Joseba Oyarbide

Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

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J. M. Aizpurua

University of the Basque Country

Raluca M. Fratila

Instituto de Nanociencia y Materiales de Aragón

NÁ

Noelia Álvarez

Tecnalia

Patxi Azpiroz

Euskadiko Parke Teknologikoa

I. Braceras

Tecnalia

Nerea Briz

Tecnalia

Enrique Ipiñazar

Tecnalia

Eva Balentová

University of the Basque Country

Claudio Palomo

University of the Basque Country

Azucena Jiménez

Universidad de Oviedo

Cooperative Institutions

University of the Basque Country

Tecnalia

Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

University of Zurich

Euskadiko Parke Teknologikoa

Centre National de la Recherche Scientifique

University of Twente

Centro de Investigaciones Biológicas Margarita Salas

Ayuntamiento de San Sebastián

CIC biomaGUNE

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Cyclic RGD β‐Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells

ChemBioChem (2011)

J. M. Aizpurua José Ignacio Ganboa Claudio Palomo Iraida Loinaz Joseba Oyarbide

RGD peptidomimetics touch DNA: A few RGD cyclic peptidomimetics, each incorporating a densely substituted β-lactam moiety, were prepared, and their effect on extracellular adhesion and intracellular gene regulation through αVβ3 integrin was studied in human endothelial cells (HUVECs). Surprisingly, the cyclic tetrapeptide with a deleted glycine residue and its parent RGD peptidomimetic displayed practically opposite angiogenic gene-regulation activity.

Peptidomimetic

Tetrapeptide

RGD motif

Moiety

10.1002/cbic.201000572

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Citations (18)

Plasma Polymerized Silylated Ciprofloxacin as an Antibiotic Coating

Plasma Processes and Polymers (2011)

I. Braceras Patxi Azpiroz Nerea Briz Raluca M. Fratila Joseba Oyarbide

Abstract Locally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e.g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating using N,O‐bis‐tert‐butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa , and S. aureus . magnified image

Plasma polymerization

10.1002/ppap.201000160

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Citations (11)

Fabrication and Characterization of a Novel Bioactive Poly(ether-ether-ketone) Scaffold for Bone Tissue Engineering (Poster)

Loughborough University Institutional Repository (Loughborough University) (2015)

Beatriz Olalde Joseba Oyarbide Ana Ayerdi Patxi Azpiroz Ruben Fernandez

Polyether ether ketone

Characterization

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Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics

Organic Letters (2006)

Claudio Palomo J. M. Aizpurua Eva Balentová Azucena Jiménez Joseba Oyarbide

Ring opening of α-substituted-α-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure α,α'-disubstituted β-lactam scaffolds, novel types of ditopic reverse turn surrogates. The procedure is general, short, and high yielding and starts from handy α-substituted serinates and α-amino acid derivatives.

Enantiopure drug

Peptidomimetic

Alpha (finance)

Lactam

BETA (programming language)

10.1021/ol0626241

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Citations (51)

“Plasma‐Click” Based Strategy for Obtaining Antibacterial Surfaces on Implants

Plasma Processes and Polymers (2013)

I. Braceras Joseba Oyarbide Patxi Azpiroz Nerea Briz Enrique Ipiñazar

Abstract Biomaterials with surface antibacterial properties are promising components for medical implants that might provide an alternative to conventional systemic antibiotic treatments. Herein is reported a general method, based on plasma polymerization techniques, to promote the formation of “clickable surfaces” which can be conjugated with chemically modified antibiotics (e.g., azido‐vancomycin) under very mild conditions. The procedure is comprised of three operations: (i) surface alkylcarboxylation with acrylic acid/CO 2 plasma, (ii) alkyne functionalization by condensation with propargylamine, and (iii) in situ Cu(I)‐catalyzed alkyne–azide conjugation with azidovancomycin. The antibacterial activity of the resulting functionalized surfaces has been assessed against Staphylococcus epidermidis . magnified image

Surface Modification

Alkyne

Biomaterial

Plasma polymerization

10.1002/ppap.201200058

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Citations (15)