Xinge Zhao

Shanghai Jiao Tong University

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Jinjun Li

ZheJiang Academy of Agricultural Sciences

Taoyang Chen

Qidong Liver Cancer Prevention Research

Hua Tian

Peking University

Fangyu Zhao

Tsinghua University

Xiaoxia Chen

Guangzhou University

Lianer Zhou

Renji Hospital

Hong Li

Harbin Medical University

Chao Ge

Renji Hospital

Haiyang Xie

Zhejiang University

Xianxian Li

Beijing University of Chinese Medicine

Cooperative Institutions

Shanghai Jiao Tong University

Shanghai Cancer Institute

Renji Hospital

State Key Laboratory of Oncogene and Related Genes

Fudan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Capital Medical University

Cancer Institute (WIA)

Tianjin Medical University

University of Chinese Academy of Sciences

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The Application of Group Technology for CNC Manufacturing

Machine Design and Research (2006)

Xinge Zhao

Multi-variety parts and small batch production are the main production characteristic of a certain company. How to improve the productivity even to reach a large batch size production is a critical project of this company. This article uses the group technology to divide the 124 parts into 9 groups based on the CNC manufacturing process and order quantity. Then we arranged the 9 groups on 11 different CNC machines. After such grouping, the productivity was increased 26%, and the production cost was reduced 20%.

Group technology

Batch production

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STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1

Oncogene (2022)

Xiaoxia Chen Zhenyu Wang Xinge Zhao Lili Zhang Lianer Zhou

10.1038/s41388-022-02273-2

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Citations (9)

TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma

Cellular Oncology (2024)

Xuejie Min Fen Lin Xinge Zhao Junming Yu Chao Ge

Chromatin immunoprecipitation

Immunoprecipitation

HCCS

Proximity ligation assay

ribosome biogenesis

10.1007/s13402-024-01014-9

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Citations (1)

FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

Frontiers in Oncology (2022)

Zhenyu Wang Xiaoxia Chen Lianer Zhou Xinge Zhao Chao Ge

F-box proteins are critical for malignancy because they control the turnover of key proteins that govern multiple cellular processes. F-box protein 9 (FBXO9) belongs to the F-box protein family and exhibits oncogenic properties in hematological malignancies. However, the function and molecular mechanism of FBXO9 in hepatocellular carcinoma (HCC) remain unclear. Here, we report that FBXO9 was remarkably overexpressed in HCC. Loss- and gain-of-function experiments showed that FBXO9 facilitates HCC cell proliferation and metastasis both in vitro and in vivo. Mechanistically, as a direct upstream transcription factor, FBXO9 is regulated by zinc finger protein 143 (ZNF143) and accelerates tumor growth and metastasis by targeting the F-box and WD repeat domain containing 7 (FBXW7) for ubiquitination and degradation. Additionally, we found that with FBXO9 knockdown, HCC cells were more sensitive to treatment with lenvatinib and sorafenib. In summary, our results demonstrate that a ZNF143-FBXO9-FBXW7 signaling regulatory axis may be involved in tumor progression in HCC, and suggest that FBXO9 could be a potential biomarker and therapeutic target for HCC.

Lenvatinib

10.3389/fonc.2022.930220

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Citations (8)