Munenori Nagao

Tohoku Medical and Pharmaceutical University Hospital

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Chikashi Shibata

Tohoku Medical and Pharmaceutical University Hospital

Michiaki Unno

Tohoku University

Kazuhiro Watanabe

Tohoku University

Takeshi Naitoh

Kitasato University

Kouhei Fukushima

Aishin Memorial Hospital

Shinobu Ohnuma

Tohoku University

Iwao Sasaki

Ministry of Health Labour and Welfare

Yuji Funayama

Sendai Red Cross Hospital

Fuyuhiko Motoi

Yamagata University

Hiroaki Musha

Yamagata University

Cooperative Institutions

Tohoku University

149

Tohoku University Hospital

Tohoku Medical and Pharmaceutical University

Tohoku Medical and Pharmaceutical University Hospital

Kyoto University

Tochigi Medical Center

Hokkaido University

Tohoku Rosai Hospital

The University of Tokyo

Tohoku Medical Megabank Organization

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Correction: Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease

PLoS ONE (2019)

Hirofumi Chiba Yoichi Kakuta Yoshitaka Kinouchi Yosuke Kawai Kazuhiro Watanabe

[This corrects the article DOI: 10.1371/journal.pone.0194036.].

10.1371/journal.pone.0212148

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Citations (9)

A Case of Chronic Intestinal Pseudo-Obstruction Secondary to Primary Amyloidosis

The Japanese Journal of Gastroenterological Surgery (2009)

Manabu Sato Chikashi Shibata Terutada Kobayashi Tatsuya Ueno Makoto Kinouchi

短期間で増悪した原発性アミロイドーシスに伴う続発性慢性偽性腸閉塞症（secondary chronic intestinal pseudo-obstruction；以下，Secondary CIP）を経験した．症例は56歳の男性で，2004年より腹部膨満感が出現し近医で特発性CIPと診断された．2005年初めより症状が増悪したため，イレウスチューブを5か月間以上留置するも改善せず，2006年に当科紹介・入院となった．イレウスチューブから連日2,000 ml以上の排液を認め，イレウスチューブの再挿入時に十二指腸穿孔が疑われ緊急手術となった．術中所見では十二指腸損傷は同定できなかったが，Treitz靭帯から回盲弁の口側100 cmまでの小腸の著明な拡張，腸管壁の脆弱化が認められたため，小腸を約300 cm切除し，空腸瘻を作成した．病理組織学的検査所見で原発性アミロイドーシスに続発するCIPの診断となったが，術後半年で原病死した．原発性アミロイドーシスに伴うCIPは予後不良であり，対処療法しかないのが現状である．

Primary (astronomy)

Intestinal pseudo-obstruction

10.5833/jjgs.42.551

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Citations (2)

A Case Report: Repeat Ileal Pouch-anal Anastomosis in a Patients with Severe Ulcerative Colitis Complicated with Intractable Perianastomotic Abscess

The Japanese Journal of Gastroenterological Surgery (2007)

Yuji Funayama Munenori Nagao Kouhei Fukushima Chikashi Shibata Takayuki Mizoi

回腸肛門吻合術後に難治性吻合部膿瘍を合併したため, 回腸J嚢を再造設し, 回腸肛門再吻合を行った重症潰瘍性大腸炎の1例を経験し, 良好な結果を得たので報告する. 症例は32歳の男性で, 重症潰瘍性大腸炎に対し分割的回腸肛門吻合術を施行したが, ストーマ閉鎖前の回腸.造影にて吻合部周囲に筋筒内膿瘍(cuff abscess)形成が認められた. 難治性のため吻合部の掻爬, 膿瘍ドレナージ, 筋筒部分切除, 再吻合を3度にわたり行ったが, 改善が見られないため, 吻合部を含む回腸J嚢切除と新J嚢回腸肛門再吻合を行った. 術後経過は良好で回腸ストーマ閉鎖後は, 夜間のsoilingはあるもののほぼ満足すべき排便機能を保っている.

Cuff

Pouch

Ileostomy

10.5833/jjgs.40.752

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[Multidisciplinary Treatment for Squamous Cell Carcinoma of the Anal Canal].

PubMed (2017)

Hideaki Karasawa Shinobu Ohnuma Kazuhiro Watanabe Takahiro Tsuchiya Hirofumi Imoto

Chemoradiotherapy(CRT)has been recognized as a standard treatment for locoregional squamous cell carcinoma of the anal canal in Western countries. However, surgery had historically been considered as a standard treatment and there are only a few reports on CRT for anal canal cancer in Japan. In this study, we analyzed medical records of 5 anal canal cancer patients treated with CRT in our hospital between 2005 and 2015. Patients' characteristics were as follows: median age, 70 years (range 42-80 years); male/female, 1/4; and clinical Stage I / III a/ III b, 3/1/1. The regimens of chemotherapy were MMC plus 5-FU in 4 patients and CDDP in 1 patient. The median follow-up period was 30 months(range, 6 to 100 months). After CRT, 4 patients achieved complete response. The other patient with partial response underwent salvage surgery. All patients were alive without recurrence. In conclusion, our retrospective study showed that CRT is considered to be a standard treat- ment for anal canal cancer.

Chemoradiotherapy

Medical record

Anal Carcinoma

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[A Case of Undifferentiated Carcinoma of the Sigmoid Colon That Responded to Paclitaxel and Carboplatin Chemotherapy].

PubMed (2016)

Shingo Toyama Katsuyoshi Kudoh Shinobu Ohnuma Satoko Sato Naoki Tanaka

We report a case of a 72-year-old woman who was initially diagnosed with ovarian cancer with peritoneal carcinomatosis. Systemic chemotherapy consisting of paclitaxel and carboplatin(TC)was administered. Although a partial response(PR)was achieved after the 4 courses of TC, this regimen was discontinued due to severe adverse events. Ten months after discontinuation of TC, because abdominal CT and colonoscopy showed an intra-tumoral abscess caused by invasion of the tumor to the sigmoid colon, abdominal total hysterectomy, bilateral salpingo-oophorectomy, and a Hartmann's operation were performed to control the disease symptoms. Pathological examination revealed that the tumor was an undifferentiated carcinoma of the sigmoid colon. This case report suggests that the TC regimen may be effective for treating undifferentiated carcinoma of the colon.

Carboplatin

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Citations (1)

Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by <i>Serratia marcescens</i>: A Case Report and Literature Review

Internal Medicine (2021)

Akane Suzuki Shori Abe Kaori Koyama Shinju Suzuki Munenori Nagao

Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). An 85-year-old man presented with pancytopenia and skin lesions, and the bone marrow exhibited 79.6% CD4+, CD56+, CD123+, and TCL-1+ abnormal cells, with a normal karyotype; he was thus diagnosed with BPDCN. While being followed without chemotherapy, he was admitted due to sepsis induced by Serratia marcescens, which was successfully treated with antibiotics. Notably, his blood cell counts improved, and the skin lesions disappeared. To our knowledge, this is the first reported case of spontaneous regression of BPDCN with a decrease in tumor cells in the bone marrow following sepsis.

10.2169/internalmedicine.5820-20

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Citations (5)

[A Case of Leiomyosarcoma of the Small Intestine with Intestinal Hemorrhage Due to Intraluminal Penetration].

PubMed (2017)

Takahiro Tsuchiya Naoki Tanaka Munenori Nagao Kazuhiro Watanabe Hirofumi Imoto

A 40-year-old man was referred to our hospital because of severe anemia and small intestinal tumor revealed by computed tomography. The enteroscopy exam showed the intraluminal penetration of the tumor, which was considered as a cause of anemia. Although emergency operation was performed laparoscopically, intraoperative findings indicated tumor invasion into peritoneum, and we converted from laparoscopic surgery to open surgery that included concomitant peritoneum resection. Histopathological findings showed spindle-shaped tumor cells with severe atypia. Immunohistochemical study showed tumor cells to be positive for aSMA, but negative for c-kit and CD34, then we diagnosed the tumor as leiomyosarcoma of the ileum. Since leiomyosarcoma of the small intestine is a rare entity, we have reported with literature consideration.

Concomitant

Jejunum

Atypia

Enteroscopy

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Citations (0)

Effects of Calcitonin Gene-Related Peptide on Colonic Motility and Defecation in Conscious Dogs

Journal of Gastrointestinal Surgery (2018)

Tomoyuki Ono Munenori Nagao Hirofumi Imoto Kazuhiro Watanabe Naoki Tanaka

10.1007/s11605-018-3858-y

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