Haruhiko Miyayama

Kumamoto City Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A STUDY OF TWENTY CASES OF VILLOUS TUMOR OF THE LARGE INTESTINE

The journal of the Japanese Practical Surgeon Society (1992)

Y Ueno Kazuharu Nagao Masakazu Matsuda Kenichiro BABA Reiki Nishimura

Villous tumor of the colon is rare in Japan compared to that in the USA or Europe, but is an interesting disease in terms of its carcinogenesis and surgical treatment. Twenty legions of villous tumors in the colon treated at our hospital from January 1983 to December 1988 were examined clinically and pathologically. The average age was 61.3 years and the male-to-female ratio was equivalent. The frequent first onset of symptom was anal bleeding. It was most frequently found in the sigmoid colon and rectum. About 55% of the patients were associated with cancer. There was no relationship in the size of tumors between benign adenomas and cancers in adenoma. There was also no relationship in the macroscopical types of tumors between them. Histologically the cancers were more frequently associated with villous adenomas compared with tubulo-villous adenomas. In the treatment, the benign adenomas and cancers invading the muscle layer were polypectomized through endoscopes or with trans anal surgical resections. On the other hand, large benign adenomas and cancers with under the invasion depth of submucosa were treated by radical colectomy with dessection of the regional lymphnodes. In a final analysis, we assume that the cancers from villous tumors of the colon predominantly involve cancers from villous adenomas. Moreover, it is important that the villous tumor of the lower rectum should be resected first of all.

Villous adenoma

Submucosa

Large intestine

Tubular adenoma

10.3919/ringe1963.53.900

Cite

Citations (0)

An autopsy case of primary choriocarcinoma of the lung in a man.

The Journal of the Japanese Society of Clinical Cytology (1999)

Haruhiko Miyayama Toshio Baba Kiminari KAWANO Kouji SHIMAMOTO Ritsuo MATSUMOTO

性器外に原発する絨毛癌の中で, 肺原発の男性絨毛癌はまれである. 最近, その発生起源を腺癌の異分化に求める説も唱えられている.本症例は, 76歳, 男性で背部痛と血疾で来院. 喀疾細胞診で, class V肺腺癌が疑われたが, 胸部X線写真, CT検査にて両肺野に腫瘍陰影はなく, 入院精査中に肺出血で死亡, 剖検された.剖検にて, 右下肺S9に血腫状の鳩卵大の腫瘍があり, 縦隔, 後腹膜, 睾丸には異常なく, 肺原発の男性絨毛癌であることが判明した. 組織学的に, 異型性のあるcytotrophoblasts (CTs) およびsyncytiotrophoblasts (STs) にきわめて類似した腫瘍細胞から成る絨毛癌の形態をとり, とくに塊状に増殖したCTsを取り囲むように, 合胞性のSTsが被覆した部位もみられた. 免疫組織化学でSTsはβ-hCGが強陽性であった. 本例では, 明らかな腺癌部分はなく, 増殖したCTs細胞塊に混じって, ごく少数ながら, 上皮性膜抗原 (EMA) に陽性を示す細胞がみられた.肺原発絨毛癌の組織発生に関して, 原始胚細胞の迷入ではなく, 気管支上皮の異分化ないし脱分化によって発生することを示唆する興味ある症例である.

Syncytiotrophoblasts

10.5795/jjscc.38.254

Cite

Citations (1)

CHARACTERISTICS OF POLYGLUCOSE PARTICLES NEWLYSYNTHESIZED BY THE PHOSPHORYLASE-BRANCHING GLYCOSYLTRANSFERASE SYSTEM IN VARIOUS TISSUE CELLS UNDER HISTOCHEMICAL CONDITIONS

ACTA HISTOCHEMICA ET CYTOCHEMICA (1977)

Haruhiko Miyayama

Branching (polymer chemistry)

10.1267/ahc.10.218

Cite

Citations (5)

[Brain metastases from Wilms' tumor without systemic involvement--a case report and review].

PubMed (1992)

S. Yoshioka K. Iribe Haruhiko Miyayama Y Ushio

A 3-year-old boy presented with multiple brain metastases 21 months after the resection of stage II Wilms' tumor. Metastasis to other organs was not found. He was treated by total removal of a large metastatic tumor in the left temporal lobe and post-operative radiotherapy and chemotherapy. He has been in complete remission for 20 months after surgery. Cerebral metastasis from Wilms' tumor without systemic metastases is very rare. It is speculated that brain metastases occurred in this patient because most of the anticancer agents used in the primary treatment for Wilms' tumor were not able to cross the blood brain barrier.

Primary tumor

Blood cancer

Brain tumor

Source

Cite

Citations (3)

Announcement

Cerebrovascular Diseases (1995)

Daiva Rastenytė Jaakko Tuomilehto Cinzia Sarti Žygimantas Čepaitis Juozas Bluzhas

10.1159/000107984

Cite

Citations (2)

Late Thorotrast Injury--A Surgical Case of Non-vascularly Induced Malignancy

Mitsuo Sasaki Akira Ishihara Haruhiko Miyayama S. Yano

Thorotrast

Source

Cite

Citations (0)

Direct immunoperoxidase staining for regan isoenzyme of alkaline phosphatase in human tumor tissues

Cancer (1976)

Haruhiko Miyayama George J. Doellgast Vincent A. Memoli Lalita Gandbhir William H. Fishman

Immunoperoxidase staining for Regan isoenzyme of alkaline phosphatase was performed on cryostat sections of five human tumor tisssues. With a direct immunoperoxidase staining for the localization of Regan isoenzyme at the light and electron microscope levels, sections previously fixed with 0.05 M phosphate-buffered 4% paraformaldehyde were reacted with rabbit antisera to human placenta alkaline phosphatase conjugated to horseradish peroxidase. Comparison of conventional histochemistry and immunohistochemistry for Regan isoenzyme indicated that strong specific immunoperoxidase staining appeared on the cell membrane surface, and a diffuse one, in the cytoplasm of lung and colon cancer tissue cells showing L-phenylalanine-sensitive alkaline phosphatase. No immunoperoxidase reaction was obtained in tumor cells showing sensitivity to L-homoarginine or lacking aklaline phosphatase activity.

Immunoperoxidase

Placental alkaline phosphatase

Paraformaldehyde

Horseradish peroxidase

10.1002/1097-0142(197609)38:3<1237::aid-cncr2820380325>3.0.co;2-2

Cite

Citations (23)

[Two cases of inflammatory pseudotumor of the lung].

PubMed (1989)

Taeko Shirakawa Koichiro Fukuda Shinobu Takenaka Kiyoshi Shima Kenichiro BABA

Two cases of inflammatory pseudotumor of the lung were reported. Case 1. A 68 year-old man was referred to our hospital because of an abnormal shadow on chest X-ray. He had a history of pneumonia in the right upper lobe five months before. The chest X-ray film revealed a coin lesion in the right upper lung field (S1), the same segment as the previous pneumonia. Although RPF and INH were administered for three months, the shadow did not change, and cough and sputum continued. In order to confirm the diagnosis, open thoracotomy was performed and microscopic findings of the resected tumor showed inflammatory pseudotumor; proliferation of fibrous tissue with infiltration by inflammatory cells (plasma cells, lymphocytes and a few neutrophils). Case 2. A 35 year-old man was admitted to our hospital because of an abnormal shadow on chest X-ray, i.e. a coin lesion with vascular indentation in the left lower lung field (S8). A wedge resection including the mass was performed, and histopathologic examination revealed inflammatory pseudotumor, or plasma cell granuloma; proliferation of fibrous connective tissue with infiltration by predominantly mature plasma cells. Both patients have been doing well after the operation. We also reviewed 46 cases reported in the Japanese literature and discussed various aspects of this disease. Of 10 patients who had a history of previous respiratory tract infection, 8 had histopathologic features with various inflammatory cells, including many lymphocytes, as in our Case 1. Although the common etiology of inflammatory pseudotumor is obscure, we suppose that in some cases the lesion may be a result of post-inflammatory repair process.

Plasma cell granuloma

Wedge resection

Granulation tissue

Chest radiograph

Source

Cite

Citations (1)

Electron-histochemical Observations of Synthesized Polyglucose Particles in the Blood Capillary

ACTA HISTOCHEMICA ET CYTOCHEMICA (1973)

Haruhiko Miyayama Khoji Shigenaga Tadao Takeuchi

Source

Cite