Gita Shafiee

Tehran University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ramin Heshmat

Tehran University of Medical Sciences

124

Bagher Larijani

Tehran University of Medical Sciences

Mostafa Qorbani

Tehran University of Medical Sciences

Afshin Ostovar

Tehran University of Medical Sciences

Roya Kelishadi

Isfahan University of Medical Sciences

Mohammad Esmaeil Motlagh

Ahvaz Jundishapur University of Medical Sciences

Iraj Nabipour

Bushehr University of Medical Sciences

Noushin Fahimfar

Tehran University of Medical Sciences

Zeinab Ahadi

Tehran University of Medical Sciences

Farshad Sharifi

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

315

Shahid Beheshti University of Medical Sciences

University of Tehran

Shariati Hospital

Iran University of Medical Sciences

Isfahan University of Medical Sciences

Jahrom University of Medical Sciences

Alborz University of Medical Sciences

Bushehr University of Medical Sciences

Ministry of Health and Medical Education

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Trend of passive smoking and associated factors in Iranian children and adolescents: the CASPIAN studies

BMC Public Health (2022)

Mohammad Reza Hashemi-Aghdam Gita Shafiee Mehdi Ebrahimi Hanieh‐Sadat Ejtahed Mehdi Yaseri

Abstract Background It is well documented that, similar to active smokers, passive smokers are also at an increased risk of developing non-communicable diseases, and it could impose high financial costs on the healthcare system. This study aimed to evaluate the trend of passive smoking and related determinants during the three phases of a school-based surveillance program. Methods This is a secondary study using the national data obtained from three phases of the surveillance program entitled The Childhood and Adolescence Surveillance and Prevention of Adult Noncommunicable Disease (CASPIAN) study, conducted from 2008 to 2014 on Iranian children and adolescents living in urban and rural areas of 30 provinces in Iran. Participants were selected by cluster multistage sampling method. Results Overall, the study participants consisted of 33,288 students (50.5% boys) with a mean (± SD) age of 12.8 ± 3.2 years. The passive smoking rate was significantly increased from 35.6% in 2008 to 43.2% in 2015 among children and adolescents. According to the multivariate logistic regression, father’s university education, mother’s employment, life satisfaction, and socioeconomic status had a protective role regarding second-hand smoke exposure. In contrast, the father’s self-employment had a positive role in increasing the rate of passive smoking. Conclusion Considering the increasing trend of passive smoking and its considerable adverse health effects, it is necessary to implement large-scale public interventions to reduce the rate and hazards of exposure to tobacco smoke.

Biostatistics

Passive smoking

Non-communicable disease

10.1186/s12889-022-13045-8

Cite

Citations (7)

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

Iranian journal of pathology (2019)

Fatemeh Khatami Bagher Larijani Ramin Heshmat Shirzad Nasiri Hiva Saffar

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior. Methods: In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls. Results: Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001). Conclusion: RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.

10.30699/ijp.2019.94401.1922

Cite

Citations (16)

The association of parental obesity with physical activity and sedentary behaviors of their children: the CASPIAN-V study

Jornal de Pediatria (2017)

Pooneh Angoorani Ramin Heshmat Hanieh‐Sadat Ejtahed Mohammad Esmaeil Motlagh Hasan Ziaodini

Low physical activity and sedentary behaviors, two important determinants of childhood obesity, may be influenced by parental lifestyle and weight status. This study aims to determine the association of parental weight status with children's physical activity and screen time.This study was conducted on 14,440 Iranian schools students, aged 7-18 years, and one of their parents, who participated in the large national school-based surveillance program. The children's screen-based and physical activities were evaluated based on the World Health Organization's Global School Student Health Survey. Children and parental height, weight, and waist circumference were measured using standardized methods.Overall, 14,274 students and one of their parents completed the survey (participation rate: 99%). Mean (standard deviation) age of students was 12.3 (3.2) years, and the prevalence of low physical activity and high screen time was 58.2% and 17.7%, respectively. In multivariate model, the parental general obesity and abdominal obesity increased the odds of children having low physical activity, by 21% and 13%, respectively. Parental overweight, general obesity, and abdominal obesity increased the odds of the combination of low physical activity/high screen time in children by 33%, 26%, and 20%, respectively.This study showed that parental obesity was associated with increased screen-based activities and low physical activity in children. Focus on parental weight status, as an important factor influenced by their lifestyle, can be helpful for preventing sedentary behaviors in their children.

Screen Time

Abdominal obesity

Odds

Sedentary lifestyle

10.1016/j.jped.2017.06.024

Cite

Citations (30)

Association of 25-hydroxy vitamin d with bone turnover markers and bone mineral density in an Iranian elderly population : bushehr elderly health (beh) program

Osteoporosis International (2019)

Safoora Gharibzadeh Noushin Fahimfar Gita Shafiee Ramin Heshmat Neda Mehrdad

Bone remodeling

Source

Cite

Citations (0)

Is frequency of potato and white rice consumption associated with cardiometabolic risk factors in children and adolescents: the CASPIAN-V study

BMC Cardiovascular Disorders (2020)

Fereshteh Baygi Mostafa Qorbani Mohammad Esmaeil Motlagh Gita Shafiee Kourosh Nouri

Abstract Background This study evaluated the association of frequency of potato and rice consumption with cardiometabolic risk factors in children and adolescents. Methods This nationwide cross-sectional survey was conducted on 14,400 children and adolescents. Fasting blood was obtained from a sub-sample of 4200 randomly selected students. Physical examination and laboratory tests were conducted under standard protocols. Metabolic Syndrome (Mets) was defined based on the Adult Treatment Panel III criteria modified for the pediatric age group. The self-reported frequency consumption of white rice and potato was reported on a daily or non-daily basis. Results The participation rate for the whole study and for blood sampling were 99 and 91.5%, respectively. Overall, 49.4% of the participants were girls while 50.6% were boys. The frequency of daily consumption of white rice and potato was 84.4 and 21.3%, respectively. In the multivariable linear regression model, daily consumption of potato increased body mass index (β: 0.05, SE: 0.20, p = 0.010), waist (β: 0.63, SE: 0.24, p = 0.008), and hip circumferences (β: 0.62, SE: 0.26, p = 0.019). Moreover, in the multivariable logistic regression, daily consumption of potato was significantly associated with an increased risk of overweight (OR: 1.21, 95% CI: 1.04–1.39, P = 0.012). The potato and rice consumption had no statistically significant association with other cardiometabolic risk factors. Conclusions Daily consumption of potato was significantly associated with higher anthropometric measures, whereas rice consumption had no statistically significant association with cardiometabolic risk factors. Future research to examine the possible obesogenic effects of intake of potato on children and adolescents is recommended.

Cross-sectional study

Consumption

10.1186/s12872-020-01524-y

Cite

Citations (4)

Low Bone Mineral Density and Associated Factors Among People Living With HIV in Kerman, Iran: A Cross-Sectional Study in 2021–2022

Journal of the Association of Nurses in AIDS Care (2025)

Homeira Rashidi Soheil Mehmandoost Noushin Fahimfar Hamid Reza Aghaei Meybodi Sahar Hosseinian

Chronic diseases such as osteoporosis and low bone mineral density (BMD) are significant public health concerns for people living with HIV (PLWH), especially with the increased life expectancy because of antiretroviral therapy (ART). This study evaluated the prevalence and associated factors of low BMD among 94 PLWH in Kerman, Iran, from September 2021 to February 2022. Using dual-energy X-ray absorptiometry, BMD was measured, with low BMD defined by specific T-scores and Z-scores. Predictors were assessed through interviews, medical records, and blood tests. Bivariable and multivariable logistic regression models identified associations between low BMD and various factors. The study found a 51.1% prevalence of low BMD, with significant associations with hypogonadism (adjusted odds ratio [aOR]: 3.19), longer ART duration (aOR per month: 1.02), and lower body mass index (aOR per unit: 0.83). The findings highlight the need for regular screening and timely intervention for low BMD among PLWH, particularly with prolonged ART use.

Cross-sectional study

10.1097/jnc.0000000000000521

Cite

Citations (1)

RELATIONSHIP BETWEEN BRONCHIAL ANTHRACOFIBROSIS AND PULMONARY TUBERCULOSIS: AUTOPSY FINDINGS

Emamhadi Mohammadali Mostafazadeh Babak Masjedi Mohammadreza Moslem Bahadori Gita Shafiee

The purpose of this study was to evaluate the characteristics of anthracofibrosis and the relationship between bronchial anthracofibrosis (BAF) and tuberculosis during autopsy in the Iranian Legal Medicine Organization (LMO). In this cross-sectional study, 385 subjects who had died from 2007 to 2010 were examined. A questionnaire having information such as the deceased ' s age, sex, ethnicity, smoking status and occupation was filled out for each subject. Subjects in whom autopsied lungs revealed definite obligation, edema, bronchial stricture and dark pigmentation within mucosa were considered to have anthracofibrosis. Pulmonary tuberculosis was considered with typical granulomatous in bronchial biopsy or smear positive. During the 4-year period, we evaluated 385 cases, 48(12.5%) of whom had BAF. Of these, 60.4% were female. Mean age of subjects with anthracofibrosis was 67.08±8.4 yr. Pulmonary tuberculosis was demonstrated in 24 (50%) of cases with BAF. According to bronchi features, the anatomical distribution of BAF in 60.4% cases was multiple. Anthracofibrosis more commonly occurred in right middle lobe bronchus (47.92%). This study revealed a significant correlation between BAF and pulmonary tuberculosis (P=0.001). So, BAF is one of the infrequent symptoms of pulmonary tuberculosis. In patients with anthracofibrosis and pulmonary symptoms, TB would be taken into consideration.

Cite

Citations (1)

Identification of candidate genes and proteins in aging skeletal muscle (sarcopenia) using gene expression and structural analysis

PeerJ (2018)

Gita Shafiee Yazdan Asgari Akbar Soltani Bagher Larijani Ramin Heshmat

Sarcopenia is an age-related disease characterized by the loss of muscle mass and muscle function. A proper understanding of its pathogenesis and mechanisms may lead to new strategies for diagnosis and treatment of the disease. This study aims to discover the underlying genes, proteins, and pathways associated with sarcopenia in both genders. Integrated analysis of microarray datasets has been performed to identify differentially expressed genes (DEGs) between old and young skeletal muscles. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were then performed to uncover the functions of the DEGs. Moreover, a protein-protein interaction (PPI) network was constructed based on the DEGs. We have identified 41,715 DEGs, including 19 downregulated and 41,696 upregulated ones, in men. Among women, 3,015 DEGs have been found, with 2,874 of them being upregulated and 141 downregulated genes. Among the top up-regulated and downregulated genes, the ribosome biogenesis genes and genes involved in lipid storage may be closely related to aging muscles in men and women respectively. Also, the DEGs were enriched in the pathways including those of ribosome and Peroxisome proliferator-activated receptor (PPAR) in men and women, respectively. In the PPI network, Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1), Cullin 3 (CUL3) and P53 have been identified as significant hub proteins in both genders. Using the integrated analysis of multiple gene expression profiles, we propose that the ribosome biogenesis genes and those involved in lipid storage would be promising markers for sarcopenia in men and women, respectively. In the reconstructed PPI network, neurotrophic factors expressed in skeletal muscle are essential for motoneuron survival and muscle fiber innervation during development. Cullin E3 ubiquitin ligase (Cul3) is an important component of the ubiquitin-proteasome system-it regulates the proteolysis. P53 is recognized as a central regulator of the cell cycle and apoptosis. These proteins, which have been identified as the most significant hubs, may be involved in aging muscle and sarcopenia.

KEGG

Candidate gene

10.7717/peerj.5239

Cite

Citations (24)

The association of opioid consumption and osteoporosis in old men: Bushehr Elderly Health (BEH) program

Archives of Osteoporosis (2022)

Mahnaz Sanjari Hossein Yarmohammadi Noushin Fahimfar Safoora Gharibzadeh Kazem Khalagi

10.1007/s11657-022-01181-y

Cite

Citations (2)

Bushehr Elderly Health (BEH) Programme, phase I (cardiovascular system)

BMJ Open (2015)

Afshin Ostovar Iraj Nabipour Bagher Larijani Ramin Heshmat Hossein Darabi

Purpose The main objective of the Bushehr Elderly Health Programme, in its first phase, is to investigate the prevalence of cardiovascular risk factors and their association with major adverse cardiovascular events. Participants Between March 2013 and October 2014, a total of 3000 men and women aged ≥60 years, residing in Bushehr, Iran, participated in this prospective cohort study (participation rate=90.2%). Findings to date Baseline data on risk factors, including demographic and socioeconomic status, smoking and medical history, were collected through a modified WHO MONICA questionnaire. Vital signs and anthropometric measures, including systolic and diastolic blood pressure, weight, height, and waist and hip circumference, were also measured. 12-lead electrocardiography and echocardiography were conducted on all participants, and total of 10 cc venous blood was taken, and sera was separated and stored at –80°C for possible future use. Preliminary data analyses showed a noticeably higher prevalence of risk factors among older women compared to that in men. Future plans Risk factor assessments will be repeated every 5 years, and the participants will be followed during the study to measure the occurrence of major adverse cardiac events. Moreover, the second phase, which includes investigation of bone health and cognition in the elderly, was started in September 2015. Data are available at the Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran, for any collaboration.

10.1136/bmjopen-2015-009597

Cite

Citations (62)