonged-action calcium channel blockers.
Objective:To study effects of losartan on level of brain natriuretic peptide(BNP) in patients with essential hypertension(EH) complicated left ventricular hypertrophy(LVH) and its significance.Methods:The 100 EH patients with normal left ventricular ejection fraction(LVEF) were selected,and there were 58 cases complicated with LVH and 42 pure EH cases.Another 50 healthy subjects were regard as healthy control group.Plasma levels of BNP were compared among the three groups.EH+LVH group were given losartan for six months,the changes of BNP level and left ventricular mass index(LVMI) were compared before and after treatment.Results: ① Plasma level of BNP of EH + LVH group was significantly higher than those of pure EH group and healthy control group [(62.21±9.70) pg/ml vs.(39.35±10.57) pg/ml vs.(13.89±5.34) pg/ml,P0.01];② Concentration of BNP was positively correlated with LVMI(r=0.44,P0.05);③ Compared with before treatment,there were significant decrease in plasma level of BNP [(62.21±9.70) pg/ml vs.(38.78±7.94) pg/ml] and LVMI [(128.71±12.64) g/m2 vs.(107.36±11.32) g/m2] in EH + LVH group after six-month treatment with losartan,P0.01 both.Conclusion:Losartan can significantly decrease level of brain natriuretic peptide and reverse left ventricular hypertrophy in patients with hypertension complicated left ventricular hypertrophy.
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