DataExpo GAKG DeepReport Navigation

Copyright©2015-2024 Acemap, Inc. Shanghai Jiao Tong University. All rights reserved.

沪ICP备18028330号

FH

Frédéric H.‐T. Allain

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Antoine Cléry

ETH Zurich

Fred F. Damberger

ETH Zurich

Sébastien Campagne

ETH Zurich

Mario Schubert

ETH Zurich

Gunnar Jeschke

ETH Zurich

Maxim Yulikov

ETH Zurich

Alexander Leitner

ETH Zurich

Leonidas Emmanouilidis

ETH Zurich

Christophe Maris

ETH Zurich

Cyril Dominguez

University of Leicester

Cooperative Institutions

ETH Zurich

University of Zurich

École Polytechnique Fédérale de Lausanne

Centre National de la Recherche Scientifique

Board of the Swiss Federal Institutes of Technology

University of Basel

Howard Hughes Medical Institute

Inserm

University of Cambridge

University of California, Los Angeles

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Structures of Large RNA Molecules and Their Complexes

Methods in enzymology on CD-ROM/Methods in enzymology (2015)

Sarah A. Woodson Frédéric H.‐T. Allain

10.1016/s0076-6879(15)x0011-5

Cite

Citations (7)

The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity

Nature Communications (2024)

Lucı́a Álvarez Kevin Haubrich Louisa Iselin Laurent Gillioz Vincenzo Ruscica

10.1038/s41467-024-52918-x

Cite

Citations (2)

Probing the Interactions of Splicing Regulatory Small Molecules and Proteins with U1 snRNP Using NMR Spectroscopy

Methods in molecular biology (2022)

Sébastien Campagne Tebbe de Vries Frédéric H.‐T. Allain

snRNP

Spliceosome

Splicing factor

10.1007/978-1-0716-2521-7_15

Cite

Citations (1)

RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing

Nature Communications (2023)

Ahmed Moursy Antoine Cléry Stefan Gerhardy A Betz Sanjana Rao

Abstract The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus sequence bound to each RRM. High-resolution NMR structures show that RRM2 recognizes a 5´-GNGG-3´ motif leading to an unusual mille-feuille topology. These structures also reveal how RRM1 preferentially interacts with a CC-dinucleotide upstream of this motif, and how the inter-RRM linker and the region C-terminal to RRM2 contribute to cooperative RNA-binding. Structure-guided functional studies show that Npl3 genetically interacts with U2 snRNP specific factors and we provide evidence that Npl3 melts U2 snRNA stem-loop I, a prerequisite for U2/U6 duplex formation within the catalytic center of the B act spliceosomal complex. Thus, our findings suggest an unanticipated RNA chaperoning role for Npl3 during spliceosome active site formation.

snRNP

Spliceosome

Small nuclear RNA

RNA recognition motif

Sequence motif

10.1038/s41467-023-42962-4

Cite

Citations (2)

Solution structure of the RRM of SRp20

Y.F. Hargous Frédéric H.‐T. Allain

10.2210/pdb2i38/pdb

Cite

Citations (0)

Conformation of Polypyrimidine Tract Binding Protein in Solution

Structure (2006)

Maxim V. Petoukhov Tom P. Monie Frédéric H.‐T. Allain Stephen Matthews Stephen Curry

Polypyrimidine tract-binding protein

Polypyrimidine tract

10.1016/j.str.2006.04.005

Cite

Citations (63)

Structure of the SAM domain of Vts1p

Frédéric H.‐T. Allain

10.2210/pdb2es6/pdb

Cite

Citations (0)

Novel three-dimensional 1H?13C?31P triple resonance experiments for sequential backbone correlations in nucleic acids

Journal of Biomolecular NMR (1995)

Gabriele Varani Fareed Aboul‐ela Frédéric H.‐T. Allain C.C. Gubser

Dihedral angle

10.1007/bf00211759

Cite

Citations (32)

Structural basis of the non-coding RNA RsmZ acting as a protein sponge

Olivier Duss Erich Michel Maxim Yulikov Mario Schubert Gunnar Jeschke

Sponge

10.1038/nature13271

Cite

Citations (194)

RNA sequence‐ and shape‐dependent recognition by proteins in the ribonucleoprotein particle

EMBO Reports (2005)

Richard Štefl Lenka Skříšovská Frédéric H.‐T. Allain

RNA recognition motif

RNA Silencing

RNA-induced transcriptional silencing

Ribonucleoprotein particle

Riboswitch

10.1038/sj.embor.7400325

Cite

Citations (178)

More pages