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Fatemeh Moradi

Iran University of Medical Sciences

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Mohammad Taghi Joghataei

Iran University of Medical Sciences

Ronak Shabani

Iran University of Medical Sciences

Mehdi Mehdizadeh

Iran University of Medical Sciences

Auob Rustamzadeh

Qazvin University of Medical Sciences

Mohammad Reza Vaez Mahdavi

Shahed University

Malihe Tabarrai

Tehran University of Medical Sciences

Rafieh Alizadeh

Tehran University of Medical Sciences

Fatemeh Nejatbakhsh

Tehran University of Medical Sciences

Mehrdad Bakhtiyari

Iran University of Medical Sciences

Parichehr Pasbakhsh

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

Iran University of Medical Sciences

University of Tehran

Shahid Beheshti University of Medical Sciences

Tarbiat Modares University

Shiraz University of Medical Sciences

Isfahan University of Medical Sciences

Iranshahr University

Islamic Azad University, Tehran

Shahid Beheshti University

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Methods of preparation of egg and therapeutic uses: a review perspective of Persian Medicine

Food and Health (2020)

Fatemeh Moradi Malihe Tabarra Fatemeh Nejatbakhsh

10.53388/fthc202002004

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Cell therapy in spinal cord injury: a mini- reivew.

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Soraya Mehrabi Sanaz Eftekhari Fatemeh Moradi Hamdollah Delaviz Bagher Pourheidar

Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, our more recent strategy was application of cytokines. We observed a significant improvement in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI.

Olfactory ensheathing glia

Stem Cell Therapy

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Citations (8)

TO STUDY OF THE EXECUTION ROLE OF REGION ORIENTED PLAN OF TEHRAN MUNICIPALITY OVER SUSTAINABLE DEVELOPMENT OF NEIGHBORHOOD

Shaali Jafar Mirzaeian Katayoon Fatemeh Moradi

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Human Olfactory Ecto-mesenchymal Stem Cells Displaying Schwann-cell-like Phenotypes and Promoting Neurite Outgrowth in Vitro

Basic and Clinical Neuroscience Journal (2021)

Maedeh Entezari Mehrdad Bakhtiari Fatemeh Moradi Masoud Mozafari Zohreh Bagher

Strategies of Schwann cell (SC) transplantation for regeneration of peripheral nerve injury involve many limitations. Stem cells can be used as alternative cell source for differentiation into Schwann cells. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ectomesenchymal stem cells (OE-MSCs) derived from neural crest can spontaneously differentiate into SC lineage.OE-MSCs were isolated from human nasal mucosa and characterized by the mesenchymal and neural crest markers. The cells were cultured in glial growth factors-free medium and further investigated in terms of the phenotypic and functional properties.Immunocytochemical staining and real-time PCR analysis indicated that the cultured OE-MSCs expressed SCs markers, SOX10, p75, S100, GFAP and MBP, differentiation indicative. It was found that the cells could secrete neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Furthermore, after co-cultured with PC12, the mean neurite length was enhanced by OE-MSCs.The findings indicated that OE-MSCs could be differentiated spontaneously into SC-like phenotypes, suggesting their applications for transplantation in peripheral nerve injuries.

Neurite

Schwann cell

Olfactory mucosa

10.32598/bcn.2021.3542.1

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Evaluation of the Functional Recovery in Sciatic Nerve Injury following the Co-transplantation of Schwann and Bone Marrow Stromal Stem Cells in Rat.

Sam Zarbakhsh Fatemeh Moradi Mohammad Taghi Joghataei Mehrdad Bahktiari Korosh Mansouri

Transplantation of bone marrow stromal cells (BMSCs) or Schwann cells (SCs) can increase axonal regeneration in peripheral nerve injuries. Based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury. We pursued to evaluate the effects of BMSCs and SCs co-transplantation on the functional recovery after sciatic nerve injury in rat.In this experimental research, adult male Wistar rats (n = 32, 250-300g) were used, BMSCs and SCs were cultured, and the SCs were confirmed with anti S100 antibody. Rats were randomly divided into 4 groups (n = 8 in each group): 1-control group: silicon tube filled with fibrin gel without cells; 2-BMSCs group: silicon tube filled with fibrin gel seeded with BMSCs; 3-SCs group: silicon tube filled with fibrin gel seeded with SCs and 4-co-transplantation group: silicone tube filled with fibrin gel seeded with BMSCs and SCs. The left sciatic nerve was exposed, a 10 mm segment removed, and a silicone tube interposed into this nerve gap. BMSCs and SCs were transplanted separately or in combination into the gap. BMSCs were labeled with anti-BrdU and SCs were labeled with DiI. After 12 weeks electromyographic and functional assessments were performed and analyzed by one-way analysis of variance (ANOVA).Electromyographic and functional assessments showed a significant difference between the experimental groups and controls. Electromyography measures were significantly more favourable in SCs transplantation group as compared to BMSCs transplantation and co-transplantation groups (p < 0.05). Functional assessments showed no statistically significant difference among the BMSCs, SCs and co-transplantation groups (p < 0.05).Transplantation of BMSCs and SCs separately or in combination have the potential to generate functional recovery after sciatic nerve injury in rat. The electromyography evaluation showed a greater improvement after SCs transplantation than BMSCs or the co-transplantation of BMSCs and SCs.

Sciatic nerve injury

Peripheral nerve injury

Schwann cell

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Citations (13)

Rosuvastatin attenuates total-tau serum levels and increases expression of miR-124-3p in dyslipidemic Alzheimer's patients: a historic cohort study

Metabolic Brain Disease (2024)

Farnoosh Usefi Auob Rustamzadeh Zahra Ghobadi Nader Sadigh Nafiseh Mohebi

10.1007/s11011-024-01371-2

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Tree detection using UAV based imagery system based on Random Forest classification

Fatemeh Moradi Farhad Samadzadegan Farzaneh Dadrass Javan Ahmad Toosi

Recent advances in remote sensing have provided access to UAV aerial imagery, among different sensors mountable on UAVs optical cameras are the most cost-effective ones. Therefore, in this study, an optical camera is used to extract the class of trees from other urban features. Two sets of data are used, the first area has an area of 3.07 hectares and a GSD of 2.23cm, and the second one has an area of 104.5 hectares and a GSD of 8.75cm. The classification is done in two cases using Random Forest, in the first case we use only the visible image and the feature vectors extracted from it. In the second scenario, considering that both study sites are related to urban areas and the land is almost flat, in addition to the image, DSM is also used as a feature vector. The results show that with the addition of the digital surface model (DSM) the total accuracy of the classification compared to only visible data in the two study areas increases by about 16 and 12 percent, respectively, and reaches 93 and 90 percent. In the second part of the article, we examine the effect of reducing feature space using PCA and compare it with the situation in which all features are used for classification. According to the results, if all the extracted features are used, the processing time will increase and the total accuracy will decrease due to the dependencies in some feature spaces.

Feature (linguistics)

Feature vector

Tree (set theory)

Contextual image classification

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Human Umbilical Cord Mesenchymal Stem Cells Differentiated into Neuron-Like Cells via Laminin and Schwann Cells

Archives of Iranian Medicine (2021)

F Javanmard Morteza Koruji Fatemeh Moradi Mohammad Reza Kochakian Seyed Akbar Moosavi

Human umbilical cord mesenchymal stem cells (hUMSCs) have been considered to repair damaged tissues and cells. This study aims to investigate the differentiation efficiency affected by Schwann cells (SCs) and laminin and also compare them to other strategies using chemicals or growth factors.SCs and hUMSCs were separated from dorsal root ganglion of rats and newborn human umbilical cords (hUCs), respectively, and then cultured. The marker expressions of mesenchymal stem cells (MSCs), hematopoietic and endothelial for hUMSCs were confirmed by flow cytometry. The hUMSCs were cultured in four groups: 1) control, 2) co-culture with SCs (C), 3) laminin (L), and 4) co-culture with SCs treated by laminin (CL). The expression of protein and gene-related differentiation NSE, MAP2 and β-tubulin were examined by real-time polymerase chain reaction (PCR) and immunocytochemistry after 12 days.The flow cytometry analysis revealed high expression of mesenchymal and low expression of hematopoietic and endothelial markers, where the SCs expressed S100 at a high level (97.4%±2.25). The expression of NSE, MAP2 and β-tubulin increased significantly in the C, L and CL groups compared to the control group (P<0.001), where the CL group had the highest expression among the groups [7.59±0.126, 7.87±0.191, 6.36±0.420, respectively, (P<0.01)]. Also, the expression of neural proteins was significantly increased in tested groups in comparison to the control group.Combined laminin and SCs co-culturing with hUMCSs could be the most effective strategy for neural differentiation.

Cord lining

10.34172/aim.2021.78

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Explaining the Components of Reflective Thinking Based on Fuzzy Topsis Analysis

Strategies for Policy in Science and Education-Strategii na Obrazovatelnata i Nauchnata Politika (2022)

Fatemeh Moradi Lida Mousavi Sedigheh Hosseini

Reflective thinking paradigm contains a set of trainings based on the pattern of mental tools and it helps its users to be able to present the educational materials in a framework that embraces the nature of thinking, various learning activities and the learning based on reflective, creative and critical forms of thinking. Reviewing of the related literature shows that most of the challenges are due to learning and learning-related factors. Accordingly, the present study examines the thinking level of senior postgraduate engineering students of Shahre- Rey University. For this purpose, the Reflective Thinking Questionnaire (RTQ) developed by Kember et al. (2000) was used. TOPSIS method was used to evaluate the thinking level of the subjects. The results showed that habitual action, which is one of the skills of reflective thinking, is ranked first and perception is ranked last, which means that the senior postgraduate engineering students learn superficially. It is suggested to ask professors and teachers to hold classes that train reflective thinking skills, so that they can be a good and appropriate model of using reflective thinking skills for their students. So that students can improve their thinking levels and succeed in their math problems solving and these learners have good academic progress.

Reflective thinking

10.53656/str2022-2-6-exp

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Comparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats.

Arash Sarveazad Mehrdad Bakhtiari Asrin Babahajian Atusa Janzade Ali Fallah

Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injection of Chondroitinase ABC. Aim of present study was to answer to this question: which one is more efficient for Improvement of locomotor recovery after SCI in rat? Transplantation of hADSCs or injection of ChABC.

Glial scar

Cresyl violet

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Citations (22)