Piotr Laudański

Medical University of Warsaw

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Mirosław Wielgoś

Ministry of Interior and Administration

Jacek Szamatowicz

Medical University of Białystok

Grzegorz Raba

East European State Higher School in Przemyśl

Sławomir Wołczyński

Institute of Animal Reproduction and Food Research

Robert Spaczyński

Medical University of Lodz

Tadeusz Issat

Polish Mother’s Memorial Hospital Research Institute

T Laudański

Medical University of Białystok

Karol Charkiewicz

Medical University of Białystok

Damian Warzecha

Central Clinical Hospital

Piotr Sieroszewski

Medical University of Lodz

Cooperative Institutions

Medical University of Białystok

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Medical University of Warsaw

University Clinical Hospital In Bialystok

University of Białystok

Medical University of Lodz

Jagiellonian University

Medical University of Silesia

University of Tartu

Postgraduate School of Molecular Medicine

Competence Centre on Health Technologies (Estonia)

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Stanowisko Polskiego Towarzystwa Ginekologicznego w sprawie debaty publicznej dotyczącej postulowanych zmian w zakresie prawnej dopuszczalności wykonywania zabiegu przerywania ciąży

Mirosław Wielgoś Dorota Bomba‐Opoń Piotr Laudański Wojciech Rokitaⴕ Robert Spaczyński

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Expression of estrogen receptors alpha and beta in term human myometrium.

PubMed (2004)

Piotr Laudański S Redźko Jerzy Przepieść Mariusz Koda Sławomir Wołczyński

Myometrium

Alpha (finance)

Estrogen receptor alpha

BETA (programming language)

Estrogen receptor beta

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Endometrial receptivity and its relationship with clinical factors in patients with recurrent implantation failure

European Journal of Obstetrics & Gynecology and Reproductive Biology (2024)

Katarzyna Pankiewicz Katarzyna Opuchlik Piotr Pierzyński Tadeusz Issat Piotr Laudański

Implantation failure

Receptivity

10.1016/j.ejogrb.2023.08.254

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Chemokine growth-regulated-α: a possible role in the pathogenesis of endometriosis

Gynecological Endocrinology (2002)

Jacek Szamatowicz Piotr Laudański Iwona M. Tomaszewska M Szamatowicz

AbstractEndometriosis is a common disease in women at reproductive age. We investigated the concentration of neutrophil-activating factor (growth-regulated gene-α; GRO-α) (a member of the chemokine family), in peritoneal fluid of infertile women with or without endometriosis. Peritoneal fluid was obtained laparoscopically from 22 women with and 21 without visible endometriotic lesions. GRO-α concentration was measured by the use of an ELISA kit. Median concentration of GRO-α was 87.65 ± 56.19 pg/ml in the study group and 60.72 ± 11.98 pg/ml in the control group. The distribution of data differed from normal, therefore logarithmic transformation of data was performed. Concentration of GRO-α was significantly higher in the peritoneal fluid of women with endometriosis when compared with controls (p = 0.05). No correlation between concentration of GRO-α, stage of endometriosis, duration of infertility or sex steroid hormone levels was found. The study shows that GRO-α may play a role in the pathogenesis of endometriosis, possibly by chemoattraction and activation of neutrophils present in higher numbers in the peritoneal fluid of women with endometriosis. It is also feasible that the angiogenic properties of GRO-α might prompt the progression of endometriotic lesions.KeywordsENDOMETRIOSIS GRO-ALPHA PERITONEAL FLUID

Peritoneal fluid

Pathogenesis

10.1080/713603033

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Profiling of Selected MicroRNAs in Proliferative Eutopic Endometrium of Women with Ovarian Endometriosis

BioMed Research International (2015)

Piotr Laudański Radosław Charkiewicz Agnieszka Tołwińska Jacek Szamatowicz Angelika Edyta Charkiewicz

It has been well documented that aberrant expression of selected microRNAs (miRNAs) might contribute to the pathogenesis of disease. The aim of the present study is to compare miRNA expression by the most comprehensive locked-nucleic acid (LNA) miRNA microarray in eutopic endometrium of patients with endometriosis and control. In the study we recruited 21 patients with endometriosis and 25 were disease-free women. The miRNA expression profiles were determined using the LNA miRNA microarray and validated for selected molecules by real-time PCR. We identified 1198 human miRNAs significantly differentially altered in endometriosis versus control samples using false discovery rate of <5%. However only 136 miRNAs showed differential regulation by fold change of at least 1.3. By the use of selected statistical analysis we obtained 45 potential pathways that might play a role in the pathogenesis of endometriosis. We also found that natural killer cell mediated cytotoxicity pathway was found to be inhibited which is consistent with previous studies. There are several pathways that may be potentially dysregulated, due to abnormal miRNA expression, in eutopic endometrium of patients with endometriosis and in this way contribute to its pathogenesis.

Pathogenesis

Fold change

10.1155/2015/760698

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Citations (45)

Determination of cathepsins B, D and G concentration in eutopic proliferative endometrium of women with endometriosis by the surface plasmon resonance imaging (SPRI) technique

European Journal of Obstetrics & Gynecology and Reproductive Biology (2013)

Piotr Laudański Ewa Gorodkiewicz Barbara Ramotowska Radosław Charkiewicz Mariusz Kuźmicki

Histopathology

Adenomyosis

Endometrial biopsy

10.1016/j.ejogrb.2013.01.024

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Citations (37)

Pierwotna niewydolność jajników — patogeneza, diagnostyka i leczenie

Ginekologia i Perinatologia Praktyczna (2019)

Gabriela Sosnowska Piotr Laudański

Pierwotna niewydolnośc jajnikow dotyka az 1% kobiet w wieku rozrodczym i jest przyczyną wielu problemow natury zarowno zdrowotnej, jak i psychicznej pacjentek. Na rozwoj tego schorzenia mają wplyw zaburzenia genetyczne, autoimmunologiczne, metaboliczne oraz narazenie na substancje toksyczne, szczegolnie u pacjentek onkologicznych. Istotna jest wczesna diagnostyka oraz identyfikacja podloza problemu, co pozwala szybko i skutecznie wdrozyc hormonalną terapie zastepczą, opracowac plan rozrodu oraz otoczyc pacjentke kompleksową opieką. Konsekwencjami nieleczonej niewydolności jajnikow mogą byc: nieplodnośc, osteoporoza, choroby serca, depresja oraz objawy hipoestrogenizmu obnizające jakośc zycia. W ponizszej pracy zwrocono uwage na aspekty pierwotnej niewydolności jajnikow z zakresu nauk podstawowych i klinicznych opierając sie o aktualną wiedze i rekomendacje ekspertow.

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Effect of short-term, low-dose treatment with tamoxifen in patients with primary dysmenorrhea

Gynecological Endocrinology (2006)

Piotr Pierzyński J Swiatecka Edward Oczeretko Piotr Laudański Satish Batra

Current treatment of painful periods and other symptoms related to primary dysmenorrhea (PD) is usually commenced with non-steroidal anti-inflammatory drugs or oral contraceptives, which fails in about 10% of affected patients. Tamoxifen, a selective estrogen-receptor modulator (SERM), has been demonstrated to directly inhibit uterine contractions, causing improvement in uterine blood flow. It could be considered for application in selected groups of dysmenorrheic patients, for instance carriers of breast cancer-associated antigen (BRCA) genes, breast cancer survivors or women with advanced endometriosis. Thus the aim of the present study was to investigate the effect of short-term treatment with tamoxifen on PD and PD-related symptoms, as well as its direct effect on parameters of intrauterine pressure during the painful menstruation, in a group of dysmenorrheic patients. After two cycles of administration of tamoxifen we noted a significant decrease in bleeding together with reductions in the severity of menstrual cramps, diarrhea, headache, fatigue and anxiety. In intrauterine pressure assessments, tamoxifen significantly decreased propagation of uterine contractions. In conclusion, SERMs such as tamoxifen may constitute a therapeutic option in selected groups of patients, improving dysmenorrheic symptoms. Additionally to its receptor-mediated effects, tamoxifen was shown to exert a direct influence on uterine contractile activity that may explain the decrease of menstrual pain and cramps noted in the studied group.

Menstruation

10.1080/09513590601030233

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Citations (9)

[The role of nitric oxide in carcinogenesis and progression of neoplastic processes].

PubMed (2001)

Piotr Laudański Tomasz Anchim Sławomir Wołczyński

The aim of the review is to outline the current knowledge about the role of nitric oxide in the processes of proliferation and apoptosis in tumor. Special emphasis has been placed on its direct cytotoxic influence on a cell where as a highly active free radical it may compromise different cellular functions. Nitric oxide literature, regarding its role in the pathogenesis of some gynecological and breast cancer has been briefly reviewed.

Pathogenesis

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Eotaxin-2 as a potential marker of preterm premature rupture of membranes: A prospective, cohort, multicenter study

Advances in Clinical and Experimental Medicine (2021)

Grzegorz Raba Marian Kacerovský Piotr Laudański

Background.Despite advances in medicine, there is currently no effective procedure for predicting and the early diagnosis of preterm premature rupture of membranes (pPROM).Objectives.To apply measurements of selected biochemical markers of inflammation for diagnosing cases of pPROM without clinical signs of infection.Materials and methods.This is a prospective cohort study.Three groups were compared, a study group: 82 women between 22 and 37 weeks of pregnancy hospitalized due to pPROM, a control group: 64 women between 22 and 37 weeks of pregnancy in the 1 st stage of preterm labor with intact fetal membranes, and a reference group: 99 women between 37 and 42 weeks of pregnancy in the 1 st stage of physiological term labor and intact fetal membranes.To assess the concentration of cytokines, a multiplex method was used for measurement of: IGFBP-1, IGFBP-2, BDNF, L-selectin, E-selectin, PECAM-1, ICAM-1, and VCAM-1, MIP-1d, MIP-3b, BLC, eotaxin-1, and eotaxin-2.Results.Out of the studied molecules, we found that eotaxin-2 concentrations in the study group were significantly lower than in the control group and the reference group: 9.22 pg/mL compared to 13.76 pg/mL and 14. 14 pg/mL (p = 0.014), respectively.We also showed that serum concentration of eotaxin-2 below 8.24 pg/mL could be used as a cut-off level of pPROM (sensitivity: 0.58; specificity: 0.57).Conclusions.Findings of significant differences in eotaxin-2 can be the basis for further studies on the use of this molecule as a biochemical marker of pPROM.

10.17219/acem/130609

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