John C. Rasmussen

Brown Foundation

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Eva M. Sevick‐Muraca

The University of Texas Health Science Center at Houston

102

Melissa B. Aldrich

Brown Foundation

I‐Chih Tan

Einstein Medical Center Philadelphia

Caroline E. Fife

Intel (United States)

Banghe Zhu

The University of Texas Health Science Center at Houston

Erik A. Maus

The University of Texas Health Science Center at Houston

Chinmay Darne

The University of Texas MD Anderson Cancer Center

Ron J. Karni

The University of Texas Health Science Center at Houston

Milton V. Marshall

Houston Independent School District

Yujie Lu

Guangxi Medical University

Cooperative Institutions

The University of Texas Health Science Center at Houston

Baylor College of Medicine

The University of Texas MD Anderson Cancer Center

Brown Foundation

Memorial Hermann

Institute for Molecular Medicine

University of Houston

Harvard University

The University of Texas at Austin

Baptist Hospital of Miami

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Fully parallel adaptive finite element simulation using the simplified spherical harmonics approximations for frequency-domain fluorescence-enhanced optical imaging

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2011)

Yujie Lu Banghe Zhu Haiou Shen John C. Rasmussen Ge Wang

Fluorescence-enhanced optical imaging/tomography may play an important role in preclinical research and clinical diagnostics as a type of optical molecular. Time- and frequency-domain measurement can acquire more measurement information, reducing the ill-posedness and improving the reconstruction quality of fluorescence-enhanced optical tomography. Although the diffusion approximation (DA) theory has been extensively in optical imaging, high-order photon migration models must be further investigated for application to complex and small tissue volumes. In this paper, a frequency-domain fully parallel adaptive finite element solver is developed with the simplified spherical harmonics (SP_N) approximations. To fully evaluate the performance of the SP_N approximations, a fast tetrahedron-based Monte Carlo simulator suitable for complex heterogeneous geometries is developed using the convolution strategy to realize the simulation of the fluorescence excitation and emission. With simple and real digital mouse phantoms, the results show that the significant precision and speed improvements are obtained from the parallel adaptive mesh evolution strategy.

Optical Tomography

Solver

Convolution (computer science)

10.1117/12.873587

Cite

Citations (0)

Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2014)

Yujie Lu Chinmay Darne I‐Chih Tan Banghe Zhu John C. Rasmussen

A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.

Tomographic reconstruction

Optical Tomography

Siemens

Diffuse optical imaging

Multimodality

10.1117/12.2057818

Cite

Citations (1)

Determining the Performance of Fluorescence Molecular Imaging Devices Using Traceable Working Standards With SI Units of Radiance

IEEE Transactions on Medical Imaging (2015)

Banghe Zhu John C. Rasmussen Maritoni Litorja Eva M. Sevick‐Muraca

To date, no emerging preclinical or clinical near-infrared fluorescence (NIRF) imaging devices for noninvasive and/or surgical guidance have their performances validated on working standards with SI units of radiance that enable comparison or quantitative quality assurance. In this work, we developed and deployed a methodology to calibrate a stable, solid phantom for emission radiance with International System of Units (SI) units of mW ·sr ^-1 ·cm ^-2 for use in characterizing the measurement sensitivity of ICCD and IsCMOS detection, signal-to-noise ratio, and contrast. In addition, at calibrated radiances, we assess transverse and lateral resolution of ICCD and IsCMOS camera systems. The methodology allowed demonstration of superior SNR of the ICCD over the IsCMOS technology and superior resolution of the IsCMOS over the ICCD approach. Contrast depended upon the camera settings (binning and integration time) and gain of intensifier. Finally, because the architecture of CMOS and CCD camera systems results in vastly different performance, we comment on the utility of these technologies for small animal imaging as well as clinical applications for noninvasive and surgical guidance.

Image intensifier

CMOS Sensor

10.1109/tmi.2015.2496898

Cite

Citations (41)

Imaging the Lymphatic Response to Manual Lymphatic Drainage and Pneumatic Compression Devices

Journal of Vascular Surgery Venous and Lymphatic Disorders (2019)

John C. Rasmussen Caroline E. Fife Eva M. Sevick‐Muraca

10.1016/j.jvsv.2019.01.002

Cite

Citations (1)

Lymphatic imaging in unsedated infants and children

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2017)

John C. Rasmussen Duraisamy Balaguru William I. Douglas John P. Breinholt Matthew R. Greives

Primary lymphedema and lymphatic malformations in the pediatric population remains poorly diagnosed and misunderstood due to a lack of information on the underlying anatomy and function of the lymphatic system. Diagnostics for the lymphatic vasculature are limited, consisting of lymphoscintigraphy or invasive lymphangiography, both of which require sedation that can restrict use in infants and children. As a result, therapeutic protocols for pediatric patients with lymphatic disorders remain sparse and with little evidence to support them. Because near-infrared fluorescence (NIRF) imaging enables image acquisition on the order of tenths of seconds with trace administration of fluorescent dye, sedation is not necessary. The lack of harmful radiation and radioactive contrast agents further facilitates imaging. Herein we summarize our experiences in imaging infants and children who are suspected to have disorders of the lymphatic vascular system using indocyanine green (ICG) and who have developed chylothorax following surgery for congenital heart defects. The results show both anatomical as well as functional lymphatic deficits in children with congenital disease. In the future, NIRF lymphatic imaging could provide new opportunities to tailor effective therapies and monitor responses. The opportunity to use expand NIRF imaging for pediatric diagnostics beyond the lymphatic vasculature is also afforded by the rapid acquisition following trace administration of NIRF contrast agent.

Indocyanine Green

Lymphatic vessel

Chylothorax

Lymphangiogenesis

10.1117/12.2256753

Cite

Citations (0)

NIR fluorescence imaging for in vivo assessment of normal and diseased lymphatics

I‐Chih Tan John C. Rasmussen Milton V. Marshall Erik A. Maus Caroline E. Fife

We employed non-invasive near-infrared (NIR) imaging to assess the lymphatic structure and function in normal human subjects and subjects diagnosed with unilateral lymphedema (LE). Imaging was performed following microdose, intradermal administrations of indocyanine green (ICG) in arms or legs. Half of the subjects received manual lymph drainage (MLD) treatment. Apparent lymph velocities and periods between lymphatic propulsion events were calculated from images. Noteworthy difference in lymphatic structure between normal and LE subjects was seen. The lymphatic function was significantly improved after MLD.

Indocyanine Green

10.1364/biomed.2010.bwd5

Cite

Citations (0)

Assessing Lymphatic Response to Cancer Treatments Using Near-Infrared Fluorescence Imaging

International Journal of Radiation Oncology*Biology*Physics (2014)

I‐Chih Tan Ron J. Karni John C. Rasmussen Eva M. Sevick‐Muraca

Indocyanine Green

10.1016/j.ijrobp.2013.11.112

Cite

Citations (0)

Improvement of fluorescence-enhanced optical tomography with improved optical filtering and accurate model-based reconstruction algorithms

Journal of Biomedical Optics (2011)

Yujie Lu Banghe Zhu Chinmay Darne I‐Chih Tan John C. Rasmussen

The goal of preclinical fluorescence-enhanced optical tomography (FEOT) is to provide three-dimensional fluorophore distribution for a myriad of drug and disease discovery studies in small animals. Effective measurements, as well as fast and robust image reconstruction, are necessary for extensive applications. Compared to bioluminescence tomography (BLT), FEOT may result in improved image quality through higher detected photon count rates. However, background signals that arise from excitation illumination affect the reconstruction quality, especially when tissue fluorophore concentration is low and/or fluorescent target is located deeply in tissues. We show that near-infrared fluorescence (NIRF) imaging with an optimized filter configuration significantly reduces the background noise. Model-based reconstruction with a high-order approximation to the radiative transfer equation further improves the reconstruction quality compared to the diffusion approximation. Improvements in FEOT are demonstrated experimentally using a mouse-shaped phantom with targets of pico- and subpico-mole NIR fluorescent dye.

Diffuse optical imaging

Reconstruction algorithm

Fluorescence-lifetime imaging microscopy

Optical Tomography

Heavy traffic approximation

10.1117/1.3659291

Cite

Citations (14)

Towards 3D Quantification of Dermal Lymphatic Backflow as an Indicator of Lymphatic Disease

Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN) (2022)

John C. Rasmussen Melissa B. Aldrich Eva M. Sevick‐Muraca Carolina Gutiérrez Ron J. Karni

Herein is described the integration of 3D computer vision and near-infrared fluorescent lymphatic imaging devices towards the quantification of abnormal dermal backflow as a clinical indicator of lymphatic failure and its response to physiotherapy.

Backflow

Lymphatic vessel

10.1364/translational.2022.jtu3a.40

Cite

Citations (1)

Dermal Backflow Seen Through Near-Infrared Fluorescence Imaging: An Early Response to Cancer Treatments in Head and Neck for the Detection of Lymphedema

International Journal of Radiation Oncology*Biology*Physics (2016)

Syed Naqvi Ron J. Karni I‐Chih Tan John C. Rasmussen Melissa B. Aldrich

Indocyanine Green

Backflow

Lymphatic vessel

10.1016/j.ijrobp.2015.12.184

Cite

Citations (1)