V. I. Surovtsev

State Research Center for Applied Microbiology and Biotechnology

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V. M. Borzenkov

State Research Center for Applied Microbiology and Biotechnology

M. A. Borozdina

State Research Center for Applied Microbiology and Biotechnology

V. V. Gusev

Sumy National Agrarian University

T. V. Fedorov

State Research Center for Applied Microbiology and Biotechnology

O. I. Smotrov

Ministry of Health of the Russian Federation

ВЗ

В. З. Плетнев

Institute of Bioorganic Chemistry

V. P. Chuprunov

State Research Center for Applied Microbiology and Biotechnology

Vladimir P. Levchuk

State Research Center for Applied Microbiology and Biotechnology

A. N. Baydus

State Research Center for Applied Microbiology and Biotechnology

T. V. Fjodorov

State Research Center for Applied Microbiology and Biotechnology

Cooperative Institutions

State Research Center for Applied Microbiology and Biotechnology

Ministry of Health of the Russian Federation

A. N. Kosygin Moscow State Textile University

Taras Shevchenko National University of Kyiv

Pskov State University

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Institute of Bioorganic Chemistry

Russian Academy of Sciences

Institute of Immunological Engineering

Omsk State Technical University

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Obtaining Bacteriocins by Chromatographic Methods

Advances in Bioscience and Biotechnology (2014)

Valery N. Borzenkov V. I. Surovtsev I. A. Dyatlov

Bacteriocins are a large group of chromosome or plasmid-encoded and ribosomally synthesized low-molecular-weight (2 to 6 kDa) antimicrobial and amphiphilous peptides produced by Gr+ or Gr- bacteria [1]. Their low toxicity as well as the absence of allergenicity and reactogenicity is confirmed by testing selected bacteriocins [2] [3]. Bacteriocins can be widely used as preservatives and antibiotic alternatives in medicine. Nisin, a Streptococcus lactis-derived bacteriocin, has been in practice in food industry for a long time. A relevant product contains about 2.5% of nisin. For medical use (e.g., when injected into the blood stream), highly purified drugs are required. However, the yield of bacteriocins accounts for no more than a few percents from the total activity in the culture liquid. In this paper, we propose methods (by example of two B. subtilis strains), allowing to increase the yield up to ~80%. It is believed that other bacteriocins may be purified by these methods and with the same yield.

Lantibiotics

10.4236/abb.2014.55054

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Citations (8)

Effect of chemical modification on the cryoprecipitation of monoclonal human cryoglobulin M

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (1984)

Igor V. Kosarev V. I. Surovtsev V.P. Zav′yalov

Chemical modification

Cryoglobulins

Tetranitromethane

10.1016/0167-4838(84)90215-2

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