Tianjiao Ji

National Center for Nanoscience and Technology

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Shuangli Zhu

National Institute for Viral Disease Control and Prevention

Dongmei Yan

National Institute for Viral Disease Control and Prevention

Yong Zhang

National Institute for Viral Disease Control and Prevention

Guangjun Nie

National Center for Nanoscience and Technology

Wenbo Xu

Second Affiliated Hospital of Harbin Medical University

Qian Yang

National Institute for Viral Disease Control and Prevention

Yang Song

Renmin University of China

Dongyan Wang

Heilongjiang University of Chinese Medicine

Jinbo Xiao

National Institute for Viral Disease Control and Prevention

Ruifang Zhao

National Center for Nanoscience and Technology

Cooperative Institutions

Chinese Academy of Sciences

168

University of Chinese Academy of Sciences

122

Chinese Academy of Medical Sciences & Peking Union Medical College

120

National Center for Nanoscience and Technology

National Institute for Viral Disease Control and Prevention

Jilin University

Shanghai Jiao Tong University

Harvard University

Zhengzhou University

Chinese Center For Disease Control and Prevention

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Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China

Pathogens (2022)

Wenhui Wang Huan Fan Shuaifeng Zhou Shikang Li Alitengsaier NIGEDELI

Echovirus, a member of the Enterovirus B (EV-B) family, has led to numerous outbreaks and pandemics, causing a broad spectrum of diseases. Based on the national hand, foot, and mouth disease (HFMD) surveillance system, seven strains of echovirus 33 (E33) were isolated from Mainland of China between 2010 and 2018. The whole genomes of these strains were isolated and sequenced, and phylogenetic trees were constructed based on the gene sequences in different regions of the EV-B prototype strains. It was found that E33 may be recombined in the P2 and P3 regions. Five genotypes (A-E) were defined based on the entire VP1 region of E33, of which the C gene subtype was the dominant gene subtype at present. Recombinant analysis showed that genotype C strains likely recombined with EV-B80, EV-B85, E13, and CVA9 in the P2 and P3 regions, while genotype E had the possibility of recombination with CVB3, E3, E6, and E4. Results of Bayesian analysis indicated that E33 may have appeared around 1955 (95% confidence interval: 1945-1959), with a high evolutionary rate of 1.11 × 10-2 substitution/site/year (95% highest posterior density (HPD): 8.17 × 10-3 to 1.4 × 10-2 substitution/site/year). According to spatial transmission route analysis, two significant transmission routes were identified: from Australia to India and from Oman to Thailand, which the E33 strain in Mainland of China likely introduced from Mexico and India. In conclusion, our study fills the gaps in the evolutionary analysis of E33 and can provide important data for enterovirus surveillance.

Echovirus

Mega-

10.3390/pathogens11111379

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Citations (0)

Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models

Nanomedicine Nanotechnology Biology and Medicine (2016)

Feng Li Xiao Zhao Hai Wang Ruifang Zhao Tianjiao Ji

FOLFIRINOX

Pancreatic tumor

10.1016/j.nano.2015.12.226

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Citations (6)

Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy

Nano Letters (2020)

Na Yu Tao Liu Xi Zhang Ningqiang Gong Tianjiao Ji

The use of glycoside prodrugs is a promising strategy for developing new targeted medicines for chemotherapy. However, the in vivo utility of such prodrugs is hindered by insufficient activation and the lack of convenient synthetic methods. We have developed an innovative strategy for synthesizing ketal glycoside prodrugs that are unique in being activated by a dual enzyme- and acid-triggered self-immolative mechanism. Amphiphilic glucosyl acetone-based ketal-linked etoposide glycoside prodrug isomers were synthesized and fabricated into excipient-free nanoparticles for effective cancer prodrug monotherapy. Hydrolysis of the glycosidic linkage or the ketal linkage triggered hydrolysis of the other linkage, which resulted in spontaneous self-immolative hydrolysis of the prodrugs. Nanoparticles of the prodrug isomer that was the most labile in a lysosome-mimicking environment displayed high intratumoral accumulation and strong antitumor activity in an A549 xenograft mouse model. Our strategy may be useful for the development of stimulus-responsive self-immolative prodrugs and their nanomedicines.

Glycosidic bond

10.1021/acs.nanolett.0c01973

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Citations (45)

Predicting the tissue depth for remote triggering of drug delivery systems

Journal of Controlled Release (2018)

Alina Y. Rwei Bruce Wang Tianjiao Ji Daniel S. Kohane

Ex vivo

10.1016/j.jconrel.2018.07.033

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Citations (8)

Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for breast tumor multi-organ metastasis inhibition

Acta Pharmaceutica Sinica B (2023)

Chen Li Jiayan Lang Yazhou Wang Zhaoxia Cheng Ma‐Li Zu

As a representative chemotherapeutic drug, docetaxel (DTX) has been used for breast cancer treatment for decades. However, the poor solubility of DTX limits its efficacy, and the DTX based therapy increases the metastasis risk due to the upregulation of C–X–C chemokine receptor type 4 (CXCR4) expression during the treatment. Herein, we conjugated CXCR4 antagonist peptide (CTCE) with DTX (termed CTCE–DTX) as an anti-metastasis agent to treat breast cancer. CTCE–DTX could self-assemble to nanoparticles, targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX efficacy. Thus, the CTCE–DTX NPs achieved promising efficacy on inhibiting both bone-specific metastasis and lung metastasis of triple-negative breast cancer. Our work provided a rational strategy on designing peptide–drug conjugates with synergistic anti-tumor efficacy.

CXCR4 antagonist

10.1016/j.apsb.2023.03.024

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Citations (12)

Multiple genotypes of Echovirus 11 circulated in mainland China between 1994 and 2017

Scientific Reports (2019)

Jie Li Dongmei Yan Li Chen Yong Zhang Yang Song

Abstract Echovirus 11 (E-11) is one of the most frequently isolated enteroviruses causing meningitis and other diseases such as hand, foot, and mouth disease (HFMD) and acute flaccid paralysis (AFP). Fifty-nine newly determined E-11 VP1 sequences from the China AFP and HFMD surveillance network and 500 E-11 VP1 sequences obtained from the GenBank database, which were associated with 12 categories of diseases, were screened for phylogenetic analysis. Based on the standard method of genotype classification, E-11 strains circulated worldwide were reclassified into six genotypes as A, B, C, D, E, and F, in which genotype F is newly divided, and genotypes A and C are further divided into A1–5 and C1–4 by this research, whereas genotype D was still divided into D1–5 as in a previous study of Oberste et al . Sub-genotype A1 was the predominant sub-genotype in mainland China between 2008–2017, whereas sub-genotype D5 was the predominant sub-genotype circulated outside China from 1998–2014. However, genotype and sub-genotype spectra showed statistical significance among AFP and HFMD cases (χ 2 = 60.86, P < 0.001), suggesting that different genotypes might have a tendency to cause different diseases. Strengthening the surveillance of E-11 might provide further information about pathogenic evolution or specific nucleotide mutation associated with different clinical diseases.

Echovirus

10.1038/s41598-019-46870-w

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Citations (26)

BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging

Acta Biomaterialia (2018)

Yanfei Wang Aoune Barhoumi Rong Tong Weiping Wang Tianjiao Ji

10.1016/j.actbio.2018.03.029

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Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin

Nano Letters (2017)

Qian Liu Claudia M. Santamaria Tuo Wei Chao Zhao Tianjiao Ji

The efficacy of tetrodotoxin (TTX), a very potent local anesthetic, is limited by its poor penetration through barriers to axonal surfaces. To address this issue, we encapsulated TTX in hollow silica nanoparticles (TTX-HSN) and injected them at the sciatic nerve in rats. TTX-HSN achieved an increased frequency of successful blocks, prolonged the duration of the block, and decreased the toxicity compared to free TTX. In animals injected with fluorescently labeled HSN, the imaging of frozen sections of nerve demonstrated that HSN could penetrate into nerve and that the penetrating ability of silica nanoparticles was highly size-dependent. These results demonstrated that HSN could deliver TTX into the nerve, enhancing efficacy while improving safety.

Tetrodotoxin

Penetration (warfare)

10.1021/acs.nanolett.7b02461

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Citations (38)

Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength

Nano Letters (2017)

Alina Y. Rwei Bruce Wang Tianjiao Ji Changyou Zhan Daniel S. Kohane

On-demand pain relief systems would be very helpful additions to the armamentarium of pain management. Near-infrared triggered drug delivery systems have demonstrated the potential to provide such care. However, challenges remain in making such systems as stimulus-sensitive as possible, to enhance depth of tissue penetration, repeatability of triggering, and safety. Here we developed liposomes containing the local anesthetic tetrodotoxin and also containing a photosensitizer and gold nanorods that were excitable at the same near-infrared wavelength. The combination of triggering mechanisms enhanced the photosensitivity and repeatability of the system in vitro when compared with liposomes with a single photoresponsive component. In vivo, on-demand local anesthesia could be induced with a low irradiance and short irradiation duration, and liposomes containing both photosensitizer and gold nanorods were more effective than those containing just one photoresponsive component. Tissue reaction was benign.

Topical anesthetic

10.1021/acs.nanolett.7b04176

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Citations (30)

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

Nano Letters (2018)

Keman Cheng Yanping Ding Ying Zhao Shefang Ye Xiao Zhao

Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential for steady codelivery of various drugs, especially small molecules, therapeutic peptides, and nucleic acids, thereby realizing controllable drug release, increase of drug bioavailability, and reduction of adverse effects. Herein, a therapeutic peptide assembling nanoparticle that can sequentially respond to dual stimuli in the tumor extracellular matrix was designed for tumor-targeted delivery and on-demand release of a short d-peptide antagonist of programmed cell death-ligand 1 (DPPA-1) and an inhibitor of idoleamine 2,3-dioxygenase (NLG919). By concurrent blockade of immune checkpoints and tryptophan metabolism, the nanoformulation increased the level of tumor-infiltrated cytotoxic T cells and in turn effectively inhibited melanoma growth. To achieve this, an amphiphilic peptide, consisting of a functional 3-diethylaminopropyl isothiocyanate (DEAP) molecule, a peptide substrate of matrix metalloproteinase-2 (MMP-2), and DPPA-1, was synthesized and coassembled with NLG919. The nanostructure swelled when it encountered the weakly acidic tumor niche where DEAP molecules were protonated, and further collapsed due to the cleavage of the peptide substrate by MMP-2 that is highly expressed in tumor stroma. The localized release of DPPA-1 and NLG919 created an environment which favored the survival and activation of cytotoxic T lymphocytes, leading to the slowdown of melanoma growth and increase of overall survival. Together, this study offers new opportunities for dual-targeted cancer immunotherapy through functional peptide assembling nanoparticles with design features that are sequentially responsive to the multiple hallmarks of the tumor microenvironment.

Cancer Immunotherapy

10.1021/acs.nanolett.8b01071

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Citations (288)