Farid Abedin Dorkoosh

Tehran University of Medical Sciences

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Morteza Rafiee‐Tehrani

Tehran University of Medical Sciences

Mohsen Amini

Tehran University of Medical Sciences

Morteza Rafiee Tehrani

Tehran University of Medical Sciences

Hamid Akbari Javar

Tehran University of Medical Sciences

Jaleh Varshosaz

Isfahan University of Medical Sciences

Hans E. Junginger

National University of Singapore

Ebrahim Saadat

Tehran University of Medical Sciences

Somayeh Handali

Tehran University of Medical Sciences

Naser Tavakoli

Isfahan University of Medical Sciences

Jaber Emami

Isfahan University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

250

University of Tehran

136

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

Tarbiat Modares University

Shiraz University of Medical Sciences

Isfahan University of Medical Sciences

Pasteur Institute of Iran

Shahid Beheshti University

American Pharmacists Association

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Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers.

Pharmaceutical Research (2002)

Farid Abedin Dorkoosh J. Coos Verhoef J.H.M. Verheijden Morteza Rafiee‐Tehrani Gerrit Borchard

10.1023/a:1020416918624

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Citations (55)

Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat.

PubMed (2010)

Jaleh Varshosaz Fatemeh Ahmadi Jaber Emami Naser Tavakoli Mohsen Minaiyan

Ulcerative colitis is characterized by local inflammation. Targeting drugs directly to the site of injury has the benefit of lower adverse effects and more effective therapy. The aim of this study was colon targeted delivery of budesonide to deliver the major part of the drug to the colon.Matrix tablets of budesonide from solid dispersion of drug with dextran were prepared using different drug to polymer ratios and three molecular weights of dextran. The physical evaluation and drug release behavior were studied. In vivo efficacy of the selected formulation against acetic acid induced colitis in rats was evaluated and compared to the control (untreated) and references (mesalazine and budesonide suspensions) groups.The results showed that solid dispersion of budesonide with dextran in the ratio of 1:7 using molecular weight (MW) of 10,000 dextran (SDT710) released 25% of the drug in the first 6 hours and 100% in caecal and colonic contents. It could target the drug to colon with improvement in some of the inflammatory signs of induced ulcerative colitis in rat. Treatment with SDT710 could improve not only the percent of involvement also macroscopic damage parameters. The macroscopic parameters included weight/length ratio of the colon, ulcer area, damage score, and ulcer index reduced in comparison to the control group and conventional suspension of budesonide; however, only weight/length ratio was significant.In the experimental model studied, the new colonic delivery system significantly improved the efficacy of budesonide in the weight/length ratio of the colon in induced colitis in rats.

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Citations (12)

Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view

Biochimica et Biophysica Acta (BBA) - General Subjects (2021)

Ali Najmeddin Mina Bahrololoumi Shapourabadi Mahdi Behdani Farid Abedin Dorkoosh

2019-20 coronavirus outbreak

10.1016/j.bbagen.2021.129974

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Citations (15)

Artificial Neural Networks Modeling of Release of Olanzapine From Glycerol Monooleate Matrices

Letters in Drug Design & Discovery (2013)

Gita Bagheri Ebrahim Vasheghani‐Farahani Mehdi Ardjmand Hossein Attar Farid Abedin Dorkoosh

The important aim of this research was to develop an appropriate model to predict relationships between three casual factors on the responses based on an artificial neural network (ANN). As model formulation, 28 types of gels were prepared. The weight ratio of GMO/water (w/w) and PEG 300/GMO (w/w), percentage of Olanzapine (OZ) were selected as input data. Entrapment efficacy, maximum percentage of release, particle size and viscosity were estimated as gel characterization. A set of gel characterization and input data were employed as tutorial data for ANN methodology by using neural network toolbox in Matlab. Different topologies have been performed in order to determine the single network with good performance and accuracy. Four training algorithms (Levenberg–Marquardt, Bayesian- Regularization, BFGS Quasi-Newton, and Gradient Descent) were applied to train ANNs containing different numbers of hidden layers with various nods. The ability to predict the responses of all the algorithms were in the order of: BR > LM >BFGS> GD. Keywords: Artificial neural network, Multilayer perceptron, Training algorithms, Olanzapine, Glycerol monooleate.

Broyden–Fletcher–Goldfarb–Shanno algorithm

Perceptron

Multilayer perceptron

10.2174/1570180811666131227193958

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Citations (2)

Cardiac tissue engineering, biomaterial scaffolds, and their fabrication techniques

Polymers for Advanced Technologies (2021)

Marjan Roshandel Farid Abedin Dorkoosh

Abstract Cardiovascular diseases are the first cause of mortality around the globe. One of the promising treatment procedures is regenerating or repairing the heart tissues. Regarding this, in tissue engineering, there are variety of methods that researchers could use for scaffolds fabrication. In this review paper, some of the biomaterials and techniques, by means of which biomaterial scaffolds can be generated, are explained. Furthermore, some recent studies, in which scaffolds have been used for the cardiac tissues, have been presented, which can lead researchers to pursue more precise studies.

Biomaterial

10.1002/pat.5273

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Citations (30)

Preparation of budesonide–dextran conjugates using glutarate spacer as a colon-targeted drug delivery system:in vitro/in vivoevaluation in induced ulcerative colitis

Journal of drug targeting (2010)

Jaleh Varshosaz Jaber Emami Fatemeh Ahmadi Naser Tavakoli Mohsen Minaiyan

An oral colon-targeted formulation of budesonide was developed for treatment of ulcerative colitis. Budesonide conjugates were prepared using glutarate spacer and different molecular weights (MW) of dextran and their degree of substitution (DS), solubility, and stability were examined. Drug release in the presence of rat colonic contents was studied. In vivo efficacy was studied against acetic-acid induced colitis in rat. DS was dependent on polymer MW and was 7.40 ± 0.18, 5.20 ± 0.35, and 13.80 ± 0.48 mg/100 mg conjugate for MW 10,000, 70,000, and 500,000, respectively. Solubility of drug in conjugates of MW 10,000 and 70,000 was increased and was dependent on DS. The conjugates were stable in HCl 0.1 N, phosphate buffer solutions pH 6.8, and 7.4 incubated at 37°C within 6 h and degradation rate constants were <0.009 h−1. Less than 10% of budesonide was released in contents of stomach and small intestine and it was increased significantly after incubating with colonic contents. The conjugate prepared using dextran 70,000 was selected for in vivo studies that could decrease the macroscopic and microscopic scores of induced colitis compared with mesalasine and budesonide suspension.

Conjugate

Liberation

10.3109/10611861003801826

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Citations (38)

Transport of Octreotide and Evaluation of Mechanism of Opening the Paracellular Tight Junctions Using Superporous Hydrogel Polymers In Caco-2 Cell Monolayers

Journal of Pharmaceutical Sciences (2004)

Farid Abedin Dorkoosh Corine A.N. Broekhuizen Gerrit Borchard Morteza Rafiee‐Tehrani J. Coos Verhoef

Paracellular transport

Caco-2

10.1002/jps.10570

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Citations (43)

Comparison of 0.2% chlorhexidine mouthwash with and without anti-discoloration system in patients with chronic periodontitis: A randomized controlled clinical trial

Journal of Advanced Periodontology & Implant Dentistry (2019)

Siamak Yaghobee Farid Abedin Dorkoosh Farnaz Kouhestani Ghazaleh Mozafari Hoori Aslroosta

Background. Chemical plaque control, an adjunct to mechanical approaches, could improve the maintenance of patients with different types of periodontitis. Chlorhexidine, the gold standard in chemical plaque control, might have some side effects; the most determining one is tooth discoloration. Anti-discoloration systems (ADS) have been added to minimize brownish tooth discoloration. This study aimed to evaluate the staining potential and clinical efficacy of chlorhexidine with and without ADS in patients with chronic periodontitis. Methods. In this randomized controlled trial, 46 patients with chronic periodontitis were randomly allocated to two groups. Each patient used 10 mL of mouthwash A (CHX without ADS) or B (CHX with ADS, including sodium metabisulfite and ascorbic acid) twice a day for two weeks. After a two-week interval, they used the second mouthwash. At the beginning and the end of each two-week cycle, plaque index (PI), bleeding on probing (BoP), and staining index were recorded. Results. There was no significant difference between mouthwash A and B in the reduction of BoP and PI. The staining index was significantly lower after rinsing with mouthwash B compared to mouthwash A. Conclusion. CHX mouthwash containing ADS has similar efficacy in microbial plaque control and reduction of BOP as CHX without ADS, with the advantage of lower stain formation on tooth surfaces in patients with chronic periodontitis.

Bleeding on probing

Tooth discoloration

Stain

10.15171/japid.2019.011

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Citations (2)

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat.

PubMed (2012)

Jaleh Varshosaz Jaber Emami Naser Tavakoli Mohsen Minaiyan Nakisa Rahmani

The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 h), pH of 7.4 (4 h) and pH of 6.8 in the absence as well as presence of rat cecal contents (18 h). Finally the selected formulation was evaluated on trinitrobenzenesulfonic acid (TNBS) induced ulcerative colitis in rat model, in comparison with conventional UC treatments. The dissolution profiles of pectin coated pellets showed that the release of budesonide in presence of rat cecal content depended on adjuvant polymer, the ratio of pectin to polymer and film thickness. Coated pellets, prepared out of pectin and Surelease at a ratio of 1:3 at coating level of 35% (w/w), could increase budesonide release statistically in presence of rat cecal content, while they released no drug in pH of 1.2 and 7.4. Animal experiments revealed the therapeutic efficacy of pectin/Surelease-coated pellets of budesonide in alleviating the conditions of TNBS-induced colitis model as reflected by weight gain, as well as improvement of clinical, macroscopic and microscopic parameters of induced colitis. This confirmed the ability of the optimized formulation for targeted drug delivery of budesonide to colon.

Pectin

Pellet

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Citations (20)

Preparation, statistical optimisation andin vitrocharacterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide

Journal of Microencapsulation (2016)

Nika Bahari Javan Leila Rezaie Shirmard Nersi Jafary Omid Hamid Akbari Javar Morteza Rafiee Tehrani

The purpose of this study was the preparation, optimisation and in vitro characterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box–Behnken methodology. The morphological properties of NPs were assessed by both SEM and transmission electron microscopy (TEM). Encapsulation of Teriparatide within the NPs and lacking of chemical bonds between drug and copolymers were proved by XRPD, FTIR and DSC. The structural stability of Teriparatide after processing was confirmed by fluorescence spectrometry. The average size of optimised NPs was 250.0 nm with entrapment efficiency (EE) of 89.5% and drug loading (DL) of 5.0%. Teriparatide release from optimised NPs led to 64.4% release over 30 days and it showed a diffusion-based mechanism. Based on the favourable results, PHBV/PLGA blend NPs could be a promising candidate for designing a controlled release formulation of Teriparatide.

PLGA

Box–Behnken design

Glycolic acid

Teriparatide

10.1080/02652048.2016.1208296

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Citations (20)