Stéphanie Brette

Centre de Recherche en Économie et Statistique

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Stéphane Lafitte

Centre Hospitalier Universitaire de Bordeaux

Patricia Réant

Université de Bordeaux

Raymond Roudaut

Centre Hospitalier Universitaire de Bordeaux

H Douard

Centre Hospitalier Universitaire de Bordeaux

Pierre Dos Santos

Université de Bordeaux

Marianne Lafitte

Université de Bordeaux

Jacques Clémenty

Hôpital Cardiologique du Haut-Lévêque

R. Roudaut

Hôpital Cardiologique du Haut-Lévêque

R Roudaut

Centre Hospitalier Universitaire de Bordeaux

Frédéric Sacher

Université de Bordeaux

Cooperative Institutions

Hôpital Cardiologique du Haut-Lévêque

Centre Hospitalier Universitaire de Bordeaux

Inserm

Université de Bordeaux

Lille’s Cardiology Hospital

Electrophysiology and Heart Modeling Institute

Centre de Recherche Cardio-Thoracique de Bordeaux

Bordeaux Population Health

Centre Hospitalier Universitaire d'Angers

Université d'Angers

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08-75 - LONGITUDINAL LEFT VENTRICULAR DYSFUNCTION PRECEDES RADIAL DYSFUNCTION IN THE TIME COURSE OF SYSTOLIC HEART FAILURE: A VECTOR VELOCITY IMAGING STUDY

Rachid Elbelghiti Stéphane Lafitte Patricia Réant Hasna Belghiti Stéphanie Brette

Systole

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[Thrombosis of valvular prostheses: the role of medical treatment].

Archives des maladies du coeur et des vaisseaux (2006)

Raymond Roudaut M E Lorient-Roudaut Sophie Lafitte Stéphanie Brette

Thromboses of valvular prostheses represent a rare but serious complication for mechanical valves, and are sometimes fatal. Obstructive thromboses present an immediate threat to life, while the more common, more insidious, non-obstructive thromboses are essentially manifested by thrombo-embolic events. These thromboses often occur at times of insufficient anticoagulation, especially during the first post-operative year and during treatment breaks for non-cardiac surgery, an increasingly common situation. The therapeutic management of an 'obstructive' thrombosis is above all surgical. However, fibrinolysis represents an effective alternative, although it does present a not insignificant risk of systemic embolism (in the order of 10 to 15%). The main indications for fibrinolysis are thromboses of right heart valves, and for left heart prostheses, patients in a very unstable haemodynamic state, remoteness from a cardiac surgery centre, any surgical contraindications, and cases where a large thrombus has been excluded by trans-oesophageal ultrasound. In cases of contraindications to both surgery and fibrinolysis, treatment with heparin might be proposed, but without any great hopes of completely unblocking the prosthesis. Treatment of a 'non-obstructive' thrombosis is primarily medical: optimising anticoagulation with intravenous heparin, or even the addition of aspirin. When the thrombus is large and mobile, surgery should be envisaged if medical treatment fails.

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[Cardiac manifestations of laminopathies].

PubMed (2004)

Stéphanie Brette I. Pénisson-Besnier Dupuis Jm Gisèle Bonne J Victor

Dilated cardiomyopathy (DCM) of genetic origin represents about 25% of all so-called primary DCM. Cases due to mutation of the gene which codes the lamins A and C (LMNA) carry a poor prognosis with a high risk of sudden death. The finding of primary DCM in a young person associated with conduction defects or arrhythmias should lead to investigation for mutation of the gene of lamins A and C, even in the absence of a suggestive family history. The authors report 5 cases of DCM, with and without associated skeletal muscular disease, due to laminopathies.

LMNA

Dilated Cardiomyopathy

Emerin

Sudden Death

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Additional benefit of exercise training in patients with cardiac resynchronization therapy

European Journal of Cardiovascular Prevention & Rehabilitation (2006)

M. Courregelongue Pierre Bordachar Stéphanie Brette Stéphane Lafitte R Roudaut

Exercise therapy

10.1097/00149831-200605001-00376

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Hématome intrapariétal aortique

Journal of Thoracic and Cardiovascular Surgery (2006)

Raymond Roudaut Stéphane Lafitte Stéphanie Brette V. Latrabe

10.1684/mtc.2006.0004

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Automated function imaging: a new operator-independent strain method for assessing left ventricular function

Archives of cardiovascular diseases (2008)

H. Belghiti Stéphanie Brette Stéphane Lafitte Patricia Réant Fabienne Picard

Cardiac Imaging

Ventricular Function

Speckle tracking echocardiography

10.1016/s1875-2136(08)71798-4

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Citations (129)

Abstract 1843: Automated Function Imaging (AFI): A New Onboard and Clinically Applicable Method of LV Global Function Assessment by Speckle Tracking.

Circulation (2006)

Stéphanie Brette Stéphane Lafitte Patricia Réant Marianne Lafitte Hans Hurger Goldsmith

Tracking (education)

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An Ultrasound Speckle Tracking (Two-Dimensional Strain) Analysis of Myocardial Deformation in Professional Soccer Players Compared With Healthy Subjects and Hypertrophic Cardiomyopathy

The American Journal of Cardiology (2007)

Viviane Richand Stéphane Lafitte Patricia Réant Karim Serri Marianne Lafitte

Strain (injury)

Tracking (education)

10.1016/j.amjcard.2007.02.063

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Does abdominal obesity have a similar impact on cardiovascular disease and diabetes? A study of 91 246 ambulant patients in 27 European Countries

European Heart Journal (2009)

Keith A.A. Fox Jean‐Philippe Després A Richard Stéphanie Brette John Deanfield

Differences in cardiovascular risk factors across Europe provide an opportunity to examine the impact of adiposity on the frequency of diabetes and cardiovascular disease (CVD).The International Day for Evaluation of Abdominal obesity (IDEA) study evaluated the prevalence of abdominal obesity, elevated body mass index (BMI), and other cardiometabolic risk factors among primary care patients. Abdominal obesity predicted increased diabetes risk, despite socio-economic, demographic, and risk factor differences. Cardiovascular disease was at least two-fold more frequent in Eastern Europe vs. Northwest Europe (P < 0.0001) and 2.5-fold more vs. Southern Europe (P < 0.0001). Waist circumference (WC) predicted increased (P < 0.0001) age- and BMI-adjusted risks of CVD and diabetes. In women, odds ratios (95% confidence intervals) for CVD per 1 SD increase in WC were: Northwest Europe 1.28 (1.18-1.40); Southern Europe 1.26 (1.16-1.37); and Eastern Europe 1.10 (1.03-1.18). Values for diabetes were 1.72 (1.58-1.88), 1.45 (1.35-1.56), and 1.59 (1.46-1.73), with similar findings in men.Abdominal obesity impacted similarly on the frequency of diabetes across Europe, despite regional differences in cardiovascular risk factors and CVD rates. Increasing abdominal obesity may offset future declines in CVD, even where CVD rates are lower.

Abdominal obesity

10.1093/eurheartj/ehp371

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Citations (60)

04-40 - IMPROVEMENT OF LEFT VENTRICULAR DEFORMATION AFTER CATHETER ABLATION FOR ISOLATED PAROXYSMAL ATRIAL FIBRILLATION IN PATIENTS WITH NORMAL EJECTION FRACTION: A 2D STRAIN STUDY

Circulation (2007)

Patricia Réant Stéphane Lafitte Pierre Jaı̈s Frédéric Sacher Nicolas Derval

Background: Paroxysmal isolated atrial fibrillation (AF) is generally associated with normal left ventricular (LV) ejection fraction. Recently, echocardiographs have been implemented by 2-dimensional (2D) strain technique, a new tool based on speckle tracking which allows accurate evaluation of the three components of LV deformation (circumferential, radial and longitudinal strains). Objective: The aim of this prospective study was to evaluate whether 2D strain evaluation could point out alteration of LV deformation in patients with paroxysmal AF and normal ejection fraction in comparison with controls; to evaluate the evolution of the different strain components after AF catheter ablation. Methods: Patients with isolated paroxysmal AF were investigated with a VIVID7 (General Electric) before ablation, at 1 month (M+1) and at 6 month (M+6) after catheter ablation. Statistical analysis was performed with a paired Student t-test. Results: Thirty consecutive patients (mean 56.8 ± 12.7 years, 6 women) with isolated paroxysmal AF (since mean 9.3 years) and 30 controls were investigated. Before ablation, no significant difference was observed in term of LV ejection fraction between the 2 groups (p ns). In patients with paroxysmal AF, global longitudinal strain (GLS) and global circumferential strain (GCS) were significantly reduced compared to controls: GLS was −17.7 ± 2.4% vs −21.8 ± 2.2% in controls (p Conclusions: Paroxysmal AF induced subclinical LV dysfunction as demonstrated by the decrease in longitudinal and circumferential strains in patients with normal ejection fraction. In our patients, these parameters of LV dysfunction were improved after AF catheter ablation.

Paroxysmal atrial fibrillation

Subclinical infection

Strain (injury)

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