Renato Puga

Hospital Israelita Albert Einstein

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Helena Brentani

Universidade de São Paulo

Nelson Hamerschlak

Hospital Israelita Albert Einstein

Paulo Vidal Campregher

Hospital Israelita Albert Einstein

Dirce Maria Carraro

AC Camargo Hospital

Cláudia Malheiros Coutinho‐Camillo

AC Camargo Hospital

Fernando Augusto Soares

AC Camargo Hospital

Tarcila Santos Datoguia

Hospital Israelita Albert Einstein

Welbert Oliveira Pereira

Hospital Israelita Albert Einstein

Ricardo Helman

Hospital Israelita Albert Einstein

Fábio Pires de Souza Santos

Hospital Israelita Albert Einstein

Cooperative Institutions

Universidade de São Paulo

219

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Federal de São Paulo

Hospital Israelita Albert Einstein

Hospital São Paulo

AC Camargo Hospital

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal do Rio Grande do Sul

Universidade Estadual Paulista (Unesp)

Universidade Brasil

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Identifying a biomarker network for corticosteroid resistance in asthma from bronchoalveolar lavage samples

Molecular Biology Reports (2016)

José Eduardo Vargas Bárbara N. Porto Renato Puga Renato T. Stein Paulo Márcio Pitrez

Subnetwork

CCR3

CXCL1

10.1007/s11033-016-4007-x

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Citations (18)

Early Gene Expression Changes in Skeletal Muscle from SOD1G93A Amyotrophic Lateral Sclerosis Animal Model

Cellular and Molecular Neurobiology (2014)

G. P. de Oliveira Jéssica Ruivo Maximino Mariana Maschietto Edmar Zanoteli Renato Puga

10.1007/s10571-014-0029-x

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Citations (30)

Correction: Corrigendum: An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder

Scientific Reports (2016)

Leandro de Araújo Lima Ana Cecília Feio-dos-Santos Síntia Belangero Ary Gadelha Rodrigo A. Bressan

Scientific Reports 6: Article number: 22851; published online: 07 March 2016; updated: 24 May 2016 The Acknowledgements section in this Article is incomplete. “This work was supported by the National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; National Council for Scientific and Technological Development; grant number 573974/2008-0) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; Research Support Foundation of the State of São Paulo; grant number 2008/57896-8).

10.1038/srep25861

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Citations (4)

Analysis of Patterns of Co-Occurrence and Mutual Exclusivity of Gene Mutations in Philadelphia-Negative Myeloproliferative (Ph-negative MPNs) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPNs)

Blood (2017)

Fabio P S Santos Raquel M. Alves‐Paiva Renato Puga Giulliana Ar Goncalves Tarcila Santos Datoguia

Myeloproliferative Disorders

Myeloproliferative neoplasm

10.1182/blood.v130.suppl_1.2934.2934

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Identification of Gene Networks Associated with the Anti-Leukemic Effect of Anti-Inflammatory Drugs on Acute Myeloid Leukemia Cell Lines

Blood (2021)

Victória Tomaz Karina Griesi‐Oliveira Renato Puga Fábio Pires de Souza Santos Nelson Hamerschlak

Prednisolone

Nimesulide

Propidium iodide

10.1182/blood-2021-153903

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Gene expression profile of stromal cells from potential metastatic sites in breast cancer patients

BMC Proceedings (2013)

Paulo Roberto Del Valle Maria LH Katayama Dirce Maria Carraro Renato Puga Eduardo Carneiro de Lyra

Methods Fibroblasts primary culture was established from 11 breast cancer patients. Expression analysis was evaluated in PT (n=4), N+ (n=3) and BM (n=4) through a customized cDNA microarray platform (4,800 ORESTES) analyzed by SAM (TMEV; FDR 0%) and functional analysis was performed using DAVID. Technical validation was performed in 6 samples and biological validation was performed in fibroblasts obtained from others 25 patients as evaluated by RT-qPCR.

10.1186/1753-6561-7-s2-p54

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Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Oxidative Medicine and Cellular Longevity (2019)

Cristiano Trindade André Luiz Mendes Juchem Temenouga Nikolova Guecheva Iuri Marques de Oliveira Priscila dos Santos Silveira

Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.

Tellurium

10.1155/2019/2510936

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Citations (8)

Messenger RNA expression of Pabpnl1 and Mbd3l2 genes in oocytes and cleavage embryos

Fertility and Sterility (2009)

Fernando H. Biase Lúcia Martelli Renato Puga Silvana Giuliatti Weruska Karyna Freitas Santos-Biase

Embryo quality

In vitro maturation

10.1016/j.fertnstert.2009.08.051

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Citations (10)

Correction: Poly (A)⁺Transcriptome Assessment of ERBB2-Induced Alterations in Breast Cell Lines

PLoS ONE (2011)

Dirce Maria Carraro Elisa Napolitano Ferreira Gustavo de Campos Molina Renato Puga Eduardo F. Abrantes

10.1371/annotation/b8888ae6-e402-43af-a425-6fd5e58deef6

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Citations (1)

Co-expression network of neural-differentiation genes shows specific pattern in schizophrenia

BMC Medical Genomics (2015)

Mariana Maschietto Ana Carolina Tahira Renato Puga Leandro de Araújo Lima Daniel Mariani

Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism is unknown due to the difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was to find neuronal differentiation genes disrupted in schizophrenia and to evaluate those genes in post-mortem brain tissues from schizophrenia cases and controls. We analyzed differentially expressed genes (DEG), copy number variation (CNV) and differential methylation in human induced pluripotent stem cells (hiPSC) derived from fibroblasts from one control and one schizophrenia patient and further differentiated into neuron (NPC). Expression of the DEG were analyzed with microarrays of post-mortem brain tissue (frontal cortex) cohort of 29 schizophrenia cases and 30 controls. A Weighted Gene Co-expression Network Analysis (WGCNA) using the DEG was used to detect clusters of co-expressed genes that werenon-conserved between adult cases and controls brain samples. We identified methylation alterations potentially involved with neuronal differentiation in schizophrenia, which displayed an over-representation of genes related to chromatin remodeling complex (adjP = 0.04). We found 228 DEG associated with neuronal differentiation. These genes were involved with metabolic processes, signal transduction, nervous system development, regulation of neurogenesis and neuronal differentiation. Between adult brain samples from cases and controls there were 233 DEG, with only four genes overlapping with the 228 DEG, probably because we compared single cell to tissue bulks and more importantly, the cells were at different stages of development. The comparison of the co-expressed network of the 228 genes in adult brain samples between cases and controls revealed a less conserved module enriched for genes associated with oxidative stress and negative regulation of cell differentiation. This study supports the relevance of using cellular approaches to dissect molecular aspects of neurogenesis with impact in the schizophrenic brain. We showed that, although generated by different approaches, both sets of DEG associated to schizophrenia were involved with neocortical development. The results add to the hypothesis that critical metabolic changes may be occurring during early neurodevelopment influencing faulty development of the brain and potentially contributing to further vulnerability to the illness.

DISC1

Human brain

10.1186/s12920-015-0098-9

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Citations (50)