Wedad Z. Mostafa

Tanta University

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Medhat El‐Mofty

Cairo University

Samia Esmat

Cairo University

Randa Youssef

Cairo University

Rehab A. Hegazy

Cairo University

Suzan Shalaby

Cairo University

Manal Bosseila

Cairo University

Heba M. Mashaly

Cairo University

Marwa M. Fawzy

Cairo University

Marwa F. Hussein

Cairo University

Marwa S. El‐Hawary

Cairo University

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Cairo University

102

Ain Shams University

University Dermatology

Tanta University

National Research Centre

King Faisal University

Alexandria University

Zagazig University

Fayoum University

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Comparative study between combined follicular and epidermal cell suspension versus epidermal cell suspension in treatment of stable vitiligo

Archives of Dermatological Research (2025)

Engi Seif E. Shaker Samar Saeed Abdelkawy Abdelaal Wedad Z. Mostafa Samia Othman Nassar

Vitiligo

Suspension culture

Suspension

10.1007/s00403-025-03813-y

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Citations (0)

Narrow band Ultraviolet B 311 nm in the treatment of vitiligo: two right–left comparison studies

Photodermatology Photoimmunology & Photomedicine (2006)

Medhat El Mofty Wedad Z. Mostafa Samia Esmat Randa Youssef Omar Abu-Azzam

Aim: Evaluation of narrow band ultraviolet B (NB UVB 311 nm) in the treatment of vitiligo by two independent studies. The first study compared NB UVB with a well‐established therapeutic modality, psoralen ultraviolet A (PUVA), and the second study was conducted to find out whether psoralen might add to its efficacy. Methods: In the first study, 15 patients were exposed on the left half of their body to UVB 311 nm and then exposed on their right half to UVA after ingestion of psoralen. In the second study, 20 patients were exposed to UVB 311 nm on the left side of the body, followed by ingestion of psoralen and exposure to NB UVB 311 nm 90 min later to the right side of the body. In both studies, while exposing one side, the other was protected by an UV‐proof gown. Thus two right–left comparative studies were carried out simultaneously, namely: UVB 311 nm vs. PUVA and UVB 311 nm vs. PUVB 311 nm. Results: In the first study, comparison of PUVA and NB UVB 311 nm showed no difference either in the degree of response or in the incidence of complications. In the second study, comparison of PUVB and UVB showed equal clinical improvement on both sides. The cumulative dose needed to achieve the same response on the PUVB side was lower than that on the UVB side, but the difference was not statistically significant. The incidence of phototoxic reactions was significantly higher on the PUVB treated body half. Conclusion: NB UVB 311 nm has similar repigmentary effects as PUVA. The addition of psoralen does not increase its efficacy.

Vitiligo

Ultraviolet b

PUVA therapy

Ultraviolet

Phototoxicity

10.1111/j.1600-0781.2006.00189.x

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Citations (63)

Protocol of Kasr Al-Ainy’s phototherapy unit − Cairo University for the management of photoresponsive skin diseases − part 1

Journal of the Egyptian Womenʼs Dermatologic Society (2022)

Medhat El‐Mofty Wedad Z. Mostafa Samia Esmat Randa M. Youssef Manal Bosseila

One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and we believe dermatologists dealing with such diseases in their hospitals or clinics, can find it helpful and applicable to get better results with their patients. In part 1, the general measures of the protocol will be discussed.

10.4103/jewd.jewd_58_21

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Citations (2)

A large scale analytical study on efficacy of different photo(chemo)therapeutic modalities in the treatment of psoriasis, vitiligo and mycosis fungoides

Dermatologic Therapy (2010)

Medhat El‐Mofty Wedad Z. Mostafa Manal Bosseila Randa Youssef Samia Esmat

Psoriasis, vitiligo, and mycosis fungoides (MF) are among the most frequently treated dermatological diseases by photo(chemo)therapy. The objectives are to determine which photo (chemo) therapeutic modality could achieve the best response in the treatment of psoriasis, vitiligo, and MF. The design used in this study is retrospective analytical study. The study included 745 patients' records; 293 with psoriasis, 309 with vitiligo, and 143 with early MF, treated in the Phototherapy Unit, Dermatology Department, Kasr El-Aini Hospital, Cairo University by either psoralen and ultraviolet A (PUVA), narrow band ultraviolet B (NB-UVB), psoralen and narrow band UVB (P-NBUVB), broad band UVB (BB-UVB), or broad band UVA (ΒΒ-UVA). Data were retrieved from the computer database of the unit and statistically analyzed. In psoriasis, oral and topical PUVA and NB-UVB were found to be equally effective, whereas oral PUVA had significantly better results than both UVA and BB-UVB at the end of therapy. In generalized vitiligo, PUVA and P-NBUVB had significantly better results than NB-UVB alone. In early MF, there was no statistically significant difference between the response to oral PUVA and NB-UVB. PUVA and NB-UVB are good choices in patients with psoriasis and early stage MF, whereas PUVA appears the best choice in the treatment of vitiligo.

Vitiligo

PUVA therapy

Ultraviolet b

Ultraviolet therapy

10.1111/j.1529-8019.2010.01345.x

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Citations (33)

New insights into leukotrichia in nonsegmental vitiligo: A cross-sectional study

Indian Journal of Dermatology Venereology and Leprology (2019)

Rania M. Mogawer Maha Fathy Elmasry Wedad Z. Mostafa

Leukotrichia has been considered a predictor of poor outcome in vitiligo. However, studies considering the different clinical aspects of leukotrichia in vitiligo patients are few.Our aim was to conduct a detailed clinical study to provide insights into the relevance and associations of leukotrichia in non-segmental vitiligo.In this cross-sectional study, vitiligo patients attending the dermatology outpatient clinic and phototherapy unit at Cairo University Hospital over a period of 6 months (April-September 2016) were included. Family history, clinical details, the Vitiligo Global Issues Consensus Conference classification, the Dermatology Life Quality Index, Vitiligo Area and Severity Index, Vitiligo Extent Score, Vitiligo Disease Activity Score and Vellus Score were determined and these measurements were correlated to leukotrichia.Out of the 101 patients studied, leukotrichia was found in 47 (46.5%) patients, with vellus hair involved in 37 (78.7%), terminal hairs in 30 (63.8%) and both in 20 (42.5%) patients. Vellus hair involvement was significantly higher in generalized bilaterally symmetrical vitiligo than in acrofacial or unclassified vitiligo. The incidence of scalp leukotrichia also was higher in generalized symmetrical vitiligo than in acrofacial vitiligo. The Vellus Score showed significant associations with Vitiligo Area and Severity Index, Vitiligo Extent Score and the Dermatology Life Quality Index.This was a short-term study with a small sample size. Prognostic and therapeutic correlations were not studied; prospective longitudinal studies are needed for further evaluation.Leukotrichia was found in almost half of the studied sample and its frequency varied among the different types of vitiligo.

Vitiligo

Vellus hair

Phototype

Outpatient clinic

10.4103/ijdvl.ijdvl_49_18

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Citations (10)

Medical ethical standards in dermatology: an analytical study of knowledge, attitudes and practices

Journal of the European Academy of Dermatology and Venereology (2014)

Wedad Z. Mostafa Rania Abdel Hay Mona Ibrahim El Lawindi

Abstract Background Dermatology practice has not been ethically justified at all times. Objective The objective of the study was to find out dermatologists' knowledge about medical ethics, their attitudes towards regulatory measures and their practices, and to study the different factors influencing the knowledge, the attitude and the practices of dermatologists. Methods This is a cross‐sectional comparative study conducted among 214 dermatologists, from five Academic Universities and from participants in two conferences. A 54 items structured anonymous questionnaire was designed to describe the demographical characteristics of the study group as well as their knowledge, attitude and practices regarding the medical ethics standards in clinical and research settings. Five scoring indices were estimated regarding knowledge, attitude and practice. Inferential statistics were used to test differences between groups as indicated. The Student's t ‐test and analysis of variance were carried out for quantitative variables. The chi‐squared test was conducted for qualitative variables. The results were considered statistically significant at a P > 0.05. Results Analysis of the possible factors having impact on the overall scores revealed that the highest knowledge scores were among dermatologists who practice in an academic setting plus an additional place; however, this difference was statistically non‐significant ( P = 0.060). Female dermatologists showed a higher attitude score compared to males ( P = 0.028). The highest significant attitude score ( P = 0.019) regarding clinical practice was recorded among those practicing cosmetic dermatology. The different studied groups of dermatologists revealed a significant impact on the attitude score ( P = 0.049), and the evidence‐practice score ( P < 0.001). Conclusion Ethical practices will improve the quality and integrity of dermatology research.

10.1111/jdv.12489

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Citations (0)

Dermoscopic evaluation of tranexamic acid versus Vitamin C, with microneedling in the treatment of melasma: a comparative, split-face, single-blinded study

Journal of Dermatological Treatment (2021)

Asmaa Ibrahim Tahoun Wedad Z. Mostafa Marwa Ahmed Amer

Melasma is a complex pigmentary disorder with challenging management.Evaluation of efficacy of topical tranexamic acid (TXA) versus Vitamin C (Vit C) with microneedling (MN) in melasma therapy.In 30 females with melasma, after 4 weeks of using Modified Kligman's formula, the right side of the face was treated with MN + TXA and the left with MN + Vit C for five biweekly sessions. Wood's light, dermoscopy, Melasma Area and Severity Index (MASI), MASI malar right and malar left (MASIMR and MASIML), Visual Analogue Score (VAS), and Dermatology Life Quality Index (DLQI) were evaluated at weeks 0, 4, 12, and 16.Both MASIMR and MASIML decreased significantly (p < .001). Both sides exhibited significant diminution in dark fine granules (p-value < .001), homogeneous pigmentation (p-value = .005) and pseudoreticular brown network (p-value = .028). However, telangiectasia significantly improved only on the TXA treated side (p = .002). DLQI improved significantly on both sides (p < .001). In some patients transformation of mixed to dermal melasma was depicted.MN followed by Vit C or TXA is successful in melasma management, the latter being advantageous vis-a-vis dermal vascularity and epidermal pigmentation. Dermoscopic evaluation appears crucial in choosing optimum treatment in each patient.

Melasma

10.1080/09546634.2021.1871582

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Citations (17)

RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA TREATED WITH PHENYTOIN

International Journal of Dermatology (1992)

ABDULAZIZ A. ABAHUSSEIN AHMAD A. AL‐ZAYIR Wedad Z. Mostafa Anezi N. Okoro

Abstract Three patients with severe recessive dystrophic epidermolysis bullosa were treated with oral phenytoin and palliative and supportive measures for variable periods. Their progress was compared with that of three milder cases managed only with palliative and supportive measures. The phenytoin‐treated group showed marked decrease in blister count, increase in trauma tolerance, a rise in hemoglobin level, and considerable weight gain. The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.

10.1111/j.1365-4362.1992.tb01385.x

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Citations (12)

Trichoscopic Diagnosis of Structural Hair Defects in a Clinical Setting: A Cross-Sectional Analytical Study

Skin Pharmacology and Physiology (2022)

Rania Abdel Hay Khadiga S. Sayed Wedad Z. Mostafa Haidy Atef Afifi Leila Zeiad Gad

Trichoscopy is a simple, noninvasive procedure practiced in the diagnosis of a multitude of scalp and hair disorders. Hair shaft abnormalities usually represent a diagnostic challenge to dermatologists.The aim of the study was to determine the practicality, versatility, and value of using the handheld dermoscope in the assessment of hair shaft abnormalities and the diagnosis of different hair/scalp disorders.Eight hundred and seven patients of both sexes, aged from 1 to 76 years, with complaints pertaining to scalp and hair, were the subjects of the study. All patients were examined by the handheld dermoscope, and 400 were additionally examined by the folliscope, digital dermoscope, or their hairs mounted for light microscopy.Based on trichoscopic findings, more than half the patients demonstrated thinned terminal hairs and a predominance of single-haired scalp pilosebaceous units (57% and 55.5%, respectively). Over a quarter of the patients showed hair diameter heterogeneity, upright regrowing hairs, and increased vellus hairs (37%, 31%, and 25%, respectively). Other trichoscopic findings included scalp scaling (19%), hair weathering (12%), thinned wavy hairs (10.5%), brush-like hair fractures (9%), exclamation mark hairs (9%), and longitudinal cleavage (trichoptilosis) (8%). The clinical diagnostic spectrum was topped by the following diagnoses in order of frequency: female pattern hair loss, telogen effluvium, traction alopecia, and trichotillomania. Trichodynia appeared to be significantly associated with numerous hair shaft abnormalities.Most hair shaft abnormalities can be reliably diagnosed with high accuracy using a handheld dermoscope in an office setting. Skillful knowledge of dermoscopy is an important aid in the diagnosis of hair and scalp disorders.

Cross-sectional study

10.1159/000526597

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Citations (3)

Disseminated Cryptococcosis with Cutaneous Lesions

The Journal of Dermatology (1996)

Wedad Z. Mostafa Elia Anis Ishak E. M. Ekladious Heba H. Arnaout

Abstract A case of disseminated cryptococcosis in an HIV‐negative patient presenting with cutaneous lesions is described for the first time in Egypt. The patient, a 16‐year‐old male, presented with cough, expectoration, loss of weight, and cutaneous lesions, mainly on the face and trunk. The lesions consisted of vegetating crusted plaques discharging purulent to sanguinous fluid and flattened, shiny, erythematous to brownish plaques. Anorexia, headache and personality changes soon followed. Histopathological examination of lesions was highly suggestive of a deep mycosis, particularly cryptococcosis. The fulminant disease advanced with central nervous system involvement. The progression was not arrested when systemic antifungal therapy was administered late in the disease course. Pathological examination of lungs, liver, pancreas and spleen revealed disseminated infection with no evidence of other underlying pathology. Disseminated cryptococcosis is a morbid infection, rare in an area where heightened awareness and raised index of suspicion will surely allow earlier diagnosis, management and better prognosis

Fulminant

Anorexia

10.1111/j.1346-8138.1996.tb03999.x

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Citations (6)