Yoshiko Furukawa

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Effects of Verapamil, Zatebradine, and E-4031 on the Pacemaker Location and Rate in Response to Sympathetic Stimulation in Dog Hearts

Journal of Pharmacology and Experimental Therapeutics (1999)

Yoshiko Furukawa Yusuke Miyashita Koichi Nakajima Masamichi Hirose Fumio Kurogouchi

To investigate whether slow inward Ca2+ current (ICa), hyperpolarization-activated inward current (If), and a rapid type of delayed rectifier K+ current (IKr) similarly act on the pacemaker location, sinoatrial node region, and subsidiary superior and inferior pacemaker regions, we studied the effects of verapamil, zatebradine, and E-4031 on the atrial rate and the 3-ms earliest activation region (EAR) determined from the isochronal activation sequence map in the autonomically decentralized heart of the anesthetized dog. Three blockers decreased atrial rate similarly. Verapamil shifted the EAR from the SA node region to the inferior pacemaker region. The EAR induced by zatebradine was variable, but the EAR induced by E-4031 tended to shift to the inferior pacemaker region. Sympathetic nerve stimulation increased atrial rate and shifted the EAR to the superior pacemaker region. Verapamil attenuated the increased atrial rate by 28%, and it shifted the EAR to the lower pacemaker regions consistently. Zatebradine also attenuated the increased rate by 53% and shifted the EAR from the anterior to the posterior-superior right atrium. On the other hand, E-4031 affected neither the rate nor the EAR in response to sympathetic stimulation. These results suggest that ICa, If, and IKr inhibitors differentially influence the pacemaker activity among three pacemaker regions when sympathetic tone is absent or present and that the role of ICa, If, and IKr of the pacemaker cells distributed in the atrial pacemaker complex is different in the dog heart in situ.

Atrium (architecture)

10.1016/s0022-3565(24)38277-1

Cite

Citations (16)

Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice

Neuroscience Letters (2014)

Mitsunari Nakajima Chisa Nishikawa Yuki Miyasaka Yoshiaki Kikkawa Hisamichi Mori

Auditory System

Auditory brainstem response

Inferior Colliculi

Stimulus (psychology)

Startle response

10.1016/j.neulet.2014.02.061

Cite

Citations (2)

1P190 Oligomerization control of the flagellum-specific ATPase FliI in Salmonella

Seibutsu Butsuri (2005)

Tohru Minamino A. Tahara Ken‐ichi Kazetani Yoshiko Furukawa Keiichi Namba

10.2142/biophys.45.s79_2

Cite

Citations (0)

Preparation of orally disintegrating tablets from active ingredients of citrus peel by direct powder compression for the maintenance of brain function

Food Science and Technology Research (2021)

Shohei Nakamura Sae Abe Kazuki Miyoshi Yoshiaki Amakura Satoshi Okuyama

Citrus kawachiensis peel (PCK), a new functional food material, may prolong the healthy life expectancy of aging populations. Tableting PCK could facilitate its worldwide distribution and consumption. A PCK dosage form that is easy to swallow should be prepared for ease of use by the elderly. We investigated the fabrication of orally disintegrating (OD) tablets with the required commercial strength and disintegration time. We formulated OD tablets comprising PCK powder, crospovidone, vinylpyrrolidone vinyl acetate copolymer, light anhydrous silicic acid, D-mannitol, and magnesium stearate. The tablets were prepared using a rotary tableting press. Tableting was optimized by setting the target hardness to 30−50 N and target disintegration time to ≤ 2 min. When tableting was performed at a compression pressure of 7.5 kN, the hardness was 40 N and disintegration time was 1.5 min. The OD tablet containing a high proportion of PCK possessed the properties preferred and required for commercial products.

Tableting

Anhydrous

10.3136/fstr.27.573

Cite

Citations (1)

Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol

Neuroscience Letters (1999)

Hidefumi Fukumitsu Ayako Sometani Makoto Ohmiya Atsumi Nitta Hiroshi Nomoto

Intraperitoneal injection

10.1016/s0304-3940(99)00691-6

Cite

Citations (18)

Left partial anomalous pulmonary venous return to the innominate and hepatic veins

Nihon Naika Gakkai Zasshi (2000)

Naoki Ito Shin‐ichi Maie Yoshiko Furukawa K Arima Satoshi Akizuki

Venous return curve

Hepatic veins

10.2169/naika.89.1185

Cite

Citations (2)

Parasympatholytic effects of vecuronium are mediated by nicotinic and muscarinic receptors in hearts of anesthetized dogs.

Journal of Pharmacology and Experimental Therapeutics (1992)

Masato Narita Yoshiko Furukawa Makoto Murakami Manabu Takei L M Ren

We investigated the blocking effects of vecuronium and pancuronium on the negative chronotropic and dromotropic responses to stimulation of the parasympathetic nerves in the anesthetized, open-chest dog. We stimulated the intracardiac parasympathetic nerves to the SA nodal region (SAP stimulation) or to the atrioventricular nodal region (AVP stimulation). SAP stimulation or AVP stimulation selectively decreased heart rate or increased atrioventricular conduction time, respectively. Vecuronium and pancuronium inhibited the chronotropic response to SAP stimulation and the dromotropic response to AVP stimulation in a dose-dependent manner. The ID50 of each drug for the dromotropic response was less than that for the chronotropic response. The blocking effect of vecuronium on the negative cardiac responses to parasympathetic stimulation was about 10-fold less potent than that of pancuronium. These results suggest that the blocking effects of vecuronium and pancuronium on the negative chronotropic and dromotropic responses to parasympathetic stimulation differ from those of atropine in the heart. In the isolated right atrium perfused with blood from the support dog, vecuronium, injected into the external jugular vein of the support dog, dose-dependently inhibited the negative chronotropic and inotropic responses to carbachol or SAP stimulation and the negative followed by positive chronotropic and inotropic responses to nicotine. The ID50 values for carbachol, nicotine and SAP stimulation were not significantly different. These results suggest that parasympatholytic effects of vecuronium are mediated by not only muscarinic receptors but also neuronal nicotinic receptors in hearts of anesthetized dogs.

10.1016/s0022-3565(25)10797-0

Cite

Citations (4)

Effects of Production-line Squeezing Techniques and Heat Treatment on Functional Components of <i>Citrus kawachiensis</i> (Kawachi bankan) Fruits

Food Science and Technology Research (2019)

Rie Haramiishi Morio Yoshimura Satoshi Okuyama Naohiro Fukuda Takahisa Tamai

We previously reported that Citrus kawachiensis peel is abundant in auraptene (AUR), 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), nobiletin (NBT), naringin (NGIN), and narirutin (NRTN). All of the above are known as citrus functional components, and a part of these is extracted from the peel into the juice during fruit squeezing. In the present study, we demonstrated that while squeezing method did not affect the composition of compounds in the juice, the contents were affected. Heat treatment for a longer duration led to AUR decomposition, while HMF, NBT, NGIN, and NRTN did not decompose. These 5 components were stable in hot ethanol after 24 h.

Line (geometry)

10.3136/fstr.25.809

Cite

Citations (0)

3P199 Study of the periplasmic fragment of MotB, a stator component of the flagellar motor from Salmonella

Seibutsu Butsuri (2005)

Satoshi Kojima Yoshiko Furukawa Tohru Minamino Keiichi Namba

Fragment (logic)

Component (thermodynamics)

10.2142/biophys.45.s253_3

Cite

Citations (0)