Meixian Huang

The University of Texas MD Anderson Cancer Center

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Mi-Ae Lyu

The University of Texas MD Anderson Cancer Center

Simrit Parmar

The University of Texas MD Anderson Cancer Center

Tara Sadeghi

The University of Texas MD Anderson Cancer Center

Mitsutaka Nishimoto

Osaka Metropolitan University

Takeshi Inukai

University of Yamanashi

Christopher R. Flowers

The University of Texas MD Anderson Cancer Center

Ke Zeng

University of Science and Technology

Kumiko Goi

University of Yamanashi

Masako Abe

University of Yamanashi

Hiroaki Goto

Kanagawa Children's Medical Center

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

University of Yamanashi

University of Yamanashi Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

The University of Texas Health Science Center at Houston

Zhejiang University

Moffitt Cancer Center

John Wiley & Sons (United States)

Hangzhou First People's Hospital

Southern Medical University

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Adoptive Cord Blood T Regulatory Cell Therapy Leads to Resolution of Inflammation and Decreased Proteinuria in Lupus Nephritis

Blood (2020)

Mi-Ae Lyu Joseph D. Khoury Meixian Huang Mitsutaka Nishimoto Ke Zeng

10.1182/blood-2020-140420

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Citations (2)

Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes

Frontiers in Transplantation (2024)

Ke Zeng Hongbing Ma Meixian Huang Mi-Ae Lyu Tara Sadeghi

Adoptive therapy with umbilical cord blood (UCB) T-regulatory (Treg) cells can prevent graft vs. host disease (GVHD). We hypothesize that UCB Tregs can treat GVHD and synergize with ruxolitinib, Jak2 inhibitor, to improve outcomes.

Ruxolitinib

Cord blood

10.3389/frtra.2024.1448650

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Citations (1)

Additional file 1 of Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines

Figshare (2020)

Minori Tamai Meixian Huang Keiko Kagami Masako Abe Shinpei Somazu

Additional file 1: Table S1. Karyotype, age, patient status at the cell establishment, and SNP genotypes and gene expression level of ARID5B in cell lines.

10.6084/m9.figshare.12922917

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PSK1regulates expression ofSOD1involved in oxidative stress tolerance in yeast

FEMS Microbiology Letters (2013)

Meixian Huang Qinghong Xu Kazuhiro Mitsui Zhaojun Xu

The Per-ARNT-Sim (PAS) domain serine/threonine kinase PAS kinase is involved in energy flux and protein synthesis. In yeast, PSK1 and PSK2 are two partially redundant PASK homologs. We recently generated PSK2 deletion mutant and showed that Psk2 acts as a nutrient-sensing protein kinase to modulate Ultradian clock-coupled respiratory oscillation in yeast. Here, we show that deletion of PSK1 increased the sensitivity of yeast cells to oxidative stress (H2 O2 treatment) and partially inhibited cell growth; however, the growth of the PSK2-deleted mutant was similar to that of the wild type. Superoxide dismutase-1 (SOD1) mRNA and protein levels were lower in PSK1-deletion mutant than the wild type. The mRNA levels of stress response genes CTT1, HSP104, ATH1, NTH1 and SOD2 were similar in both the PSK1-deleted mutant and wild-type yeast. Furthermore, intracellular accumulation of reactive oxygen species (ROS) was noted in PSK1-deleted mutant. These results suggest that PSK1 induces SOD1 expression to protect against oxidative stress in yeast.

Wild type

PAS domain

SOD2

10.1111/1574-6968.12329

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Citations (13)

Steroids, fatty acids and ceramide from the mushroom Stropharia rugosoannulata Farlow apud Murrill

Biochemical Systematics and Ecology (2019)

Qing‐Xiang Yan Meixian Huang Peng Sun Shixian Cheng Qiang Zhang

Phytochemical

10.1016/j.bse.2019.103963

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Citations (23)

Plasma osteopontin concentration correlates with the severity of hepatic fibrosis and inflammation in HCV-infected subjects

Clinica Chimica Acta (2010)

Wen-bao Huang Zhu Guo-xian Meixian Huang Guo‐qiang Lou Yi Liu

Osteopontin

10.1016/j.cca.2010.01.029

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Citations (52)

Analysis of Copy Number Abnormalities of 86 Acute Lymphoblastic Leukemia Cell Lines Based on the Genetic Subtypes

Blood (2015)

Chihiro Tomoyasu Toshihiko Imamura Mio Yano Daisuke Asai Meixian Huang

CDKN2B

ETV6

ABL

10.1182/blood.v126.23.1424.1424

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Analysis on the distribution and their drug resistance of pathogenic bacteria from nosocomial infection in our hospital in 2009

Chinese Journal of Health Laboratory Technology (2010)

Meixian Huang

Objective:To study pathogens distribution and their drug-resistance characteristics of the bacterial infection in our hospital in 2009 so as to offer a reference for prevention and control of nosocomial infectiong.Methods: The clinical isolates were identified with BACTEC 9120 or PHN IX100.Results: A total of 1925 nosocomial pathogens were collected in 2009.Gram-negative bacilli accounted for 60.3%.The main pathogens were Pseudomonas aeruginosa,Escherichia coli,Klebsiella pneumoniae,A cinetobacter spp.For Enterobacteriaceae strains,the susceptibility rates to cefoperazone/ sulbactam,imipenem and amikacin were found to be above 75.About 17.2% and 31.3 % of P.aeruginosa isolates were resistant to cefoperazone/ sulbactam and imipenem.Gram-positive cocci accounted for 29.2%,most of them were staphylococci.About 42.4 % of S.aureus isolates were MRSA,66.6% of coagulase-negative Staphy lococcus isolates were meticillin-resistant.Fungi accounted for 10.5 %.Most of them were Candida albicans.The susceptibility tests have not be regularly performed for fungi at present.Conclusion: P.aerugionosa and S.aureus are the main pathogens to cause nosocomial infection in our hospital showing multi-drug-resistance during 2009.To emphasize on the recognition of the nosocomial infections and the drug-resistance,it is important to be taken certain preventive measure.

Sulbactam

Cefoperazone

Amikacin

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Adoptive Therapy with Allogeneic Cord Blood T Regulatory Cells Improves Transfusion Requirement in Bone Marrow Failure Syndromes

Blood (2021)

Tapan M. Kadia Naveen Pemmaraju Musa Yılmaz Naval Daver Li Li

Aplastic anemia

Cell therapy

10.1182/blood-2021-153864

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[Effects of dl-demethylcoclaurine on electrophysiological properties of porcine myocardial cells (author's transl)].

PubMed (1982)

Wang Bk Chen Yl Shang Mingyi Jin Zj Yu Gr

Action potentials of isolated ventricular myocardial fibers of pigs and the electrophysiological actions of dl-demethylcoclaurine (DMC) on the porcine myocardial cells were studied by glass microeletrodes. The action potentials of porcine ventricular myocardial fibers were similar to those of other mammalian hearts. Amplitude of the action potential was 115±9 mV, duration of action potential 242±30 ms, resting membrane potential -85±5 mV and the maximum rise of depolarization of action potential 151±27 V/s. After perfusion with normal Tyrode’s solution containing DMC 5 μg/ml,the amplitude of action potential was increased and the duration of action potential was prolonged, the amplitude and the duration of plateau of action potential were increased and the slope of phase 2 of action potential was reduced (P<0.05). The resting potential, the slope of phase 3 and the maximum depolarization rate of phase O of action potential did not change. In Tyrode’s solution containing Mn++ 3 mM, these electrophysiological actions of DMC disappeared. DMC may abolish the conduction block induced by K+-rich solution. In Tyrode’s solution containing K+ 32 mM, the upstroke of action potential showed 2 phases under influence of DMC. The 2nd phase disappeared when Mn+ + was added. All findings indicate that DMC can be considered as an activator of the slow channel. The electrophysiological mechanism and clinical significance of DMC were discussed.

Cardiac action potential

Ventricular action potential

Action potential

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Citations (3)