Carla Di Gennaro

University of Turin

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Giuseppe Palasciano

University of Bari Aldo Moro

Elena Succurro

Magna Graecia University

Giacomo Emmi

Monash Medical Centre

Andrea Maria Maresca

University of Insubria

Alice Valoriani

University of Verona

Laura Stefani

University of Florence

Giampaolo Damiani

Pasquale Agosti

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Pier Mannuccio Mannucci

University of Milan

Gabriella D’Aurizio

Catholic University of America

Cooperative Institutions

Policlinico S.Orsola-Malpighi

200

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

192

Azienda Ospedaliera Universitaria Senese

185

Ospedale San Paolo

182

IRCCS Ospedale San Raffaele

180

Istituti di Ricovero e Cura a Carattere Scientifico

108

University of Milan

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Sapienza University of Rome

University of Turin

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Topographic Pattern-Based Nomogram to Guide Keraring Implantation in Eyes with Mild to Moderate Keratoconus: Visual and Refractive Outcome

Journal of Clinical Medicine (2025)

Ugo de Sanctis Paolo Caselgrandi Carla Di Gennaro Cecilia Tosi Enrico Borrelli

Background: To assess the outcome of Keraring (Mediphacos, Brazil) implantation according to a topographic pattern-based nomogram in eyes with mild to moderate keratoconus. Materials and Methods: A topographic pattern-based nomogram was used to guide Keraring selection in 47 consecutive eyes with stage I-II keratoconus (Amsler-Krumeich staging), which underwent femtosecond laser-assisted implantation at a single center. Electronic data of LogMar uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) manifest refraction and tomographic analysis (Pentacam HR, Oculus, Germany) measured preoperatively and at the last postoperative examination were retrospectively analyzed. Results: Mean follow-up was 18.8 months. (range 3–35). Mean UDVA improved (p < 0.001) from 0.87 ± 0.27 to 0.35 ± 0.21. UDVA increased on average by 5.13 lines. Mean CDVA improved from 0.21 ± 0.10 to 0.09. ± 0.07, and the proportion of eyes with CDVA ≥ 20/25 increased from 29.8% to 85.1% after surgery. No eyes lost lines of CDVA. The Alpins correction index of astigmatism was 0.77 and the mean refractive cylinder decreased from 4.99 ± 1.89 to −2.31 ± 1.47 D (p < 0.001). Mean and maximal keratometry was reduced on average by −2.10 ± 1.42 D and −3.02 ± 3.68 D, respectively (p < 0.001). The RMS of corneal high-order aberrations dropped from 3.296 ± 1.180 µm to 2.192 ± 0.919 µm, and that of vertical coma from −2.656 ± 1.189 µm to −1.427 ± 1.024 µm (p < 0.001). All topometric indices improved after surgery. Conclusions: Planning Keraring implantation using the topographic pattern-based nomogram is very effective and safe in eyes with mild to moderate keratoconus. Using that nomogram of UDVA and CDVA are clinically significant.

Nomogram

Astigmatism

10.3390/jcm14030870

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HTA106 What Are the Main Drivers for Decision-Making Regarding the Incorporation of a Healthcare Technology By CONITEC in Brazil? A Study in the Cardiovascular, Oncology, and Respiratory Fields

Value in Health (2023)

Iara Muller Bernz Carla Di Gennaro Karlyse Claudino Belli

10.1016/j.jval.2023.09.1790

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Psychopathological profile and health-related quality of life (HRQOL) in patients with hepatocellular carcinoma (HCC) and cirrhosis

Clinical and Experimental Medicine (2013)

Vincenzo Ostilio Palmieri Santovito Daniela Francesco Margari Madia Lozupone Francesco Minerva

Depression

10.1007/s10238-013-0267-0

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Citations (31)

Liver stiffness evaluated by means of ARFI is related not only to fibrosis in patients with hepatitis C virus-related chronic hepatitis

Journal of Hepatology (2017)

Annamaria Gesualdo Felicia D’Alitto L Ricci Carla Di Gennaro Enrica Settimo

Hepatitis virus

10.1016/s0168-8278(17)30891-7

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Analysis of CA/GT microsatellite polymorphism in IVS8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a study of Italian CF families

Clinical Genetics (1992)

Gabriella Restagno S. Garnerone Carla Di Gennaro Marina Ferrone A. O. Carbonara

Forty‐six CF Italian patients and their parents were screened for a highly polymorphic microsatellite consisting of a variable number of CA/GT repeats in intron 8 of the CFTR gene. A strong degree of association was found between alleles 2 and 6 and the CF mutation ΔF508. Moreover, considering the haplotypes at the closely linked locus D7S23 and the microsatellite's alleles, a strong linkage disequilibrium was again found for ΔF508 and also for non‐ΔF508 CF chromosomes and the eight commonest haplotypes (B2, B6, C7, A6, A7, B7, D2 and D7). These data, compared with those described in the Spanish population, further support the common origin of the ΔF508 mutation in Southern European populations.

10.1111/j.1399-0004.1992.tb03262.x

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Citations (2)

ΔF508 deletion in cystic fibrosis in Italian families

Human Genetics (1990)

Gabriella Restagno S. Garnerone Carla Di Gennaro O. Varetto N Ansaldi

Human genetics

ΔF508

Metabolic disease

10.1007/bf02428293

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Citations (2)

Preliminary experience with binding pancreaticojejunostomy

European Journal of Surgical Oncology (2010)

Stefano Silvestri M Garino Donata Campra D. Cassine A Franchello

Jejunostomy

Pancreatic fistula

10.1016/j.ejso.2010.06.069

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Citations (1)

Long-term management of chronic heart failure patients in internal medicine

Internal and Emergency Medicine (2019)

Anna Belfiore Vincenzo Ostilio Palmieri Carla Di Gennaro Enrica Settimo Maria Grazia De Sario

10.1007/s11739-019-02024-4

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Citations (15)

Gastrointestinal stromal tumor: Our experience

European Journal of Surgical Oncology (2012)

Carla Di Gennaro M Garino G R Fronda Sergio Sandrucci

Stromal tumor

Neoplasm

10.1016/j.ejso.2012.07.080

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Citations (1)

Carrier detection for prenatal diagnosis of hemophilia A in Italian families.

PubMed (1992)

N Cappello Gabriella Restagno S. Garnerone Carla Di Gennaro L Perugini

The results obtained from a comparative analysis between phenotypic bioassays as the ratio of factor VIII: C clotting activity to factor VIII: C-related antigen, and DNA haplotypes from RFLP's TaqI/St14 and BclI/F8A in 12 hemophilia A (HeA) families are described.DNA from HeA patients and related at-risk women has been analyzed by Southern blotting with two probes: the intragenic F8A and the extragenic St14. Factor VIII: C coagulant activity was measured by a one-stage method, and the Factor VIII-related antigen (FVIII: RAg) was assayed with bidimensional electrophoresis. Linkage analysis was performed with the LINKAGE computer programs; in particular, the risks of carrying HeA were calculated using the MLINK program.The observed heterozygosity for the flanking marker DXS 52 (TaqI/St14 RFLP) in combination with intragenic BclI/F8A polymorphism was 0.94. A statistically significant difference in frequency was detected at the DXS 52 locus (allele 4) in comparison with other Caucasian populations. Linkage analysis made it possible to combine the plasma bioassay values with the DNA marker haplotypes to determine the probability of carriership; 22 females at risk were investigated: 4 of them were identified as carriers and 18 were excluded. The risk of carrying hemophilia A for some women at risk in six families is reported.This study compares a classic method and DNA analysis in genetic counselling for hemophilia A. In some cases the two methods may give different results when identifying carriers in at-risk families. From these data it is possible to conclude that DNA analysis combined with the phenotypic bioassays for carrier detection gives more information that the two analyses taken separately.

TaqI

Genetic linkage

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Citations (2)