Yiliu Zhang

Second Xiangya Hospital of Central South University

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Wei Lu

Central South University

Yijun Ren

Fanjingshan National Nature Reserve

Shuwen Deng

Central South University

Xiqian Chen

Second Xiangya Hospital of Central South University

Wei Lü

Second Xiangya Hospital of Central South University

Chuxin Huang

Second Xiangya Hospital of Central South University

Niangui Xu

Second Xiangya Hospital of Central South University

Xiaohan Fang

Anhui University

Qiang He

Zhejiang Chinese Medical University

Lei Qiang

Second Affiliated Hospital of Nanjing Medical University

Cooperative Institutions

Central South University

Second Xiangya Hospital of Central South University

Anhui University

Xiangya Hospital Central South University

University of Electronic Science and Technology of China

Zhejiang University

Zhejiang Chinese Medical University

University of Chinese Academy of Sciences

Zhejiang Provincial People's Hospital

Hangzhou Medical College

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Frontiers in Neurology (2020)

Chuxin Huang Yiliu Zhang Shuwen Deng Yijun Ren Wei Lu

Guillain-Barré syndrome (GBS) is mainly associated with preceding exposure to an infectious agent, although the precise pathogenic mechanisms and causes remain unknown. Increasing evidence indicates an association between trauma-related factors and GBS. Here, we performed a systematic review, summarized the current scientific literature related to the onset of GBS associated with trauma, and explored the possible pathogenesis. A literature search of various electronic databases was performed up to May 2020 to identify studies reporting diverse trauma-related triggers of GBS. Data were extracted, summarized descriptively, and evaluated with respect to possible mechanisms. In total, 100 publications, including 136 cases and 6 case series involving GBS triggered by injury, surgery, intracranial hemorrhage, and heatstroke, met our eligibility criteria. The median age of the patients was 53 [interquartile range (IQR) 45-63] years, and 72.1% of the patients were male. The median number of days between the trigger to onset of GBS symptoms was 9 (IQR 6.5-13). Overall, 121 patients (89.0%) developed post-injury/surgical GBS, whereas 13 (9.6%) and 2 (1.5%) patients had preexisting spontaneous intracranial hemorrhage and heatstroke, respectively. The main locations of injury or surgeries preceding GBS were the spine and brain. Based on available evidence, we highlight possible mechanisms of GBS induced by these triggers. Moreover, we propose the concept of "trauma-related GBS" as a new research direction, which may help uncover more pathogenic mechanisms than previously considered for typical GBS triggered by infection or vaccination.

Interquartile range

Heatstroke

10.3389/fneur.2020.588290

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Comparisons of Growth Hormone Transgenic Channel Catfish (Ictalurus punctatus), and Channel Catfish Transgenic for Gonadotropin Releasing Hormone Knockout Genes Grown in Earthen Ponds at High Density

Yiliu Zhang

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Role of Butylphthalide in Immunity and Inflammation: Butylphthalide May Be a Potential Therapy for Anti-Inflammation and Immunoregulation

Oxidative Medicine and Cellular Longevity (2022)

Yiliu Zhang Yijun Ren Xiqian Chen Shuwen Deng Wei Lü

Inflammation and immunity play an essential role in disease pathogenesis. 3-N-Butylphthalide (NBP), a group of compounds extracted from seeds of Apium graveolens (Chinese celery), has been demonstrated as an efficient and effective therapy for ischemic stroke. The amount of research on NBP protective effect is increasing at pace, such as microcircular reconstruction, alleviating inflammation, ameliorating brain edema and blood-brain barrier (BBB) damage, mitochondrial function protection, antiplatelet aggregation, antithrombosis, decreasing oxidative damage, and reducing neural cell apoptosis. There has been increasing research emphasizing the association between NBP and immunity and inflammation in the past few years. Hence, it is aimed at reviewing the related literature and summarizing the underlying anti-inflammatory and immunoregulatory function of NBP in various disorders.

Apium graveolens

Pathogenesis

Stroke

10.1155/2022/7232457

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miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism

Frontiers in Cell and Developmental Biology (2020)

Xiqian Chen Shuwen Deng Lei Qiang Qiang He Yijun Ren

Objective: To explore the relationship between miR-7-5p and brain edema after intracerebral hemorrhage and the role of butylphthalide (NBP) in brain edema after intracerebral hemorrhage. Method: Routine blood testing, C-reactive protein results, and computed tomography data were collected 1, 7, and 14 days after intracerebral hemorrhage in six patients. Levels of MMP-9, ZO-1, occludin, IL-6, TNF-α, and miR-7-5p were detected in each patient's serum. Sixty male Sprague–Dawley rats were randomly divided into sham operation, intracerebral hemorrhage, and NBP treatment groups. Dry–wet weight was used to assess brain edema, and Evans blue staining was used to assess the permeability of the blood–brain barrier. Expression levels of IL-6, TNF-α, ZO-1 and occludin, PI3K, AKT, p-AKT, AQP4, and miR-7-5p were analyzed in the rat brains. Result: The blood neutrophil–lymphocyte ratio (NLR) on day 1 was associated with the area of brain edema on day 7. The expression of miR-7-5p decreased after intracerebral hemorrhage, and as a result, the inhibition of the PI3K/AKT pathway was weakened. The decreased inhibition of the PI3K/AKT pathway resulted in an increase in AQP4 expression, which further aggravated brain edema. NBP can upregulate the expression of miR-7-5p, affecting these pathways to reduce brain edema. Conclusion: After intracerebral hemorrhage, miR-7-5p expression in brain tissue is reduced, which may increase the expression of AQP4 by activating the PI3K/AKT pathway. NBP can inhibit this process and reduce brain edema.

Evans Blue

Occludin

Brain Edema

10.3389/fcell.2020.598020

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Case Report: Delayed Guillain-Barré syndrome following trauma: A case series and manage considerations

Frontiers in Surgery (2022)

Yiliu Zhang Chuxin Huang Wei Lu Qing Hu

To analyze clinical associations between Guillain-Barré syndrome (GBS) and trauma.We retrospectively reviewed the data of eight patients with post-traumatic GBS between July 2011 and December 2018 at the Second Xiangya Hospital, China, and analyzed the triggers, clinical manifestation, examination results, treatment, prognosis, and potential mechanism related to post-traumatic GBS.The included patients had GBS preceded by no risk factors other than trauma. Their age ranged from 15 to 60 years (the median age was 52 years), and six patients were males. The potential traumatic triggers included spinal surgery (n = 2), high-intensity exercise (n = 2), traumatic brain injury (n = 1), excessive fatigue (n = 1), ischemic stroke (n = 1), and cardiopulmonary resuscitation (n = 1). The major manifestation was symmetrical limb weakness and/or numbness in all patients. The diagnosis of GBS was based on the results of electromyography, albumino-cytological dissociation, or antiganglioside antibody in cerebrospinal fluid, and other diseases were excluded. Immunotherapy improved symptoms, except in one patient who died.Trauma is a probable risk factor for GBS that is very easily overlooked, thereby leading to misdiagnosis in clinical practice. We emphasize a new concept of post-traumatic GBS to promote doctors' awareness when they meet people with weakness and sensory deficits after trauma, which benefit early diagnosis, timely treatment, and reduced mortality rate of GBS.

10.3389/fsurg.2022.903334

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Dynamic Event-Triggered Mechanism of SOC Balancing for Battery Energy Storage System

2021 China Automation Congress (CAC) (2022)

Haitao Jia Zhiyong Zhu Yiliu Zhang Shikai Wu Annan Zheng

This paper studies the state of charge (SOC) balancing control for distributed battery energy storage systems (BESS). SOC gives the information of holding capacity when the battery is charged or discharged. A dynamic event triggering coordination consensus algorithm is proposed under an undirected topology by introducing internal dynamic variables. Multi-agent consensus theory is utilized to achieve SOC balance. Lyapunov function is constructed to illustrate the battery management system asymptotically stable. Compared with the conventional event-triggered mechanism (ETM), the introduction of dynamic ETM can reduce more consumption of communication. Finally, Simulation is presented to show the validity and effectiveness of the dynamic ETM.

State of charge

10.1109/cac57257.2022.10055082

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Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China

Acta Neurologica Belgica (2020)

Xiqian Chen Yijun Ren Yiliu Zhang Wei Lu

10.1007/s13760-020-01455-7

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Effects of butyphthalide on microglia polarization after intracerebral hemorrhage and the underlying mechanisms.

PubMed (2022)

Yiliu Zhang Wei Lü Niangui Xu

Because intracerebral hemorrhage (ICH) has high morbidity, disability and mortality, it is significant to find new and effective treatments for ICH. This study aims to explore the effect of butyphthalide (NBP) on neuroinflammation secondary to ICH and microglia polarization.

CD68

10.11817/j.issn.1672-7347.2022.210527

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Could Sporadic Creutzfeldt-Jakob Disease Be Underdiagnosed in China? Experience From Four Cases

Frontiers in Neurology (2020)

Yiliu Zhang Xiaomei Wu Yang Chen Wenping Gu Wei Lu

Background: Creutzfeldt-Jakob Disease (CJD) is a rapidly progressive neurodegenerative disease caused by the misfolded version of the cellular prion protein. Here we report four cases of sporadic CJD (sCJD) and describe the diagnostic methods available in order avoid missed or delayed recognition of CJD in China. Case presentation: We report four patients diagnosed with sCJD between March 2018 and December 2019 at Xiangya Hospital and the Second Xiangya Hospital of Central South University. All patients were admitted to the hospital because of a progressive cognitive decline. Although their routine tests and biochemical indicators in the cerebrospinal fluid (CSF), as well as computed tomography (CT) imaging, did not reveal any apparent abnormalities, the presence of “cortical ribboning” was incidentally found on diffusion-weighted imaging (DWI). The patients were subsequently diagnosed with CJD based on positive testing for 14-3-3 protein in their CSF, and the presence of periodic sharp and slow wave complexes (PSWCs) on their electroencephalograms (EEG). Additionally, two of patients was confirmed pathological examination of cerebral biopsies demonstrating neuronal loss, gliosis and spongiform changes. Conclusions: CJD is a rare disease and is easily misdiagnosed by clinician in China due to a lack of recognition and awareness of CJD. Based on our experience described in this report, enhanced vigilance for CJD is required for patients with rapidly progressive dementia in China and other developing countries. DWI, EEG and detection of 14-3-3 protein in CSF should be performed in order to achieve a timely diagnosis of CJD.

Gliosis

Creutzfeldt-Jakob Syndrome

10.3389/fneur.2020.00763

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