Beatriz G. Gálvez

Universitat de Miguel Hernández d'Elx

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Giulio Cossu

Vita-Salute San Raffaele University

Laura M. Pérez

University of Tarapacá

Alicia G. Arroyo

Centro de Investigaciones Biológicas Margarita Salas

Maurilio Sampaolesi

Sapienza University of Rome

Beatriz de Lucas

Universidad Europea de Madrid

Aurora Bernal

UiT The Arctic University of Norway

Silvia Brunelli

University of Milano-Bicocca

Alejandro Lucía

Research Institute Hospital 12 de Octubre

Diego Covarello

Vita-Salute San Raffaele University

Nuria San Martín

Spanish National Centre for Cardiovascular Research

Cooperative Institutions

Universidad Autónoma de Madrid

University of Milan

Instituto de Salud Carlos III

Istituti di Ricovero e Cura a Carattere Scientifico

Vita-Salute San Raffaele University

Universidad Europea de Madrid

Centro de Investigación Biomédica en Red

Universidad Complutense de Madrid

Spanish National Centre for Cardiovascular Research

Research Institute Hospital 12 de Octubre

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A systematic review of lifestyle-based interventions for managing Alzheimer's disease: Insights from randomized controlled trials

Journal of Alzheimer s Disease (2024)

Sara Martínez‐López Mariangela Tabone Sara Clemente-Velasco Maria del Rocío González-Soltero María Bailén

Background Alzheimer's disease (AD) presents a significant challenge in healthcare, prompting exploration into non-pharmacological interventions to complement traditional treatments. Objective This systematic review explores the efficacy of lifestyle-based interventions in managing AD. Methods A comprehensive literature search was conducted in PubMed, Web of Science, and Scopus between 2018 and 2023, selecting randomized controlled trials examining factors such as exercise, diet, stress, and cognitive training in AD patients. Results The review revealed physical exercise as the predominant non-pharmacological intervention, accompanied by dietary modifications, cognitive training, and therapies such as mindfulness and music. While exercise demonstrated improvements in quality of life, its cognitive benefits were limited. Modified diets, such as Atkins and ketogenic, displayed inconsistent effects on cognitive function but influenced other health-related parameters. Additionally, probiotic therapy and novel cognitive training technologies were explored. Conclusions Despite some interventions showing promise in enhancing cognitive function and slowing disease progression, uncertainties remain regarding the dose-response relationship, underlying mechanisms, and potential synergistic effects. Moreover, consideration of genetic and sex-based disparities is warranted. This synthesis underscores the need for further research to elucidate the nuances of non-pharmacological interventions in managing AD effectively. PROSPERO registration number CRD42023432823

10.1177/13872877241292829

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Citations (3)

Adipokines disrupt cardiac differentiation and cardiomyocyte survival

International Journal of Obesity (2019)

Laura M. Pérez Beatriz de Lucas Aurora Bernal Beatriz G. Gálvez

10.1038/s41366-019-0455-4

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Citations (5)

Cardiac-derived mesoangioblasts can differentiate into autorhythmic myocytes

Andrea Barbuti Beatriz G. Gálvez Alessia Crespi Benedetta Terragni A. Tognati

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Affinity of Malassezia and Other Yeasts for Pulmonary Lipids

Mycopathologia (2024)

Violeta Esteban Pablo Gilabert Consuelo Ferrer Beatriz G. Gálvez Eusebi Chiner

Pulmonary surfactant, the primary substance lining the epithelium of the human Lower Respiratory Tract (LRT), is rich in lipids, with dipalmitoyl-phosphatidylcholine (DPPC) being the most abundant. Although surfactants are known to have antifungal activity against some yeast species, the significant presence of species like Malassezia restricta in the lung mycobiome suggests that these yeasts may exhibit some level of lipo-tolerance or even lipo-affinity for pulmonary lipids. This study explored the affinity and tolerance of yeasts, identified as significant members of the lung microbiome, to pulmonary lipids through culture-based methods. Eleven species from the genera Malassezia, Candida (including the new genera Nakaseomyces and Meyerozyma), and Cryptococcus were tested for their growth on media containing pulmonary lipids such as DPPC and commercial porcine surfactant and in other culture medium that contain non-pulmonary lipids such as glycerol monostearate and tweens. The yeasts' lipo-affinity or lipo-tolerance was assessed based on their growth on these lipids compared to standard media, specifically Modified Leeming Notman Agar (MLNA) for Malassezia species and Sabouraud Dextrose Agar (SDA) for the other genera. The addition of DPPC or surfactant to the media enhanced the growth of most Malassezia yeasts and some Cryptococcus species. C. parapsilosis, Meyerozyma guilliermondii and Cryptococcus neoformans s.s. showed similar growth to that on the standard media, while the other yeasts primarily demonstrated lipo-tolerance without lipo-affinity for these compounds. To our knowledge, this is the first report on the influence of pulmonary lipids on the in vitro growth of Malassezia spp. and other yeast members of the lung mycobiome. Some yeasts, such as Malassezia restricta, commonly found in the lower respiratory tract (LRT), exhibit specific affinity for lung lipids like DPPC and commercial porcine surfactant. This finding suggests that lung lipids may play a significant role in shaping the LRT mycobiome.

Malassezia

Candida parapsilosis

10.1007/s11046-024-00910-w

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Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities

Cancer Research (2004)

Rubén A. Bartolomé Beatriz G. Gálvez Natividad Longo Françoise Baleux Goos N.P. van Muijen

Abstract Tissue invasion by tumor cells involves their migration across basement membranes through activation of extracellular matrix degradation and cell motility mechanisms. Chemokines binding to their receptors provide chemotactic cues guiding cells to specific tissues and organs; they therefore could potentially participate in tumor cell dissemination. Melanoma cells express CXCR4, the receptor for the chemokine stromal cell-derived factor-1α (SDF-1α). Using Matrigel as a model, we show that SDF-1α promotes invasion of melanoma cells across basement membranes. Stimulation of membrane-type 1 matrix metalloproteinase (MT1-MMP) activity by SDF-1α was necessary for invasion, involving at least up-regulation in the expression of this metalloproteinase, as detected in the highly metastatic BLM melanoma cell line. Moreover, SDF-1α triggered the activation of the GTPases RhoA, Rac1, and Cdc42 on BLM cells, and expression of dominant-negative forms of RhoA and Rac1, but not Cdc42, substantially impaired the invasion of transfectants in response to SDF-1α, as well as the increase in MT1-MMP expression. Furthermore, CXCR4 expression on melanoma cells was notably augmented by transforming growth factor-β1, a Matrigel component, whereas anti-transforming growth factor-β antibodies inhibited increases in CXCR4 expression and melanoma cell invasion toward SDF-1α. The identification of SDF-1α as a potential stimulatory molecule for MT1-MMP as well as for RhoA and Rac1 activities during melanoma cell invasion, associated with an up-regulation in CXCR4 expression by interaction with basement membrane factors, could contribute to better knowledge of mechanisms stimulating melanoma cell dissemination.

Matrigel

CDC42

10.1158/0008-5472.can-03-3398

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Citations (138)

Affinity of Malassezia and other yeasts for pulmonary lipids

Research Square (Research Square) (2024)

Violeta Esteban Pablo Gilabert Consuelo Ferrer Beatriz G. Gálvez Eusebi Chiner

Abstract Pulmonary surfactant is the main substance that lines the epithelium of the human Lower Respiratory Tract (LRT). It has a high lipidic content, being dipalmitoyl-phosphatidylcholine (DPPC) the most abundant one. Although surfactants have a well-known antifungal activity for some yeast species, the important presence of species like Malassezia restricta in the lung mycobiome, leads to the idea that these yeasts may have some lipo-tolerance or even lipoaffinity for pulmonary lipids. A culture-based study of affinity and tolerance to pulmonary lipids by yeasts described as important members of the lung microbiome has been carried out. Ten species belonging to the genera Malassezia, Candida (including the new genera Nakaseomyces and Meyerozyma ) and Cryptococcus , were tested for their ability to grow on media containing pulmonary lipids such as DPPC and commercial porcine surfactant. Lipoaffinity or lipo-tolerance was considered on the basis of their growth on standard media, considered as such the Modified Leeman Notman Agar (MLNA) for Malassezia species, and the Sabouraud Dextrose Agar (SDA) for the other genera. The addition of DPPC or surfactant to the media assayed resulted in increased growth of Malassezia yeasts and one of the Cryptococcus species. C. parapsilosis showed similar growth to the one obtained in the standard media and the other tested yeasts mainly showed lipo-tolerance but not lipoaffinity for these compounds. To our knowledge, this is the first report on the influence of pulmonary lipids in the in vitro development of Malassezia spp and other yeasts members of the lung mycobiome.

Malassezia

10.21203/rs.3.rs-4187603/v1

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Citations (0)

Influence of Cytokines on Inflammatory Eye Diseases: A Citation Network Study

Journal of Clinical Medicine (2022)

Beatriz G. Gálvez Clara Martínez-Pérez César Villa Collar Cristina Álvarez-Peregrina Miguel Ángel Sánchez‐Tena

The main objective of this study was to use citation networks to analyze the relationship between different publications on the impact of cytokines at an ocular level and their authors. Furthermore, the different research areas will be identified, and the most cited publications determined.A search was performed in the Web of Science (WoS) database using the following keywords: "cytokine", "inflammatory", and "eye disease" for the period from 1990 to October 2021. The Citation Network Explorer and the CiteSpace software were then used to analyze the different publications.3127 publications with 8955 citations generated on the web were found. The largest number of publications on this topic emerged in 2018 and the authors with the largest number of publications addressing this area of research were Peizeng Yang (1.4%), Aize Kijlstra (1.3%), and Stephen C. Pflugfelder (1.2%).the citation network has provided a comprehensive and objective analysis of the main studies on the influence of cytokines in ocular inflammatory diseases.

Web of science

Impact factor

10.3390/jcm11030661

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Citations (7)

Correction: Corrigendum: Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs

Nature (2014)

Maurilio Sampaolesi Stéphane Blot Giuseppe D’Antona Nicolas Granger Rossana Tonlorenzi

10.1038/nature13143

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Citations (2)

Skeletal Muscle Differentiation of Embryonic Mesoangioblasts Requires Pax3 Activity

Stem Cells (2008)

Graziella Messina Dario Sirabella Stefania Monteverde Beatriz G. Gálvez Rossana Tonlorenzi

Mesoangioblasts have been characterized as a population of vessel-associated stem cells able to differentiate into several mesodermal cell types, including skeletal muscle. Here, we report that the paired box transcription factor Pax3 plays a crucial role in directing mouse mesoangioblasts toward skeletal myogenesis in vitro and in vivo. Mesoangioblasts isolated from the aorta of Pax3 null embryos are severely impaired in skeletal muscle differentiation, whereas most other differentiation programs are not affected by the absence of Pax3. Moreover, Pax3(-/-) null mesoangioblasts failed to rescue the myopathic phenotype of the alpha-sarcoglycan mutant mouse. In contrast, mesoangioblasts from Pax3 gain of function, Pax3(PAX3-FKHR/+), mice display enhanced myogenesis in vitro and are more efficient in regenerating new muscle fibers in this model of muscular dystrophy. These data demonstrate that Pax3 is required for the differentiation of mesoangioblast stem cells into skeletal muscle, in keeping with its role in orchestrating entry into the myogenic program.

PAX3

10.1634/stemcells.2008-0503

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Citations (33)

Functional Assays of Stem Cell Properties Derived from Different Niches

Methods in molecular biology (2018)

Beatriz de Lucas Laura M. Pérez Beatriz G. Gálvez

Crosstalk

Stem cell niche

10.1007/7651_2018_175

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