Stephen A. Burns

Indiana University Bloomington

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Ann E. Elsner

Indiana University Bloomington

127

Thomas Gast

Aeon Imaging (United States)

Toco Yuen Ping Chui

New York Eye and Ear Infirmary

Xiaofeng Qi

The University of Texas Southwestern Medical Center

Kaitlyn Sapoznik

University of Houston

Lucie Sawides

Consejo Superior de Investigaciones Científicas

Susana Marcos

Consejo Superior de Investigaciones Científicas

Alberto de Castro

Instituto de Óptica "Daza de Valdés"

Ting Luo

Ningbo University

Joel A. Papay

Indiana University Bloomington

Cooperative Institutions

Indiana University Bloomington

Smith-Kettlewell Eye Research Institute

Harvard University

Massachusetts Eye and Ear Infirmary

Indiana University

Johns Hopkins University

University of Rochester

Instituto de Óptica "Daza de Valdés"

Boston University

The Ohio State University

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Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

International Journal of Endocrinology (2018)

Sonja Karst Jan Lammer Salma Radwan Hanna Kwak Paolo S. Silva

To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques.Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images.Individual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging.Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT.AOSLO imaging provides detailed, noninvasive in vivo visualization of DR lesions enhancing the assessment of morphological characteristics. These unique AOSLO attributes may enable new insights into the pathological changes of DR in response to disease onset, development, regression, and response to therapy.

Scanning laser ophthalmoscopy

10.1155/2018/7492946

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Henle Fiber Layer Phase Retardation Changes Associated With Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science (2014)

Dean A. VanNasdale Ann E. Elsner Todd Peabody Kimberly D. Kohne Victor E. Malinovsky

Purpose.: To quantify and compare phase retardation amplitude and regularity associated with the Henle fiber layer (HFL) between nonexudative AMD patients and age-matched controls using scanning laser polarimetry (SLP) imaging. Methods.: A scanning laser polarimeter was used to collect 15 × 15° macular-centered images in 25 patients with nonexudative AMD and 25 age-matched controls. Raw image data were used to compute macular phase retardation maps associated with the HFL. Consecutive, annular regions of interest from 0.5 to 3.0° eccentricity, centered on the fovea, were used to generate intensity profiles from phase retardation data and analyzed with two complementary techniques: a normalized second harmonic frequency (2f) of the fast Fourier Transform (FFT) analysis and a curve fitting analysis using a 2f sine function. Paired t-tests were used to compare the normalized 2f FFT magnitude at each eccentricity between the two groups, the eccentricity that yielded the maximum normalized 2f FFT between paired individuals across the two groups, and curve fitting RMS error at each eccentricity between the two groups. Results.: Normalized 2f FFT components were lower in the AMD group at each eccentricity, with no difference between the two groups in the maximum normalized 2f FFT component eccentricity. The root-mean-square (RMS) error from curve fitting was significantly higher in the AMD group. Conclusions.: Phase retardation changes in the central macula indicate loss and/or structural alterations to central cone photoreceptors in nonexudative AMD patients. Scanning laser polarimetry imaging is a noninvasive method for quantifying cone photoreceptor changes associated with central macular disease.

Eccentricity (behavior)

10.1167/iovs.14-14459

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Citations (9)

Murray’s law and vascular branching in normal and diabetic subjects

Investigative Ophthalmology & Visual Science (2015)

Ting Luo Thomas Gast Tyler J. Vermeer Stephen A. Burns

Branching (polymer chemistry)

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Multimodal imaging of Cellular Changes in Choroidal Nevi following Laser Treatment

Investigative Ophthalmology & Visual Science (2016)

Kaitlyn Sapoznik Todd Peabody Patricia Henderson Lucie Sawides Thomas Gast

Laser Treatment

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Effect of Phase Reversals on Perception of Complex Visual Stimuli

Investigative Ophthalmology & Visual Science (2005)

A.Y. Leonova Josie McLellan Stephen A. Burns

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Improve Adaptive Optics Wavefront Control Accuracy for Retinal Imaging With Dual-influence-matrix Method

Wennan Zou Stephen A. Burns

Deformable Mirror

Matrix (chemical analysis)

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Depolarization properties of the normal human fovea measured by the GDx-MM

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2009)

Wai-Sze Tiffany Lam Russell A. Chipman K. Twietmeyer Yanming Zhou Kurt R. Denninghoff

A custom imaging Mueller matrix retinal polarimeter (the GDx-MM) is built. Mueller matrix images of normal human fovea were acquired with the GDx-MM over a 9° field at 780nm and have been analyzed for depolarization index and the variation of degree of polarization with incident polarization state. The degree of polarization (DoP) was often above 50% and varied in complex ways as a function of the incident polarization states. The depolarization properties around the macula loosely correlated with the retardance image. High spatial frequency depolarizing structures were evident throughout the fovea.

Mueller calculus

Polarimeter

Degree of polarization

10.1117/12.828480

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Cone Optical Density in Retinitis Pigmentosa

Ann E. Elsner Stephen A. Burns Louis A. Lobes

We use two noninvasive, psychophysical techniques to study the foveal cones of patients with retinitis pigmentosa. The techniques, steady-state color matching and dynamic color matching, are based on the fact that a color match depends on the optical density of the photopigment contained in the cones 1 - 4 . Reduction of the number of cones or neural deficits will not affect the color match so long as the observer can do the task. These techniques provide estimates of 1) the optical density of the cones at a given retinal illuminance, 2) the illuminance that reduces optical density by half (the half-bleach illuminance or I O ), and 3) the rate of change in optical density 3 - 4 . To examine patients with minimal cone damage, we recruit patients in the early phases of disease with good visual acuity, 20/20-20/50. Patients, aged 14-46, vary as to the inheritance pattern and age of onset of night vision problems. All have reduced amplitude or extinguished photopic and scotopic ERG responses.

Scotopic vision

Mesopic vision

10.1364/navs.1986.tub1

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Spectral sensitivity as determined by the minimally distinct border criterion and heterochromatic flicker photometry

Stephen A. Burns

Spectral sensitivity

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Integrating Ear and Scalp Acupuncture Techniques into the Care of Blast-Injured United States Military Service Members with Limb Loss

The Journal of Alternative and Complementary Medicine (2006)

Richard C. Niemtzow Jeffrey M. Gambel Joseph M. Helms Arnyce R. Pock Stephen A. Burns

10.1089/acm.2006.597

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Citations (2)